-
公开(公告)号：US20110217267A1
公开(公告)日：2011-09-08
申请号：US13072705
申请日：2011-03-26
IPC分类号： A61K35/76 , C12N9/78 , C12N15/85 , C12N15/86 , C12N15/867 , C12N5/10 , C12N7/01 , C07H21/00 , A61K48/00 , A61P35/00 , A61P19/02
CPC分类号： C12N7/00 , A61K2039/505 , C07K14/55 , C07K14/57 , C07K16/2818 , C07K2317/622 , C07K2319/00 , C12N9/1077 , C12N9/78 , C12N15/113 , C12N15/86 , C12N2310/141 , C12N2740/13043 , C12N2840/102 , C12N2840/203 , C12Y305/04001
摘要： This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.
摘要翻译： 本公开提供了修饰的胞嘧啶脱氨酶（CDs）。 本公开进一步涉及表达或包含此类修饰的CD的细胞和载体以及在治疗疾病和病症中使用这些修饰的CD的方法。
-
公开(公告)号：US06241982B1
公开(公告)日：2001-06-05
申请号：US08468646
申请日：1995-06-06
IPC分类号： A61K4800
CPC分类号： A01K67/033 , A01K67/0275 , A01K2217/05 , A01K2217/30 , A01K2227/105 , A01K2267/03 , A61K35/13 , A61K38/2013 , A61K38/217 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/70514 , C07K2319/00 , C12N7/00 , C12N9/1211 , C12N15/8509 , C12N15/86 , C12N2710/16622 , C12N2740/13022 , C12N2740/15022 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16322 , C12N2830/001 , C12N2830/60 , C12N2840/20
摘要： The present invention provides recombinant viral vectors carrying a vector construct which directs the expression of a gene product (e.g., HSVTK) that activates a compound with little or no cytotoxicity into a toxic product. Also provided are methods of destroying or inhibiting pathogenic agents in a warm blooded animal, comprising the step of administering to the animal a viral vector such as that described above, in order to inhibit or destroy the pathogenic agent.
摘要翻译： 本发明提供携带载体构建体的重组病毒载体，其引导将毒性产物激活具有很少或不具有细胞毒性的化合物的基因产物（例如HSVTK）的表达。 还提供了在温血动物中破坏或抑制病原体的方法，包括向动物施用如上所述的病毒载体以抑制或破坏病原体的步骤。
-
13.发明授权Method for making reflection defective retroviral vectors for infecting human cells 失效复制用于感染人细胞的有缺陷的逆转录病毒载体的方法
公开(公告)号：US5856185A
公开(公告)日：1999-01-05
申请号：US472109
申请日：1995-06-07
申请人： Harry E. Gruber , Douglas J. Jolly , James G. Respess , Paul K. Laikind , Jack R. Barber , Daniel C. St. Louis , Sunil D. Chada , Stephen M. W. Chang , John F. Warner
发明人： Harry E. Gruber , Douglas J. Jolly , James G. Respess , Paul K. Laikind , Jack R. Barber , Daniel C. St. Louis , Sunil D. Chada , Stephen M. W. Chang , John F. Warner
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/21 , A61K48/00 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/73 , C12N5/10 , C12N7/04 , C12N9/12 , C12N15/85 , C12N15/867 , C07H21/04 , C12N15/48
CPC分类号： A01K67/033 , A61K38/2013 , A61K38/217 , A61K39/0011 , A61K39/12 , A61K39/21 , C07K14/005 , C07K14/70514 , C12N15/8509 , C12N15/86 , C12N7/00 , C12N9/1211 , A01K2217/05 , A01K2227/105 , A01K2267/01 , A01K2267/03 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , A61K35/13 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2740/13023 , C12N2740/13032 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.
