Soluble neuropilin/growth factor receptor fusion proteins
    16.
    发明授权
    Soluble neuropilin/growth factor receptor fusion proteins 失效
    可溶性神经蛋白/生长因子受体融合蛋白

    公开(公告)号:US07420042B2

    公开(公告)日:2008-09-02

    申请号:US10303786

    申请日:2002-11-26

    IPC分类号: C12P21/08 C07K14/71

    摘要: Complexes of a protein selected from the group consisting of VEGF-B167, VEGF-C, VEGF-D and processed VEGF-B186 and analogs thereof and the neuropilin-1 (NP-1) receptor, the extracellular domain or a ligand-binding fragment or analogue thereof; the use of such complexes in assays for growth factor proteins having substantially the same binding affinity for a cell surface receptor as VEGF-B167, VEGF-C, VEGF-D or processed VEGF-B186 and/or in promoting or antagonizing a cellular response mediated by VEGF-B167, VEGF-C, VEGF-D and/or processed VEGF-B186; and specific binding partners, e.g. antibodies, for such complexes.

    摘要翻译: 选自VEGF-B 167,VEGF-C,VEGF-D和加工的VEGF-B 186和其类似物的蛋白质的复合物和神经毡蛋白-1 (NP-1)受体,细胞外结构域或其配体结合片段或其类似物; 对于对VEGF-B 167,VEGF-C,VEGF-D或加工的VEGF-B细胞表面受体具有基本上相同的结合亲和力的生长因子蛋白的测定中使用这种复合物 186和/或促进或拮抗由VEGF-B 167,VEGF-C,VEGF-D和/或经加工的VEGF-B 186介导的细胞应答; 和特异性结合配偶体,例如 抗体。

    Neuropilin/growth factor complexes and uses thereof
    17.
    发明授权
    Neuropilin/growth factor complexes and uses thereof 失效
    神经蛋白/生长因子复合物及其用途

    公开(公告)号:US06515105B1

    公开(公告)日:2003-02-04

    申请号:US09421365

    申请日:1999-10-19

    IPC分类号: C07K100

    摘要: Complexes of a protein selected from the group consisting of VEGF-B167, VEGF-C, VEGF-D and processed VEGF-B186 and analogs thereof and the neuropilin-1 (NP-1) receptor, the extracellular domain or a ligand-binding fragment or analogue thereof; the use of such complexes in assays for growth factor proteins having substantially the same binding affinity for a cell surface receptor as VEGF-B167, VEGF-C, VEGF-D or processed VEGF-B186 and/or in promoting or antagonizing a cellular response mediated by VEGF-B167, VEGF-C, VEGF-D and/or processed VEGF-B186; and specific binding partners, e.g. antibodies, for such complexes.

    摘要翻译: 选自VEGF-B167,VEGF-C,VEGF-D和加工的VEGF-B186及其类似物的蛋白质与神经蛋白-1(NP-1)受体,细胞外结构域或配体结合片段的复合物 或其类似物; 对于对VEGF-B167,VEGF-C,VEGF-D或加工的VEGF-B186具有基本上与细胞表面受体具有相同结合亲和力的生长因子蛋白和/或促进或拮抗细胞应答介导的生长因子蛋白 通过VEGF-B167,VEGF-C,VEGF-D和/或加工的VEGF-B186; 和特异性结合配偶体,例如 抗体。

    Antibodies specific for vascular endothelial growth factor-B
    19.
    发明授权
    Antibodies specific for vascular endothelial growth factor-B 失效
    血管内皮生长因子B特异性抗体

    公开(公告)号:US06331301B1

    公开(公告)日:2001-12-18

    申请号:US08851896

    申请日:1997-05-06

    IPC分类号: C07K1622

    CPC分类号: C07K14/52 A61K38/00

    摘要: VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.

    摘要翻译: 具有促进血管内皮细胞有丝分裂和增殖的生长因子的PDGF家族的VEGF-B多肽,编码这些多肽的DNA序列,含有它们的药物组合物和与它们反应的抗体。 VEGF-B多肽可用于刺激血管发生以及诊断应用。