公开(公告)号：US20100005855A1

公开(公告)日：2010-01-14

申请号：US12170145

申请日：2008-07-09

申请人： Doug Silva ,  Jim Archer ,  Sky Countryman ,  Kory Kelly

发明人： Doug Silva ,  Jim Archer ,  Sky Countryman ,  Kory Kelly

IPC分类号： G01N30/02

CPC分类号： G01N30/6004 ,  G01N30/6047 ,  G01N30/6078 ,  G01N2030/0015

摘要： A connector for fastening a gas chromatography capillary column to chromatography equipment includes a securing nut and ferrule on a first portion of the connector for releasably holding the capillary column in a position relative to a second portion of the connector. The first portion rotates relative to the first portion and translates a limited amount relative to the first portion. A pin on the first portion extending into an annular groove around a circumference of the first portion may allow this rotation and limited translation. The second portion has a threaded end adapted to screw into the chromatography equipment with the first portion remaining relatively rotation free as the second portion is screwed into place.

摘要翻译： 用于将气相色谱毛细管柱紧固到色谱设备的连接器包括在连接器的第一部分上的固定螺母和套圈，用于将毛细管柱可释放地保持在相对于连接器的第二部分的位置。 第一部分相对于第一部分旋转并且相对于第一部分平移有限的量。 在第一部分上延伸到围绕第一部分的圆周的环形槽中的销可以允许这种旋转和有限的平移。 第二部分具有适于螺旋进入色谱设备的螺纹端，当第二部分拧入就位时，第一部分保持相对旋转自由。

公开(公告)号：US20090266143A1

公开(公告)日：2009-10-29

申请号：US11988997

申请日：2006-07-05

申请人： Matthias Rebhan ,  Daniel Sickert

发明人： Matthias Rebhan ,  Daniel Sickert

IPC分类号： G01N30/16

CPC分类号： B01J20/282 ,  B01J20/205 ,  B01J20/28007 ,  B01J2220/54 ,  B01J2220/84 ,  B82Y30/00 ,  G01N30/6043 ,  G01N30/6078 ,  G01N30/64 ,  G01N2030/525

摘要： In a chromatograph, a separation column is disposed between an injection system and a detector. The separation column includes a bundle of capillaries which are formed of carbon nanotubes with a typical diameter of 0.5 nm to 5 nm and may number in the several hundreds.

摘要翻译： 在色谱仪中，分离柱设置在注射系统和检测器之间。 分离柱包括一束毛细管，其由典型直径为0.5nm至5nm的碳纳米管形成，并且数量可以为几百个。

公开(公告)号：US07261813B2

公开(公告)日：2007-08-28

申请号：US10915735

申请日：2004-08-10

申请人： Richard Kenneth Marcus ,  Rayman Dupre Stanelle

发明人： Richard Kenneth Marcus ,  Rayman Dupre Stanelle

IPC分类号： B01D15/08

CPC分类号： B01D15/08 ,  B01D15/22 ,  B01J20/261 ,  B01J20/262 ,  B01J20/28014 ,  B01J20/28023 ,  B01J20/28042 ,  B01J20/28095 ,  B01J20/285 ,  B01J2220/54 ,  B01J2220/62 ,  B01J2220/82 ,  G01N30/6043 ,  G01N30/6078 ,  G01N30/6091 ,  G01N2030/528

摘要： Monolithic cartridges including a plurality of nominally aligned polymer fibers can be used as stationary phase materials for liquid chromatography separations. Bundles of fibers are packed together so as to form capillary channels between the fibers. Different polymer compositions permit the “chemical tuning” of the separation process. The fibers can be physically or chemically bonded at spaced locations throughout the cartridge or can be packed together under pressure by use of an encasing wrap to form the capillary channels. Use of fibers allows a wide range of liquid flow rates with very low backpressures. Applications in HPLC, cap-LC, prep-scale separations, analytical separations, waste remediation/immobilization, extraction of selected organic molecules/ions from solution, purification of liquid streams (process waste, drinking water, pure solvents), selective extraction of cell matter and bacteria from growth media, and immobilization of cell matter and bacteria are envisioned.

