公开(公告)号：US4371520A

公开(公告)日：1983-02-01

申请号：US316042

申请日：1981-10-28

申请人： Yahiro Uemura ,  Takashi Goto ,  Yoshiaki Kano ,  Satoshi Funakoshi

发明人： Yahiro Uemura ,  Takashi Goto ,  Yoshiaki Kano ,  Satoshi Funakoshi

IPC分类号： A61K38/00 ,  C07K16/06 ,  A61K39/00

CPC分类号： C07K16/065 ,  A61K38/00 ,  Y10S530/83 ,  Y10S530/831

摘要： A process for preparing immunoglobulin suitable for intravenous injection, comprising treating with an acid a plasma or fraction I+II+III, fraction II+III, fraction II, or fraction III (hereinafter these are sometimes referred collectively to as starting material) obtained from plasma by Cohn's cold alcohol fractionation method, and subjecting to fractionation using an alkylene oxide polymer or copolymer having a molecular weight of 2,000 to 20,000.

摘要翻译： 一种制备适用于静脉注射的免疫球蛋白的方法，包括用酸将血浆或级分I + II + III，级分II + III，级分II或级分III（以下有时统称为原料） 等离子体，并使用分子量为2,000〜20,000的烯化氧聚合物或共聚物进行分馏。

公开(公告)号：US4335099A

公开(公告)日：1982-06-15

申请号：US185929

申请日：1980-09-10

申请人： Satoshi Funakoshi ,  Katuhiro Uriyu ,  Yahiro Uemura ,  Katashi Nakane ,  Akio Yamane

发明人： Satoshi Funakoshi ,  Katuhiro Uriyu ,  Yahiro Uemura ,  Katashi Nakane ,  Akio Yamane

IPC分类号： A61K39/395 ,  A61K9/32 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K38/00 ,  A61P37/04 ,  C07K16/12 ,  A61K9/34 ,  A61K9/36 ,  A61K9/40 ,  A61K31/74 ,  A61K31/78 ,  A61K31/79 ,  A61K39/00

CPC分类号： C07K16/12 ,  A61K9/4891 ,  A61K9/5073 ,  A61K38/00 ,  Y10S424/804

摘要： A method of treating hypoproteinemia is disclosed in which an enteric film coated IgA-rich gamma globulin is administered orally to a person suffering therefrom until total serum content and plasma content are restored. The film coating is soluble in neutral or alkaline media by insoluble in acid media.

摘要翻译： 公开了一种治疗低蛋白血症的方法，其中将含有肠溶膜的含有IgA的γ球蛋白经口给予患有这种血小板的人，直至全部血清含量和血浆含量恢复。 薄膜包衣在酸性介质中不溶于中性或碱性介质。

公开(公告)号：US4010074A

公开(公告)日：1977-03-01

申请号：US683239

申请日：1976-05-04

申请人： Yahiro Uemura ,  Katuhiro Uriyu ,  Satoshi Funakoshi

发明人： Yahiro Uemura ,  Katuhiro Uriyu ,  Satoshi Funakoshi

IPC分类号： C12N9/72 ,  C07G7/02

CPC分类号： C12N9/6462 ,  C12Y304/21073 ,  Y10S435/815

摘要： Highly purified urokinase is obtained in a high yield by adsorbing urokinase from an aqueous crude urokuinase solution including human urine at a pH of about 4.0 to about 7.0 on a water-insoluble polysaccharide containing agarose and agaropectin, for example, agar and Sepharose, and by eluting urokinase with an alkaline solution (pH of about 8 to 11) or concentrated salt solution.

