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92 条记录 (耗时 0.046 秒)

    HERNIA PATCH
    14.
    发明申请
    HERNIA PATCH 审中-公开
    赫尼亚·帕特

    公开(公告)号：US20110144667A1

    公开(公告)日：2011-06-16

    申请号：US12877919

    申请日：2010-09-08

    申请人： Anthony Richard Horton ,  Paul Martakos ,  Steve A. Herweck ,  Theodore Karwoski ,  Joseph F. Ferraro

    发明人： Anthony Richard Horton ,  Paul Martakos ,  Steve A. Herweck ,  Theodore Karwoski ,  Joseph F. Ferraro

    IPC分类号： A61B17/08

    CPC分类号： A61F2/0063 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2220/0075 ,  A61F2230/0004 ,  A61F2250/0018 ,  A61F2310/00389 ,  A61K31/20 ,  A61L31/10 ,  A61L31/14 ,  A61L31/148

    摘要： A hernia patch supporting tissue in-growth conforms to a tissue wall upon surgical installation and fixation within a patient. The hernia patch can include a base and positioning straps. The base is formed of two layers that are affixed to each other around the perimeter of the patch, for example by stitching. A stabilizing washer is provided between the two layers, and the stitch is provided peripherally around the stabilizing washer, keeping the washer free-floating between the layers. The base, positioning straps, and stabilizing washer are formed of a structure that does not separate the layers of the implant or form a space in the form of a pocket, and promotes more uniform and confluent tissue incorporation or in-growth after implantation. The hernia patch may further include a hydrolysable bioabsorbable cross-linked coating of a fatty acid based material, such as an omega-3 fatty acid based material.

    摘要翻译： 支撑组织生长的疝补片在外科手术安装和固定在患者体内时符合组织壁。 疝补片可以包括基部和定位带。 底座由两层相互贴合，例如通过拼接而在贴片的周边彼此固定。 在两层之间设有一个稳定的垫圈，并且在周向围绕稳定垫圈设置线圈，保持垫片在层之间自由浮动。 基部，定位带和稳定垫圈由不分离植入物层或形成袋状空间的结构形成，并且在植入后促进更均匀和汇合的组织结合或生长。 疝补片可以进一步包括基于脂肪酸的材料如ω-3脂肪酸基材料的可水解生物可吸收的交联涂层。

    DRUG DELIVERY COATING FOR USE WITH A MEDICAL DEVICE AND METHODS OF TREATING VASCULAR INJURY
    15.
    发明申请
    DRUG DELIVERY COATING FOR USE WITH A MEDICAL DEVICE AND METHODS OF TREATING VASCULAR INJURY 审中-公开
    用于医疗设备的药物输送涂料和治疗血管损伤的方法

    公开(公告)号：US20100004738A1

    公开(公告)日：2010-01-07

    申请号：US11919315

    申请日：2006-04-28

    申请人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Theodore Karwoski ,  Trevor Carlton

    发明人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Theodore Karwoski ,  Trevor Carlton

    IPC分类号： A61F2/82 ,  A61F2/00 ,  A61K31/439 ,  A61M25/00 ,  A61B17/03

    CPC分类号： A61K31/436 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/434 ,  A61L2300/45

    摘要： The present inventions provide various embodiments of methods for one or more of treating vascular injury, neointima proliferation and/or local inflammation in a mammal by locally administering therapeutic compound comprising a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the therapeutic compound comprises a bio-absorbable carrier component carrier component at least partially formed of a cellular uptake inhibitor and a cellular uptake enhancer, a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the present invention provides for controlled delivery, which is at least partially characterized by total and relative amounts of a cellular uptake inhibitor and cellular uptake enhancer in a bio-absorbable carrier component.