摘要翻译： 包括多个名义上排列的聚合物纤维的单片墨盒可用作液相色谱分离的固定相材料。 纤维束被包装在一起，以在纤维之间形成毛细通道。 不同的聚合物组合物允许分离过程的“化学调节”。 纤维可以在整个药筒的间隔位置物理地或化学地结合，或者可以通过使用包装包装在压力下包装在一起以形成毛细通道。 纤维的使用允许具有非常低的背压的宽范围的液体流速。 应用于HPLC，cap-LC，预分离分离，分析分离，废物修复/固定，从溶液中萃取选定的有机分子/离子，液体流净化（工艺废物，饮用水，纯溶剂），细胞的选择性提取 生长介质中的物质和细菌，以及细胞和细菌的固定化。

公开(公告)号：US20070062874A1

公开(公告)日：2007-03-22

申请号：US11599497

申请日：2006-11-13

申请人： Abdul Malik ,  Abuzar Kabir ,  Chetan Shende

发明人： Abdul Malik ,  Abuzar Kabir ,  Chetan Shende

IPC分类号： B01D15/08

CPC分类号： B01J20/285 ,  B01D15/206 ,  B01D15/265 ,  B01J20/28047 ,  B01J20/286 ,  B01J2220/54 ,  B01J2220/86 ,  G01N30/56 ,  G01N30/6078 ,  G01N2030/567

摘要： A capillary column (10) includes a tube structure having inner walls (14) and a sol-gel substrate (16) coated on a portion of inner walls (14) to form a stationary phase coating (18) on inner walls (14). The sol solution used to prepare the sol-gel substrate (16) has at least one baseline stabilizing reagent and at least one surface deactivation reagent resulting in the sol-gel substrate (16) having at least one baseling stabilizing reagent residual and at least one surface deactivating reagent residual. A method of making the sol-gel solution is by mixing suitable sol-gel prescursors to form the solution, stabilizing the solution by adding at least one baseline stabilization reagent, deactivating the solution by adding at least one surface deactivation reagent to the solution, and reacting the solution in the presence of at least one catalyst.

摘要翻译： 毛细管柱（10）包括具有内壁（14）的管结构和涂覆在内壁（14）的一部分上以在内壁（14）上形成固定相涂层（18）的溶胶 - 凝胶基质（16） 。 用于制备溶胶 - 凝胶基质（16）的溶胶溶液具有至少一种基线稳定剂和至少一种表面失活试剂，导致溶胶 - 凝胶基质（16）具有至少一种碱化稳定剂残留物和至少一种 表面钝化试剂残留。 制备溶胶 - 凝胶溶液的方法是通过混合合适的溶胶 - 凝胶前体形成溶液，通过加入至少一种基线稳定剂来稳定溶液，通过向溶液中加入至少一种表面失活试剂来使溶液失活，以及 在至少一种催化剂存在下使溶液反应。

公开(公告)号：US20060175238A1

公开(公告)日：2006-08-10

申请号：US11054901

申请日：2005-02-10

申请人： Roy Lautamo

发明人： Roy Lautamo

IPC分类号： B01D15/08

CPC分类号： B01D15/206 ,  B01D15/22 ,  B01J20/286 ,  B01J20/3272 ,  B01J2220/54 ,  B01J2220/86 ,  C08G77/12 ,  G01N30/6073 ,  G01N30/6078 ,  G01N2030/567

摘要： Disclosed are deactivated surfaces for use in chromatographic separations, such as capillary gas chromatography, comprising a surface material coated with a deactivating polymer comprising high surface energy-generating groups and groups for end-capping reactive silanols. Also disclosed are columns comprising such surfaces, methods of making and using the surfaces, and kits for facilitating the same.

摘要翻译： 公开了用于色谱分离的失活表面，例如毛细管气相色谱法，其包括涂覆有包含高表面能产生基团的失活聚合物的表面材料和用于封端反应性硅烷醇的基团。 还公开了包括这种表面的柱，制造和使用表面的方法以及用于促进其的试剂盒。

公开(公告)号：US06730216B2

公开(公告)日：2004-05-04

申请号：US09978110

申请日：2001-10-15

申请人： Menno Heringa ,  Jacobus Duvekot

发明人： Menno Heringa ,  Jacobus Duvekot

IPC分类号： B01D1508

CPC分类号： G01N30/6047 ,  G01N30/6078

摘要： An assembly consisting of a winding structure 1 around which a chromatographic column 6 can be wound, and an information carrier 7 which can be connected to said winding structure 1. This assembly offers a rigid and convenient means to handle one or two chromatographic columns of longer lengths. The information carrier 7 contains the chromatographic column identification information as well as several tools, such as a tool 13 to hold one or two chromatographic column connectors 11, a ruler to measure column insertion lengths and clips 12 to hold column ends, and clips to hold column extensions.

