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11.发明申请GENETICALLY ENGINEERED MICROBIAL STRAINS INCLUDING CHLORELLA PROTOTHECOIDES LIPID PATHWAY GENES 有权遗传工程微生物菌株，包括氯霉素原生质体脂肪道路基因公开(公告)号：US20140178950A1
公开(公告)日：2014-06-26
申请号：US14099704
申请日：2013-12-06
Applicant: Solazyme, Inc.
Inventor： Scott Franklin , Shane Brubaker , George N. Rudenko , Riyaz Bhat , Matthew Shoa-Azar , Aravind Somanchi , Aren Ewing
IPC: C12P7/64
CPC classification number: C12P7/6463 , C12N15/52
Abstract: Genetically engineered microbial, e.g., Chlorella protothecoides, cells producing microbial oils are useful as a food additive and a source of renewable fuels and industrial chemicals. Lipid biosynthesis genes for Auxenochlorella protethecoides are disclosed that are useful for increasing lipid production and altering fatty acid and triacylglycerol profiles in recombinant microrganisms including cells of the genus Auxenochlorella or Prototheca.
Abstract translation: 基因工程微生物，例如原型小球藻，产生微生物油的细胞可用作食品添加剂和可再生燃料和工业化学品的来源。 本发明公开了用于增加油类生物合成的脂质体生物合成基因，其可用于增加脂质生产和改变重组微生物（包括欧洲绿叶藻或原生动物）的重组微生物中的脂肪酸和三酰甘油轮廓。
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公开(公告)号：US20160024538A1
公开(公告)日：2016-01-28
申请号：US14819117
申请日：2015-08-05
Applicant: Solazyme, Inc.
Inventor： Scott Franklin , Aravind Somanchi , Janice Wee , George Rudenko , Jeffrey L. Moseley , Walt Rakitsky
CPC classification number: C12N15/79 , A23D7/00 , A23D9/00 , A23K20/158 , C11B1/00 , C11C3/00 , C12N9/0071 , C12N9/16 , C12N9/2431 , C12N9/2465 , C12N15/67 , C12N15/8216 , C12P7/64 , C12P7/6445 , C12P7/6463 , C12Y114/19001 , C12Y301/02 , C12Y301/02014 , C12Y302/01022 , C12Y302/01026 , Y02E50/13 , Y02P30/20 , Y02T50/678
Abstract: Methods and compositions for the production of food compositions, oils, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing food compositions, and transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants.
Abstract translation: 提供了用于在重组微生物中生产食品组合物，油，燃料，油脂化合物和其它化合物的方法和组合物，包括含油微生物和这种微生物的低成本培养的方法。 包含编码例如脂肪酶，蔗糖转运蛋白，蔗糖转化酶，果糖激酶，多糖降解酶，酮酰基-ACP合成酶，脂肪酰基-ACP硫酯酶，脂肪酰辅酶A的外源基因的微藻细胞 /醛还原酶，脂肪酰辅酶A还原酶，脂肪醛还原酶，脂肪醛脱羰酶和/或酰基载体蛋白质可用于制造食品组合物，以及运输燃料如可再生柴油，生物柴油和可再生喷气燃料， 以及诸如功能流体，表面活性剂，肥皂和润滑剂的油脂化学品。
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公开(公告)号：US20150366791A1
公开(公告)日：2015-12-24
申请号：US14751527
申请日：2015-06-26
Applicant: Solazyme, Inc.
Inventor： Jeff Avila , Geoffrey Brooks , Anthony G. Day , Aravind Somanchi
CPC classification number: A61K8/0241 , A61K8/73 , A61K8/9706 , A61Q19/08 , C08B37/0003 , C12P19/04 , C12R1/89
Abstract: Provided herein are microalgal skin care compositions and methods of improving the health and appearance of skin. Also provided are methods of using polysaccharides for applications such as topical personal care products, cosmetics, and wrinkle reduction compositions. The invention also provides novel decolorized microalgal compositions useful for improving the health and appearance of skin. The invention also includes insoluble polysaccharide particles for application to human skin.
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公开(公告)号：US20150218604A1
公开(公告)日：2015-08-06
申请号：US14626505
申请日：2015-02-19
Applicant: Solazyme, Inc.
Inventor： Scott Franklin , Aravind Somanchi , Karen Espina , George Rudenko , Penelope Chua
CPC classification number: C12P7/6427 , C07C1/2078 , C07K2319/01 , C10L1/02 , C12N9/00 , C12N9/16 , C12N9/2402 , C12N15/79 , C12P7/20 , C12P7/64 , C12P7/6409 , C12P7/6418 , C12P7/6463 , C12P7/649 , C12Y301/02014 , C12Y302/01026 , Y02E50/13 , Y02P20/52 , Y02P60/877 , Y02T50/678
Abstract: Disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the oils. Methods such as transesterification, hydrogenation, hydrocracking, deoxygenation, isomerization, interesterification, hydroxylation, hydrolysis and saponification are disclosed. Novel oils containing fatty acid chain lengths of C8, C10, C12 or C14 are also disclosed and are useful as feedstocks in the methods of the invention.
