公开(公告)号：US07527604B2

公开(公告)日：2009-05-05

申请号：US11074850

申请日：2005-03-09

申请人： Wendy Naimark ,  Maria Palasis ,  Toby Freyman ,  William J. Shaw

发明人： Wendy Naimark ,  Maria Palasis ,  Toby Freyman ,  William J. Shaw

IPC分类号： A61M31/00 ,  A61M37/00

CPC分类号： A61M25/0069

摘要： A therapeutic delivery device is provided wherein a delivery body is supported by an elongate member such that the body may rotate as it delivers therapeutic to a target site. Therapeutic may be delivered by deploying delivery heads into a target site as well as by dispensing therapeutic from the delivery head. The delivery body may be cylindrically shaped, spherically shaped or shaped in various other configurations. In one embodiment the delivery body contains tracks that may roll back and forth over a target site to dispense therapeutic. In another embodiment, the delivery heads of the delivery body have internal valves that open and close in order to dispense therapeutic.

摘要翻译： 提供了一种治疗性递送装置，其中递送体由细长构件支撑，使得主体在将治疗递送至目标部位时可旋转。 可以通过将输送头部署到目标部位以及通过从输送头分配治疗剂来递送治疗剂。 输送体可以是各种其他构型的圆柱形，球形或成形。 在一个实施方案中，递送体包含可以在靶位点上来回滚动以分配治疗剂的轨迹。 在另一个实施例中，输送体的输送头具有打开和关闭的内部阀，以便分配治疗剂。

公开(公告)号：US20070055352A1

公开(公告)日：2007-03-08

申请号：US11221647

申请日：2005-09-07

申请人： Wendy Naimark ,  Peter Shank ,  Maria Palasis ,  Toby Freyman ,  Anastasia Panos ,  Samuel Epstein ,  Alexandra Rousseau

发明人： Wendy Naimark ,  Peter Shank ,  Maria Palasis ,  Toby Freyman ,  Anastasia Panos ,  Samuel Epstein ,  Alexandra Rousseau

IPC分类号： A61F2/90

CPC分类号： A61L31/16 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/075 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2230/0013 ,  A61F2250/0068 ,  A61L2300/606

摘要： A medical device for: delivering a therapeutic agent to a body lumen is described. The device may generally be a stent with an inner sidewall surface and an outer sidewall surface, with a plurality of struts having a plurality of openings therein. An inner and outer layer may be applied to the stent, forming pockets within at least a portion of the openings. The pockets may be filled with at least one therapeutic agent. The pockets may take a variety of shapes and sizes, and may be designed for release or rupture in variety of ways.

摘要翻译： 描述了用于将治疗剂递送到体腔的医疗装置。 该装置通常可以是具有内侧壁表面和外侧壁表面的支架，多个支柱在其中具有多个开口。 内层和外层可以施加到支架上，在开口的至少一部分内形成袋。 口袋可以填充有至少一种治疗剂。 口袋可以采取各种形状和尺寸，并且可以设计为以各种方式释放或破裂。

公开(公告)号：US08235937B2

公开(公告)日：2012-08-07

申请号：US13022217

申请日：2011-02-07

申请人： Maria Palasis ,  Wendy Naimark ,  Toby Freyman ,  Samuel Epstein

发明人： Maria Palasis ,  Wendy Naimark ,  Toby Freyman ,  Samuel Epstein

IPC分类号： A61M31/00

CPC分类号： A61M11/06 ,  A61M25/0054 ,  A61M2025/0057

摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.

摘要翻译： 本发明提供一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。 微粉化治疗剂以气溶胶形式或干粉形式递送。 本发明还提供了一种通过将治疗剂放置在导管中将微粉化治疗剂递送到体内的靶位点的方法，将导管定位在靶位点，并将治疗剂暴露于足以产生超音速流动的激励机制 将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。

公开(公告)号：US20120010589A1

公开(公告)日：2012-01-12

申请号：US13240792

申请日：2011-09-22

申请人： Maria Palasis ,  Timothy J. Mickley ,  Toby Freyman ,  Wendy Naimark

发明人： Maria Palasis ,  Timothy J. Mickley ,  Toby Freyman ,  Wendy Naimark

IPC分类号： A61M5/00

CPC分类号： A61M31/002 ,  A61F2/24 ,  A61F2250/0067

摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.

摘要翻译： 本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。 在一个实施例中，提供了包括身体的医疗装置。 身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。 根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。 这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。 然后释放的治疗剂可以被递送到心脏瓣膜。

公开(公告)号：US07686788B2

公开(公告)日：2010-03-30

申请号：US11070190

申请日：2005-03-03

申请人： Toby Freyman ,  Maria Palasis ,  Wendy Naimark ,  Timothy J. Mickley

发明人： Toby Freyman ,  Maria Palasis ,  Wendy Naimark ,  Timothy J. Mickley

IPC分类号： A61M5/00

CPC分类号： A61M25/0082 ,  A61M5/14526 ,  A61M5/14593 ,  A61M5/148 ,  A61M5/1483 ,  A61M25/0074 ,  A61M25/0084 ,  A61M2025/0091

摘要： A catheter having a drug delivery unit at the distal end thereof. The drug delivery unit includes an actuator capable of assuming an activated and an inactivated configuration. The drug delivery unit also includes a receptacle capable of accepting a therapeutic agent. The actuator and receptacle are in communication with each other such that the actuator transmits force to the receptacle and the receptacle accepts force from the actuator in an activated configuration of the actuator. Also provided is a method of delivering a therapeutic agent to a target site using the catheter of the present invention.

