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34 条记录 (耗时 0.022 秒)

    Sulfide resin for rubber
    16.
    发明授权
    Sulfide resin for rubber 失效
    橡胶硫化树脂

    公开(公告)号：US4308180A

    公开(公告)日：1981-12-29

    申请号：US131788

    申请日：1980-03-19

    申请人： Haruki Okamura ,  Tetsuo Yamaguchi ,  Tamaki Ishii

    发明人： Haruki Okamura ,  Tetsuo Yamaguchi ,  Tamaki Ishii

    IPC分类号： C08L7/00 ,  C08G8/00 ,  C08G8/04 ,  C08G8/20 ,  C08G8/24 ,  C08G8/28 ,  C08G75/16 ,  C08L21/00 ,  C08L23/00 ,  C08L33/00 ,  C08L33/02 ,  C08L61/06 ,  C08L61/10 ,  C08L81/00 ,  C08L101/00 ,  C08G14/04

    CPC分类号： C08G75/16 ,  C08G8/04 ,  C08G8/24 ,  C08G8/28 ,  C08L21/00 ,  C08L7/00 ,  C08L9/06 ,  C08K5/17 ,  C08K5/315 ,  C08K5/353

    摘要： A rubber composition comprising vulcanizable natural or synthetic rubber and a sulfide resin produced by (1) reacting a component (A) with a componet (B), followed by reacting with a component (D), or (2) reacting a component (A) with a component (B), followed by reacting with a component (C) and a component (D) simultaneously or sequentially, and if desired reacting the resulting phenol resin with an acylating agent, the component (A) being a phenol compound of the following formula, and/or an acylated compound thereof, ##STR1## wherein R.sub.1 and R.sub.2 are each a hydrogen atom, a hydroxyl, carboxyl, amino, C.sub.1 -C.sub.18 alkyl, C.sub.3 -C.sub.10 cycloalkyl, C.sub.3 -C.sub.10 cycloalkenyl or C.sub.7 -C.sub.12 aralkyl group or a phenyl group unsubstituted or substituted with at least one C.sub.1 -C.sub.3 alkyl group, the component (B) being a sulfur chloride or sulfur, the component (C) being an aldehyde, and the component (D) being at lest one hydroxyaryl compound of the following formula, and/or an acylated compound thereof, ##STR2## wherein R.sub.3 is a --OR.sub.6,--NHR.sub.6, --COOR.sub.6, --OCOR.sub.6, phenyl group unsubstituted or substituted with at least one C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.18 alkyl, C.sub.3 -C.sub.10 cycloalkyl, C.sub.3 -C.sub.10 cycloalkenyl or C.sub.7 -C.sub.12 aralkyl group, and R.sub.4 and R.sub.5 are each a hydrogen atom, --OR.sub.6, --NHR.sub.6,--COOR.sub.6, --0COR.sub.6, phenyl group unsubstituted or substituted with at least one C.sub.1-C.sub.3 alkyl, C.sub.1 -C.sub.18 alkyl, C.sub.3 -C.sub.10 cycloalkyl, C.sub.3 -C.sub.10 cycloalkenyl or C.sub.7 -C.sub.12 aralkyl group in which R.sub.6 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group.

    摘要翻译： （1）将组分（A）与组分（B）反应，然后与组分（D）反应，或（2）使组分（A）与组分（A）反应，制备包含可硫化天然或合成橡胶的橡胶组合物和硫化物树脂 ）与组分（B）反应，随后与组分（C）和组分（D）同时或相继反应，如果需要，使所得酚醛树脂与酰化剂反应，组分（A）为 下式，和/或其酰化化合物，其中R 1和R 2各自为氢原子，羟基，羧基，氨基，C 1 -C 18烷基，C 3 -C 10环烷基，C 3 -C 10环烯基或C 7 -C 12 芳烷基或未被取代或被至少一个C 1 -C 3烷基取代的苯基，所述组分（B）为硫化氯或硫，组分（C）为醛，组分（D）为至少一个 下式的羟基芳基化合物和/或其酰化化合物，其中R 1， 3是-OR 6，-NHR 6，-COOR 6，-OCOR 6，未被取代或被至少一个C 1 -C 3烷基，C 1 -C 18烷基，C 3 -C 10环烷基，C 3 -C 10环烯基或C 7 -C 12芳烷基取代的苯基， 并且R 4和R 5各自为氢原子，-OR 6，-NHR 6，-COOR 6，-COR 6，未被取代或被至少一个C 1 -C 3烷基，C 1 -C 18烷基，C 3 -C 10环烷基，C 3 -C 10环烯基 或其中R 6为氢原子或C 1 -C 4烷基的C 7 -C 12芳烷基。

