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公开(公告)号：US08926491B2
公开(公告)日：2015-01-06
申请号：US14020173
申请日：2013-09-06
发明人： Francis M. Creighton
CPC分类号： A61K41/00 , A61B17/22 , A61B17/22012 , A61B34/73 , A61B2017/00876 , A61B2017/22084 , A61B2017/22094 , A61B2034/733 , A61K9/0019 , A61K38/482 , A61K38/484 , A61K47/6941 , A61N2/004 , A61N2/02 , A61N2/06 , B82Y5/00 , C12Y304/21007 , C12Y304/21068 , H01F7/0273 , Y10S977/811 , Y10S977/905 , Y10S977/909
摘要： Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.
摘要翻译： 一些实施例提供了一种用于使用远程放置的产生磁场的定子在脉管系统中外部操纵磁性纳米颗粒的系统。 在一个方面，系统和方法涉及使用基于永磁体或电磁场产生定子源的流体介质中的磁性纳米颗粒的控制。 这种系统可用于增加治疗剂在诸如人类循环系统的流体培养基中的扩散，其可导致循环系统中的流体障碍（例如血管闭塞）的实质性清除，导致血流量增加。
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12.发明授权公开(公告)号：US08715150B2
公开(公告)日：2014-05-06
申请号：US13505447
申请日：2010-11-02
申请人： Francis M. Creighton
发明人： Francis M. Creighton
CPC分类号： A61K41/00 , A61B17/22 , A61B17/22012 , A61B34/73 , A61B2017/00876 , A61B2017/22084 , A61B2017/22094 , A61B2034/733 , A61K9/0019 , A61K38/482 , A61K38/484 , A61K47/6941 , A61N2/004 , A61N2/02 , A61N2/06 , B82Y5/00 , C12Y304/21007 , C12Y304/21068 , H01F7/0273 , Y10S977/811 , Y10S977/905 , Y10S977/909
摘要： The present invention relates to a system for the physical manipulation of free magnetic rotors in a circulatory system using a remotely placed magnetic field-generating stator. In one aspect, the invention relates to the control of magnetic particles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Examples of vascular occlusions targeted by the system include, but are not limited to, atherosclerotic plaques, including fibrous caps, fatty buildup, coronary occlusions, arterial stenosis, restenosis, vein thrombi, arterial thrombi, cerebral thrombi, embolisms, hemorrhages, other blood clots, and very small vessels.
摘要翻译： 本发明涉及一种用于使用远程放置的产生磁场的定子在循环系统中物理地操纵自由磁转子的系统。 一方面，本发明涉及使用基于永磁体或电磁场产生定子源的流体介质中的磁性颗粒的控制。 这种系统可用于增加治疗剂在诸如人类循环系统的流体培养基中的扩散，其可导致循环系统中的流体障碍（例如血管闭塞）的实质性清除，导致血流量增加。 系统靶向的血管闭塞的实例包括但不限于动脉粥样硬化斑块，包括纤维帽，脂肪积聚，冠状动脉闭塞，动脉狭窄，再狭窄，静脉血栓，动脉血栓，脑血栓，栓塞，出血，其他血块 ，和非常小的船只。
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公开(公告)号：US20180221041A1
公开(公告)日：2018-08-09
申请号：US15886130
申请日：2018-02-01
发明人： Francis M. Creighton , Michael E. Sabo , Gerard Epplin , Christopher Null , James Christopher Wachtman
CPC分类号： A61B17/22012 , A61B17/22 , A61B17/22004 , A61B17/32002 , A61B17/3207 , A61B2017/00345 , A61B2017/00876 , A61B2017/22084 , A61B2017/320004 , A61K41/0028 , A61M37/00 , A61M2037/0007 , B82Y5/00 , H01F7/0226 , H01F7/0273 , Y10S977/811 , Y10S977/905 , Y10S977/909
摘要： Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one embodiment, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Magnetic nanoparticles are provided having a non-specialized chemical coating facilitating association with a chemical composition by a user before infusion. Systems are provided for delivering a consistent infusion mass of magnetic nanoparticles to a patient.