摘要翻译： 由绕组结构1组成的组件可以卷绕色谱柱6，以及可连接到所述卷绕结构1的信息载体7.该组件提供了一个刚性和方便的手段来处理一个或两个更长的色谱柱 长度 信息载体7包含色谱柱识别信息以及若干工具，例如用于保持一个或两个色谱柱连接器11的工具13，测量柱插入长度的标尺和用于保持柱端的夹子12和夹持件 列扩展。

公开(公告)号：US20030189001A1

公开(公告)日：2003-10-09

申请号：US10119132

申请日：2002-04-08

申请人： Takao Tsuda; Chemco Scientific Co., Ltd. ,  Motonori Munesue

发明人： Takao Tsuda ,  Shinya Kitagawa ,  Motonori Munesue

IPC分类号： B01D015/08

CPC分类号： B01J20/286 ,  B01J20/28054 ,  B01J20/28097 ,  B01J20/282 ,  B01J2220/54 ,  B01J2220/84 ,  G01N30/52 ,  G01N30/6078 ,  G01N2030/525 ,  G01N2030/567

摘要： In an open capillary column, a stationary phase is formed on the inner wall of a capillary tube. This stationary phase comprises a number of pores on the surface of the capillary tube, and each of pore has an expanded hollow in the stationary phase. A manufacturing method of an open capillary column comprises the steps of giving alkaline treatment to an inner wall of an open capillary tube, applying one of oligo silica, oligo zirconia and oligo titania on the inner wall, filling the open capillary tube with alkaline solution to form one of a silica layer, a zirconia layer and titania layer, discharging the alkaline solution and heat-treating the capillary tube to form a base of a stationary phase. The open capillary column of the present invention comprises a stationary phase having a very large surface area. It is useful for a separation analysis field such as liquid chromatography and electrochromatography.

摘要翻译： 在开放的毛细管柱中，在毛细管的内壁上形成固定相。 该固定相包括毛细管表面上的多个孔，并且每个孔在固定相中具有膨胀的中空。 开放毛细管柱的制造方法包括以下步骤：对开放毛细管的内壁进行碱处理，在内壁上施加低氧二氧化硅，低氧二氧化锆和低氧二氧化钛之一，用碱性溶液填充开放的毛细管， 形成二氧化硅层，氧化锆层和二氧化钛层之一，排出碱溶液并热处理毛细管以形成固定相的碱。 本发明的开放毛细管柱包括具有非常大的表面积的固定相。 它对于分离分析领域如液相色谱和电色谱是有用的。

公开(公告)号：US06190616B1

公开(公告)日：2001-02-20

申请号：US08927645

申请日：1997-09-11

申请人： Stevan B. Jovanovich ,  Gregory J. Ronan ,  David J. Roach ,  Richard F. Johnston

发明人： Stevan B. Jovanovich ,  Gregory J. Ronan ,  David J. Roach ,  Richard F. Johnston

IPC分类号： G01N120

CPC分类号： G01N35/1097 ,  B01L3/5025 ,  B01L3/561 ,  B01L3/565 ,  B01L2200/026 ,  B01L2300/0838 ,  B01L2400/0406 ,  B01L2400/0622 ,  B01L2400/0644 ,  G01N30/20 ,  G01N30/24 ,  G01N30/6039 ,  G01N30/6078 ,  G01N2030/8827 ,  G02B6/3504 ,  G02B6/3558 ,  G02B6/381 ,  G02B6/3818 ,  G02B6/3825 ,  G02B6/3851 ,  G02B6/3854 ,  G02B6/3869 ,  G02B6/3877 ,  G02B6/3878 ,  G02B6/3887 ,  G02B6/3894 ,  G02B6/403 ,  Y10T137/86549 ,  Y10T436/143333 ,  Y10T436/2575

摘要： A capillary valve, connector and router where one or more cylindrical fibers, which may be capillaries, plugged capillaries, optical fibers, or the like, including at least one capillary tube are contained in a first cylindrical bundle of fibers that terminates at a first face. A second cylindrical bundle of fibers also containing one or more fibers including at least one capillary tube terminates in a second face abutting the first face. A fastener or adapter holds the members together with faces in mutually biased alignment, allowing relative rotation of the two cylindrical bundles which terminate in rotatable ferrules. Various functions achieved by rotation include a zero dead volume slide valve, a fluid router and a manifold. The fibers in each sleeve are preferably of uniform size for close symmetrical packing, but could be of disparate sizes, allowing connection of macroscale tubes to capillary tubes. A single connector member may be attached by a fastener to a reservoir or other macroscale device to bring one or more capillary tubes into fluid communication with a macroscale device. A plurality of fibers in one ferrule could allow dispensing of fluid from a single fiber in the other ferrule so that a single fiber could feed a plurality of wells through the plurality of fibers. Connection of a plurality of macroscale pumps enables push-pull fluid motion, with routing, in a capillary system formed by a plurality of fibers coupled by switches, connectors and routers. Chemical reactions, separations and analysis may be carried out with microliter volumes and smaller.

