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公开(公告)号：US4476298A
公开(公告)日：1984-10-09
申请号：US444171
申请日：1982-11-24
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/08
摘要： Novel erythromycin A derivatives of the formula ##STR1## wherein R is hydrogen or methyl, and the pharmaceutically acceptable acid addition salts thereof are disclosed. They exhibit excellent antibacterial activity against erythromycin resistant bacteria, Gram-positive bacteria and Mycoplasma species.
摘要翻译： 公开了其中R是氢或甲基的式“IMAGE”的新型红霉素A衍生物及其药学上可接受的酸加成盐。 它们对红霉素抗性细菌，革兰氏阳性菌和支原体物种具有优异的抗菌活性。
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12.发明申请THERAPEUTIC MUSCULAR DYSTROPHY DRUG HAVING BUBBLE LIPOSOME LOADED WITH MORPHOLINO AS ACTIVE INGREDIENT 有权具有作为活性成分的以摩尔作为负载的泡沫脂多糖的治疗性肌肉DYSTROPHY药物公开(公告)号：US20140155813A1
公开(公告)日：2014-06-05
申请号：US14116316
申请日：2012-04-25
CPC分类号： A61K47/48815 , A61K9/0019 , A61K9/1271 , A61K41/0028 , A61K47/24 , A61K47/6911 , C12N15/113 , C12N15/88 , C12N2310/11 , C12N2310/3233 , C12N2310/3515 , C12N2320/32 , C12N2320/33
摘要： To provide a technology for introducing a PMO with remarkably enhanced cell permeability, leading to significantly enhanced introduction efficiency to thereby provide a therapeutic drug that dramatically ameliorates a medical condition of DMD. Also provided is a therapeutic drug for Duchenne muscular dystrophy, including as an active ingredient a Bubble liposome having a specific morpholino oligomer (PMO) bound to a surface thereof, in which the PMO is introduced into a muscle fiber (muscle cell) of a muscle tissue with high efficiency by administration of the therapeutic drug into the muscle tissue or into a blood vessel followed by ultrasound irradiation to the muscle tissue transcutaneously.
摘要翻译： 为了提供引入具有显着增强的细胞渗透性的PMO的技术，导致显着提高的引入效率，从而提供显着改善DMD的医学状况的治疗药物。 还提供了杜烯肌营养不良的治疗药物，其包括作为活性成分的具有与其表面结合的特异性吗啉代低聚物（PMO）的泡沫脂质体，其中将PMO引入肌肉的肌肉纤维（肌肉细胞） 通过将治疗药物施用到肌肉组织中或进入血管，然后经皮超声照射到肌肉组织，从而高效地进行组织。
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13.发明授权Program recording and playing apparatus and portable terminal for recording and playing programs 有权程序记录和播放设备以及用于录制和播放节目的便携式终端公开(公告)号：US08413203B2
公开(公告)日：2013-04-02
申请号：US09929780
申请日：2001-08-14
申请人： Koichi Kawana , Yoko Takahashi , Makoto Korehisa
发明人： Koichi Kawana , Yoko Takahashi , Makoto Korehisa
IPC分类号： H04N7/173
CPC分类号： H04N21/4227 , H04N5/38 , H04N5/4401 , H04N5/44543 , H04N5/76 , H04N5/765 , H04N5/775 , H04N21/4135 , H04N21/42207 , H04N21/42209 , H04N21/4222 , H04N21/42221 , H04N21/43615 , H04N21/43637 , H04N21/47214
摘要： A broadcast program recording and playing apparatus includes a program management unit that manages a database storing program information for broadcast programs. A transmission unit transmits the program information stored in the database to an electronic apparatus using wireless communication. Under the control of the electronic apparatus, a control unit controls an apparatus having functions of recording and playing the broadcast programs.
摘要翻译： 广播节目记录和播放装置包括管理存储广播节目的节目信息的数据库的节目管理单元。 传输单元使用无线通信将存储在数据库中的节目信息发送到电子设备。 在电子设备的控制下，控制单元控制具有记录和播放广播节目功能的设备。
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14.发明申请Image detecting apparatus, image detecting method, and image detecting program 失效图像检测装置，图像检测方法和图像检测程序公开(公告)号：US20050044489A1
公开(公告)日：2005-02-24
申请号：US10486609
申请日：2003-06-11
申请人： Rui Yamagami , Yoko Takahashi , Osamu Date
发明人： Rui Yamagami , Yoko Takahashi , Osamu Date
IPC分类号： H04N5/76 , G11B20/10 , G11B27/00 , G11B27/034 , G11B27/10 , G11B27/32 , G11B27/34 , G11B27/36 , H04N5/91 , H04N5/93 , G06F15/00
CPC分类号： G11B27/329 , G11B27/034 , G11B27/105 , G11B27/34 , G11B27/36 , G11B2220/20 , G11B2220/2516 , G11B2220/2525 , G11B2220/61
摘要： An image detecting apparatus has an edit function with good operability and compatibility. When a chapter mark key on a remote control is pressed while an image reproducing system including an MPEG video decoder, a video signal post-processing circuit, a combining circuit, and an NTSC encoder is reproducing image data recorded on a recording medium, a CPU obtains information for identifying the image being reproduced and displayed, and then records the information on the recording medium. With reference to the image provided with a chapter mark, a still image generating circuit displays reduced still images, for example, so that a target image can be specified. Reproduction and editing can be performed with reference to the specified image.