摘要翻译： 公开了携带能够预防，抑制，稳定或逆转感染性，癌性或自身免疫性疾病的载体构建体的重组逆转录病毒。 更具体地，本发明的重组逆转录病毒可用于（a）刺激对抗原或病原性抗原的特异性免疫应答; （b）抑制病原体如病毒的功能; 和（c）抑制药剂与宿主细胞受体的相互作用。 此外，公开了感染的真核细胞和含有这种重组逆转录病毒的药物组合物。 还公开了用于生产具有独特特征的重组逆转录病毒的各种方法，以及用于生产转基因包装动物或昆虫的方法。
-
14.发明授权Recombinant retroviruses expressing a protein that converts a pro-drug into a cytotoxic agent 失效表达将前体药物转化成细胞毒性剂的蛋白质的重组逆转录病毒
公开(公告)号：US5691177A
公开(公告)日：1997-11-25
申请号：US460996
申请日：1995-06-05
IPC分类号： A01K67/027 , A61K38/00 , A61K38/19 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/21 , A61K48/00 , C07K14/155 , C07K14/16 , C07K14/73 , C12N7/04 , C12N9/12 , C12N15/867 , C12N5/08 , C12N5/10
CPC分类号： A01K67/0275 , A61K39/0011 , A61K39/12 , A61K39/21 , C07K14/005 , C07K14/70514 , C12N15/86 , C12N7/00 , C12N9/1211 , A01K2217/05 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , A61K48/00 , C12N2740/13022 , C12N2740/13023 , C12N2740/13032 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16023 , C12N2740/16134 , C12N2740/16222
摘要： Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.
摘要翻译： 公开了携带能够预防，抑制，稳定或逆转感染性，癌性或自身免疫性疾病的载体构建体的重组逆转录病毒。 更具体地，本发明的重组逆转录病毒可用于（a）刺激对抗原或病原性抗原的特异性免疫应答; （b）抑制病原体如病毒的功能; 和（c）抑制药剂与宿主细胞受体的相互作用。 此外，公开了感染的真核细胞和含有这种重组逆转录病毒的药物组合物。 还公开了用于生产具有独特特征的重组逆转录病毒的各种方法，以及用于生产转基因包装动物或昆虫的方法。
-
公开(公告)号：US09663834B2
公开(公告)日：2017-05-30
申请号：US13810403
申请日：2011-07-16
申请人： Douglas J. Jolly , Omar Perez , Amy Lin
发明人： Douglas J. Jolly , Omar Perez , Amy Lin
CPC分类号： C12Q1/702 , C12N2740/13011 , C12N2799/027 , C12Q1/701
摘要： Provided are methods and compositions useful for detecting viral infection or contamination in a biological sample.
-
公开(公告)号：US08722867B2
公开(公告)日：2014-05-13
申请号：US13072705
申请日：2011-03-26
IPC分类号： A61K48/00 , C07H21/00 , C12N15/867 , A61K35/76 , C12N15/63
CPC分类号： C12N7/00 , A61K2039/505 , C07K14/55 , C07K14/57 , C07K16/2818 , C07K2317/622 , C07K2319/00 , C12N9/1077 , C12N9/78 , C12N15/113 , C12N15/86 , C12N2310/141 , C12N2740/13043 , C12N2840/102 , C12N2840/203 , C12Y305/04001
摘要： This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.
摘要翻译： 本公开提供了修饰的胞嘧啶脱氨酶（CDs）。 本公开进一步涉及表达或包含此类修饰的CD的细胞和载体以及在治疗疾病和病症中使用这些修饰的CD的方法。
-
公开(公告)号：US20120087894A1
公开(公告)日：2012-04-12
申请号：US13376827
申请日：2010-06-17
申请人： Douglas J. Jolly , Carlos Ibanez
发明人： Douglas J. Jolly , Carlos Ibanez
CPC分类号： C12N15/86 , C12N2740/13043 , C12N2740/13051 , C12N2740/13052
摘要： The disclosure provide cell lines and methods for the production of vectors and viral particles useful in gene therapy.
摘要翻译： 本公开提供用于生产用于基因治疗的载体和病毒颗粒的细胞系和方法。
-
公开(公告)号：US20110268720A1
公开(公告)日：2011-11-03
申请号：US13001516
申请日：2009-06-30
申请人： Harry E. Gruber , Douglas J. Jolly , Kay Olmstead
发明人： Harry E. Gruber , Douglas J. Jolly , Kay Olmstead
IPC分类号： A61K31/513 , A61K48/00 , A61P35/00 , A61K38/46 , C07D239/47 , A61P31/10
CPC分类号： A61K31/513 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/4196 , A61K31/496 , A61K31/505 , A61K31/7048 , A61K38/50 , A61K38/51 , C12Y305/04001 , A61K2300/00
摘要： The disclosure provides an extended release formulation of 5-fluorocytosine. In another aspect, a method of treating a fungal disease is provided. The method comprises administering to a subject in need thereof a fungus-treating effective amount of a composition comprising 5-fluorocytosine. In yet another aspect, a method of treating a cancer is provided. The method comprises administering to a subject in need thereof a sufficient amount of an expression vector to induce expression of cytosine deaminase which is capable of converting 5-fluorocytosine to 5-fluorourcail in cells of the cancer and a cancer-treating effective amount of a composition comprising 5-fluorocytosine.