    摘要翻译： 本发明提供了通过局部施用包含mTOR靶向化合物和钙调磷酸酶抑制剂的治疗化合物来治疗哺乳动物血管损伤，新内膜增生和/或局部炎症中的一种或多种的方法的各种实施方案。 在各个方面，治疗化合物包括至少部分由细胞摄取抑制剂和细胞吸收增强剂，mTOR靶向化合物和钙调磷酸酶抑制剂形成的生物可吸收载体组分载体组分。 在各个方面，本发明提供受控递送，其至少部分地表征为生物可吸收载体组分中的细胞摄取抑制剂和细胞摄取增强剂的总量和相对量。

    Bio-absorbable oil suspension
    16.
    发明申请
    Bio-absorbable oil suspension 审中-公开
    生物吸收油悬浮液

    公开(公告)号：US20080207756A1

    公开(公告)日：2008-08-28

    申请号：US11711389

    申请日：2007-02-27

    申请人： Steve A. Herweck ,  Theodore Karwoski ,  Paul Martakos

    发明人： Steve A. Herweck ,  Theodore Karwoski ,  Paul Martakos

    IPC分类号： A61K31/20 ,  A61P39/00

    CPC分类号： A61K31/20

    摘要： Exemplary embodiments of the invention provide a dispersing liquid for coating internal body tissues with a bio-absorbable oil, a method of making the dispersing liquid, methods of using the dispersing liquid and a kit for coating internal body tissues using the dispersing liquid. The dispersing liquid includes a suspension of a bio-absorbable oil suspended in a liquid carrier. The invention results in a uniform thin coating of bio-absorbable oil on internal body tissues.

    摘要翻译： 本发明的示例性实施方案提供了用生物可吸收油涂覆内部身体组织的分散液，制备分散液的方法，使用分散液的方法和使用分散液涂覆内部身体组织的试剂盒。 分散液包括悬浮在液体载体中的生物可吸收油的悬浮液。 本发明导致生物吸收油在内部身体组织上的均匀薄涂层。

    Expandable shielded vessel support
    18.
    发明授权
    Expandable shielded vessel support 失效
    可扩展屏蔽容器支架

    公开(公告)号：US6010529A

    公开(公告)日：2000-01-04

    申请号：US759877

    申请日：1996-12-03

    申请人： Steve A. Herweck ,  Peter Gingras ,  Paul Martakos ,  Theodore Karwoski

    发明人： Steve A. Herweck ,  Peter Gingras ,  Paul Martakos ,  Theodore Karwoski

    IPC分类号： A61F2/00 ,  A61F2/06 ,  A61F2/10 ,  A61F2/24 ,  A61F2/88 ,  A61L31/04 ,  A61L31/10 ,  A61F2/04

    CPC分类号： A61F2/07 ,  A61F2/06 ,  A61F2/88 ,  A61L31/04 ,  A61L31/10 ,  A61F2/105 ,  A61F2002/072 ,  A61F2240/001 ,  Y10S623/901

    摘要： A radially expandable support body is enveloped within a cocoon. In a preferred construction, the support is a stent, and a tube of polymeric material, e.g. polytetrafluoroethylene (PTFE), passes through the interior of the stent body and is turned back upon itself over the stent to form a cuff. The assembly is then heated and the outer layer contacts and coalesces with the inner layer, closely surrounding the stent body within a folded envelope having a continuous and seamless end. In one embodiment, an end portion of the tube is expanded before folding back over the stent. The end portion, which becomes an exterior surface of the finished product, thus acquires a greater degree of porosity. Each end of the central tube may be so expanded, and folded back to seal all surfaces and both ends. The stent body itself may be a ring, or a short series of spaced-apart rings, or a wire or web, or a sheet possessing a number of apertures extending entirely through the sheet. The spaces or apertures are covered over or bridged by both the inner and outer polymer layers. The apertures, which may comprise under five to over eighty percent of the surface area of the stent, constitute regions or a grid of points through which the material is coalesced and continuously bonded, and around which strain is distributed by the support. These points or regions remain tacked together so expansion of the assembly does not delaminate the polymer or create flaps and pockets. In another embodiment, a two tube construction is cuffed and assembled into a similarly unitized and seamless stent. One tube is cuffed back, and the other tube covers the cuffed stent. In this embodiment both the tube thicknesses and porosities may differ substantially. For example the inner porosity may be selected to enhance blood flow or intimal regeneration, and the outer surface may have a porosity to encourage anchoring to external muscle tissue.