摘要翻译： 通过在含有约4.0至约7.0的pH值的人尿液水性粗尿素酶溶液中，在含有琼脂糖和琼脂糖的水不溶性多糖例如琼脂和琼脂糖上吸附尿激酶，并通过以下方式获得高纯度的尿激酶： 用碱性溶液（约8至11的pH）或浓盐溶液洗脱尿激酶。

公开(公告)号：US4692331A

公开(公告)日：1987-09-08

申请号：US583268

申请日：1984-02-24

申请人： Yahiro Uemura ,  Satoshi Funakoshi

发明人： Yahiro Uemura ,  Satoshi Funakoshi

IPC分类号： A61K9/08 ,  A61K39/395

CPC分类号： A61K39/39591

摘要： A dry .gamma.-globulin preparation capable of intravenous injection which is obtainable by polyethylene glycol fractionation of plasma is improved in its water-solubility and stability against increase of anticomplement activity and decrease of antibody titer by purifying the .gamma.-globulin fraction with respect to protein to render the residual polyethylene glycol substantially not detectable in its 5% W/V solution, adding 0.2 to 2 parts by weight of glucose based on 1 part of .gamma.-globulin, and lyophilizing its solution.

摘要翻译： 通过血浆聚乙二醇分级获得的能够静脉内注射的干性γ-球蛋白制剂通过纯化γ-球蛋白部分相对于蛋白质而提高其水溶性和稳定性，防止抗补体活性增加和抗体效价降低 使残留的聚乙二醇在其5％W / V溶液中基本上不可检测，加入基于1份γ-球蛋白的0.2至2份重量的葡萄糖，并冻干其溶液。

公开(公告)号：US4482485A

公开(公告)日：1984-11-13

申请号：US568259

申请日：1984-01-04

申请人： Satoshi Funakoshi ,  Kazuo Morimoto ,  Morio Kuboyama ,  Nobuya Yanai ,  Muneo Yamada ,  Hajime Yokota

发明人： Satoshi Funakoshi ,  Kazuo Morimoto ,  Morio Kuboyama ,  Nobuya Yanai ,  Muneo Yamada ,  Hajime Yokota

IPC分类号： C07K14/195 ,  A61K35/22 ,  A61K38/00 ,  A61K38/16 ,  A61K38/48 ,  C07K14/005 ,  C07K14/52 ,  C07K14/53 ,  C12N9/64 ,  C07G7/00

CPC分类号： C12N9/6445 ,  A61K35/22 ,  Y10S514/929 ,  Y10S530/834

摘要： Human urine-origin colony-stimulating factor and kallikrein are separated in pure form, respectively, from an aqueous solution thereof, such as a urinary protein-concentrated solution by subjecting the solution added with a stabilizer such as octyl-phenoxypolyethoxyethanaol or polyethylene glycol both having a molecular weight of 1,000-10,000, to high-performance gel filtration effective in molecular exclusive limit of 10.sup.5 -5.times.10.sup.5 as determined with globular protein.

摘要翻译： 人尿起源的集落刺激因子和激肽释放酶分别以其形式从其水溶液例如尿蛋白浓缩溶液中分离，通过使添加有稳定剂的溶液，例如辛基 - 苯氧基聚乙氧基乙醇或聚乙二醇，其均具有 分子量为1,000-10,000，以高效凝胶过滤效果，分子量极限为105-5×105，用球状蛋白质测定。

公开(公告)号：US4337256A

公开(公告)日：1982-06-29

申请号：US107613

申请日：1979-12-27

申请人： Yasushi Suzuki ,  Kunio Tsukamoto ,  Nobuyoshi Minami ,  Yukio Hasegawa ,  Michitaka Satoh ,  Norio Yamamoto ,  Katsuhiko Miyasaka ,  Takashi Mikami ,  Satoshi Funakoshi

发明人： Yasushi Suzuki ,  Kunio Tsukamoto ,  Nobuyoshi Minami ,  Yukio Hasegawa ,  Michitaka Satoh ,  Norio Yamamoto ,  Katsuhiko Miyasaka ,  Takashi Mikami ,  Satoshi Funakoshi

IPC分类号： C07D217/02 ,  A61K31/47 ,  A61K31/472 ,  A61P7/02 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07C233/12 ,  C07D217/04 ,  C07D217/12 ,  C07D217/14 ,  C07D217/16 ,  C07D217/26

CPC分类号： C07C255/00 ,  C07D217/14 ,  C07D217/16 ,  C07D217/26

摘要： Novel isoquinoline derivatives of the general formula ##STR1## wherein R represents a lower alkyl group, a lower cycloalkyl group, or a group of the formula ##STR2## in which R.sup.2 represents a hydrogen atom, a halogen atom, a methyl group, a trifluoromethyl group, a methoxy group, a methylamino group or a dimethylami no group;R.sup.1 represents a hydrogen atom or a lower alkyl group; andY represents a carboxyl group, a cyano group, a carbamoyl group, a lower alkoxycarbonyl group or a lower alkylaminocarbonyl group;or a salt thereof; a process for the production thereof.The above compound is useful as an anti-inflammatory and analgesic agent.

