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公开(公告)号：US10000488B2
公开(公告)日：2018-06-19
申请号：US15510225
申请日：2015-09-10
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Satoshi Yamamoto , Junya Shirai , Tsuneo Oda , Takashi Imada , Mitsunori Kono , Ayumu Sato , Yoshihide Tomata , Atsuko Ochida , Naoki Ishii , Yusuke Sasaki , Yoshiyuki Fukase , Tomoya Yukawa , Shoji Fukumoto
IPC: C07D471/04 , C07D401/14 , C07D413/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D239/96 , C07D409/14 , C07D403/12 , C07D401/12 , C07D417/14 , C07D417/12
CPC classification number: C07D471/04 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P1/00 , A61P11/00 , C07D239/96 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The problem of the present invention is to provide a compound having a superior RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like. The present invention relates to a compound represented by the formula (I): [wherein each symbol is as described in the DESCRIPTION] or a salt thereof, which has an RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like.
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公开(公告)号：US09834520B2
公开(公告)日：2017-12-05
申请号：US14775514
申请日：2014-03-13
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Satoshi Yamamoto , Junya Shirai , Yoshiyuki Fukase , Ayumu Sato , Mitsunori Kouno , Yoshihide Tomata , Atsuko Ochida , Kazuko Yonemori , Tsuneo Oda , Tomoya Yukawa
IPC: A61K31/517 , C07D239/72 , C07D239/96 , C07D403/12 , C07D401/12 , C07D409/12 , C07D239/80 , C07D413/12 , C07D417/12 , C07D471/04 , C07D265/36 , C07D217/24 , C07D405/06 , C07D475/04 , C07F7/08
CPC classification number: C07D239/96 , C07D217/24 , C07D239/80 , C07D265/36 , C07D401/12 , C07D403/12 , C07D405/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D475/04 , C07F7/0812
Abstract: The present invention provides a heterocyclic compound having an RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein Ar is a the partial structure (1) to the partial structure (5), Q is a bivalent group selected from the group consisting of (Ia)-(If), and B is a ring optionally having substituent(s), or a salt thereof.
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公开(公告)号：US09630924B2
公开(公告)日：2017-04-25
申请号：US15055108
申请日：2016-02-26
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Satoshi Yamamoto , Junya Shirai , Tsuneo Oda , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Yoshiyuki Fukase , Tomoya Yukawa , Shoji Fukumoto
IPC: C07D471/04 , C07D215/00 , C07D217/26 , C07F7/08 , C07D491/048 , C07D491/056 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D491/14
CPC classification number: C07D217/26 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/14 , C07F7/0812
Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
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公开(公告)号：US20160229814A1
公开(公告)日：2016-08-11
申请号：US14775514
申请日：2014-03-13
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Satoshi Yamamoto , Junya Shirai , Yoshiyuki Fukase , Ayumu Sato , Mitsunori Kouno , Yoshihide Tomata , Atsuko Ochida , Kazuko Yonemori , Tsuneo Oda , Takashi Imada , Tomoya Yukawa
IPC: C07D239/96 , C07D265/36 , C07F7/08 , C07D401/12 , C07D217/24 , C07D417/12 , C07D409/12 , C07D413/12 , C07D475/04 , C07D405/06 , C07D471/04 , C07D403/12
CPC classification number: C07D239/96 , C07D217/24 , C07D239/80 , C07D265/36 , C07D401/12 , C07D403/12 , C07D405/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D475/04 , C07F7/0812
Abstract: The present invention provides a heterocyclic compound having an RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein Ar is a the partial structure (1) to the partial structure (5), Q is a bivalent group selected from the group consisting of (Ia)-(If), and B is a ring optionally having substituent(s), or a salt thereof.