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公开(公告)号：US09883878B2
公开(公告)日：2018-02-06
申请号：US14400999
申请日：2013-05-13
发明人： Francis M. Creighton , Michael Sabo , Christopher Null , Gerard Epplin , James Christopher Wachtman
CPC分类号： A61B17/22 , A61B17/22004 , A61B17/22012 , A61B17/32002 , A61B17/3207 , A61B2017/00345 , A61B2017/00876 , A61B2017/22084 , A61B2017/320004 , A61K41/0028 , A61M37/00 , A61M2037/0007 , B82Y5/00 , H01F7/0226 , H01F7/0273 , Y10S977/811 , Y10S977/905 , Y10S977/909
摘要： Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one embodiment, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Magnetic nanoparticles are provided having a non-specialized chemical coating facilitating association with a chemical composition by a user before infusion. Systems are provided for delivering a consistent infusion mass of magnetic nanoparticles to a patient.
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公开(公告)号：US09345498B2
公开(公告)日：2016-05-24
申请号：US14581775
申请日：2014-12-23
发明人： Francis M. Creighton
CPC分类号： A61K41/00 , A61B17/22 , A61B17/22012 , A61B34/73 , A61B2017/00876 , A61B2017/22084 , A61B2017/22094 , A61B2034/733 , A61K9/0019 , A61K38/482 , A61K38/484 , A61K47/6941 , A61N2/004 , A61N2/02 , A61N2/06 , B82Y5/00 , C12Y304/21007 , C12Y304/21068 , H01F7/0273 , Y10S977/811 , Y10S977/905 , Y10S977/909
摘要： Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.
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公开(公告)号：US09339664B2
公开(公告)日：2016-05-17
申请号：US14268244
申请日：2014-05-02
发明人： Francis M. Creighton
CPC分类号： A61K41/00 , A61B17/22 , A61B17/22012 , A61B34/73 , A61B2017/00876 , A61B2017/22084 , A61B2017/22094 , A61B2034/733 , A61K9/0019 , A61K38/482 , A61K38/484 , A61K47/6941 , A61N2/004 , A61N2/02 , A61N2/06 , B82Y5/00 , C12Y304/21007 , C12Y304/21068 , H01F7/0273 , Y10S977/811 , Y10S977/905 , Y10S977/909
摘要： A system for the physical manipulation of free magnetic rotors in a circulatory system using a remotely placed magnetic field-generating stator is provided. In one embodiment, the invention relates to the control of magnetic particles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Examples of vascular occlusions targeted by the system include, but are not limited to, atherosclerotic plaques, including fibrous caps, fatty buildup, coronary occlusions, arterial stenosis, restenosis, vein thrombi, arterial thrombi, cerebral thrombi, embolisms, hemorrhages, other blood clots, and very small vessels.
摘要翻译： 提供了一种用于使用远程放置的磁场产生定子在循环系统中物理地操纵自由磁转子的系统。 在一个实施例中，本发明涉及使用基于永磁体或电磁场产生定子源的流体介质中的磁性颗粒的控制。 这种系统可用于增加治疗剂在诸如人类循环系统的流体培养基中的扩散，其可导致循环系统中的流体障碍（例如血管闭塞）的实质性清除，导致血流量增加。 系统靶向的血管闭塞的实例包括但不限于动脉粥样硬化斑块，包括纤维帽，脂肪积聚，冠状动脉闭塞，动脉狭窄，再狭窄，静脉血栓，动脉血栓，脑血栓，栓塞，出血，其他血块 ，和非常小的船只。
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公开(公告)号：US08313422B2
公开(公告)日：2012-11-20
申请号：US13471908
申请日：2012-05-15
申请人： Francis M. Creighton
发明人： Francis M. Creighton
CPC分类号： A61K41/00 , A61B17/22 , A61B17/22012 , A61B34/73 , A61B2017/00876 , A61B2017/22084 , A61B2017/22094 , A61B2034/733 , A61K9/0019 , A61K38/482 , A61K38/484 , A61K47/6941 , A61N2/004 , A61N2/02 , A61N2/06 , B82Y5/00 , C12Y304/21007 , C12Y304/21068 , H01F7/0273 , Y10S977/811 , Y10S977/905 , Y10S977/909
摘要： Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.
