公开(公告)号：US10660068B2

公开(公告)日：2020-05-19

申请号：US14896610

申请日：2014-06-06

Applicant: Stichting VU-VUMC ,  FOM-Nikhef

Inventor： Henk Jan Bulten ,  Johannes Franciscus Josephina Van Den Brand

IPC: H04W72/00 ,  H04W72/04 ,  H04W52/02 ,  H04B7/26 ,  H04W84/18

Abstract: A method for managing communication in a wireless mesh network comprising a plurality of wireless nodes and a wireless node for use in such network are described, wherein said method may comprise: providing a time slot schedule (frame), preferably a TDMA time slot schedule (frame), comprising one or more time slots, including a transmission time slot enabling a node to transmit a broadcast message, a reception time slot enabling a node to receive a broadcast message from one or more other nodes; and/or a sleep time slot for configuring said node in an idle state; and, assigning said time slots to nodes in said network on the basis of the position of said nodes in said network.

公开(公告)号：US20170322215A1

公开(公告)日：2017-11-09

申请号：US15528322

申请日：2015-11-18

Applicant: Stichting Katholieke Universiteit ,  Stichting VU-Vumc

Inventor： Anna Catharina Navis ,  Wilhelmus Petrus Johannes Leenders ,  Thomas Würdinger

IPC: G01N33/574 ,  G01N33/74 ,  C07K14/71 ,  C12Q1/68

CPC classification number: G01N33/5748 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/2863 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/574 ,  G01N33/74 ,  G01N2333/71

Abstract: The present invention relates to the fields of medicine and molecular diagnostics. In particular, it relates to a novel method for the treatment, prevention and/or delay of cancer and to a diagnostic method involving detection of a novel auto-active and intracellular mutant of MET.

公开(公告)号：US20140154182A1

公开(公告)日：2014-06-05

申请号：US14122691

申请日：2012-05-30

Applicant: Pieter Jacob Klein ,  Athansios Metaxas ,  Albert Dirk Windhorst ,  Johannes Antonius Maria Christiaans ,  Bart Nicolaas Maria van Berckel

Inventor： Pieter Jacob Klein ,  Athansios Metaxas ,  Albert Dirk Windhorst ,  Johannes Antonius Maria Christiaans ,  Bart Nicolaas Maria van Berckel

IPC: C07C279/18 ,  C07C277/08 ,  A61K51/04

CPC classification number: C07C279/18 ,  A61K31/155 ,  A61K51/04 ,  C07B59/001 ,  C07B2200/05 ,  C07C277/08 ,  C07C319/20 ,  C07C323/44

Abstract: The invention is directed to a N,N-substituted guanidine compound or a salt or solvate thereof according to formula (1), R1RNC(NH)NR2R3, wherein R1 is methyl and R2 is hydrogen. R3 is a organic group comprising a halogen and thiomethyl substituted phenyl group. R is an organic group comprising a substituted aryl group Z wherein the substituent group is —Y—R4, wherein Y is a heteroatom chosen from the group consisting of O, S and N and R4 is a fluorinated organic group.

Abstract translation: 本发明涉及根据式（1）的N，N-取代的胍化合物或其盐或溶剂合物，R1RNC（NH）NR2R3，其中R1是甲基，R2是氢。 R3是包含卤素和硫代甲基取代的苯基的有机基团。 R是包含取代的芳基Z的有机基团，其中取代基是-Y-R 4，其中Y是选自O，S和N的杂原子，R4是氟化有机基团。

公开(公告)号：US20140135604A1

公开(公告)日：2014-05-15

申请号：US14130478

申请日：2012-07-04

Applicant: Miguel Angel Cuesta Valentin ,  Alexander Amold Frederik Adriaan Veenhof

Inventor： Miguel Angel Cuesta Valentin ,  Alexander Amold Frederik Adriaan Veenhof

IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/026 ,  A61B5/0205 ,  A61B5/022 ,  A61B5/0215

CPC classification number: A61B5/4848 ,  A61B5/0053 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/02233 ,  A61B5/026 ,  A61B5/0261 ,  A61B5/14551 ,  A61B5/42

Abstract: The invention relates to a system for predicting the viability of a body tissue in a patient. The system comprises a computing device, and a first pressure measuring device for measuring local perfusion pressure in the body tissue of the patient. This measuring device is connected to the computing device. A second pressure measuring device is provided for measuring the systemic perfusion pressure of the patient, said second pressure measuring device being connected to the computing device. A feedback indicator is connected to the computing device and is adapted to indicate the viability of the tissue calculated by the computing device on the basis of the measured local and systemic perfusion pressures. The invention also includes a method of predicting the viability of the body tissue and to the first pressure measuring device.

Abstract translation: 本发明涉及一种用于预测患者体内组织活力的系统。 该系统包括计算装置和用于测量患者的身体组织中的局部灌注压力的第一压力测量装置。 该测量装置连接到计算设备。 提供第二压力测量装置，用于测量患者的全身灌注压力，所述第二压力测量装置连接到计算装置。 反馈指示器连接到计算设备，并且适于基于测量的局部和全身灌注压力来指示由计算设备计算的组织的存活力。 本发明还包括预测身体组织和第一压力测量装置的活力的方法。

公开(公告)号：US20130196873A1

公开(公告)日：2013-08-01

申请号：US13809960

申请日：2011-07-15

Applicant: Thomas Würdinger ,  Rolf Jonas Nilsson

Inventor： Thomas Würdinger ,  Rolf Jonas Nilsson

IPC: C12Q1/68

CPC classification number: C12Q1/6827 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

Abstract: The present invention relates to a method of analyzing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