摘要翻译： 图像检测装置具有良好的可操作性和兼容性的编辑功能。 当包括MPEG视频解码器，视频信号后处理电路，组合电路和NTSC编码器的图像再现系统在再现记录在记录介质上的图像数据的同时按下遥控器上的章节标记键时，CPU 获取用于识别被再现和显示的图像的信息，然后将该信息记录在记录介质上。 参考具有章标记的图像，静止图像生成电路例如显示缩小的静止图像，使得可以指定目标图像。 可以参照指定的图像进行再现和编辑。
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15.发明授权
公开(公告)号：US5452146A
公开(公告)日：1995-09-19
申请号：US161391
申请日：1993-12-06
申请人： Hiroshige Okamoto , Hiraku Inoue , Yoko Takahashi , Yutaka Miki
发明人： Hiroshige Okamoto , Hiraku Inoue , Yoko Takahashi , Yutaka Miki
CPC分类号： G11B5/02 , G11B15/026 , G11B5/0086 , G11B5/035
摘要： A recording current setting method comprises the steps of: recording signals on a tape by changing, by steps, recording current for the tape; detecting a reproduced signal level at each recording current; and determining an optimal recording current from a middle point between a first recording current at which a reproduced signal level first exceeds a threshold level as a result of increasing, by steps, the recording current and a second recording current at which a reproduced signal level first exceeds the threshold level as a result of decreasing, by steps, the recording current. An information signal recording apparatus using the method is also disclosed.
摘要翻译： 记录电流设定方法包括以下步骤：通过逐步改变记录磁带的电流来在磁带上记录信号; 在每个记录电流下检测再现信号电平; 并且通过逐步地增加记录电流和再现信号电平的第二记录电流，从再现信号电平首先超过阈值电平的第一记录电流之间的中点确定最佳记录电流 作为通过逐步减小记录电流的结果，超过阈值水平。 还公开了使用该方法的信息信号记录装置。
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16.发明授权Therapeutic muscular dystrophy drug having bubble liposome loaded with morpholino as active ingredient 有权具有负载吗啉代作为活性成分的气泡脂质体的治疗性肌营养不良药物公开(公告)号：US09457102B2
公开(公告)日：2016-10-04
申请号：US14116316
申请日：2012-04-25
CPC分类号： A61K47/48815 , A61K9/0019 , A61K9/1271 , A61K41/0028 , A61K47/24 , A61K47/6911 , C12N15/113 , C12N15/88 , C12N2310/11 , C12N2310/3233 , C12N2310/3515 , C12N2320/32 , C12N2320/33
摘要： To provide a technology for introducing a PMO with remarkably enhanced cell permeability, leading to significantly enhanced introduction efficiency to thereby provide a therapeutic drug that dramatically ameliorates a medical condition of DMD. Also provided is a therapeutic drug for Duchenne muscular dystrophy, including as an active ingredient a Bubble liposome having a specific morpholino oligomer (PMO) bound to a surface thereof, in which the PMO is introduced into a muscle fiber (muscle cell) of a muscle tissue with high efficiency by administration of the therapeutic drug into the muscle tissue or into a blood vessel followed by ultrasound irradiation to the muscle tissue transcutaneously.
