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公开(公告)号：US20200279726A1
公开(公告)日：2020-09-03
申请号：US16878049
申请日：2020-05-19
Applicant: Waters Technologies Corporation
Inventor： Scott J. Geromanos , Marc V. Gorenstein , Daniel Golick , Steven J. Ciavarini
Abstract: A method of analyzing a complex sample includes performing a sequential chromatographic-IMS-MS analysis of a sample to obtain a plurality of experimental mass spectra having isotopic clusters, wherein each spectrum of the plurality of spectra is associated with a chromatographic retention time and an ion-mobility drift time. The method also includes calculating a model isotopic cluster of a precursor or product ion associated with a candidate compound in the sample, in correspondence to the natural isotopic-abundance ratios of elements composing the compound. The method further includes comparing peaks of the model isotopic cluster to corresponding peaks of an isotopic cluster of one of the experimental mass spectra to extract one or more saturated or interfered peaks of the experimental isotopic cluster, wherein at least one of the peaks of the experimental isotopic cluster is un-saturated and un-interfered.
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公开(公告)号：US09770678B2
公开(公告)日：2017-09-26
申请号：US14687290
申请日：2015-04-15
Applicant: Waters Technologies Corporation
Inventor： Michael R. Jackson , Christopher Seith , Steven J. Ciavarini , Kara O'Donnell , John Angelosanto , John Leason
CPC classification number: B01D19/0073 , B01D15/08 , B01D15/16 , B01D19/0036 , B01D19/0063 , B01D19/0068 , G01N30/14 , G01N30/26 , G01N30/34
Abstract: Described is a method for vacuum degassing of a liquid such as a solvent for a liquid chromatography system. The method includes modulating application of a vacuum to a fluid channel of a degasser so that each volume of a liquid drawn from the degasser experiences a residence time that is equal to the residence times of the other volumes. The residence time is determined as a time that the volume resides in the fluid channel under application of the vacuum and to a magnitude of the applied vacuum. The method is advantageous for use with liquid chromatography systems where differences in the diffusion rates of solvents into the degasser vacuum can otherwise introduce error into the composition gradient of a mobile phase.
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3.发明申请公开(公告)号：US20130308415A1
公开(公告)日：2013-11-21
申请号：US13949806
申请日：2013-07-24
Applicant: Waters Technologies Corporation
Inventor： Joshua A. Shreve , Steven J. Ciavarini
IPC: B01F15/02
CPC classification number: B01F15/0479 , B01D15/14 , B01F15/0216 , G01N30/34 , G01N30/36 , G01N35/00871 , G01N35/1097 , G01N2030/347 , G01N2035/00544 , G05D11/133
Abstract: Described is a method of reducing liquid composition errors in a low-pressure mixing pump system. Packets representing the switching intervals of each component of the desired fluid mixture are provided to an intake of the mixing pump system. For each packet, a switching time associated with at least one of the components in the packet is modulated. Modulated switching times are based on time offsets that are specifically selected according to the undesirable frequency characteristic of an intake response of the mixing pump system. The average of the volumes contributed by the packets thus modulated is equal to a component volume that achieves a desired proportion of the component in the output flow of the mixing pump system. Modulated switching times enable the reduction or elimination of composition error in the output flow of the mixing pump system.
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公开(公告)号：US20200266042A1
公开(公告)日：2020-08-20
申请号：US16745827
申请日：2020-01-17
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： Scott J. Geromanos , Steven J. Ciavarini , Curt Devlin
Abstract: Techniques for performing data acquisition and analysis are described. A multi-mode acquisition strategy may be performed which iteratively selects mass isolation windows of different sizes in different scan cycles to acquire experimental data. The mass isolation windows selected may provide for acquiring elevated energy scan data for a defined set of m/z values. Single scan data analysis may be performed. Data analysis may include forming precursor charge clusters, chaining precursor charge clusters having the same mass to charge ratio to form peaks profiles, and using criteria to align precursor and product ions of the experimental data. Unsupervised and supervised clustering may be performed using a database and composite ion spectra formed from experimental data. Also described are a small molecule acquisition enhancement and additional techniques applicable for biopharmaceutical and other applications.
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公开(公告)号：US20180321198A1
公开(公告)日：2018-11-08
申请号：US15967752
申请日：2018-05-01
Applicant: Waters Technologies Corporation
Inventor： Abhijit Tarafder , Michael O. Fogwill , Joshua A. Shreve , Joseph D. Michienzi , Steven J. Ciavarini
Abstract: The present disclosure relates generally to a system and a method for improving performance of a chromatography system using a highly-compressible fluid based mobile phase (e.g., CO2). In particular, the present disclosure relates to a system that uses a conduit, such as a convergent-divergent nozzle, for reducing pressure noise in a chromatography system using a highly-compressible fluid based mobile phase. The chromatography system can include a conduit, such as a convergent-divergent nozzle, disposed downstream of the column to reduce or prevent the propagation of pressure or density pulses from a back pressure regulator.