Abstract translation: 本发明提供具有RORγt抑制作用的杂环化合物。 本发明涉及由式（I）表示的化合物：其中Ar是部分结构（5）的部分结构（1），Q是选自（Ia） - （If ），B是任选具有取代基的环或其盐。
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公开(公告)号：US20150018547A1
公开(公告)日：2015-01-15
申请号：US14380215
申请日：2013-02-22
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Nobuyuki Takakura , Yoshihiro Banno , Yoshito Terao , Atsuko Ochida , Sachie Morimoto , Shuji Kitamura , Yoshihide Tomata , Tsuneo Yasuma , Minoru Ikoma , Kei Masuda
IPC: C07D333/60 , C07D307/80 , C07D495/04 , C07D417/12 , C07D333/70 , C07D333/64 , C07D409/12 , C07D405/12
CPC classification number: C07D333/60 , C07D307/79 , C07D307/80 , C07D307/81 , C07D307/84 , C07D333/54 , C07D333/64 , C07D333/70 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/12 , C07D417/12 , C07D495/04
Abstract: The present invention provides a compound having a GOAT inhibitory action, which is useful for the prophylaxis or treatment of obesity and the like, and has superior efficacy. The present invention is a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
Abstract translation: 本发明提供具有GOAT抑制作用的化合物，其可用于预防或治疗肥胖症等，并且具有优异的疗效。 本发明是由式（I）表示的化合物：其中各符号如说明书中所定义，或其盐。
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Patent Agency Ranking
公开(公告)号：US20140228409A1
公开(公告)日：2014-08-14
申请号：US14346071
申请日：2012-09-21
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Satoshi Yamamoto , Junya Shirai , Yoshiyuki Fukase , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Kazuko Yonemori , Hideyuki Nakagawa
IPC: C07D401/12 , C07D209/08 , C07D209/88
CPC classification number: C07D401/12 , A61K31/403 , A61K31/404 , C07D209/08 , C07D209/88
Abstract: The present invention provides a fused heterocyclic compound having an RORγt inhibitory action. The present invention relates to a compound represented by the formula (I′): wherein each symbol is as defined in the specification, provided that 2-(2-((4-cyanophenyl)amino)-2-oxoethoxy)-N-(9-ethyl-9H-carbazol-3-yl)acetamide and N-(4-cyanophenyl)-N′-(9-ethyl-9H-carbazol-3-yl)-3-methylpentanediamide are excluded, or a salt thereof.
Abstract translation: 本发明提供具有RORγt抑制作用的稠合杂环化合物。 本发明涉及由式（I'）表示的化合物：其中每个符号如说明书中所定义，条件是2-（2 - （（2-氰基苯基）氨基）-2-氧代乙氧基）-N-（ 9-乙基-9H-咔唑-3-基）乙酰胺和N-（4-氰基苯基）-N' - （9-乙基-9H-咔唑-3-基）-3-甲基戊二酰胺或其盐。
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公开(公告)号：US12077522B2
公开(公告)日：2024-09-03
申请号：US17256330
申请日：2019-06-27
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Tatsuhiko Fujimoto , Koichiro Fukuda , Hiromichi Sugimoto , Kentaro Rikimaru , Yoshihiro Banno , Takahiro Matsumoto , Norihito Tokunaga , Yoshihide Tomata , Yuji Ishichi , Shogo Marui , Tsuneo Oda , Tohru Miyazaki , Yasutaka Hoashi , Yasushi Hattori , Yuichi Kajita , Yuhei Miyanohana , Tatsuki Koike
IPC: C07D401/14 , C07D211/56 , C07D405/14
CPC classification number: C07D401/14 , C07D211/56 , C07D405/14
Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
18.发明授权公开(公告)号：US10093629B2
公开(公告)日：2018-10-09
申请号：US15321609
申请日：2015-06-30
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Satoshi Yamamoto , Junya Shirai , Tsuneo Oda , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Yoshiyuki Fukase , Tomoya Yukawa , Shoji Fukumoto
IPC: C07D217/26 , C07D491/056 , C07D491/048 , C07F7/08 , C07D471/04 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D491/14
Abstract: Provided are heterocyclic compounds having a RORγt inhibitory action represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US10053468B2
公开(公告)日：2018-08-21
申请号：US14902309
申请日：2014-07-02
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Satoshi Yamamoto , Junya Shirai , Hiroyuki Watanabe , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Yoshiyuki Fukase , Tomoya Yukawa
IPC: C07D491/056 , C07D217/26 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D471/04 , C07D491/048 , C07D401/12 , C07D413/12 , C07D491/04 , C07D413/14 , C07D401/04 , C07D405/12 , C07F7/08
CPC classification number: C07D491/056 , C07D217/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D491/04 , C07D491/048 , C07F7/0812
Abstract: The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. wherein each symbol is as defined in the specification.
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公开(公告)号：US09650343B2
公开(公告)日：2017-05-16
申请号：US15055156
申请日：2016-02-26
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Satoshi Yamamoto , Junya Shirai , Tsuneo Oda , Mitsunori Kono , Atsuko Ochida , Takashi Imada , Hidekazu Tokuhara , Yoshihide Tomata , Naoki Ishii , Michiko Tawada , Yoshiyuki Fukase , Tomoya Yukawa , Shoji Fukumoto
IPC: C07D471/04 , C07D215/00 , C07D217/26 , C07F7/08 , C07D491/048 , C07D491/056 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D491/14
CPC classification number: C07D217/26 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/14 , C07F7/0812
Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
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