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    Valve switch modulation for reducing errors due to oscillations of the inlet fluid of a pump system
    11.
    发明授权
    Valve switch modulation for reducing errors due to oscillations of the inlet fluid of a pump system 有权
    阀开关调节，用于减少由于泵系统的入口流体的振荡引起的误差

    公开(公告)号：US08622609B2

    公开(公告)日：2014-01-07

    申请号：US13949806

    申请日：2013-07-24

    Applicant: Waters Technologies Corporation

    Inventor： Joshua A. Shreve ,  Steven J. Ciavarini

    IPC: B01F13/00

    CPC classification number: B01F15/0479 ,  B01D15/14 ,  B01F15/0216 ,  G01N30/34 ,  G01N30/36 ,  G01N35/00871 ,  G01N35/1097 ,  G01N2030/347 ,  G01N2035/00544 ,  G05D11/133

    Abstract: Described is a method of reducing liquid composition errors in a low-pressure mixing pump system. Packets representing the switching intervals of each component of the desired fluid mixture are provided to an intake of the mixing pump system. For each packet, a switching time associated with at least one of the components in the packet is modulated. Modulated switching times are based on time offsets that are specifically selected according to the undesirable frequency characteristic of an intake response of the mixing pump system. The average of the volumes contributed by the packets thus modulated is equal to a component volume that achieves a desired proportion of the component in the output flow of the mixing pump system. Modulated switching times enable the reduction or elimination of composition error in the output flow of the mixing pump system.

    Abstract translation: 描述了在低压混合泵系统中减少液体组成误差的方法。 表示所需流体混合物的每个组分的切换间隔的分组被提供给混合泵系统的进气口。 对于每个分组，调制与分组中的至少一个分量相关联的切换时间。 调制切换时间基于根据混合泵系统的进气响应的不期望的频率特性而特别选择的时间偏移。 由如此调制的分组贡献的卷的平均值等于在混合泵系统的输出流中实现组分的期望比例的分量体积。 调制切换时间可以减少或消除混合泵系统的输出流量中的组成误差。

    Method and an apparatus for analyzing a complex sample
    12.
    发明授权
    Method and an apparatus for analyzing a complex sample 有权

    公开(公告)号：US10115576B2

    公开(公告)日：2018-10-30

    申请号：US14563022

    申请日：2014-12-08

    Applicant: Waters Technologies Corporation

    Inventor： Scott J. Geromanos ,  Marc V. Gorenstein ,  Daniel Golick ,  Steven J. Ciavarini

    IPC: G01N30/86 ,  H01J49/00 ,  G01N27/62 ,  G01N30/72

    Abstract: A method of analyzing a complex sample includes performing a sequential chromatographic-IMS-MS analysis of a sample to obtain a plurality of experimental mass spectra having isotopic clusters, wherein each spectrum of the plurality of spectra is associated with a chromatographic retention time and an ion-mobility drift time. The method also includes calculating a model isotopic cluster of a precursor or product ion associated with a candidate compound in the sample, in correspondence to the natural isotopic-abundance ratios of elements composing the compound. The method further includes comparing peaks of the model isotopic cluster to corresponding peaks of an isotopic cluster of one of the experimental mass spectra to extract one or more saturated or interfered peaks of the experimental isotopic cluster, wherein at least one of the peaks of the experimental isotopic cluster is un-saturated and un-interfered.

    METHOD AND AN APPARATUS FOR ANALYZING A COMPLEX SAMPLE
    14.
    发明申请
    METHOD AND AN APPARATUS FOR ANALYZING A COMPLEX SAMPLE 审中-公开
    用于分析复杂样品的方法和装置

    公开(公告)号：US20150170892A1

    公开(公告)日：2015-06-18

    申请号：US14563022

    申请日：2014-12-08

    Applicant: Waters Technologies Corporation

    Inventor： Scott J. Geromanos ,  Marc V. Gorenstein ,  Daniel Golick ,  Steven J. Ciavarini

    IPC: H01J49/00 ,  G01N27/62 ,  G01N30/72 ,  H01J49/40

    CPC classification number: H01J49/004 ,  G01N27/622 ,  G01N30/72 ,  G01N30/7233 ,  G01N30/8631 ,  G01N30/8679 ,  H01J49/0036

    Abstract: A method of analyzing a complex sample includes performing a sequential chromatographic-IMS-MS analysis of a sample to obtain a plurality of experimental mass spectra having isotopic clusters, wherein each spectrum of the plurality of spectra is associated with a chromatographic retention time and an ion-mobility drift time. The method also includes calculating a model isotopic cluster of a precursor or product ion associated with a candidate compound in the sample, in correspondence to the natural isotopic-abundance ratios of elements composing the compound. The method further includes comparing peaks of the model isotopic cluster to corresponding peaks of an isotopic cluster of one of the experimental mass spectra to extract one or more saturated or interfered peaks of the experimental isotopic cluster, wherein at least one of the peaks of the experimental isotopic cluster is un-saturated and un-interfered.