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Patent Agency Ranking
公开(公告)号：US09722519B2
公开(公告)日：2017-08-01
申请号：US14463149
申请日：2014-08-19
Applicant: Waters Technologies Corporation
Inventor： Joshua A. Shreve , Steven J. Ciavarini
CPC classification number: H02P8/14 , F04B17/03 , F04B49/065 , F04B2203/0207 , F04B2203/0209 , G01N30/34 , G01N2030/326
Abstract: Systems and methods for operating a stepper motor of a pump at a desired low velocity include memory for storing information corresponding to an intake velocity profile. The intake velocity profile represents an optimized acceleration curve for operating the stepper motor over a range of motor velocities during an intake cycle. A processor of a system controller dynamically accesses the memory during the intake cycle to acquire the information representing the intake velocity profile and issues a series of pulses to the stepper motor based on this information. In response to the pulses, the stepper motor accelerates in accordance with the optimized acceleration curve represented by the intake velocity profile. The optimized acceleration curve is based on the available torque of the stepper motor across a range of motor velocities and enables the motor to operate with greater torque utilization and less margin than traditional linear acceleration profiles.
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7.发明授权Valve switch modulation for reducing errors due to oscillations of the inlet fluid of a pump system 有权阀开关调节，用于减少由于泵系统的入口流体的振荡引起的误差公开(公告)号：US09126164B2
公开(公告)日：2015-09-08
申请号：US14521514
申请日：2014-10-23
Applicant: Waters Technologies Corporation
Inventor： Joshua A. Shreve , Steven J. Ciavarini
CPC classification number: B01F15/0479 , B01D15/14 , B01F15/0216 , G01N30/34 , G01N30/36 , G01N35/00871 , G01N35/1097 , G01N2030/347 , G01N2035/00544 , G05D11/133
Abstract: Described is a method of reducing liquid composition errors in a low-pressure mixing pump system. Packets representing the switching intervals of each component of the desired fluid mixture are provided to an intake of the mixing pump system. For each packet, a switching time associated with at least one of the components in the packet is modulated. Modulated switching times are based on time offsets that are specifically selected according to the undesirable frequency characteristic of an intake response of the mixing pump system. The average of the volumes contributed by the packets thus modulated is equal to a component volume that achieves a desired proportion of the component in the output flow of the mixing pump system. Modulated switching times enable the reduction or elimination of composition error in the output flow of the mixing pump system.
Abstract translation: 描述了在低压混合泵系统中减少液体组成误差的方法。 表示所需流体混合物的每个组分的切换间隔的分组被提供给混合泵系统的进气口。 对于每个分组，调制与分组中的至少一个分量相关联的切换时间。 调制切换时间基于根据混合泵系统的进气响应的不期望的频率特性而特别选择的时间偏移。 由如此调制的分组贡献的卷的平均值等于在混合泵系统的输出流中实现组分的期望比例的分量体积。 调制切换时间可以减少或消除混合泵系统的输出流量中的组成误差。
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公开(公告)号：US11137380B2
公开(公告)日：2021-10-05
申请号：US16878049
申请日：2020-05-19
Applicant: Waters Technologies Corporation
Inventor： Scott J. Geromanos , Marc V. Gorenstein , Daniel Golick , Steven J. Ciavarini
IPC: G01N30/86 , H01J49/00 , G01N27/622 , G01N30/72
Abstract: A method of analyzing a complex sample includes performing a sequential chromatographic-IMS-MS analysis of a sample to obtain a plurality of experimental mass spectra having isotopic clusters, wherein each spectrum of the plurality of spectra is associated with a chromatographic retention time and an ion-mobility drift time. The method also includes calculating a model isotopic cluster of a precursor or product ion associated with a candidate compound in the sample, in correspondence to the natural isotopic-abundance ratios of elements composing the compound. The method further includes comparing peaks of the model isotopic cluster to corresponding peaks of an isotopic cluster of one of the experimental mass spectra to extract one or more saturated or interfered peaks of the experimental isotopic cluster, wherein at least one of the peaks of the experimental isotopic cluster is un-saturated and un-interfered.
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公开(公告)号：US20190131117A1
公开(公告)日：2019-05-02
申请号：US16173473
申请日：2018-10-29
Applicant: Waters Technologies Corporation
Inventor： Scott J. Geromanos , Marc V. Gorenstein , Daniel Golick , Steven J. Ciavarini
CPC classification number: H01J49/004 , G01N27/622 , G01N30/72 , G01N30/7233 , G01N30/8631 , G01N30/8679 , H01J49/0036
Abstract: A method of analyzing a complex sample includes performing a sequential chromatographic-IMS-MS analysis of a sample to obtain a plurality of experimental mass spectra having isotopic clusters, wherein each spectrum of the plurality of spectra is associated with a chromatographic retention time and an ion-mobility drift time. The method also includes calculating a model isotopic cluster of a precursor or product ion associated with a candidate compound in the sample, in correspondence to the natural isotopic-abundance ratios of elements composing the compound. The method further includes comparing peaks of the model isotopic cluster to corresponding peaks of an isotopic cluster of one of the experimental mass spectra to extract one or more saturated or interfered peaks of the experimental isotopic cluster, wherein at least one of the peaks of the experimental isotopic cluster is un-saturated and un-interfered.
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10.发明申请公开(公告)号：US20150346168A1
公开(公告)日：2015-12-03
申请号：US14822527
申请日：2015-08-10
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： Steven J. Ciavarini , Stanley P. Pensak, JR. , Jeffrey W. Finch , Keith Fadgen , Hongji Liu
CPC classification number: G01N30/34 , G01N30/32 , G01N2030/326 , G05D11/132
Abstract: A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump and an organic pump are mixed to fill a storage capillary while a downstream point from the storage capillary is vented to atmosphere. After gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only the aqueous pump runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system uses feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp.
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