摘要翻译： 新的通式为（I）的异喹啉衍生物其中R表示低级烷基，低级环烷基或下式的基团：

公开(公告)号：US4137307A

公开(公告)日：1979-01-30

申请号：US788921

申请日：1977-04-19

申请人： Satoshi Funakoshi ,  Takao Omura ,  Takeshi Ohshiro

发明人： Satoshi Funakoshi ,  Takao Omura ,  Takeshi Ohshiro

IPC分类号： A61L2/00 ,  C07K14/47 ,  A61K37/04 ,  A61K37/06 ,  C07G7/00

CPC分类号： A61L2/0023 ,  C07K14/47 ,  Y10S530/806 ,  Y10S530/83 ,  Y10S530/831

摘要： An aqueous solution of haptoglobin is obtained by subjecting an aqueous solution of .alpha. and .beta.-globulin fractions of human blood plasma to further fractionation by use of ammonium sulfate, collecting fractions precipitated at a concentration between 30% and 40% saturation of ammonium sulfate, contacting a reconstituted aqueous solution of the collected fractions with an anion exchanger to adsorb haptoglobin on said anion exchanger, selectively eluting the haptoglobin from the anion exchanger, and then concentrating the resulting aqueous eluate solution. The aqueous solution of haptoglobin is subjected to heat treatment in the presence of a selected stabilizing agent for inactivating hepatitis B virus at an optional step of the process.The thus obtained aqueous solution of haptoglobin has less than 10% hypotensive activity, highly stable during storage, and free from the risk of hepatitis B virus infection. This haptoglobin preparation is used for prevention and treatment of renal disorders caused by hemolysis.

摘要翻译： 接触球蛋白的水溶液是通过使人血浆的α和β-球蛋白部分的水溶液通过使用硫酸铵进一步分级而获得的，收集以硫酸铵的30％至40％饱和浓度沉淀的级分，接触 用阴离子交换剂重新收集的级分的水溶液以吸附所述阴离子交换剂上的触珠蛋白，从阴离子交换剂中选择性洗脱触珠蛋白，然后浓缩所得的水性洗脱液。 在所选择的用于灭活乙型肝炎病毒的稳定剂的存在下，在该方法的任选步骤，对触珠蛋白的水溶液进行热处理。

公开(公告)号：US4113712A

公开(公告)日：1978-09-12

申请号：US664983

申请日：1976-03-08

申请人： Satoshi Funakoshi

发明人： Satoshi Funakoshi

IPC分类号： A61K39/00 ,  C07K14/02 ,  G01N33/576 ,  G01N33/96 ,  A61K39/12 ,  A61K39/42 ,  C07G7/00 ,  G01N33/16

CPC分类号： C07K14/005 ,  G01N33/5764 ,  G01N33/96 ,  A61K39/00 ,  C12N2730/10122 ,  Y10S436/82 ,  Y10S436/826 ,  Y10S530/806 ,  Y10S530/831

摘要： Hepatitis B surface antigen particles composed of single polypeptide subunits having a molecular weight of about 55,000 dalton are prepared by heating hepatitis B surface antigen in isotonic sodium chloride solution at about neutral pH containing a surfactant capable of delipidation such as alkali-metal salts of bile acids or of lauroylsarcosinic acid, or poloxyethylene alkylphenol containing an average oxyethylene of 7 to 10 molecules, or polyoxyethylene sorbitan monoalkylester containing an average oxyethylene of 20 molecules.A uniform hepatitis B surface antigen particle thus obtained has a spherical form 18 to 22 nm in diameter with an empty core, a molecular weight of about 2,200,000 dalton, and the characteristic of low toxicity.This hepatitis B surface antigen particle is useful for the preparation of vaccines, as a standard antigen reagent for testing hepatitis B surface antigen and the antibody, and as an antigen for immunizing animals to obtain a highly specific and strong antibody.

