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    Urotensin II receptor antagonists
    11.
    发明授权
    Urotensin II receptor antagonists 有权
    促肾上腺素II受体拮抗剂

    公开(公告)号：US08258301B2

    公开(公告)日：2012-09-04

    申请号：US12527973

    申请日：2008-05-12

    申请人： Brian Nicholas Cook ,  Anne Bettina Eldrup ,  Ingo Andreas Mugge ,  Fariba Soleymanzadeh ,  Sanxing Sun ,  Yunlong Zhang

    发明人： Brian Nicholas Cook ,  Anne Bettina Eldrup ,  Ingo Andreas Mugge ,  Fariba Soleymanzadeh ,  Sanxing Sun ,  Yunlong Zhang

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04

    摘要： Compounds of the formula (I) wherein R1, R2, R3, R4, R5, R6, W, and Y are as described herein, or a tautomer, prodrug, solvate, or salt thereof. These compounds are useful as inhibitors of Urotensin II and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the interaction of Urotensin II with its receptor, including cardiovascular diseases. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds, and intermediates useful in these processes.

    摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，R 6，W和Y如本文所述的式（I）化合物，或其互变异构体，前药，溶剂化物或盐。 这些化合物可用作促进罗素素II的抑制剂，因此可用于治疗通过促肾上腺素II与其受体（包括心血管疾病）的相互作用介导或维持的各种疾病和病症。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

    SYSTEM AND METHOD FOR DETECTION OF PULMONARY EMBOLISM
    12.
    发明申请
    SYSTEM AND METHOD FOR DETECTION OF PULMONARY EMBOLISM 有权
    用于检测肺动脉栓塞的系统和方法

    公开(公告)号：US20120190992A1

    公开(公告)日：2012-07-26

    申请号：US13438682

    申请日：2012-04-03

    申请人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

    发明人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

    IPC分类号： A61B5/0215 ,  A61B5/042 ,  A61B5/021

    CPC分类号： A61B5/0215 ,  A61B5/02007 ,  A61B5/02108 ,  A61B5/08 ,  A61B5/412 ,  A61B5/6846 ,  A61B5/7275

    摘要： Systems and methods provide for ambulatorily sensing pulmonary artery pressure from within a patient, and producing a pulmonary artery pressure measurement from the sensed pulmonary artery pressure. Power is ambulatorily provided within the patient to facilitate sensing of the pulmonary artery pressure and producing of the pulmonary artery pressure measurement. Acute pulmonary embolism is detected based on a change or rate of change in the pulmonary artery pressure measurement. An alert is preferably generated in response to detecting pulmonary embolism.

    摘要翻译： 系统和方法提供了从患者体内动态感测肺动脉压力，并从感测到的肺动脉压力产生肺动脉压力测量。 在患者体内设置动力以便于感测肺动脉压力并产生肺动脉压力测量。 基于肺动脉压力测量的变化或变化率来检测急性肺栓塞。 响应于检测到肺栓塞，优选产生警报。

    COMPOUND ROTOR SYSTEM OF WIND POWERED ENGINE
    13.
    发明申请
    COMPOUND ROTOR SYSTEM OF WIND POWERED ENGINE 失效
    风力发动机复合转子系统

    公开(公告)号：US20110163552A1

    公开(公告)日：2011-07-07

    申请号：US13062391

    申请日：2009-09-03

    申请人： Yunlong Zhang ,  Hongying Zhang

    发明人： Yunlong Zhang ,  Hongying Zhang

    IPC分类号： F03D9/00 ,  F03D11/02

    CPC分类号： F03D7/0276 ,  F03D1/025 ,  F03D15/00 ,  F05B2260/403 ,  Y02E10/72

    摘要： The present invention provides a controllable compound rotor system for the WECS, with a pilot rotor working under low wind speed conditions and a main rotor working under high speed conditions. By proper switching of the clutch, the WECS can not only achieve a greater starting torque under low wind speed conditions, as well as to capture and utilize the low wind-speed wind energy after being started, but also give full play to the advantage of the main rotor having the excellent wind capturing efficiency under high wind speed and high turning speed conditions. Thus the WECS can capture and utilize wind energy under both low and high wind speed conditions, which greatly expands the speed and zone range wherein the WECS can be applied, facilitating wide application of the WECS.

