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20 条记录 (耗时 0.03 秒)

    C2-C5-Alkyl-Imidazole-Bisphosphonates
    12.
    发明申请
    C2-C5-Alkyl-Imidazole-Bisphosphonates 有权
    C2-C5-烷基 - 咪唑 - 二膦酸酯

    公开(公告)号：US20090143337A1

    公开(公告)日：2009-06-04

    申请号：US12323696

    申请日：2008-11-26

    申请人： Sven Weiler ,  Leo Widler ,  Jean-Michel Rondeau ,  Simona Cotesta ,  Wolfgang Jahnke

    发明人： Sven Weiler ,  Leo Widler ,  Jean-Michel Rondeau ,  Simona Cotesta ,  Wolfgang Jahnke

    IPC分类号： A61K31/675 ,  C07F9/40 ,  A61P19/08

    CPC分类号： C07F9/6506

    摘要： C2-C5-Alkyl-substituted [(imidazol-1-yl)-1-hydroxy-1-phosphono-ethyl]-phosphonic acids, as well as methods or processes for their manufacture, their use in the manufacture of pharmaceutical formulations, their use in the treatment of diseases, methods of using them in the treatment of diseases, pharmaceutical formulations encompassing them and/or the compounds for use in the treatment of diseases, are described. The compounds are able to inhibit excessive or inappropriate bone resorption and for the treatment of other diseases which are caused by excessive prenylation of target proteins, such as Hutchinson-Gilford progeria syndrome. The compounds are of the formula I, wherein one of R1 and R2 is hydrogen and the other is C2-C5-alkyl that is branched or unbranched, and can be in free form, in the form of an ester, and/or of a salt.

    摘要翻译： C2-C5-烷基取代的[（咪唑-1-基）-1-羟基-1-膦酰基 - 乙基] - 膦酸，以及其制备方法或方法，它们在药物制剂的制备中的用途，它们 描述了用于治疗疾病，用于治疗疾病的方法，包括它们的药物制剂和/或用于治疗疾病的化合物。 该化合物能够抑制过度或不适当的骨吸收和用于治疗由靶向蛋白过度异戊二烯化引起的其他疾病，例如Hutchinson-Gilford progeria综合征。 该化合物具有式I化合物，其中R 1和R 2之一是氢，另一个是支链或非支链的C 2 -C 5 - 烷基，并且可以是酯的游离形式，和/或 盐。

    PHENYLALKYL-IMIDAZOLE-BISPHOSPHONATE COMPOUNDS
    15.
    发明申请
    PHENYLALKYL-IMIDAZOLE-BISPHOSPHONATE COMPOUNDS 审中-公开
    苯基 - 咪唑 - 二磷酸酯化合物

    公开(公告)号：US20110257131A1

    公开(公告)日：2011-10-20

    申请号：US13141249

    申请日：2009-12-21

    申请人： Simona Cotesta ,  Wolfgang Jahnke ,  Jean-Michel Rondeau ,  Sven Weiler ,  Leo Widler

    发明人： Simona Cotesta ,  Wolfgang Jahnke ,  Jean-Michel Rondeau ,  Sven Weiler ,  Leo Widler

    IPC分类号： A61K31/675 ,  A61P19/00 ,  A61P43/00 ,  C07F9/572

    CPC分类号： C07F9/6506

    摘要： (Unsubstituted or substituted phenyl)-alkyl-substituted [(imidazol-1-yl)-1-hydroxy-1-phosphono-ethyl]-phosphonic, as well as methods or processes for their manufacture, their use in the manufacture of pharmaceutical formulations, their use in the treatment of diseases, methods of using them in the treatment of diseases, pharmaceutical formulations encompassing them and/or the compounds for use in the treatment of diseases, are disclosed. The compounds are able to inhibit excessive or inappropriate bone resorption. The compounds are of the formula I, wherein one of R1 and R2 are as defined in the specification, and can be in free form, in the form of an ester, and/or of a salt.

    摘要翻译： （未取代或取代的苯基） - 烷基取代的[（咪唑-1-基）-1-羟基-1-膦酰基 - 乙基] - 膦酸，以及其制备方法或方法，它们在制备药物制剂中的用途 ，它们在疾病治疗中的应用，用于治疗疾病的方法，包括它们的药物制剂和/或用于治疗疾病的化合物。 这些化合物能够抑制过量或不适当的骨吸收。 化合物是式I化合物，其中R 1和R 2之一如说明书中所定义，并且可以为酯的形式的游离形式和/或盐。

    C2-C5-Alkyl-Imidazole-Bisphosphonates
    16.
    发明申请
    C2-C5-Alkyl-Imidazole-Bisphosphonates 审中-公开
    C2-C5-烷基 - 咪唑 - 二膦酸酯

    公开(公告)号：US20110224173A1

    公开(公告)日：2011-09-15

    申请号：US13116671

    申请日：2011-05-26

    申请人： Sven Weiler ,  Leo Widler ,  Jean-Michel Rondeau ,  Simona Cotesta ,  Wolfgang Jahnke

    发明人： Sven Weiler ,  Leo Widler ,  Jean-Michel Rondeau ,  Simona Cotesta ,  Wolfgang Jahnke

    IPC分类号： A61K31/675 ,  C07F9/6506 ,  A61P19/00

    CPC分类号： C07F9/6506

    摘要： C2-C5-Alkyl-substituted [imidazol-1-yl)-1-hydroxy-1-phosphono-ethyl]-phosphonic acids, as well as methods or processes for their manufacture, their use in the manufacture of pharmaceutical formulations, their use in the treatment of diseases, methods of using them in the treatment of diseases, pharmaceutical formulations encompassing them and/or the compounds for use in the treatment of diseases, are described. The compounds are able to inhibit excessive or inappropriate bone resorption and for the treatment of other diseases which are caused by excessive prenylation of target proteins, such as Hutchinson-Gilford progeria syndrome. The compounds are of the formula I, wherein one of R1 and R2 is hydrogen and the other is C2-C5-alkyl that is branched or unbranched, and can be in free form, in the form of an ester, and/or of a salt.

    摘要翻译： C2-C5-烷基取代的[咪唑-1-基] -1-羟基-1-膦酰基 - 乙基]膦酸，以及其制备方法或方法，它们在制备药物制剂中的用途，它们的用途 在治疗疾病方面，使用它们治疗疾病的方法，包括它们的药物制剂和/或用于治疗疾病的化合物。 该化合物能够抑制过度或不适当的骨吸收和用于治疗由靶向蛋白过度异戊二烯化引起的其他疾病，例如Hutchinson-Gilford progeria综合征。 该化合物具有式I化合物，其中R 1和R 2之一是氢，另一个是支链或非支链的C 2 -C 5 - 烷基，并且可以是酯的游离形式，和/或 盐。