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113 条记录 (耗时 0.023 秒)

    Photolabile pro-fragrances
    13.
    发明授权
    Photolabile pro-fragrances 有权
    不透明亲香料

    公开(公告)号：US09068151B2

    公开(公告)日：2015-06-30

    申请号：US14140604

    申请日：2013-12-26

    申请人： Henkel AG & Co. KGaA

    发明人： Thomas Gerke ,  Christian Kropf ,  Ursula Huchel ,  Axel Griesbeck ,  Olga Mayer

    IPC分类号： C11D3/50 ,  C07C403/24 ,  C07C45/69 ,  C07C49/798 ,  C07C49/15

    CPC分类号： C11D3/507 ,  C07C45/69 ,  C07C49/15 ,  C07C49/798 ,  C07C2101/16 ,  C07C2601/16

    摘要： Fragrances having a fresh character are usually very volatile and therefore not very economical in typical applications such as washing or cleaning processes for example. For that reason they have to be used in relatively large amounts in order to bring about appropriate effects. The present invention describes photolabile pro-fragrances that allow for a greatly improved persistence of the fragrance impression, in particular one having a fresh character, in typical applications. A more economical use of the fragrances in question can be ensured in this way.

    摘要翻译： 具有新鲜特性的香料通常是非常易挥发的，因此在典型的应用例如洗涤或清洗方法中不是很经济。 因此，为了产生适当的效果，必须使用相对较大的量。 本发明描述了在典型应用中允许香味印象，特别是具有新鲜特性的香味印象的持久性大大改善的光不透明亲香料。 以这种方式可以确保更经济地使用所讨论的香料。

    METHOD FOR PRODUCING NORBORNENE DERIVATIVE
    16.
    发明申请
    METHOD FOR PRODUCING NORBORNENE DERIVATIVE 失效
    生产诺贝恩衍生物的方法

    公开(公告)号：US20120108851A1

    公开(公告)日：2012-05-03

    申请号：US13379133

    申请日：2010-05-13

    申请人： Shinichi Komatsu ,  Hisashi Sone ,  Takeshi Koike ,  Sayako Kawahama

    发明人： Shinichi Komatsu ,  Hisashi Sone ,  Takeshi Koike ,  Sayako Kawahama

    IPC分类号： C07C45/61

    CPC分类号： C07C45/68 ,  C07C45/69 ,  C07C45/80 ,  C07C2602/42 ,  C07C2603/94 ,  C07C49/643 ,  C07C49/683 ,  C07C49/798

    摘要： A method for producing a norbornene derivative includes forming a Mannich base represented by any of general formulae (5) to (7) by reacting a carbonyl compound represented by any of general formulae (1) to (3) and an amine compound represented by general formula (4) with each other in an acidic solvent, to thereby obtain a reaction liquid comprising the Mannich base in the acidic solvent, wherein the acidic solvent comprises a formaldehyde derivative and 0.01 mol/L or more of an acid represented by formula HX; reacting the Mannich base and a diene compound represented by general formula (8) with each other by adding an organic solvent, a base in an amount of 1.0 to 20.0 equivalents to the acid, and the diene compound to the reaction liquid, and then heating the reaction liquid, to thereby form the norbornene derivative represented by any of general formulae (9) to (11).

    摘要翻译： 降冰片烯衍生物的制造方法包括通过使由通式（1）〜（3）中的任一个表示的羰基化合物与通式（1）〜（3）所示的胺化合物反应而形成由通式（5）〜（7）中任一项所示的曼尼希碱， 式（4）在酸性溶剂中彼此反应，从而在酸性溶剂中获得包含曼尼希碱的反应液，其中酸性溶剂包含甲醛衍生物和0.01mol / L以上由式HX表示的酸; 使曼尼希碱和通式（8）表示的二烯化合物相互反应，加入有机溶剂，碱的量为1.0至20.0当量，向反应液中加入二烯化合物，然后加热 反应液，从而形成由通式（9）至（11）中的任一个表示的降冰片烯衍生物。

    Indane compounds and their pharmaceutical use
    20.
    发明授权
    Indane compounds and their pharmaceutical use 失效
    吲哚化合物及其药物用途

    公开(公告)号：US06433021B1

    公开(公告)日：2002-08-13

    申请号：US09453444

    申请日：1999-12-03

    申请人： Neil Frankish ,  Helen Sheridan ,  John Walsh ,  Michael Jordan

    发明人： Neil Frankish ,  Helen Sheridan ,  John Walsh ,  Michael Jordan

    IPC分类号： A61K3112

    CPC分类号： C07C49/835 ,  C07C35/32 ,  C07C45/64 ,  C07C45/72 ,  C07C49/252 ,  C07C49/683 ,  C07C49/747 ,  C07C49/798

    摘要： Indane compounds of general formulae (1) to (4) and their pharmaceutical use, particularly to achieve mast cell stabilising activity and/or anti-inflammatory activity are described. In these formulae R1 to R7 may be selected from: H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, cyclopentyl, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino, hydroxyamino, amine oxide groups, azo groups, cyano, hydrazino groups, hydrazide groups, hydrazone groups, indane, indene, imide groups, iminoether groups, ureyl groups, oxime, nitro, nitrate, nitrite, nitroso groups, nitirile, heterocyclic groups containing hetero atoms selected from one or more of N, O or S, aralkyl groups, aryl groups, mono and polybenzoid aryl groups, substituted aryl groups, thiol, thioureyl, phenylthiol groups, sulphonic acid groups, sulphoxide groups, sulphone groups, carboxylic acid groups of C1 to C10 which may be substituted or unsubstituted, alkyl, substituted alkyl groups, acyl groups, substituted acyl groups; where R1 and R3 may together represent a double bond and wherein in (CH2)n, n is 0 to 8.

    摘要翻译： 描述了通式（1）至（4）的茚满化合物及其药物用途，特别是实现肥大细胞稳定活性和/或抗炎活性。 在这些式中，R 1至R 7可以选自：H，卤素，羟基，烷氧基，芳氧基，乙酰氧基，羧基，环戊基，烷基羰基，氢羰基，氨基，酰氨基，烷基氨基，羟基氨基，氧化胺基，偶氮基，氰基， 肼基，酰肼基，腙基，茚满，茚，酰亚胺基，亚氨基醚基，脲基，肟，硝基，硝酸根，亚硝酸根，亚硝基，亚硝基，含有选自N，O中的一个或多个的杂原子的杂环基， S，芳烷基，芳基，单和多亚苄基芳基，取代的芳基，硫醇，硫脲基，苯硫醇基，磺酸基，亚砜基，砜基，可被取代或未取代的C1至C10的羧酸基，烷基 取代的烷基，酰基，取代的酰基; 其中R 1和R 3可以一起表示双键，并且其中在（CH 2）n中，n是0至8。