    摘要翻译： 径向可扩展的支撑体被包围在茧内。 在优选的结构中，支撑件是支架，以及聚合物材料管，例如。 聚四氟乙烯（PTFE）穿过支架主体的内部并在支架上自身转回以形成袖带。 然后将组件加热并且外层与内层接触并聚结，在具有连续和无缝端部的折叠外壳内紧密地围绕支架主体。 在一个实施例中，管的端部在折回到支架之前膨胀。 成为成品的外表面的端部因此获得更大程度的孔隙率。 中心管的每个端部可以如此膨胀，并且被折回以密封所有表面和两端。 支架主体本身可以是一个环，或一系列间隔开的环，或者线或腹板，或者具有完全贯穿片材的多个孔的片。 空间或孔被内聚合物层和外聚合物层覆盖或桥接。 可以包括支架表面积的五到八十成以上的孔构成区域或网格，通过该点或网格将材料聚结并连续地结合，并且通过支撑分布在哪个应变附近。 这些点或区域保持粘合在一起，因此组件的膨胀不会分解聚合物或产生襟翼和口袋。 在另一个实施例中，将双管结构压合并组装成相似的单元化且无缝的支架。 一根管子被套在后面，另一根管子覆盖着袖口支架。 在该实施例中，管的厚度和孔隙度可能基本上不同。 例如，可以选择内部孔隙率以增强血流或内膜再生，并且外表面可以具有孔隙度以促进锚定到外部肌肉组织。

    Tissue separating device with reinforced support for anchoring mechanisms
    19.
    发明授权
    Tissue separating device with reinforced support for anchoring mechanisms 有权
    组织分离装置，具有用于锚固机构的加强支撑

    公开(公告)号：US09592324B2

    公开(公告)日：2017-03-14

    申请号：US11980155

    申请日：2007-10-30

    申请人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    发明人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    IPC分类号： A61L31/14 ,  A61L31/08

    CPC分类号： A61L31/14 ,  A61F2/0063 ,  A61L31/08

    摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with reinforced sections or portions to aid with the fastening of the barrier device for implantation purposes and prohibits or substantially reduces the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.

    摘要翻译： 阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。 如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。 底层结构可以是手术网的形式。 阻挡装置还设置有加强部分或部分，以帮助阻挡装置紧固以用于植入目的，并且禁止或基本上减少过度拉伸和撕裂的发生。 阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。

    Barrier layer with underlying medical device and one or more reinforcing support structures
    20.
    发明授权
    Barrier layer with underlying medical device and one or more reinforcing support structures 有权
    具有底层医疗装置和一个或多个加强支撑结构的阻隔层

    公开(公告)号：US09492596B2

    公开(公告)日：2016-11-15

    申请号：US11701799

    申请日：2007-02-02

    申请人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    发明人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    IPC分类号： A61F2/02 ,  A61L31/14 ,  A61L31/16

    CPC分类号： A61L31/145 ,  A61F2/0063 ,  A61F2/82 ,  A61F2002/0086 ,  A61F2002/009 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/606

    摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with anchoring reinforcements to aid with the fastening of the barrier device for implantation purposes and reinforcing truss sections or portions that prohibit or substantially reduce the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.

    摘要翻译： 阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。 如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。 底层结构可以是手术网的形式。 隔离装置还设置有锚固加强件，以帮助阻挡装置的固定用于植入目的，并且加强桁架部分或部分，其禁止或基本上减少过度拉伸和撕裂的发生。 阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。