    摘要翻译： 本发明提供了一种用于WECS的可控复合转子系统，其中先导转子在低风速条件下工作，主转子在高速条件下工作。 通过适当切换离合器，WECS不但能够在低风速条件下实现更大的启动转矩，而且可以在起动后捕获和利用低风速的风能，同时充分发挥 主转子在高风速和高转速条件下具有优良的风力捕获效率。 因此，WECS可以在低和高风速条件下捕获和利用风能，大大扩展了可应用WECS的速度和区域范围，有助于WECS的广泛应用。

    System and Method for Detection of Pulmonary Embolism
    14.
    发明申请
    System and Method for Detection of Pulmonary Embolism 有权
    肺栓塞检测系统及方法

    公开(公告)号：US20090281396A1

    公开(公告)日：2009-11-12

    申请号：US12414465

    申请日：2009-03-30

    申请人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

    发明人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

    IPC分类号： A61B5/0215 ,  A61B5/0205

    CPC分类号： A61B5/0215 ,  A61B5/02007 ,  A61B5/02108 ,  A61B5/08 ,  A61B5/412 ,  A61B5/6846 ,  A61B5/7275

    摘要： Systems and methods provide for ambulatorily sensing pulmonary artery pressure from within a patient, and producing a pulmonary artery pressure measurement from the sensed pulmonary artery pressure. Power is ambulatorily provided within the patient to facilitate sensing of the pulmonary artery pressure and producing of the pulmonary artery pressure measurement. Acute pulmonary embolism is detected based on a change or rate of change in the pulmonary artery pressure measurement. An alert is preferably generated in response to detecting pulmonary embolism.

    摘要翻译： 系统和方法提供了从患者体内动态感测肺动脉压力，并从感测到的肺动脉压力产生肺动脉压力测量。 在患者体内设置动力，以便于感测肺动脉压力并产生肺动脉压力测量。 基于肺动脉压力测量的变化或变化率来检测急性肺栓塞。 响应于检测到肺栓塞，优选产生警报。

    Devices and Methods for Measurement of Vessel Elasticity and Blood Pressure
    15.
    发明申请
    Devices and Methods for Measurement of Vessel Elasticity and Blood Pressure 审中-公开
    容器弹性和血压测量装置和方法

    公开(公告)号：US20090093729A1

    公开(公告)日：2009-04-09

    申请号：US11866523

    申请日：2007-10-03

    申请人： Yunlong Zhang ,  Bin Mi ,  Yongxing Zhang

    发明人： Yunlong Zhang ,  Bin Mi ,  Yongxing Zhang

    IPC分类号： A61B5/0215

    CPC分类号： A61B5/02158 ,  A61B5/02007 ,  A61B5/02125 ,  A61B5/0285 ,  A61B5/029 ,  A61B5/1107 ,  A61B5/6876 ,  A61B5/6884 ,  A61B2562/0261 ,  A61B2562/0266

    摘要： Embodiments of the invention are related to devices and methods for measuring arterial elasticity and/or blood pressure, amongst other things. In an embodiment, the invention includes an implantable medical device having a sensor element that is configured to engage a vessel of a patient. The sensor element is further configured to generate a signal in response to bending of the sensor element, where bending occurs as a result of changes in the pressure within the vessel. The implantable medical device further includes a controller in signal communication with the sensor element, where the controller is configured to store information regarding the signal generated by the sensor element. Other embodiments are also included herein.

    摘要翻译： 本发明的实施例涉及用于测量动脉弹性和/或血压的装置和方法等。 在一个实施例中，本发明包括具有传感器元件的可植入医疗装置，该传感器元件构造成与患者的血管接合。 传感器元件还被配置为响应于传感器元件的弯曲而产生信号，其中由于容器内的压力变化而发生弯曲。 可植入医疗装置还包括与传感器元件信号通信的控制器，其中控制器被配置为存储关于由传感器元件产生的信号的信息。 本文还包括其它实施例。

    USING ACOUSTIC ENERGY TO COMPUTE A LUNG EDEMA FLUID STATUS INDICATION
    16.
    发明申请
    USING ACOUSTIC ENERGY TO COMPUTE A LUNG EDEMA FLUID STATUS INDICATION 有权
    使用声学能量计算肺动脉流体状态指示

    公开(公告)号：US20090036777A1

    公开(公告)日：2009-02-05

    申请号：US11833502

    申请日：2007-08-03

    申请人： Yunlong Zhang ,  Yongxing Zhang ,  Paul E. Zarembo

    发明人： Yunlong Zhang ,  Yongxing Zhang ,  Paul E. Zarembo

    IPC分类号： A61B8/00

    CPC分类号： A61B8/12 ,  A61B5/0031 ,  A61B5/08 ,  A61B5/4878 ,  A61B8/4472

    摘要： Systems and methods for monitoring lung edema fluid status, such as monitoring the presence or absence of pulmonary edema, in a subject using information about responsive acoustic energy echoes from a lung are described. The system comprises, among other things, an implantable device including an acoustic transducer configured to emit acoustic energy to a lung and to receive one or more responsive acoustic energy echoes from a lung. In an example, the implantable device includes a cardiac function management device having an acoustic window in a body thereof. In another example, the implantable device includes one or more subcutaneous leads. An implantable or external processor circuit is configured to receive information about the acoustic energy echoes to compute and provide a lung edema fluid status indication; such information may include an increased number or special pattern of acoustic energy echoes received or a decreased time between successively received echoes.