摘要翻译： 一种在其远端具有药物输送单元的导管。 药物递送单元包括能够承受激活和非活化构型的致动器。 药物递送单元还包括能够接受治疗剂的容器。 致动器和容器彼此连通，使得致动器将力传递到插座，并且插座在致动器的激活配置中接受来自致动器的力。 还提供了使用本发明的导管将治疗剂递送到靶位点的方法。

公开(公告)号：US20050013870A1

公开(公告)日：2005-01-20

申请号：US10622293

申请日：2003-07-17

申请人： Toby Freyman ,  Wendy Naimark ,  Maria Palasis

发明人： Toby Freyman ,  Wendy Naimark ,  Maria Palasis

IPC分类号： A61K35/12 ,  A61L27/36 ,  C12N5/071 ,  C12N5/00

CPC分类号： A61L27/3683 ,  A61K35/12 ,  A61L27/3633 ,  A61L2430/40 ,  C12N5/0679 ,  C12N2510/00

摘要： The present invention relates generally to decellularized extracellular matrix of conditioned body tissues. The decellularized extracellular matrix contains a biological material, preferably vascular endothelial growth factor (VEGF), produced by the conditioned body tissue that is in an amount different than the amount of the biological material that the body tissue would produce absent the conditioning. The invention also relates to methods of making and methods of using said decellularized extracellular matrix. Specifically, the invention relates to treating defective, diseased, damaged or ischemic cells, tissues or organs in a subject by administering, injecting or implanting the decellularized extracellular matrix of the invention into a subject in need thereof. The invention is further directed to a tissue regeneration scaffold for implantation into a subject inflicted with a disease or condition that requires tissue or organ repair, regeneration and/or strengthening. Additionally, the invention is directed to a medical device, preferably a stent or an artificial heart, having a surface coated or covered with the decellularized extracellular matrix of the invention or having a component comprising the decellularized extracellular matrix of the invention for implantation into a subject, preferably a human. Methods for making the tissue regeneration scaffold and methods for manufacturing a coated or covered medical device having a component comprising decellularized extracellular matrix of conditioned body tissues are also provided.

摘要翻译： 本发明一般涉及条件性身体组织的脱细胞细胞外基质。 脱细胞的细胞外基质包含生物材料，优选血管内皮生长因子（VEGF），其由条件的身体组织产生，其量不同于身体组织在没有调理的情况下将产生的生物材料的量。 本发明还涉及制备方法和使用所述脱细胞的细胞外基质的方法。 具体地，本发明涉及通过将本发明的脱细胞的细胞外基质施用，注射或植入有需要的受试者来治疗受试者中的有缺陷，患病，损伤或缺血的细胞，组织或器官。 本发明进一步涉及用于植入患有需要组织或器官修复，再生和/或加强的疾病或病症的受试者的组织再生支架。 另外，本发明涉及一种医疗装置，优选支架或人造心脏，其具有被本发明的脱细胞细胞外基质包被或覆盖的表面，或者具有包含本发明的脱细胞的细胞外基质的组分用于植入受试者 ，优选人。 还提供了用于制备组织再生支架的方法和用于制造具有包括经脱细胞的细胞外细胞外基质的组分的涂覆或覆盖的医疗装置的方法。

公开(公告)号：US20110130715A1

公开(公告)日：2011-06-02

申请号：US13022217

申请日：2011-02-07

申请人： Maria Palasis ,  Wendy Naimark ,  Toby Freyman ,  Samuel Epstein

发明人： Maria Palasis ,  Wendy Naimark ,  Toby Freyman ,  Samuel Epstein

IPC分类号： A61M5/00

CPC分类号： A61M11/06 ,  A61M25/0054 ,  A61M2025/0057

摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.

摘要翻译： 本发明提供一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。 微粉化治疗剂以气溶胶形式或干粉形式递送。 本发明还提供了一种通过将治疗剂放置在导管中将微粉化治疗剂递送到体内的靶位点的方法，将导管定位在靶位点，并将治疗剂暴露于足以产生超音速流动的激励机制 将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。

公开(公告)号：US20080085294A1

公开(公告)日：2008-04-10

申请号：US11538683

申请日：2006-10-04

申请人： Toby Freyman ,  Robert Herrmann ,  Wendy Naimark ,  Maria Palasis

发明人： Toby Freyman ,  Robert Herrmann ,  Wendy Naimark ,  Maria Palasis

IPC分类号： A61F2/00

CPC分类号： A61L31/16 ,  A61L31/148 ,  A61L2300/604

摘要： This invention comprises an apparatus for treating an atherosclerotic plaque in a coronary artery of a mammal by placing at or proximate to an entrance to the coronary artery and upstream of the vulnerable plaque, and an effective amount of a therapeutic agent for the treatment of the plaque. This invention comprises delivering a deposition of a therapeutic drug high in the coronary arterial tree for treatment of downstream vulnerable plaques. The invention also comprises slow release formulation and delivery of an apparatus that is totally degradable or removed and/or replaced.