    Abstract translation: 分析复杂样品的方法包括对样品进行顺序色谱-MS-MS分析以获得具有同位素簇的多个实验质谱，其中多个光谱的每个光谱与色谱保留时间和离子 漂移时间 该方法还包括计算与样品中候选化合物相关的前体或产物离子的模型同位素簇，对应于构成化合物的元素的天然同位素丰度比。 该方法还包括将模拟同位素簇的峰与实验质谱之一的同位素簇的相应峰进行比较，以提取实验同位素簇的一个或多个饱和或干扰的峰，其中实验的至少一个峰 同位素簇是不饱和和不受干扰的。

    Techniques for processing of mass spectral data
    17.
    发明授权
    Techniques for processing of mass spectral data 有权

    公开(公告)号：US11011359B2

    公开(公告)日：2021-05-18

    申请号：US16745827

    申请日：2020-01-17

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： Scott J. Geromanos ,  Steven J. Ciavarini ,  Curt Devlin

    IPC: H01J49/00 ,  G01N30/72 ,  G01N30/86 ,  G01N33/68 ,  G16C20/70

    Abstract: Techniques for performing data acquisition and analysis are described. A multi-mode acquisition strategy may be performed which iteratively selects mass isolation windows of different sizes in different scan cycles to acquire experimental data. The mass isolation windows selected may provide for acquiring elevated energy scan data for a defined set of m/z values. Single scan data analysis may be performed. Data analysis may include forming precursor charge clusters, chaining precursor charge clusters having the same mass to charge ratio to form peaks profiles, and using criteria to align precursor and product ions of the experimental data. Unsupervised and supervised clustering may be performed using a database and composite ion spectra formed from experimental data. Also described are a small molecule acquisition enhancement and additional techniques applicable for biopharmaceutical and other applications.

    SOLVENT DELIVERY SYSTEM FOR LIQUID CHROMATOGRAPHY THAT MAINTAINS FLUID INTEGRITY AND PRE-FORMS GRADIENTS
    18.
    发明申请
    SOLVENT DELIVERY SYSTEM FOR LIQUID CHROMATOGRAPHY THAT MAINTAINS FLUID INTEGRITY AND PRE-FORMS GRADIENTS 有权

    公开(公告)号：US20210123891A1

    公开(公告)日：2021-04-29

    申请号：US17143814

    申请日：2021-01-07

    Applicant: Waters Technologies Corporation

    Inventor： Steven J. Ciavarini ,  Stanley P. Pensak, JR. ,  Jeffrey W. Finch ,  Keith Fadgen ,  Hongji Liu

    IPC: G01N30/34 ,  G01N30/32 ,  G05D11/13

    Abstract: A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump and an organic pump are mixed to fill a storage capillary while a downstream point from the storage capillary is vented to atmosphere. After gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only the aqueous pump runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system uses feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp.

    Techniques for mass analyzing a complex sample based on nominal mass and mass defect information
    19.
    发明授权
    Techniques for mass analyzing a complex sample based on nominal mass and mass defect information 有权

    公开(公告)号：US10825672B2

    公开(公告)日：2020-11-03

    申请号：US15819793

    申请日：2017-11-21

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： Scott J. Geromanos ,  Curt Devlin ,  Steven J. Ciavarini

    IPC: H01J49/00 ,  G16B40/00 ,  G16B20/00

    Abstract: Techniques and apparatus for analyzing mass spectrometry data are described. In one embodiment, for example, an apparatus may include logic to access a product ion data set generated via mass analyzing a sample comprising a target precursor, access precursor composition information for elements of the target precursor that includes nominal mass and mass defect information, determine nominal mass (NM)-mass defect (MD) relationship information for ion fragments associated with the target precursor based on the precursor composition information, determine one or more fragment upper boundaries and one or more fragment lower boundaries, extract candidate ion fragments from the ion fragments via applying the one or more fragment upper boundaries and the one or more fragment lower boundaries to the NM-MD relationship information, and determine target ion fragments from the plurality of candidate ion fragments based on fragmentation efficiency information associated with the candidate ion fragments. Other embodiments are described and claimed.

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