公开(公告)号：US06759673B2

公开(公告)日：2004-07-06

申请号：US10162197

申请日：2002-06-05

申请人： Taizo Akimoto ,  Masashi Hakamata

发明人： Taizo Akimoto ,  Masashi Hakamata

IPC分类号： G01N2304

CPC分类号： G01T1/2014

摘要： A radiation image readout apparatus scans an excitation light in a main scanning direction and a sub scanning direction over a stimulable phosphor sheet, on which radiation energy has been stored, and detects the stimulated emission emitted thereupon; wherein, various types of phosphor sheets can be read out at a high resolution and high sensitivity. The excitation light energy level for obtaining an adequate sensitivity for each type of phosphor sheet is obtained. A controller controls the intensity of the excitation light emitted from the light source and the speed of the scanning mechanism, that is, the readout speed, whereby the excitation light projected onto a phosphor sheet of which the diffusion rate has been controlled by the inclusion therein of an navy blue colorant is of a greater energy level than the excitation light projected onto the white stimulable phosphor sheet not containing the navy blue colorant.

摘要翻译： 放射线图像读出装置在主扫描方向和副扫描方向上扫描已经存储有辐射能的可刺激的荧光体片，并检测其上发射的受激发射; 其中可以以高分辨率和高灵敏度读出各种类型的荧光片。 获得用于获得每种类型的荧光粉片的足够灵敏度的激发光能级。 控制器控制从光源发射的激发光的强度和扫描机构的速度，即读出速度，由此投射到通过包含其中的扩散速率被控制的荧光体片上的激发光 的海蓝色着色剂的能量水平比投射到不含海蓝色着色剂的白色可激发荧光粉片上的激发光更大。

公开(公告)号：US20110242541A1

公开(公告)日：2011-10-06

申请号：US13076368

申请日：2011-03-30

申请人： Masashi Hakamata

发明人： Masashi Hakamata

IPC分类号： G01N21/55 ,  G02B5/04 ,  G02B27/56

CPC分类号： G01N21/648 ,  G01N21/05

摘要： The shape of a prism is set such that an excitation light beam that enters the prism to cause surface plasmon resonance to be generated is not irradiated onto the corners of the prism after being totally reflected within the prism. The angle of a surface that the excitation light exits the prism is set to an angle at which the excitation light beam is not totally reflected. Thereby, the excitation light beam returning to a light source, and being scattered within the prism are prevented, and therefore the accuracy of measurements can be improved.

摘要翻译： 棱镜的形状被设定为使得入射到棱镜中以产生表面等离子体共振的激发光束在棱镜中被全反射之后不会照射到棱镜的角上。 激发光离开棱镜的表面的角度被设定为激发光束未被全反射的角度。 由此，防止了返回到光源并在棱镜内散射的激发光束，因此能够提高测量精度。

公开(公告)号：US07193703B2

公开(公告)日：2007-03-20

申请号：US11322350

申请日：2006-01-03

申请人： Masashi Hakamata ,  Tatsuo Fujikura

发明人： Masashi Hakamata ,  Tatsuo Fujikura

IPC分类号： G01N1/10

CPC分类号： G01N21/553 ,  G01N21/05 ,  G01N2021/058

摘要： A surface plasmon resonance sensor unit includes a prism. A thin film has a first surface and a sensing surface. The first surface overlies the prism to constitute a thin film/prism interface. The sensing surface immobilizes a sample in sample fluid. Illuminating light is applied to the interface in a form satisfying a condition for total internal reflection, to create attenuated total reflection in the illuminating light reflected by the interface. An angle of incidence of the illuminating light upon the attenuated total reflection is changed upon (bio)chemical reaction of the sample on the sensing surface. The sensor unit includes an enclosing cover, secured to the prism, for covering the sensing surface. A lower recess is formed in the prism, and positioned at the sensing surface. The lower recess constitutes a flow channel for flow of the sample fluid on the sensing surface.

摘要翻译： 表面等离子体共振传感器单元包括棱镜。 薄膜具有第一表面和感测表面。 第一表面覆盖棱镜以构成薄膜/棱镜界面。 感测表面将样品固定在样品流体中。 照明光以满足全内反射条件的形式施加到界面，以在由界面反射的照明光中产生衰减的全反射。 减弱的全反射后的照明光的入射角随着样品在感测表面的（生物）化学反应而改变。 传感器单元包括固定到棱镜的封闭盖，用于覆盖传感表面。 在棱镜中形成下凹槽，并位于感测面上。 下凹部构成用于在感测表面上流动样品流体的流动通道。

公开(公告)号：US20060146333A1

公开(公告)日：2006-07-06

申请号：US11322350

申请日：2006-01-03

申请人： Masashi Hakamata ,  Tatsuo Fujikura

发明人： Masashi Hakamata ,  Tatsuo Fujikura

IPC分类号： G01N21/55

CPC分类号： G01N21/553 ,  G01N21/05 ,  G01N2021/058

摘要： A surface plasmon resonance sensor unit includes a prism. A thin film has a first surface and a sensing surface. The first surface, overlies the prism to constitute a thin film/prism interface. The sensing surface immobilizes a sample in sample fluid. Illuminating light is applied to the interface in a form satisfying a condition for total internal reflection, to create attenuated total reflection in the illuminating light reflected by the interface. An angle of incidence of the illuminating light upon the attenuated total reflection is changed upon (bio)chemical reaction of the sample on the sensing surface. The sensor unit includes an enclosing cover, secured to the prism, for covering the sensing surface. A lower recess is formed in the prism, and positioned at the sensing surface. The lower recess constitutes a flow channel for flow of the sample fluid on the sensing surface.