摘要翻译： 本发明包括一种用于通过放置在冠状动脉入口处或接近于冠状动脉入口处和易损斑块上游来治疗哺乳动物冠状动脉中的动脉粥样硬化斑块的装置，以及有效量的用于治疗斑块的治疗剂 。 本发明包括在冠状动脉树中输送高度治疗药物的沉积物以治疗下游脆弱斑块。 本发明还包括缓释制剂和递送完全可降解或除去和/或更换的装置。

公开(公告)号：US20070178137A1

公开(公告)日：2007-08-02

申请号：US11344156

申请日：2006-02-01

申请人： Toby Freyman ,  Wendy Naimark ,  Maria Palasis

发明人： Toby Freyman ,  Wendy Naimark ,  Maria Palasis

IPC分类号： A61K35/12 ,  A61K38/20 ,  A61K38/13 ,  A61K31/573 ,  A61K31/4745 ,  A61K38/44 ,  A61K31/192

CPC分类号： A61F2/02 ,  A61F2/0077 ,  A61F2/07 ,  A61F2230/008 ,  A61F2250/0039 ,  A61F2250/0067

摘要： A medical device includes a carrier and an agent. The agent is formulated to control inflammation of biological tissue, such as heart tissue, and is releasably coupled to the carrier. The carrier is configured to be disposed in operative proximity to the biological tissue to be treated by the agent. In one embodiment, the carrier is configured to release the agent or otherwise deliver the agent to the biological tissue, thus controlling inflammation of the tissue. Also, a method to improve healing of biological tissue includes placing a medical device proximate to the heart of a patient, where the medical device has a carrier and an agent configured to control inflammation, the agent is releasably coupled to the carrier. In one embodiment, the method includes causing the agent to be released from the carrier.

摘要翻译： 医疗器械包括载体和药剂。 制剂用于控制诸如心脏组织的生物组织的炎症，并且可释放地联接到载体上。 载体被配置为设置在操作中接近要由药剂处理的生物组织。 在一个实施方案中，载体被配置为释放试剂或以其它方式将试剂递送到生物组织，从而控制组织的炎症。 此外，改善生物组织愈合的方法包括将医疗装置放置在靠近患者心脏的位置，其中医疗装置具有载体和被配置成控制炎症的药剂，药剂可释放地联接到载体上。 在一个实施例中，该方法包括使得试剂从载体释放。

公开(公告)号：US20050158450A1

公开(公告)日：2005-07-21

申请号：US11073848

申请日：2005-03-08

申请人： Maria Palasis ,  Wendy Naimark ,  Tim Mickley ,  Toby Freyman

发明人： Maria Palasis ,  Wendy Naimark ,  Tim Mickley ,  Toby Freyman

IPC分类号： A61L31/08 ,  B05B13/02 ,  B05C3/10 ,  B05D1/00 ,  B05D1/02 ,  B05D3/00

CPC分类号： B05D1/02 ,  A61L31/08 ,  B05B13/0235 ,  B05C3/10 ,  B05D1/002 ,  B05D2258/00

摘要： An improved method and apparatus for high-volume production of coated stents with highly uniform stent coatings using a roll coating technique is provided. In a first embodiment, uncoated stents are placed onto rotating stent holders with automated stent handling equipment. The holders are mounted on an endless conveyer belt which advances the stents toward a stent coater. As the stents advance through the coater, the holders rotate, thereby rolling the stents about their longitudinal axes as coating material is sprayed toward them, ensuring the stents are uniformly coated on their exterior and interior surfaces. After the conveyer turns to carry the coated stents back toward the loading area, the rotating stents pass again through the coating spray, downstream of the initial coating location, thereby increasing the efficient utilization of the coating material. The conveyer then advances the coated stents to an unloading area for removal before the holders return to the stent loading area to receive new stents.

摘要翻译： 提供了一种用于使用辊涂技术高度均匀支架涂层的大量生产涂层支架的改进方法和装置。 在第一实施例中，将未涂覆的支架放置在具有自动支架处理设备的旋转支架支架上。 保持器安装在环形输送带上，将支架推向支架涂布机。 当支架通过涂布机前进时，保持器旋转，从而当涂层材料向其喷射时，支架围绕其纵向轴线滚动，确保支架均匀地涂覆在其外表面和内表面上。 在输送机转动以将涂覆的支架运送回装载区域之后，旋转的支架再次通过涂层喷涂，在初始涂覆位置的下游，从而增加涂层材料的有效利用。 然后，输送机将涂层支架前进到卸载区域，以便在支架返回到支架装载区域之前进行移除以接收新的支架。