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公开(公告)号:US11905318B2
公开(公告)日:2024-02-20
申请号:US17011059
申请日:2020-09-03
发明人: Neil R. Cashman , Steven S. Plotkin
IPC分类号: C07K7/00 , C07K14/00 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/12 , A61K38/17 , C07K14/47 , C07K16/18 , C07K5/103 , C07K5/117 , A61K47/64 , C07K7/06 , C12N5/10 , C07K7/64 , A61P25/28 , A61K39/00 , A61K39/39 , A61K51/10 , G01N33/68 , A61K49/18 , A61K39/395 , A61K38/07 , A61K47/68 , A61K45/00 , A61K51/08 , A61K47/69 , A61K38/05 , A61K45/06 , C07K7/08 , C07K16/00 , C07K14/435 , G01N33/50 , A61L27/22 , A61L27/34 , A61L31/10 , A61L31/16 , A61L29/08 , A61L29/16
CPC分类号: C07K14/4711 , A61K38/1716 , A61K39/0007 , A61K39/39 , A61K47/643 , A61K47/646 , A61K51/1018 , A61P25/28 , C07K5/101 , C07K5/1024 , C07K7/06 , C07K7/64 , C07K16/18 , C12N5/10 , G01N33/6896 , A61K38/00 , A61K38/05 , A61K38/07 , A61K38/08 , A61K38/12 , A61K39/00 , A61K39/395 , A61K39/3955 , A61K39/39533 , A61K45/05 , A61K45/06 , A61K47/6803 , A61K47/6921 , A61K49/1818 , A61K49/1866 , A61K51/088 , A61K51/10 , A61K2039/505 , A61K2039/55505 , A61K2039/6081 , A61K2300/00 , A61L27/227 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , C07K7/08 , C07K14/435 , C07K16/00 , C07K2317/20 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/524 , C07K2317/526 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/624 , C07K2317/626 , C07K2317/70 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , G01N33/5058 , G01N2333/4709 , G01N2800/28 , G01N2800/2821 , G01N2800/387
摘要: The disclosure pertains to conformational epitopes in A-beta, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.
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公开(公告)号:US11884714B2
公开(公告)日:2024-01-30
申请号:US17835770
申请日:2022-06-08
CPC分类号: C07K14/685 , A61K38/00
摘要: The invention described herein is based in part on the discovery of a protein/peptide crosslink, which introduces fluorescent properties, and which has been applied to synthesize analogues of melanocortin and amanitin as choice peptides to be explored in the context of isoindole peptides. Without limitation, it is expected that those trained in the art of peptide synthesis and stapling would appreciate the consequences of this invention such that other peptides of varied length can be similarly constrained by isoindole staples as featured herein.
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公开(公告)号:US20240018110A1
公开(公告)日:2024-01-18
申请号:US18267987
申请日:2021-12-16
申请人: THE UNIVERSITY OF BRITISH COLUMBIA , PROVINCIAL HEALTH SERVICES AUTHORITY , ALPHA-9 THERANOSTICS INC.
发明人: François BÉNARD , Kuo-Shyan LIN , Chengcheng ZHANG , David PERRIN , Aron ROXIN , Zhengxing ZHANG , Antoine DOUCHEZ , Pargol DANESHMANDKASHANI , Samson LAI
IPC分类号: C07D257/02 , C07C235/78 , A61K51/04
CPC分类号: C07D257/02 , C07C235/78 , A61K51/0482 , A61K2123/00 , C07B2200/07 , A61K2121/00 , C07B2200/05
摘要: The present invention relates to radiolabelled compounds for in vivo imaging or treatment of diseases or conditions characterized by expression of prostate-specific membrane antigen.
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公开(公告)号:US20240018019A1
公开(公告)日:2024-01-18
申请号:US18317660
申请日:2023-05-15
发明人: Fariborz TAGHIPOUR
CPC分类号: C02F1/325 , H05K1/0204 , H05K1/181 , H05K7/20272 , C02F2201/3222 , C02F2201/3227 , C02F2307/10 , C02F2201/326 , C02F2103/026
摘要: A UV reactor irradiates a flow of fluid with UV radiation. The reactor comprises: a fluid conduit defined by a heat conducting conduit body comprising one or more heat conducting walls for permitting a flow of fluid therethrough; a UV-LED operatively connected to a PCB and oriented for directing radiation into the fluid conduit. The PCB comprises a heat conducting substrate having a first surface. The conduit body is in thermal contact with the first surface of the heat conducting substrate. Heat is dissipated from the UV-LED via the heat conducting substrate, the thermal contact between the first surface of the heat conducting substrate and the heat conducting conduit body, and from the one or more heat conducting walls of the heat conducting conduit body to the fluid flowing through the fluid conduit.