摘要翻译： 表面等离子体共振传感器单元包括棱镜。 薄膜具有第一表面和感测表面。 第一个表面覆盖棱镜，构成薄膜/棱镜界面。 感测表面将样品固定在样品流体中。 照明光以满足全内反射条件的形式施加到界面，以在由界面反射的照明光中产生衰减的全反射。 减弱的全反射后的照明光的入射角随着样品在感测表面的（生物）化学反应而改变。 传感器单元包括固定到棱镜的封闭盖，用于覆盖传感表面。 在棱镜中形成下凹槽，并位于感测面上。 下凹部构成用于在感测表面上流动样品流体的流动通道。

公开(公告)号：US08665444B2

公开(公告)日：2014-03-04

申请号：US13076368

申请日：2011-03-30

申请人： Masashi Hakamata

发明人： Masashi Hakamata

IPC分类号： G01N21/55

CPC分类号： G01N21/648 ,  G01N21/05

摘要： The shape of a prism is set such that an excitation light beam that enters the prism to cause surface plasmon resonance to be generated is not irradiated onto the corners of the prism after being totally reflected within the prism. The angle of a surface that the excitation light exits the prism is set to an angle at which the excitation light beam is not totally reflected. Thereby, the excitation light beam returning to a light source, and being scattered within the prism are prevented, and therefore the accuracy of measurements can be improved.

摘要翻译： 棱镜的形状被设定为使得入射到棱镜中以产生表面等离子体共振的激发光束在棱镜中被全反射之后不会照射到棱镜的角上。 激发光离开棱镜的表面的角度被设定为激发光束未被全反射的角度。 由此，防止了返回到光源并在棱镜内散射的激发光束，因此能够提高测量精度。

公开(公告)号：US20110236262A1

公开(公告)日：2011-09-29

申请号：US13071142

申请日：2011-03-24

申请人： Kazuyoshi HORII ,  Tomonari Sendai ,  Akihiro Komatsu ,  Mitsuaki Uchida ,  Masashi Hakamata ,  Junpei Shiraishi ,  Daisuke Hibe ,  Yasunori Ohta ,  Akira Ito

发明人： Kazuyoshi HORII ,  Tomonari Sendai ,  Akihiro Komatsu ,  Mitsuaki Uchida ,  Masashi Hakamata ,  Junpei Shiraishi ,  Daisuke Hibe ,  Yasunori Ohta ,  Akira Ito

IPC分类号： B01J19/00

CPC分类号： G01N21/648 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2200/143 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0877 ,  B01L2400/0487 ,  B01L2400/082

摘要： A biological substance detecting apparatus that enables stable detection and quantitative analysis of biologically derived target substances is provided. The biological substance detecting apparatus employs a sensor chip provided with a fine flow channel through which a sample liquid is caused to flow, and a sensor surface that adsorbs a biologically derived target substance. Light is irradiated onto the sensor surface, and light emitted by the adsorbed target substance or a labeling substance bound thereto is detected. A flow speed controlling means, for controlling the flow speed of the sample liquid that flows through the fine flow channel to a value within a range such that the adsorption speed of the target substance is not controlled by dispersion.

摘要翻译： 提供一种能够对生物衍生的靶物质进行稳定检测和定量分析的生物物质检测装置。 生物物质检测装置采用设置有流过样品液的微细流路的传感器芯片和吸附生物衍生的靶物质的传感器表面。 光照射到传感器表面上，并且检测被吸附的目标物质发出的光或与其结合的标记物质。 一种流量控制装置，用于将流过细流动通道的样品液体的流速控制在使得目标物质的吸附速度不受分散控制的范围内的值。

公开(公告)号：US07740908B2

公开(公告)日：2010-06-22

申请号：US11362741

申请日：2006-02-28

申请人： Yukou Saito ,  Masashi Hakamata

发明人： Yukou Saito ,  Masashi Hakamata

IPC分类号： B05D3/12 ,  B05D3/04

CPC分类号： G01N21/553 ,  Y10T428/31511 ,  Y10T428/31692 ,  Y10T428/31855

摘要： It is an object of the present invention to provide a method for producing a solid substrate used for sensors having a film with a small film thickness distribution, and a solid surface used for sensors having a film with a small film thickness distribution. The present invention provides a method for producing a solid substrate for sensors that has a coating on the surface using spin coating, wherein a substrate to be coated is rotated in an atmosphere in which the vapor pressure of coating solvent is 50% to 100% with respect to the saturation vapor pressure so as to form a thin film of a coating solution on said substrate to be coated.