    摘要翻译： 描述了使用关于来自肺的响应性声能回波的信息来监测受试者肺水肿液体状态的系统和方法，例如监测受试者是否存在肺水肿。 除其他之外，该系统包括可植入装置，其包括被配置为向肺发出声能并且接收来自肺的一个或多个响应声能回波的声学换能器。 在一个示例中，可植入装置包括其身体中具有声窗口的心脏功能管理装置。 在另一示例中，可植入装置包括一个或多个皮下引线。 植入式或外部处理器电路被配置为接收关于声能回波的信息，以计算并提供肺水肿状态指示; 这样的信息可以包括接收的声能回波的增加的数量或特殊模式或连续接收的回波之间的减少的时间。

    Measurement of Cardiac Performance Wtih Movement Sensors and Related Methods
    17.
    发明申请
    Measurement of Cardiac Performance Wtih Movement Sensors and Related Methods 失效
    心脏性能测量与运动传感器及相关方法

    公开(公告)号：US20090005829A1

    公开(公告)日：2009-01-01

    申请号：US11769402

    申请日：2007-06-27

    申请人： Bin Mi ,  Yongxing Zhang ,  Yunlong Zhang ,  James O. Gilkerson

    发明人： Bin Mi ,  Yongxing Zhang ,  Yunlong Zhang ,  James O. Gilkerson

    IPC分类号： A61N1/365 ,  A61B5/02

    CPC分类号： A61N1/056 ,  A61B5/02438 ,  A61B5/02444 ,  A61B5/6846 ,  A61B5/6851 ,  A61N1/36514 ,  A61N1/36578

    摘要： Embodiments of the invention are related to implantable devices including movement sensors and related methods for measuring cardiac performance, amongst other things. In an embodiment, the invention includes an implantable electrical stimulation lead. The electrical stimulation lead can include a lead body having a proximal end and a distal end and a sheath defining a central lumen. The lead body can further include an electrical conductor disposed within the central lumen of the sheath. The stimulation lead can further include a stimulation electrode positioned at the distal end of the lead body, the stimulation electrode in electrical communication with the electrical conductor. The electrical stimulation lead can include an flexion sensor coupled to the lead body, the movement sensor configured to generate a signal in response to movement of the lead body. In an embodiment, the invention includes a method of monitoring the condition of a heart failure patient. In an embodiment, the invention includes a method of treating unstable arrhythmia in a patient. Other embodiments are also included herein.

    摘要翻译： 本发明的实施例涉及包括运动传感器和用于测量心脏性能的相关方法的可植入装置。 在一个实施例中，本发明包括可植入电刺激引线。 电刺激引线可以包括具有近端和远端的引线主体和限定中心内腔的护套。 引线体还可以包括设置在护套的中心腔内的电导体。 刺激引线还可以包括位于引线体的远端处的刺激电极，该刺激电极与电导体电连通。 电刺激引线可以包括耦合到引线主体的屈曲传感器，所述运动传感器被配置为响应于引线主体的移动而产生信号。 在一个实施例中，本发明包括监测心力衰竭患者状况的方法。 在一个实施方案中，本发明包括治疗患者不稳定性心律失常的方法。 本文还包括其它实施例。

    METHOD AND APPARATUS FOR DETECTING NON-SUSTAINING VENTRICULAR TACHYARRHYTHMIA
    18.
    发明申请
    METHOD AND APPARATUS FOR DETECTING NON-SUSTAINING VENTRICULAR TACHYARRHYTHMIA 失效
    检测非持续性胸腔积液的方法和装置

    公开(公告)号：US20070293894A1

    公开(公告)日：2007-12-20

    申请号：US11424743

    申请日：2006-06-16

    申请人： Yunlong Zhang ,  Jaeho Kim

    发明人： Yunlong Zhang ,  Jaeho Kim

    IPC分类号： A61N1/39

    CPC分类号： A61N1/3621 ,  A61N1/3962

    摘要： An implantable medical device controls an anti-tachyarrhythmia therapy by detecting a tachyarrhythmia episode from a cardiac signal and analyzing the detected tachyarrhythmia episode in a tachyarrhythmia detection and analysis process to determine whether the anti-tachyarrhythmia therapy needs to be delivered. The tachyarrhythmia detection and classification process includes detection of inhibitory events each indicating that the tachyarrhythmia episode is of a type not to be treated by the anti-tachyarrhythmia therapy or that the tachyarrhythmia episode is not sustaining. The detection of each of the inhibitory events causes the tachyarrhythmia detection and classification process to be restarted or extended, or the delivery of the anti-tachyarrhythmia therapy to be withheld.

    摘要翻译： 可植入医疗装置通过从心脏信号检测快速性心律失常发作来控制抗快速性心律失常治疗，并在快速性心律失常检测和分析过程中分析检测到的快速性心律失常发作，以确定是否需要递送抗快速性心律失常治疗。 快速心律失常检测和分类过程包括各种抑制事件的检测，每个都表示快速性心律失常发作是不由抗慢性心律失常治疗治疗的类型，或快速性心律失常发作不能维持。 每个抑制事件的检测导致快速性心律失常检测和分类过程重新启动或延长，或者阻止抗快速性心律失常治疗的传递。