公开(公告)号：US20140231680A1

公开(公告)日：2014-08-21

申请号：US14174964

申请日：2014-02-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Darko Klinec

IPC: G01N33/49

CPC classification number: G01N33/491 ,  G01N15/06 ,  G01N21/13 ,  G01N21/253 ,  G01N21/3151 ,  G01N21/51 ,  G01N35/02 ,  G01N35/1016 ,  G01N2015/045 ,  G01N2015/0693 ,  G01N2035/0406 ,  G01N2035/1018 ,  G01N2201/066 ,  G01N2201/0662 ,  G01N2201/0668

Abstract: A method for detecting clots in a liquid is presented. The liquid is in a sample container. Light is irradiated having a first wavelength to the sample container by a first light source at a changeable vertical irradiating position (P—0 to P_n) such that the light irradiated by the first light source passes through the sample container along a first measurement path. An intensity of light having the first wavelength passing along the first measurement path and exiting the sample container is measured. Clots are detected in response to the measured intensity.

Abstract translation: 提出了一种用于检测液体中凝块的方法。 液体在样品容器中。 通过在可变的垂直照射位置（P-0至P_n）处的第一光源将具有第一波长的光照射到第一光源，使得由第一光源照射的光沿第一测量路径通过样品容器。 测量具有沿着第一测量路径通过并离开样品容器的第一波长的光的强度。 根据测量的强度检测到凝块。

公开(公告)号：US08213016B2

公开(公告)日：2012-07-03

申请号：US12805071

申请日：2010-07-12

Applicant: Andreas Muller ,  Rudiger Frank

Inventor： Andreas Muller ,  Rudiger Frank

IPC: G01N21/00

CPC classification number: G01N21/53 ,  G01N15/06 ,  G01N21/274 ,  G01N2015/0693 ,  G01N2201/061 ,  G01N2201/0662

Abstract: A turbidity measuring device having a four-beam, alternating light arrangement for registering turbidity of a measured medium includes first and second light sources L1, L2; and first and second receivers R1, R2. The direct measuring paths extend from light sources Li, through a measured medium, to receivers Ri, and indirect measuring paths extend from light sources Li, through the measured medium, to second receivers Rj; wherein i≠j; wherein turbidity can be ascertained as a function of a quotient A/B by means of an evaluating circuit; wherein A and B are functions at least of signals registered via the direct or indirect measuring paths; wherein at least a first monitor signal, which depends on the first light source, enters into one of the two terms A or B; wherein the light reaches the monitor from the first light source without interaction with the measured medium; and wherein the monitor signal is added to at least one of the signals registered via the measuring paths and entering into the term A or B.

Abstract translation: 具有用于记录测量介质的浊度的四光束交替光布置的浊度测量装置包括第一和第二光源L1，L2; 以及第一和第二接收器R1，R2。 直接测量路径从光源Li延伸通过测量介质到接收器Ri，并且间接测量路径从光源Li延伸通过测量的介质到第二接收器Rj; 其中i≠j; 其中可以通过评估电路将浊度确定为商A / B的函数; 其中A和B至少是经由直接或间接测量路径登记的信号的功能; 其中依赖于第一光源的至少第一监视信号进入两个项A或B中的一个; 其中所述光从所述第一光源到达所述监视器，而不与所述测量介质相互作用; 并且其中所述监视信号被添加到经由所述测量路径登记的信号中的至少一个并输入到所述术语A或B.

公开(公告)号：US20110172513A1

公开(公告)日：2011-07-14

申请号：US13063703

申请日：2009-11-09

Applicant: Takao Nakajima ,  Kazuhiko Fukutani

Inventor： Takao Nakajima ,  Kazuhiko Fukutani

IPC: A61B5/05

CPC classification number: G01N21/1702 ,  A61B5/0059 ,  A61B5/0095 ,  A61B5/02007 ,  G01N2201/0662

Abstract: The biological information imaging apparatus includes an acoustic wave detector 107 that detects an acoustic wave that is generated from a light absorber 105 and converts it to a first electrical signal; a photo-detector 110 that detects intensities of the light corresponding to a plurality of propagation distances of the light which propagates through the specimen 110 and converts it to a second electrical signal; a signal processing apparatus 111 that derives an average effective attenuation coefficient μeff of the specimen 110 based on the second electrical signal and derives an optical absorption coefficient μa of the specimen 110 based on the first electrical signal and the average effective attenuation coefficient μeff; and an image constructing apparatus 111 that constructs an image of the distribution of the optical absorption coefficient μa based on the distribution of the optical absorption coefficient μa.

