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11.发明申请公开(公告)号：US20170105653A1
公开(公告)日：2017-04-20
申请号：US15336652
申请日：2016-10-27
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Wentai Liu , Yi-Kai Lo , Chih-Wei Chang
IPC: A61B5/053 , A61N1/36 , A61B5/00 , A61B5/0215 , A61B5/11
CPC classification number: A61B5/0538 , A61B5/02158 , A61B5/1107 , A61B5/1108 , A61B5/4238 , A61B5/4255 , A61B5/4836 , A61B5/4839 , A61B5/686 , A61B5/6873 , A61B5/6876 , A61B2562/0215 , A61N1/36007 , A61N1/36135
Abstract: Method and apparatus for estimating bio-impedance at electrode-electrolyte interface by injecting a single low-intensity bi-phasic current stimulus having an selected inter-pulse delay first and second current pulse phases, which involves acquiring transient electrode voltage along the bi-phasic current stimulus waveform. Determining equivalent circuit parameters of an electrode, at the electrode-electrolyte/tissue interface, based on transient electrode voltage across said multiple temporal locations is also performed.
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公开(公告)号：US11944814B2
公开(公告)日：2024-04-02
申请号：US17459468
申请日：2021-08-27
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Yi-Kai Lo , Wentai Liu , Victor R. Edgerton , Chih-Wei Chang
CPC classification number: A61N1/36003 , A61N1/0551 , A61N1/3787 , A61N1/08
Abstract: A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.
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公开(公告)号：US20190329029A1
公开(公告)日：2019-10-31
申请号：US16404041
申请日：2019-05-06
Inventor： Wentai Liu , Chih-Wei Chang , Pu-Wei Wu , Chung-Yu Wu , Po-Chun Chen , Tsai-Wei Chung
Abstract: A flexible thin film metal oxide electrode fabrication methods and devices are provided and illustrated with thin film polyimide electrode formation and IrOx chemical bath deposition. Growth factors of the deposited film such as film thickness, deposition rate and quality of crystallites can be controlled by varying the solution pH, temperature and component concentrations of the bath. The methods allow for selective deposition of IrOx on a flexible substrate (e.g. polyimide electrode) where the IrOx will only coat onto an exposed metal area but not the entire device surface. This feature enables the bath process to coat the IrOx onto every individual electrode in one batch, and to ensure electrical isolation between channels. The ability to perform selective deposition, pads for external connections will not have IrOx coverage that would otherwise interfere with a soldering/bumping process.
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公开(公告)号：US20180214046A1
公开(公告)日：2018-08-02
申请号：US15939187
申请日：2018-03-28
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Wentai Liu , Chih-Wei Chang
IPC: A61B5/0408 , A61B5/0492 , A61N1/36 , A61B5/04 , A61B5/0478 , A61N1/04
CPC classification number: A61B5/04085 , A61B5/04 , A61B5/0478 , A61B5/0492 , A61B2562/046 , A61N1/0456 , A61N1/0476 , A61N1/36014
Abstract: Neural signal recording apparatus and method is described, in which a micro electrode array is utilized for performing a weighted matrix as a moving window providing superpositioning of electrode signals. A voltage distribution across the electrode array is determined as a Laplacian. The apparatus and method can be utilized in a variety of electrode sensing applications involving registering neural activity, and for electrode stimulation applications, or combinations thereof.
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Patent Agency Ranking
公开(公告)号：US20170246452A1
公开(公告)日：2017-08-31
申请号：US15506696
申请日：2015-08-27
Applicant: The Regents of the University of California
Inventor： Wentai Liu , Victor Reggie Edgerton , Chih-Wei Chang , Parag Gad
Abstract: In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and/or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and/or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.
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公开(公告)号：US20170246450A1
公开(公告)日：2017-08-31
申请号：US15506699
申请日：2015-08-27
Applicant: The Regents of the University of California
Inventor： Wentai Liu , Chih-Wei Chang
CPC classification number: A61N1/0551 , A61N1/0456 , A61N1/0476 , B05D1/005 , C23C14/08 , C23C14/30 , C23C14/5826
Abstract: In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and/or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and/or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.
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公开(公告)号：US10773074B2
公开(公告)日：2020-09-15
申请号：US15506696
申请日：2015-08-27
Applicant: The Regents of the University of California
Inventor： Wentai Liu , Victor Reggie Edgerton , Chih-Wei Chang , Parag Gad
Abstract: In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and/or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and/or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.
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公开(公告)号：US09955886B2
公开(公告)日：2018-05-01
申请号：US14990874
申请日：2016-01-08
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Wentai Liu , Chih-Wei Chang
IPC: A61B5/04 , A61B5/0408 , A61B5/0478 , A61N1/04 , A61N1/36 , A61B5/0492
CPC classification number: A61B5/04085 , A61B5/04 , A61B5/0478 , A61B5/0492 , A61B2562/046 , A61N1/0456 , A61N1/0476 , A61N1/36014
Abstract: Neural signal recording apparatus and method is described, in which a micro electrode array is utilized for performing a weighted matrix as a moving window providing superpositioning of electrode signals. A voltage distribution across the electrode array is determined as a Laplacian. The apparatus and method can be utilized in a variety of electrode sensing applications involving registering neural activity, and for electrode stimulation applications, or combinations thereof.
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公开(公告)号：US20160192854A1
公开(公告)日：2016-07-07
申请号：US14990874
申请日：2016-01-08
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Wentai Liu , Chih-Wei Chang
IPC: A61B5/0408 , A61N1/36 , A61N1/04 , A61B5/0478 , A61B5/0492
CPC classification number: A61B5/04085 , A61B5/04 , A61B5/0478 , A61B5/0492 , A61B2562/046 , A61N1/0456 , A61N1/0476 , A61N1/36014
Abstract: Neural signal recording apparatus and method is described, in which a micro electrode array is utilized for performing a weighted matrix as a moving window providing superpositioning of electrode signals. A voltage distribution across the electrode array is determined as a Laplacian. The apparatus and method can be utilized in a variety of electrode sensing applications involving registering neural activity, and for electrode stimulation applications, or combinations thereof.
Abstract translation: 描述了神经信号记录装置和方法，其中使用微电极阵列来执行加权矩阵作为提供电极信号叠加的移动窗口。 电极阵列上的电压分布被确定为拉普拉斯算子。 该装置和方法可用于涉及记录神经活动以及电极刺激应用或其组合的各种电极感测应用中。
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