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公开(公告)号:US11874501B1
公开(公告)日:2024-01-16
申请号:US17891276
申请日:2022-08-19
申请人: HUAWEI TECHNOLOGIES CANADA CO., LTD. , Queen's University at Kingston , The University of British Columbia
CPC分类号: G02B6/29383 , G02B6/29338 , G02B6/29395 , G06E3/001 , H04J14/021 , H04J14/0202
摘要: A photonic device configured to perform matrix vector multiplication operations at high frequencies is provided. The vector being multiplied by the matrix is defined by vector components at specific wavelengths. The device includes a first waveguide and a second waveguide. A series of tunable microring resonators (MRRs) are coupled to the first waveguide and to a respective series of passive delay rings (PDRs), which are coupled to the second waveguide. Each MRR/PDR pair defines a tunable matrix component (tunable weight) for a respective wavelength component of the vector. A series of controllable delay elements (CDEs) such as all-pass filters are coupled to the first waveguide, upstream from the tunable MRRs. Any tuning dependent group delay caused by the MRR/PDR pairs can be compensated by controlling the CDEs such that each wavelength components has substantially a same delay as the other wavelength components.
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公开(公告)号:US20240001002A1
公开(公告)日:2024-01-04
申请号:US18037287
申请日:2021-11-16
发明人: HONGBIN LI , LINGLAN FU
CPC分类号: A61L27/52 , A61L27/227 , A61L2430/06
摘要: The present disclosure relates to methods of preparing protein hydrogels and to protein hydrogels which may, for example, be prepared from such methods. The methods comprise denaturing a protein in an aqueous environment to produce an aqueous composition comprising overlapping polypeptide chains; crosslinking the polypeptide chains to produce a denatured protein hydrogel comprising a crosslinked network of entangled polypeptide chains; and optionally at least partially renaturing the denatured protein hydrogel.
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公开(公告)号:US20230396428A1
公开(公告)日:2023-12-07
申请号:US18203847
申请日:2023-05-31
发明人: Dylan GUNN , Ioan ISBASESCU , Dong Ju CHANG , Donney FAN , Dvir HILU
CPC分类号: H04L9/088 , H04L9/30 , H04L9/3247
摘要: A method of providing an authenticator for an event includes capturing first information of the event, obtaining a first distillation of the first information of the event. The method also includes digitally signing the first distillation of the information of the event to provide a digitally signed first distillation, and providing the digitally signed first distillation during the event for embedding into the event. The method may include obtaining a recording of the event including a digital signature and a purported first distillation, generating a second distillation of information from the second recording, authenticating the purported first distillation of information utilizing a public key associated with the private key utilized to create the digital signature, and conducting a comparison of the second distillation of the event to the purported first distillation.
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公开(公告)号:US20230389640A1
公开(公告)日:2023-12-07
申请号:US18331888
申请日:2023-06-08
IPC分类号: A42B3/06
CPC分类号: A42B3/064
摘要: Helmet prevent or mitigate cervical spine fractures, including the type of injuries associated with axial compression of the spine and fracture of the spine which may otherwise result in deformation and/or injury to the spinal cord. Helmets convert an impact force with a component aligned with the axis of the spine (a “spinally axial component”) to rotational motion. In the event of a head-first impact, such helmets flexion of the neck so that the head and the cervical spine are not aligned (or less aligned) with the direction of an impact force, thereby mitigating the likelihood and/or severity of cervical spine fractures.
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公开(公告)号:US11814432B2
公开(公告)日:2023-11-14
申请号:US16649426
申请日:2018-09-20
发明人: Li Zhou , Tobias Abel , François Meyer , Megan Levings , Nicolas Dawson , Caroline Lamarche
IPC分类号: C07K16/28 , A61K35/17 , C07K14/725 , C07K14/705 , A61K35/12
CPC分类号: C07K16/2833 , A61K35/17 , C07K14/7051 , C07K14/70517 , C07K14/70575 , A61K2035/122 , C07K2317/24 , C07K2317/33 , C07K2317/622 , C07K2319/02 , C07K2319/03
摘要: The present invention relates to a novel anti-HLA-A2 antibody, and to a chimeric antigen receptor comprising said HLA-A2 antibody. The present invention further relates to an immune cell expressing said chimeric receptor antigen, and to therapeutic uses thereof, in particular for treating or preventing graft rejection or GVHD.
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公开(公告)号:US20230355573A1
公开(公告)日:2023-11-09
申请号:US18221714
申请日:2023-07-13
IPC分类号: A61K31/352 , A61K31/05 , A61K45/06 , A61P31/04 , A61K31/015 , A61K38/12 , A61K31/00
CPC分类号: A61K31/352 , A61K31/05 , A61K45/06 , A61P31/04 , A61K31/015 , A61K38/12 , A61K31/658
摘要: Pharmaceutical formulations are provided that include at least two antibiotically active ingredients: a cannabinoid that is one or more of cannabichromene (CBC), cannabidiol (CBD) and/or cannabigerol (CBG); a sesquiterpene that is one or both of a-humulene and/or β-caryophyllene; and a lipopeptide antibiotic that is daptomycin or an analogue thereof. The antibiotically active ingredients may be provided in relative amounts that amplify their individual activities, including amounts that are synergistically effective in an assay to inhibit growth and/or reproduction of an Enterococcus faecium or an Enterococcus faecalis. Therapies are provided that utilize these formulations as anti-microbials, and provide for the combined use of two or more of the antibiotically active compounds.
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