Abstract translation: 生物信息成像装置包括声波检测器107，其检测从光吸收体105产生的声波并将其转换为第一电信号; 光检测器110，其检测与通过样本110传播的光的多个传播距离相对应的光的强度，并将其转换为第二电信号; 信号处理装置111，其基于第二电信号导出样本110的平均有效衰减系数μeff，并根据第一电信号和平均有效衰减系数μeff导出样本110的光吸收系数μa; 以及基于光吸收系数μa的分布构建光吸收系数μa的分布的图像的图像构造装置111。

公开(公告)号：US20110019194A1

公开(公告)日：2011-01-27

申请号：US12805071

申请日：2010-07-12

Applicant: Andreas Müller ,  Rüdiger Frank

Inventor： Andreas Müller ,  Rüdiger Frank

IPC: G01N21/00

CPC classification number: G01N21/53 ,  G01N15/06 ,  G01N21/274 ,  G01N2015/0693 ,  G01N2201/061 ,  G01N2201/0662

Abstract: A turbidity measuring device having a four-beam, alternating light arrangement for registering turbidity of a measured medium includes first and second light sources L1, L2; and first and second receivers R1, R2. The direct measuring paths extend from light sources Li, through a measured medium, to receivers Ri, and indirect measuring paths extend from light sources Li, through the measured medium, to second receivers Rj; wherein i≠j; wherein turbidity can be ascertained as a function of a quotient A/B by means of an evaluating circuit; wherein A and B are functions at least of signals registered via the direct or indirect measuring paths; wherein at least a first monitor signal, which depends on the first light source, enters into one of the two terms A or B; wherein the light reaches the monitor from the first light source without interaction with the measured medium; and wherein the monitor signal is added to at least one of the signals registered via the measuring paths and entering into the term A or B.

Abstract translation: 具有用于记录测量介质的浊度的四光束交替光布置的浊度测量装置包括第一和第二光源L1，L2; 以及第一和第二接收器R1，R2。 直接测量路径从光源Li延伸通过测量介质到接收器Ri，并且间接测量路径从光源Li延伸通过测量的介质到第二接收器Rj; 其中i≠j; 其中可以通过评估电路将浊度确定为商A / B的函数; 其中A和B至少是经由直接或间接测量路径登记的信号的功能; 其中依赖于第一光源的至少第一监视信号进入两个项A或B中的一个; 其中所述光从所述第一光源到达所述监视器，而不与所述测量介质相互作用; 并且其中所述监视信号被添加到经由所述测量路径登记的信号中的至少一个并输入到所述术语A或B.

公开(公告)号：US07796261B2

公开(公告)日：2010-09-14

申请号：US11792097

申请日：2005-12-01

Applicant: Henrik Vilstrup Juhl

Inventor： Henrik Vilstrup Juhl

IPC: G01N21/00

CPC classification number: G01N21/0303 ,  G01N21/31 ,  G01N2021/036 ,  G01N2201/066 ,  G01N2201/0662 ,  G01N2201/1293

Abstract: A spectrophotometer (2) comprising a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b) is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest withiA spectrophotometer (2) comprise a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b) is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest within the retained sample can be obtained.

Abstract translation: 一种分光光度计（2），包括辐射源（6），优选光辐射，被设置成朝向样品保持器（4）中的样品发射多个波长的辐射;以及检测装置8，用于在与 例子。 样品保持器（4）适于对通过样品的发射辐射呈现多个不同的路径长度。 算术单元（10; 10b）可操作地连接以接收来自检测装置（8）的与强度相关的输出，并且适于将检测到的发射的辐射的强度值存储在其波长的两个或更多个路径长度上 并且计算取决于两个路径长度中的每一个处的索引强度值的比率的值，通过该值，用分光光度计（2）存在感兴趣的物质的指示包括辐射源（6）， 优选地，光辐射被设置为以多个波长朝向样品保持器（4）中的样品发射辐射;以及检测装置8，用于在与样品相互作用之后检测辐射。 样品保持器（4）适于对通过样品的发射辐射呈现多个不同的路径长度。 算术单元（10; 10b）可操作地连接以接收来自检测装置（8）的与强度相关的输出，并且适于将检测到的发射的辐射的强度值存储在其波长的两个或更多个路径长度上 并且计算取决于两个路径长度中的每一个处的索引强度值的比率的值，通过该值，可以获得在保留的样品内存在感兴趣物质的指示。