摘要翻译： 一种毛细阀，连接器和路由器，其中一个或多个圆柱形纤维（其可以是毛细管，堵塞的毛细管，光纤等）包括至少一个毛细管，其包含在第一圆柱形纤维束中，其终止于第一面 。 还包含一个或多个包括至少一个毛细管的纤维的第二圆柱形纤维束终止于邻接第一面的第二面。 紧固件或适配器将构件以与相对偏压对准的面保持在一起，允许两个圆柱形束的相对旋转，其终止于可旋转的套圈中。 通过旋转实现的各种功能包括零死体积滑阀，流体路由器和歧管。 每个套管中的纤维优选地具有均匀的尺寸以用于紧密对称的包装，但是可以具有不同的尺寸，允许宏观尺管连接到毛细管。 单个连接器构件可以通过紧固件附接到储存器或其他宏观尺寸装置以使一个或多个毛细管与宏观尺寸装置流体连通。 一个套圈中的多个纤维可以允许从另一个套圈中的单个纤维分配流体，使得单个纤维可以通过多个纤维供给多个孔。 多个宏观泵的连接使得能够通过布线在由被开关，连接器和路由器耦合的多个光纤形成的毛细管系统中的推挽流体运动。 化学反应，分离和分析可以用微升体积和更小的方式进行。

公开(公告)号：US06190559B1

公开(公告)日：2001-02-20

申请号：US09365610

申请日：1999-08-02

申请人： Gary A. Valaskovic

发明人： Gary A. Valaskovic

IPC分类号： B01D1508

CPC分类号： B01D15/206 ,  G01N30/56 ,  G01N30/6078 ,  G01N2030/565

摘要： Method for loading a column with a packing material by inserting one end of a column to be packed into a slurry of a packing material in a volatile solvent, allowing said slurry to be drawn into said end of said column by capillary action, withdrawing said end from said slurry, and removing said volatile solvent from the slurry that has been drawn into said end of said column, through the same end of the column at which the slurry entered, and sinteriing.

摘要翻译： 通过将待包装的柱的一端插入到挥发性溶剂中的包装材料的浆料中来填充柱的方法，允许所述浆料通过毛细管作用被吸入所述塔的末端，将所述末端 从所述浆料中除去所述挥发性溶剂从已经被吸入所述塔末端的浆料中，通过浆料进入的塔的相同端部进行烧结。

公开(公告)号：US5494641A

公开(公告)日：1996-02-27

申请号：US346341

申请日：1994-11-29

申请人： Srdjan Krstanovic

发明人： Srdjan Krstanovic

IPC分类号： G01N27/447 ,  G01N30/28 ,  G01N30/60 ,  B01L11/00

CPC分类号： G01N30/6039 ,  G01N27/44704 ,  G01N2030/285 ,  G01N2030/6013 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/6078 ,  Y10S285/911

摘要： A connectorized capillary and in-line flow cell system which greatly expedites the construction of capillary zone electrophoresis (CZE) and other separation instrumentation. A capillary is mounted within a cavity formed in a body, and a mechanical fastener is positioned about the body. The inner diameter of the fastener is less than the outer diameter of the body, so that the connector may be firmly coupled to any system component having a corresponding portion adapted to accept the fastener. The connectorized capillaries thus permit permanent or semi-permanent attachment to various in-line flow cell devices such as detectors, valves, buffer reservoirs and the like. For example, an in-line conductivity detector is assembled by connecting a conductivity meter to the opposing ends of the flow cell body. Annular sensing surfaces can also be provided within the cell. The same basic flow cell structure can also be used as a discrete separation valve by forming two transverse openings in the flow cell body and by using a ferrule having a slotted or castleated end. The valve can be electrically operated by switching a ground reference electrode between two or more buffer reservoirs. The same connectorized capillaries may also be used with fused plate-type systems containing etched channels.

摘要翻译： 连接毛细管和在线流通池系统，大大加快了毛细管电泳（CZE）和其他分离仪器的建设。 毛细管安装在形成在体内的空腔内，并且机械紧固件围绕身体定位。 紧固件的内径小于主体的外径，使得连接器可以牢固地联接到具有适于接纳紧固件的相应部分的任何系统部件。 连接的毛细管因此允许永久或半永久性地连接到诸如检测器，阀，缓冲储存器等的各种在线流通池装置。 例如，通过将电导率仪连接到流动池主体的相对端而组装在线电导率检测器。 环形感应表面也可以在电池内提供。 相同的基本流动池结构也可以通过在流动池主体中形成两个横向开口并且通过使用具有开槽或拱形端部的套圈来用作离散分离阀。 通过在两个或更多个缓冲容器之间切换接地参考电极，可以对该阀进行电动操作。 同样的连接器毛细管也可用于含有蚀刻通道的熔融板式系统。