Abstract translation: 本文公开了通过制备新型甘油三酯油然后化学改性油来制造可再生化学品的方法。 公开了酯交换，氢化，加氢裂化，脱氧，异构化，酯交换，羟基化，水解和皂化等方法。 还公开了含有C8，C10，C12或C14脂肪酸链长度的新型油，并且可用作本发明方法中的原料。
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公开(公告)号：US08951777B2
公开(公告)日：2015-02-10
申请号：US13852116
申请日：2013-03-28
Applicant: Solazyme, Inc.
Inventor： Scott Franklin , Aravind Somanchi , Karen Espina , George Rudenko , Penelope Chua
IPC: C12N1/12 , C12N15/82 , C12N9/24 , C12P7/64 , C10L1/02 , C12N9/00 , C12N9/16 , C12P7/20 , C12N15/79 , C07C1/207
CPC classification number: C12P7/6427 , C07C1/2078 , C07K2319/01 , C10L1/02 , C12N9/00 , C12N9/16 , C12N9/2402 , C12N15/79 , C12P7/20 , C12P7/64 , C12P7/6409 , C12P7/6418 , C12P7/6463 , C12P7/649 , C12Y301/02014 , C12Y302/01026 , Y02E50/13 , Y02P20/52 , Y02P60/877 , Y02T50/678
Abstract: Disclosed herein are obligate heterotrophic microalgae cells containing an exogenous gene. In some embodiments the gene is a sucrose utilization gene, and further disclosed are methods of manufacturing triglyceride oils using sugar cane or sugar beets as a feedstock in a heterotrophic fermentation. In other embodiments the feedstock is depolymerized cellulosic material. Also disclosed are cells that produce medium chain fatty acids at levels not produced in non-recombinant cells of the same species and genus.
Abstract translation: 本文公开了含有外源基因的专性异养微藻细胞。 在一些实施方案中，该基因是蔗糖利用基因，并且进一步公开了使用甘蔗或甜菜作为异养发酵中的原料来制备甘油三酯油的方法。 在其它实施方案中，原料是解聚的纤维素材料。 还公开了以相同物种和属的非重组细胞中不产生的水平产生中链脂肪酸的细胞。
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Patent Agency Ranking
公开(公告)号：US08633012B2
公开(公告)日：2014-01-21
申请号：US13650024
申请日：2012-10-11
Applicant: Solazyme, Inc.
Inventor： Scott Franklin , Aravind Somanchi , Janice Wee , George Rudenko , Jeffrey L. Moseley , Walt Rakitsky , Xinhua Zhao , Riyaz Bhat
CPC classification number: C12P7/6463 , C07C69/52 , C10L1/02 , C10L2200/0476 , C10L2290/26 , C10L2290/30 , C12N9/0071 , C12N9/1029 , C12N9/16 , C12N15/52 , Y02E50/13
Abstract: Methods and compositions for the production of oil, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty acid hydroxylase, a desaturase enzyme, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants.
Abstract translation: 提供了用于在重组微生物中生产油，燃料，油化合物和其它化合物的方法和组合物，包括含油微生物和这种微生物的低成本培养的方法。 包含编码例如脂肪酶，蔗糖转运蛋白，蔗糖转化酶，果糖激酶，多糖降解酶，酮酰基-ACP合成酶，脂肪酰基-ACP硫酯酶，脂肪酰辅酶A的外源基因的微藻细胞 /醛还原酶，脂肪酰辅酶A还原酶，脂肪醛还原酶，脂肪酸羟化酶，去饱和酶，脂肪醛脱羰酶和/或酰基载体蛋白，可用于制造运输燃料如可再生柴油，生物柴油， 和可再生喷气燃料，以及油化学品如功能流体，表面活性剂，肥皂和润滑剂。
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公开(公告)号：US20130317240A1
公开(公告)日：2013-11-28
申请号：US13941357
申请日：2013-07-12
Applicant: Solazyme, Inc.
Inventor： Scott Franklin , Aravind Somanchi , George Rudenko , Riyaz Bhat , Xinhua Zhao , Risha Bond , Walter Rakitsky , Alejandro Marangoni , Diza Braksmayer
IPC: C12P7/64
CPC classification number: C12P7/6409 , A23D9/00 , A23D9/013 , C07C57/03 , C07J9/00 , C11B1/00 , C12N9/0071 , C12N9/1029 , C12N9/16 , C12N9/2402 , C12N15/113 , C12N15/8247 , C12N2310/531 , C12P7/64 , C12P7/6445 , C12P7/6463 , C12P7/6472 , C12P33/00 , C12R1/89 , C12Y203/01015 , C12Y203/0102 , C12Y203/01041 , C12Y203/01051 , C12Y203/01179 , C12Y203/0118 , C12Y302/01014 , C12Y302/01026 , Y02E50/13 , Y02P20/52
Abstract: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.