摘要翻译： 一些实施例提供了一种用于使用远程放置的产生磁场的定子在脉管系统中外部操纵磁性纳米颗粒的系统。 在一个方面，系统和方法涉及使用基于永磁体或电磁场产生定子源的流体介质中的磁性纳米颗粒的控制。 这种系统可用于增加治疗剂在诸如人类循环系统的流体培养基中的扩散，其可导致循环系统中的流体障碍（例如血管闭塞）的实质性清除，导致血流量增加。
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公开(公告)号：US08308628B2
公开(公告)日：2012-11-13
申请号：US13471871
申请日：2012-05-15
申请人： Francis M. Creighton
发明人： Francis M. Creighton
CPC分类号： A61K41/00 , A61B17/22 , A61B17/22012 , A61B34/73 , A61B2017/00876 , A61B2017/22084 , A61B2017/22094 , A61B2034/733 , A61K9/0019 , A61K38/482 , A61K38/484 , A61K47/6941 , A61N2/004 , A61N2/02 , A61N2/06 , B82Y5/00 , C12Y304/21007 , C12Y304/21068 , H01F7/0273 , Y10S977/811 , Y10S977/905 , Y10S977/909
摘要： Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.
摘要翻译： 一些实施例提供了一种用于使用远程放置的产生磁场的定子在脉管系统中外部操纵磁性纳米颗粒的系统。 在一个方面，系统和方法涉及使用基于永磁体或电磁场产生定子源的流体介质中的磁性纳米颗粒的控制。 这种系统可用于增加治疗剂在诸如人类循环系统的流体培养基中的扩散，其可导致循环系统中的流体障碍（例如血管闭塞）的实质性清除，导致血流量增加。
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公开(公告)号：US20120232329A1
公开(公告)日：2012-09-13
申请号：US13471908
申请日：2012-05-15
申请人： Francis M. Creighton
发明人： Francis M. Creighton
IPC分类号： A61N2/10
CPC分类号： A61K41/00 , A61B17/22 , A61B17/22012 , A61B34/73 , A61B2017/00876 , A61B2017/22084 , A61B2017/22094 , A61B2034/733 , A61K9/0019 , A61K38/482 , A61K38/484 , A61K47/6941 , A61N2/004 , A61N2/02 , A61N2/06 , B82Y5/00 , C12Y304/21007 , C12Y304/21068 , H01F7/0273 , Y10S977/811 , Y10S977/905 , Y10S977/909
摘要： Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.
摘要翻译： 一些实施例提供了一种用于使用远程放置的产生磁场的定子在脉管系统中外部操纵磁性纳米颗粒的系统。 在一个方面，系统和方法涉及使用基于永磁体或电磁场产生定子源的流体介质中的磁性纳米颗粒的控制。 这种系统可用于增加治疗剂在诸如人类循环系统的流体培养基中的扩散，其可导致循环系统中的流体障碍（例如血管闭塞）的实质性清除，导致血流量增加。
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公开(公告)号：US20120226093A1
公开(公告)日：2012-09-06
申请号：US13471871
申请日：2012-05-15
申请人： Francis M. Creighton
发明人： Francis M. Creighton
CPC分类号： A61K41/00 , A61B17/22 , A61B17/22012 , A61B34/73 , A61B2017/00876 , A61B2017/22084 , A61B2017/22094 , A61B2034/733 , A61K9/0019 , A61K38/482 , A61K38/484 , A61K47/6941 , A61N2/004 , A61N2/02 , A61N2/06 , B82Y5/00 , C12Y304/21007 , C12Y304/21068 , H01F7/0273 , Y10S977/811 , Y10S977/905 , Y10S977/909
摘要： Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.
摘要翻译： 一些实施例提供了一种用于使用远程放置的产生磁场的定子在脉管系统中外部操纵磁性纳米颗粒的系统。 在一个方面，系统和方法涉及使用基于永磁体或电磁场产生定子源的流体介质中的磁性纳米颗粒的控制。 这种系统可用于增加治疗剂在诸如人类循环系统的流体培养基中的扩散，其可导致循环系统中的流体障碍（例如血管闭塞）的实质性清除，导致血流量增加。
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