公开(公告)号：US20100045989A1

公开(公告)日：2010-02-25

申请号：US12311037

申请日：2007-09-17

Applicant: Jarmo Vanhanen ,  Marcus Rinkiö ,  Paivi Törmä ,  Jouko Korppi-Tommola ,  Kari Loberg ,  Jukka Elfström

Inventor： Jarmo Vanhanen ,  Marcus Rinkiö ,  Paivi Törmä ,  Jouko Korppi-Tommola ,  Kari Loberg ,  Jukka Elfström

IPC: G01N21/00

CPC classification number: G01N21/8507 ,  G01N21/15 ,  G01N33/2888 ,  G01N2201/0662

Abstract: The invention relates to a method for monitoring the condition of a medium in a channel, based on the transmission/emission of light, in which a light at a set wavelength is conducted through a medium layer defined by a measuring gap in a measuring head pushed in from an opening in the wall of the channel the intensity of the light passed through medium layer, or a variable proportional to it is measured, and the condition of the medium is evaluated, using measuring electronics, from the change of the intensity, according to established criteria. In the method, the wavelength of light used is such that the resolution of the aging phenomenon of the medium being monitored is optimal and the relationship of the temperature dependence of the medium to the measuring variable is taken into account. In addition, the invention also relates to a corresponding device.

Abstract translation: 本发明涉及一种基于光的透射/发射来监视通道中的介质的状态的方法，其中设定波长的光通过由推动的测量头中的测量间隙限定的介质层传导 从通道壁的开口处，测量通过介质层的光的强度或与其成比例的变量，并且使用测量电子学根据强度的变化来评估介质的状态，根据 建立标准。 在该方法中，使用的光的波长使得被监测的介质的老化现象的分辨率是最佳的，并且考虑介质与测量变量的温度依赖性的关系。 此外，本发明还涉及相应的装置。

公开(公告)号：US20090268204A1

公开(公告)日：2009-10-29

申请号：US12109254

申请日：2008-04-24

Applicant: Michael Tkachuk

Inventor： Michael Tkachuk

IPC: G01N21/00

CPC classification number: G01N21/3504 ,  G01N2201/0662 ,  G01N2201/0668

Abstract: An optical absorption gas analyser for determining the concentration of a target gas in a sample is disclosed. The analyser comprises a chamber for containing the sample in use; a radiation source assembly arranged to emit radiation into the chamber; a first radiation detector assembly arranged to detect radiation transmitted along a first optical path through the chamber and a second radiation detector assembly arranged to detect radiation transmitted along a second optical path through the chamber, wherein the length of the second optical path which the sample can intercept is shorter than that of the first optical path. The analyser further comprises a processor adapted to generate a sensing signal SS based on the detected radiation transmitted along the first optical path and a reference signal SR based on the detected radiation transmitted along the second optical path. The processor determines the concentration of the target gas in the sample based on a comparison of the sensing signal with the reference signal.

Abstract translation: 公开了一种用于测定样品中目标气体浓度的光吸收气体分析仪。 分析仪包括用于容纳使用中的样品的室; 辐射源组件，被布置成将辐射发射到所述腔室中; 第一辐射检测器组件，被布置成检测沿着通过所述室的第一光路传输的辐射;以及第二辐射检测器组件，其布置成检测沿着通过所述室的第二光路传输的辐射，其中所述样品可以 截距比第一光路的截距短。 分析器还包括处理器，其适于基于沿着第一光路传输的检测到的辐射和基于沿着第二光路传输的检测到的辐射的参考信号SR生成感测信号SS。 处理器基于感测信号与参考信号的比较来确定样品中目标气体的浓度。