Abstract translation: 本发明涉及一种分析患者血液样本中疾病标志物存在的方法，所述方法包括以下步骤：a）从所述血液样品中的未核化血细胞提取核酸，以提供无核细胞提取的 核酸级分，以及b）分析所述无核细胞提取的核酸级分是否存在疾病标志物，其中所述疾病标志物是所述受试者的细胞基因中的疾病特异性突变，或其中所述疾病标记 是所述受试者的细胞的基因的疾病特异性表达谱。

公开(公告)号：US10174365B2

公开(公告)日：2019-01-08

申请号：US14006089

申请日：2012-01-16

Applicant: Thomas Wurdinger ,  Rolf Jonas Nilsson

Inventor： Thomas Wurdinger ,  Rolf Jonas Nilsson

IPC: C12Q1/68 ,  C12Q1/6834 ,  C12Q1/6886

Abstract: The present invention relates to a method of analyzing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analyzing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

公开(公告)号：US10174364B2

公开(公告)日：2019-01-08

申请号：US13809960

申请日：2011-07-15

Applicant: Thomas Würdinger ,  Rolf Jonas Nilsson

Inventor： Thomas Würdinger ,  Rolf Jonas Nilsson

IPC: C12Q1/68 ,  C12Q1/6827 ,  C12Q1/6886

Abstract: The present invention relates to a method of analyzing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analyzing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

公开(公告)号：US09766180B2

公开(公告)日：2017-09-19

申请号：US14895477

申请日：2014-06-02

Applicant: Stichting VU-VUmc

Inventor： Gijs Jan Lodewijk Wuite ,  Erwin Johannes Gerard Peterman ,  Iddo Heller ,  Gerrit Sitters ,  Andrea Candelli ,  Stefan Walter Hell

IPC: G01N33/00 ,  G01N35/00 ,  G01N21/00 ,  C12Q1/68 ,  G01N21/64 ,  B01L3/00 ,  G02B21/00 ,  G02B21/16 ,  G02B21/32

CPC classification number: G01N21/6428 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2300/0877 ,  B01L2400/0454 ,  C12Q1/6816 ,  G01N21/6458 ,  G02B21/0048 ,  G02B21/0076 ,  G02B21/16 ,  G02B21/32 ,  C12Q2565/629

Abstract: The present disclosure concerns a method and system for imaging a molecular strand (MS). The method comprises providing a sample volume (SV) comprising the strand (MS); providing an excitation beam (EB) having an excitation focus (EF) in the sample volume (SV); scanning the excitation focus (EF) in the sample volume (SV) along a one dimensional scanning line (SL); trapping an end of the strand (MS) in the sample volume (SV) and extending the strand (MS) along a one-dimensional trapping line (LL) parallel to the scanning line (SL); aligning the trapping line (LL) to coincide with the scanning line (SL) to have the scanning excitation focus (EF) coincide with the strand (MS); and recording the fluorescence response (FR) as a function of a plurality of distinct scanning positions (X0) of the excitation focus (EF) along the scanning line (SL).

公开(公告)号：US20170130277A1

公开(公告)日：2017-05-11

申请号：US15319452

申请日：2015-06-19

Applicant: STICHTING VU-VUMC ,  INTERNA TECHNOLOGIES B.V.

Inventor： Gerrit Albert MEIJER ,  Begoña DIOSDADO ,  Lisette M. TIMMER ,  Edwin Pieter Johan Gerard CUPPEN ,  Eugene BEREZIKOV ,  Francesco CERISOLI ,  Roeland Quirinus Jozef SCHAAPVELD

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178

Abstract: Methods of diagnosing colorectal cancer and precursors thereof using miRNA biomarkers are disclosed, together with kits and devices for detecting the biomarkers, and uses of the biomarkers. The biomarkers described are reliably detected in stool and demonstrate significantly different expression levels in colorectal cancer patients when compared to colorectal cancer negative patients.

公开(公告)号：US20120167246A1

公开(公告)日：2012-06-28

申请号：US13318315

申请日：2010-04-30

Applicant: Francesca Quattrocchio ,  Ronald Koes ,  Kees Spelt

Inventor： Francesca Quattrocchio ,  Ronald Koes ,  Kees Spelt

IPC: C12N5/10 ,  C12N15/82 ,  A01H1/06 ,  A01H5/00 ,  A01H5/10 ,  A01H5/08 ,  A01H5/06 ,  A01H5/04 ,  A01H5/12 ,  C12N15/29 ,  A01H5/02

CPC classification number: C12N15/825 ,  A01H5/02 ,  A01H5/08 ,  C07K14/415 ,  C12N9/14 ,  C12N15/8243 ,  C12N15/8249 ,  C12N15/827

Abstract: The present invention relates generally to the field of plant molecular biology and agents useful in the manipulation of plant physiological and biochemical properties. More particularly, the present invention provides genetic and proteinaceous agents capable of modulating or altering the level of acidity or alkalinity in a cell, group of cells, organelle, part or reproductive portion of a plant. Genetically altered plants, plant parts, progeny, subsequent generations and reproductive material including flowers or flowering parts having cells exhibiting an altered cellular including vacuolar pH compared to a non-genetically altered plant are also provided.

Abstract translation: 本发明一般涉及植物分子生物学领域和用于操作植物生理和生物化学性质的试剂。 更具体地，本发明提供能够调节或改变植物的细胞，细胞组，细胞器，部分或生殖部分中的酸度或碱度水平的遗传和蛋白质剂。 还提供遗传改变的植物，植物部分，子代，后代和繁殖材料，包括花或开花部分，其具有与非遗传改变的植物相比显示改变的细胞，包括液泡pH的细胞。