    Vγ9Vδ2 T cell proliferation agent, method for producing activated Vγ9Vδ2 T cells, and uses thereof
    17.
    发明授权
    Vγ9Vδ2 T cell proliferation agent, method for producing activated Vγ9Vδ2 T cells, and uses thereof 有权
    Vγ9Vδ2T细胞增殖剂，活化的Vγ9Vδ2T细胞的制造方法及其用途

    公开(公告)号：US07749760B2

    公开(公告)日：2010-07-06

    申请号：US12316973

    申请日：2008-12-17

    申请人： Haruki Okamura ,  Shuji Kubo ,  Wen Li

    发明人： Haruki Okamura ,  Shuji Kubo ,  Wen Li

    IPC分类号： C12N5/078 ,  C12N5/0783 ,  C07K14/54 ,  C07F9/40

    CPC分类号： A61K31/663 ,  A61K38/20 ,  A61K38/2013 ,  C12N5/0638 ,  C12N2501/2302 ,  C12N2501/2318 ,  C12N2501/999 ,  Y02A50/411 ,  A61K2300/00

    摘要： A Vγ9Vδ2 T cell proliferation agent includes at least a bisphosphonate, interleukin 2, and interleukin 18. Since IL-18 has properties that improve cell viability by inhibiting cell death, IL-18 is presumably capable of acting as a cofactor for the bisphosphonate so as to significantly increase the effect of Vγ9Vδ2 T cell proliferation by the bisphosphonate and the IL-2. This allows providing a Vγ9Vδ2 T cell proliferation agent capable of growing Vγ9Vδ2 T cells with a proliferated efficiency significantly high compared to conventional methods so that the proliferated Vγ9Vδ2 T cells have a high antitumor activity and high cytokine productivity.

    摘要翻译： Vγ9Vδ2T细胞增殖剂包括至少二膦酸盐，白细胞介素2和白细胞介素18.由于IL-18具有通过抑制细胞死亡来改善细胞活力的性质，因此推测IL-18能够作为双膦酸盐的辅因子，以便 显着增加了双膦酸盐和IL-2对Vγ9Vδ2T细胞增殖的影响。 这允许提供与常规方法相比，能够以增殖效率显着增加Vγ9Vδ2T细胞的Vγ9Vδ2T细胞增殖剂，使得增殖的Vγ9Vδ2T细胞具有高抗肿瘤活性和高细胞因子生产力。

    Process for producing carboxylic acid ester
    19.
    发明授权
    Process for producing carboxylic acid ester 失效
    羧酸酯的制备方法

    公开(公告)号：US5302746A

    公开(公告)日：1994-04-12

    申请号：US44708

    申请日：1993-04-12

    申请人： Seiji Koono ,  Osamu Moriya ,  Toshio Noguchi ,  Haruki Okamura

    发明人： Seiji Koono ,  Osamu Moriya ,  Toshio Noguchi ,  Haruki Okamura

    IPC分类号： C07C67/08 ,  C07C67/58 ,  C07C69/54 ,  C07C69/52

    CPC分类号： C07C67/08

    摘要： A process for producing a carboxylic acid ester which comprises reacting a carboxylic acid with an alcohol in the presence of an acid catalyst to produce a reaction solution and neutralizing the reaction solution, characterized by using a countercurrently contacting column for neutralization, into which the esterified reaction solution is introduced at the lower portion of the column, an aqueous strong alkaline solution at a middle portion and an aqueous weak alkaline solution at an upper portion, removing a neutralized oil phase containing the carboxylic acid ester from the top of the column and removing an aqueous phase from the bottom, thereby continuously neutralizing the reaction solution.

    摘要翻译： 一种制备羧酸酯的方法，其包括在酸催化剂存在下使羧酸与醇反应以产生反应溶液并中和反应溶液，其特征在于使用逆流接触的中和柱，其中酯化反应 溶液引入塔的下部，中间部分的强碱性水溶液和上部的弱碱性水溶液，从塔的顶部除去含有羧酸酯的中和油相，并除去 水相，从而连续中和反应溶液。