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公开(公告)号：US20160186191A1
公开(公告)日：2016-06-30
申请号：US14975016
申请日：2015-12-18
Applicant: Solazyme, Inc.
Inventor： Scott Franklin , Aravind Somanchi , Janice Wee , George Rudenko , Jeffrey L. Moseley , Walter Rakitsky
CPC classification number: C12N15/79 , A23D7/00 , A23D9/00 , A23K20/158 , C11B1/00 , C11C3/00 , C12N9/0071 , C12N9/16 , C12N9/2431 , C12N9/2465 , C12N15/67 , C12N15/8216 , C12P7/64 , C12P7/6445 , C12P7/6463 , C12Y114/19001 , C12Y301/02 , C12Y301/02014 , C12Y302/01022 , C12Y302/01026 , Y02E50/13 , Y02P30/20 , Y02T50/678
Abstract: Methods and compositions for the production of oil, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants.
Abstract translation: 提供了用于在重组微生物中生产油，燃料，油化合物和其它化合物的方法和组合物，包括含油微生物和这种微生物的低成本培养的方法。 包含编码例如脂肪酶，蔗糖转运蛋白，蔗糖转化酶，果糖激酶，多糖降解酶，酮酰基-ACP合成酶，脂肪酰基-ACP硫酯酶，脂肪酰辅酶A的外源基因的微藻细胞 /醛还原酶，脂肪酰辅酶A还原酶，脂肪醛还原酶，脂肪醛脱羰酶和/或酰基载体蛋白质可用于制造运输燃料如可再生柴油，生物柴油和可再生喷气燃料，以及油脂化学品 例如功能流体，表面活性剂，肥皂和润滑剂。
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公开(公告)号：US20150125914A1
公开(公告)日：2015-05-07
申请号：US14506491
申请日：2014-10-03
Applicant: SOLAZYME, INC.
Inventor： Scott Franklin , Aravind Somanchi , George Rudenko , Riyaz Bhat , Xinhua Zhao , Jeffrey L. Moseley
CPC classification number: C12P7/64 , C11C1/002 , C11D9/00 , C12P7/6409 , C12Y203/01041 , C12Y301/02014
Abstract: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desaturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.
Abstract translation: 重组DNA技术用于产生产生具有所需脂肪酸谱和区域特异性或立体特异性谱的甘油三酯油的含油重组细胞。 基因操作包括编码硬脂酰-ACP去饱和酶，δ12脂肪酸去饱和酶，酰基-ACP硫酯酶，酮酰基-ACP合成酶和溶血磷脂酰基转移酶的那些。 所生产的油可以具有增强的氧化或热稳定性，或可用作煎炸油，起酥油，卷入起酥油，回火脂肪，可可脂替代物，润滑剂或用作各种化学方法的原料。 脂肪酸分布可以富集中链型，或者油可富含饱和不饱和饱和型甘油三酸酯。
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公开(公告)号：US20140256024A1
公开(公告)日：2014-09-11
申请号：US14285354
申请日：2014-05-22
Applicant: Solazyme, Inc.
Inventor： Scott Franklin , Aravind Somanchi , Karen Espina , George Rudenko , Penelope Chua
IPC: C12N9/24
CPC classification number: C12P7/6427 , C07C1/2078 , C07K2319/01 , C10L1/02 , C12N9/00 , C12N9/16 , C12N9/2402 , C12N15/79 , C12P7/20 , C12P7/64 , C12P7/6409 , C12P7/6418 , C12P7/6463 , C12P7/649 , C12Y301/02014 , C12Y302/01026 , Y02E50/13 , Y02P20/52 , Y02P60/877 , Y02T50/678
Abstract: Novel gene sequences from microalgae are disclosed, as well as novel gene sequences useful in the manufacture of triglyceride oils. Also disclosed are sequences and vectors that allow microalgae to be cultivated on sugar cane and sugar beets as a feedstock. In some embodiments, the vectors are useful for the purpose of performing targeted modifications to the nuclear genome of heterotrophic microalgae.
Abstract translation: 公开了来自微藻的新型基因序列，以及可用于制备甘油三酯油的新型基因序列。 还公开了允许将微藻种植在甘蔗和甜菜作为原料的序列和载体。 在一些实施方案中，载体可用于进行对异养微藻的核基因组的靶向修饰。
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