公开(公告)号：US4883953A

公开(公告)日：1989-11-28

申请号：US267109

申请日：1988-11-01

Applicant: Katsue Koashi ,  Hiroshi Yokota

Inventor： Katsue Koashi ,  Hiroshi Yokota

IPC: G01N21/35 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/359 ,  G01N21/49

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  G01N21/49 ,  G01N2021/1782 ,  G01N2021/3144 ,  G01N2021/3148 ,  G01N2021/4709 ,  G01N21/359 ,  G01N2201/065 ,  G01N2201/0662 ,  G01N2201/069 ,  Y10S250/91

Abstract: This disclosure relates to a method for measuring the concentrations of sugars in liquids by the use of near infrared as well as an apparatus for practicing said method.The method comprises a step wherein the absorption spectrum of the sugar under investigation existing at a first depth relatively close to the surface in a sample is computed by using relatively weak power of near infrared, a step wherein the absorption spectrum of the sugar under investigation existing at a relatively deep second depth in the sample is computed by using relatively strong power of infrared, and a step wherein the concentration of the sugar under investigation in the sample is determined by computing the absorption spectrum of the sugar at a different depth between said first and second depths on the basis of the results of measurement in said first and second steps. The wavelengths for the use for said absorption spectrum are selected from anyone of wavelength bands of 950-1,150 nm, 1,150-1,300 nm, and 1,300-1,450 nm.Since, according to this method, wavelengths which are shorter and closer to the visible region than in the prior art are used, the method enables the measuring light beams to penetrate deeper in a living tissue and makes it possible to measure the concentrations of sugars existing in a deeper region non-invasively.

公开(公告)号：US20230375461A1

公开(公告)日：2023-11-23

申请号：US18230670

申请日：2023-08-07

Applicant: Beihang University

Inventor： Yanyu ZHAO ,  Yubo FAN

IPC: G01N21/17 ,  G01N21/31 ,  G01N33/49

CPC classification number: G01N21/1702 ,  G01N21/3151 ,  G01N33/492 ,  G01N2201/0662 ,  G01N2201/06146

Abstract: The embodiments of the present invention disclose a method, system, device and electronic apparatus for measuring concentration of water and lipids components. The method includes acquiring an optical absorption coefficient of a sample to be measured irradiated by a light source of at least two wavelengths, wherein a wavelength of the light source of at least two wavelengths is not greater than 1000 nm; and acquiring an extinction coefficient of water irradiated by the light source of at least two wavelengths and an extinction coefficient of lipids irradiated by the light source of at least two wavelengths; determining a concentration of water in the sample to be measured and a concentration of lipids in the sample to be measured, respectively, based on the optical absorption coefficient of the sample to be measured irradiated by the light source of at least two wavelengths, the extinction coefficient of water irradiated by the light source of at least two wavelengths, and the extinction coefficient of lipids irradiated by the light source of at least two wavelengths.

公开(公告)号：US20180120224A1

公开(公告)日：2018-05-03

申请号：US15795954

申请日：2017-10-27

Applicant: Drägerwerk AG & Co. KGaA

Inventor： Peter DREYER ,  Günter STEINERT ,  Bernd-Michael DICKS ,  Ralph-Peter JACOBI

IPC: G01N21/3504 ,  G01J5/00 ,  G01N33/497

CPC classification number: G01N21/3504 ,  A61B5/08 ,  G01J5/0014 ,  G01N33/497 ,  G01N2021/3166 ,  G01N2021/3177 ,  G01N2201/0662 ,  G01N2201/0686

Abstract: A device (1) for determining the concentration of a gas component is configured with a radiation source (30) for emitting (31) a light radiation or heat radiation in an infrared wavelength range. A detector array (40) has at least two detector elements (50, 60), configured to detect the radiation generated by the radiation source (30), in an angular arrangement (52, 62) and with filter elements (51, 61). At least one of the two detector elements (50, 60) is oriented in an angular arrangement (52, 62) in relation to a vertical axis (32), so that a range of overlap (65) is obtained due to the angular arrangements (52, 62). The range of overlap (65) causes attenuations in the propagation of light, which attenuations may be due, for example, to gas molecules or moisture (400), affect both detector elements (50, 60) and are thus compensated concerning the concentration determination.