摘要翻译： 本公开提供5-氟胞嘧啶的延长释放制剂。 另一方面，提供了一种治疗真菌病的方法。 该方法包括向有需要的受试者施用真菌治疗有效量的包含5-氟胞嘧啶的组合物。 另一方面，提供了治疗癌症的方法。 该方法包括向有需要的受试者施用足够量的表达载体以诱导能够将5-氟胞嘧啶转化成癌症细胞中的5-氟尿嘧啶的胞嘧啶脱氨酶的表达和癌症治疗有效量的组合物 包含5-氟胞嘧啶。
-
公开(公告)号：US5830458A
公开(公告)日：1998-11-03
申请号：US487776
申请日：1995-06-07
IPC分类号： A01K67/027 , A61K38/00 , A61K38/19 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/21 , A61K48/00 , C07K14/155 , C07K14/16 , C07K14/73 , C12N7/04 , C12N9/12 , C12N15/867
CPC分类号： A01K67/0275 , A61K39/0011 , A61K39/12 , A61K39/21 , C07K14/005 , C07K14/70514 , C12N15/86 , C12N7/00 , C12N9/1211 , A01K2217/05 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , A61K48/00 , C12N2740/13022 , C12N2740/13023 , C12N2740/13032 , C12N2740/13043 , C12N2740/13052 , C12N2740/15022 , C12N2740/16023 , C12N2740/16134 , C12N2740/16222
摘要： Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.
摘要翻译： 公开了携带能够预防，抑制，稳定或逆转感染性，癌性或自身免疫性疾病的载体构建体的重组逆转录病毒。 更具体地，本发明的重组逆转录病毒可用于（a）刺激对抗原或病原性抗原的特异性免疫应答; （b）抑制病原体如病毒的功能; 和（c）抑制药剂与宿主细胞受体的相互作用。 此外，公开了感染的真核细胞和含有这种重组逆转录病毒的药物组合物。 还公开了用于生产具有独特特征的重组逆转录病毒的各种方法，以及用于生产转基因包装动物或昆虫的方法。
-
公开(公告)号：US5503974A
公开(公告)日：1996-04-02
申请号：US106145
申请日：1993-08-13
IPC分类号： C12N15/867 , C12Q1/04 , C12Q1/68 , C12Q1/70 , G01N33/564 , G01N33/566 , G01N33/569 , G01N33/53 , G01N33/555 , G01N33/567
CPC分类号： C12N15/86 , C12Q1/04 , C12Q1/6897 , C12Q1/70 , C12Q1/702 , G01N33/564 , G01N33/566 , G01N33/56983 , G01N33/56988 , C12N2740/13043 , G01N2800/102
摘要： A method, and groups of cells and retroviruses useful in the performance of the method, of testing for the presence or amount of a first retrovirus in a specimen. A replication defective retroviral construct having a marker sequence is exposed to the specimen and the presence or amount of a recombinant retrovirus carrying the marker sequence is tested for. The replication defective vector may be disposed in cells, with the specimen being tested for the presence or amount of a retrovirus, or it may be disposed in a retrovirus, with the specimen being a group of cells which are tested for the presence or amount of said first retrovirus. In either case, where a first retrovirus complements the defective vector, a recombinant retrovirus carrying the marker sequence will be produced. The first retrovirus to be tested for may be of a previously known, or unknown type, and may be any of a group of retroviruses.
摘要翻译： 用于实施该方法的方法以及可用于测试样品中第一逆转录病毒的存在或量的细胞和逆转录病毒组。 将具有标记序列的复制缺陷型逆转录病毒构建体暴露于标本，并测试携带标记序列的重组逆转录病毒的存在或量。 复制缺陷载体可以设置在细胞中，其中试样的逆转录病毒的存在或数量被测试，或者可以将其置于逆转录病毒中，试样是一组细胞，其被测试存在或量 第一个逆转录病毒 在任一种情况下，当第一逆转录病毒补充缺陷型载体时，将产生携带标记序列的重组逆转录病毒。 待测试的第一种逆转录病毒可以是先前已知的或未知的类型，并且可以是一组逆转录病毒中的任何一种。
-
-
-
-
-
-
-
-
-
搜索结果
50 条记录 (耗时 0.052 秒)