摘要翻译： 由分子量约55,000道尔顿的单个多肽亚单位组成的乙型肝炎表面抗原颗粒是通过在含有能够脱脂的表面活性剂的等渗氯化钠溶液中加热乙肝表面抗原来制备的，所述表面活性剂含有能够脱脂的表面活性剂，例如胆汁酸的碱金属盐 或月桂酰肌氨酸或含有7〜10分子的平均氧化乙烯的聚氧乙烯烷基苯酚，或含有20分子的平均氧化乙烯的聚氧乙烯山梨糖醇酐单烷基酯。

公开(公告)号：US4701325A

公开(公告)日：1987-10-20

申请号：US580183

申请日：1984-02-15

申请人： Yasuo Ueda ,  Yoshio Kagitani ,  Shirou Komeda ,  Satoshi Funakoshi

发明人： Yasuo Ueda ,  Yoshio Kagitani ,  Shirou Komeda ,  Satoshi Funakoshi

IPC分类号： A61K33/04 ,  A61P43/00 ,  A61K31/55

CPC分类号： A61K33/04

摘要： An alkali metal hydrogensulfite or sulfite is effective for controlling a local injury such as inflammation and vein injury occurring on the injection of an antitumor benzodiazepine compound of the formula ##STR1## wherein R.sub.1 denotes hydrogen atom, or acyl, carbamyl, or alkoxycarbonyl group; R.sub.2 denotes hydrogen atom or acyl group; and R.sub.3 denotes sulfinic acid rest, SO.sub.2 X, or sulfonic acid rest, SO.sub.3 X, X meaning hydrogen, alkali metal or alkaline earth metal. An aqueous solution containing the both can be administered by injection.

摘要翻译： 碱式金属亚硫酸氢盐或亚硫酸盐可有效地控制局部损伤，例如在注射式IMA IMA的抗肿瘤苯并二氮杂化合物时发生的炎症和静脉损伤，其中R1表示氢原子，或酰基，氨基甲酰基或烷氧基羰基; R2表示氢原子或酰基; R3表示亚硫酸基，SO2X或磺酸基，SO3X，X表示氢，碱金属或碱土金属。 可以通过注射施用含有这两者的水溶液。

公开(公告)号：US4230703A

公开(公告)日：1980-10-28

申请号：US891112

申请日：1978-03-28

申请人： Yasushi Suzuki ,  Kunio Tsukamoto ,  Nobuyoshi Minami ,  Yukio Hasegawa ,  Tadaharu Watanabe ,  Katsuhiko Miyasaka ,  Takashi Mikami ,  Satoshi Funakoshi

发明人： Yasushi Suzuki ,  Kunio Tsukamoto ,  Nobuyoshi Minami ,  Yukio Hasegawa ,  Tadaharu Watanabe ,  Katsuhiko Miyasaka ,  Takashi Mikami ,  Satoshi Funakoshi

IPC分类号： C07D223/20 ,  A61K31/55

CPC分类号： C07D223/20

摘要： Compounds of the general formula ##STR1## or their salts, esters or amide derivatives; and processes for their preparation. In the formula, R.sub.O represents hydrogen or lower alkyl, R.sub.2 represents hydrogen, halogen or nitro, R.sub.3 represents hydrogen or halogen, and R.sub.4 represents hydrogen or lower alkyl; and when R.sub.O is hydrogen, R.sub.2, R.sub.3 and R.sub.4 are all hydrogens and the group ##STR2## is present at the 2-position. These compounds exhibit superior analgesic and/or anti-inflammatory actions with little gastrointestinal troubles.

摘要翻译： 通式为“IMAGE”的化合物或其盐，酯或酰胺衍生物; 及其制备方法。 在该式中，RO表示氢或低级烷基，R2表示氢，卤素或硝基，R3表示氢或卤素，R4表示氢或低级烷基; 当RO为氢时，R2，R3和R4均为氢，组“IMAGE”存在于2位。 这些化合物表现出优异的止痛和/或抗炎作用，很少有胃肠道麻烦。