摘要翻译： 本发明的目的是提供一种用于制造具有薄膜厚度分布薄膜的传感器的固体基板的制造方法，以及用于具有薄膜厚度分布薄膜的传感器的固体表面。 本发明提供了一种用于制造传感器的固体基板的方法，该传感器在旋转涂层的表面上具有涂层，其中待涂布的基材在涂布溶剂的蒸气压为50％至100％的气氛中旋转， 相对于饱和蒸气压，以便在待涂覆的基底上形成涂层溶液的薄膜。

公开(公告)号：US20080079951A1

公开(公告)日：2008-04-03

申请号：US11864711

申请日：2007-09-28

申请人： Hiroaki YAMAMOTO ,  Toshihito Kimura ,  Hitoshi Shimizu ,  Masashi Hakamata

发明人： Hiroaki YAMAMOTO ,  Toshihito Kimura ,  Hitoshi Shimizu ,  Masashi Hakamata

IPC分类号： G01B11/30

CPC分类号： G01N21/553 ,  G01N2021/157

摘要： Provided are a detection apparatus, a detection method and an optically transparent member, which can detect a decrease in a precision. A convolution is performed by a convolution portion 80 contained in an image processing portion 38, to acquire the distribution information indicating the light intensity distribution of a light beam, which is totally reflected at the interface and which is incident at a plurality of angles to an dielectric block 52 so as to be totally reflected at the interface of the dielectric block 52. A spatial frequency resolution is performed on the light intensity distribution indicated by the distribution information acquired, by a detection precision evaluating portion 86 contained in the image processing portion 38, to thereby derive the light intensity distribution of each spatial frequency of the light beam. The precision is detected by comparing the light intensity distribution derived, with a threshold value predetermined for each spatial frequency.

摘要翻译： 提供了能够检测精度降低的检测装置，检测方法和光学透明构件。 通过包含在图像处理部分38中的卷积部分80执行卷积，以获取指示在该界面处被全反射并以多个角度入射的光束的光强度分布的分布信息 介质块52，以便在介质块52的界面处被完全反射。 由包含在图像处理部分38中的检测精度评估部分86对由所获取的分布信息指示的光强度分布执行空间频率分辨率，从而导出光束的每个空间频率的光强度分布。 通过将导出的光强度分布与针对每个空间频率预定的阈值进行比较来检测精度。

公开(公告)号：USD561054S1

公开(公告)日：2008-02-05

申请号：US29266476

申请日：2006-09-22

申请人： Nobuhiko Ogura ,  Katsuaki Muraishi ,  Hitoshi Shimizu ,  Masashi Hakamata ,  Yasunobu Sakaguchi ,  Yoshiyuki Kunuki

设计人： Nobuhiko Ogura ,  Katsuaki Muraishi ,  Hitoshi Shimizu ,  Masashi Hakamata ,  Yasunobu Sakaguchi ,  Yoshiyuki Kunuki

公开(公告)号：US20050069937A1

公开(公告)日：2005-03-31

申请号：US10951814

申请日：2004-09-29

申请人： Nobuhiko Ogura ,  Masashi Hakamata

发明人： Nobuhiko Ogura ,  Masashi Hakamata

IPC分类号： G01N33/566 ,  A61L2/00 ,  B01D67/00 ,  B01D69/10 ,  B01D69/14 ,  B01J19/00 ,  B01L3/00 ,  C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/68 ,  C40B40/06 ,  C40B60/14 ,  G01N33/53 ,  G01N35/02 ,  G01N35/10 ,  G01N37/00

CPC分类号： B01D67/0002 ,  B01D69/10 ,  B01D69/141 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00353 ,  B01J2219/00387 ,  B01J2219/00527 ,  B01J2219/00574 ,  B01J2219/00576 ,  B01J2219/00578 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00662 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01L3/5085 ,  B01L2300/069 ,  B01L2300/0819 ,  C40B40/06 ,  C40B60/14

摘要： In a biochemical analysis unit, a membrane is pressed into through holes formed in a substrate to form plural spot areas in each through hole, and the remaining membrane forms a thin layer on a rear face of the substrate. A probe solution is spotted on each spot area by a spot head. On the occasion of the spotting, a pin arrangement plate presses the biochemical analysis unit from the rear face. On the pin arrangement plate, pins are arranged at the same pitch as the spot areas. The pin arrangement plate is positioned such that the pins confront the corresponding spot areas. When the pressing is made, the pins push the thin layer to enter the corresponding through holes. Thus the pores in the thin layer are squashed, and it is prevented that the probe solution penetrate into the neighboring spot areas.

摘要翻译： 在生物化学分析单元中，将膜压入形成在基板中的通孔中，以在每个通孔中形成多个点区域，并且剩余的膜在基板的后表面上形成薄层。 探针溶液通过点头在每个斑点区域上发现。 在点样时，针布置板从后面按压生化分析单元。 在引脚排列板上，引脚以与点区域相同的间距布置。 销布置板被定位成使得销对着相应的光斑区域。 当按压时，销将推薄层进入相应的通孔。 因此，薄层中的孔被挤压，并且防止探针溶液渗入相邻的斑点区域。