摘要翻译： 为了提供引入具有显着增强的细胞渗透性的PMO的技术，导致显着提高的引入效率，从而提供显着改善DMD的医学状况的治疗药物。 还提供了杜烯肌营养不良的治疗药物，其包括作为活性成分的具有与其表面结合的特异性吗啉代低聚物（PMO）的泡沫脂质体，其中将PMO引入肌肉的肌肉纤维（肌肉细胞） 通过将治疗药物施用到肌肉组织中或进入血管，然后经皮超声照射到肌肉组织，从而高效地进行组织。
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公开(公告)号：US20130116296A1
公开(公告)日：2013-05-09
申请号：US13810030
申请日：2011-07-14
IPC分类号： C07D405/06 , C07D231/20 , C07D231/22
CPC分类号： C07D231/20 , C07D231/18 , C07D231/22 , C07D231/38 , C07D231/44 , C07D405/06 , C07D493/08
摘要： The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HT2C antagonistic action (antidepressive and anxiolytic effects), in particular, 5-HT2C inverse agonistic action comprising Compound (1): or a pharmaceutically acceptable salt thereof wherein R1, R2, R3 and R4 are independently hydrogen or C1-6 alkyl etc.; R5 is C4-7 alkyl or —(CR8R9)r-E; R6, R7, R8 and R9 are independently hydrogen, fluorine or C1-6 alkyl; A is C6-10 aryl or heteroaryl etc.; r is 1, 2, 3 or 4; E is C3-8 cycloalkyl or C6-10 aryl etc.; L is oxygen, sulfur or —NR10—; n is 1, 2 or 3; R10 is hydrogen or C1-6 alkyl etc.; and X is hydrogen or halogen etc.
摘要翻译： 本发明涉及还显示5-HT 2C拮抗作用（抗抑郁和抗焦虑作用）的5-羟色胺再摄取抑制剂，特别是包含化合物（1）：或其药学上可接受的盐的5-HT 2C反向激动作用其中R1，R2 ，R3和R4独立地是氢或C1-6烷基等; R5是C4-7烷基或 - （CR8R9）r-E; R6，R7，R8和R9独立地是氢，氟或C1-6烷基; A为C6-10芳基或杂芳基等; r为1,2,3或4; E为C3-8环烷基或C6-10芳基等; L是氧，硫或-NR10-; n为1,2或3; R 10是氢或C 1-6烷基等; X为氢或卤素等。
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公开(公告)号：US07781479B2
公开(公告)日：2010-08-24
申请号：US11795147
申请日：2006-01-12
申请人： Yoko Takahashi , Ryu Nagata , Kantaro Ushiroda
发明人： Yoko Takahashi , Ryu Nagata , Kantaro Ushiroda
IPC分类号： A61K31/405 , A61K31/404 , A61K31/192 , C07D209/04 , C07D209/12
CPC分类号： C07D233/64 , C07D209/12 , C07D231/56 , C07D235/12 , C07D471/04
摘要： A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic agent for hyperlipemia, etc. wherein the ring Z is an optionally substituted heteroaryl, W4 is a single bond, lower alkylene, etc., Ar2 is an optionally substituted aryl, etc., W3 is a single bond, lower alkylene, etc., Ar1 is an optionally substituted arylene, etc., each of W1 and W2 is an optionally substituted lower alkylene, etc., and R1 is carboxyl, an alkoxycarbonyl.
摘要翻译： 下式（1）的化合物或其前药或药学上可接受的盐可用作糖尿病药物或预防性或血糖调节剂或高脂血症治疗剂等，其中环Z为任选取代的杂芳基 W4为单键，低级亚烷基等，Ar2为任意取代的芳基等，W3为单键，低级亚烷基等，Ar1为任意取代的亚芳基等，W1，W2分别为 是任选取代的低级亚烷基等，并且R 1是羧基，烷氧基羰基。
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公开(公告)号：US20060089298A1
公开(公告)日：2006-04-27
申请号：US10508413
申请日：2003-01-17
申请人： Satoshi Omura , Hiroshi Tomoda , Masato Iwatsuki , Yoko Takahashi
发明人： Satoshi Omura , Hiroshi Tomoda , Masato Iwatsuki , Yoko Takahashi
摘要： The present invention is comprised of culturing a microorganism having ability to produce K01-B0171-B substance and/or K01-B0171-C substance in a medium, accumulating K01-B0171-B substance and/or K01-B0171-C substance in a culture fluid and isolating K01-B0171-B substance and/or, K01-B0171-C substance from the culture fluid. The obtained K01-B0171-B substance, K01-B0171-C substance or a composition of these substances is expected to be useful as a medicament of antituberculous agent.
摘要翻译： 本发明包括在培养基中培养具有生产K01-B0171-B物质和/或K01-B0171-C物质的微生物的微生物，将K01-B0171-B物质和/或K01-B0171-C物质累积在 培养液并从培养液中分离K01-B0171-B物质和/或K01-B0171-C物质。 获得的K01-B0171-B物质，K01-B0171-C物质或这些物质的组合物预期可用作抗结核药物的药物。
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公开(公告)号：USD444170S1
公开(公告)日：2001-06-26
申请号：US29118817
申请日：2000-02-16
申请人： Yoshihiro Ichi , Yoko Takahashi
设计人： Yoshihiro Ichi , Yoko Takahashi
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