公开(公告)号：US20110251392A1

公开(公告)日：2011-10-13

申请号：US13168029

申请日：2011-06-24

申请人： George Wu ,  Anantha R. Sudhakar ,  Mingsheng Huang ,  Tao Wang ,  Vijay Sabesan ,  Ji Xie ,  Frank Xing Chen ,  Marc Poirier ,  Daw-long Kwok ,  Jian Cui ,  Xiaojing Yang ,  Tiruvettipuram K. Thiruvengadam ,  Jing Liao ,  Ilia A. Zavialov ,  Hoa N. Nguyen ,  Ngiap Kie. Lim

发明人： George Wu ,  Anantha R. Sudhakar ,  Mingsheng Huang ,  Tao Wang ,  Vijay Sabesan ,  Ji Xie ,  Frank Xing Chen ,  Marc Poirier ,  Daw-long Kwok ,  Jian Cui ,  Xiaojing Yang ,  Tiruvettipuram K. Thiruvengadam ,  Jing Liao ,  Ilia A. Zavialov ,  Hoa N. Nguyen ,  Ngiap Kie. Lim

IPC分类号： C07F9/141 ,  C07C205/56 ,  C07C309/16 ,  C07D213/02 ,  C07C235/00 ,  C07C205/44 ,  C07D307/77 ,  C07D277/64

CPC分类号： C07D263/56 ,  C07C69/606 ,  C07C69/732 ,  C07C201/10 ,  C07C201/12 ,  C07C205/44 ,  C07C205/55 ,  C07C231/10 ,  C07C231/12 ,  C07C235/28 ,  C07C303/32 ,  C07C309/08 ,  C07C2601/16 ,  C07D277/64 ,  C07D307/92 ,  C07D333/56 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  C07F7/1804 ,  C07F9/58 ,  Y02P20/55 ,  C07C233/28

摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:

摘要翻译： 本申请公开了一种制备可用作凝血酶受体拮抗剂的烟肼类似物的新方法。 该方法部分基于使用手性硝基中心的碱促进的动态差向异构化。 本文教导的化学结构可以举例说明如下：

公开(公告)号：US20070190269A1

公开(公告)日：2007-08-16

申请号：US11519062

申请日：2006-09-12

申请人： Ming-Chin Cheng

发明人： Ming-Chin Cheng

IPC分类号： C07C309/16 ,  C09K19/00 ,  C09B56/04

CPC分类号： C09K19/601 ,  C07C309/50 ,  C09B43/10 ,  C09B56/04 ,  Y10T428/1041

摘要： The present invention relates to a azo dyestuff compound of the following formula (I), of which the free acid is represented by the following formula: wherein R1, R2, R3, R4, and n are defined as in the specification. The azo dyestuff compound of formula (I) of the present invention is used for preparing polarizing film. The present invention also relates to a polarizing film comprising the azo dyestuff compound of formula (I), which has excellent degree of polarization.

公开(公告)号：US20230183603A1

公开(公告)日：2023-06-15

申请号：US18045281

申请日：2022-10-10

申请人： PROMEGA CORPORATION

发明人： Sergei Saveliev ,  Daniel Simpson ,  Keith V. Wood ,  Harry Tetsuo Uyeda ,  Carolyn Woodroofe Hitko ,  Dieter Klaubert

IPC分类号： C11D1/20 ,  C07C309/10 ,  C07C309/14 ,  C07C309/15 ,  C07C309/16 ,  C07C323/12 ,  C07C329/06 ,  C07D307/40 ,  C07D307/56 ,  C07D317/22 ,  C07D333/16 ,  C11D1/14

CPC分类号： C11D1/20 ,  C07C309/10 ,  C07C309/14 ,  C07C309/15 ,  C07C309/16 ,  C07C323/12 ,  C07C329/06 ,  C07D307/40 ,  C07D307/56 ,  C07D317/22 ,  C07D333/16 ,  C11D1/143

摘要： The invention provides surfactant compounds of formulas I-IX, which can be used in methods for aiding the solubilization, digestion, preparation, analysis, and/or characterization of biological material, for example, proteins or cell membranes. The compounds can also aid in the recovery of peptides generated during protein digestion, particularly for in-gel digestion protocol. Additionally, the compounds can improve enzymatic protein deglycosylation without interfering with downstream sample preparation steps and mass spectrometric analysis. The compounds can be specifically useful as digestion aids that can be decomposed by an acid, by heat, or a combination thereof. Decomposition of the surfactants allows for facile separation from isolated samples, and/or allows for analysis of the sample without interfering with the sensitivity of various analytical techniques.

公开(公告)号：US20200263110A1

公开(公告)日：2020-08-20

申请号：US16805333

申请日：2020-02-28

申请人： PROMEGA CORPORATION

发明人： Sergei Saveliev ,  Daniel Simpson ,  Keith V. Wood ,  Harry Tetsuo Uyeda ,  Carolyn Woodroofe Hitko ,  Dieter Klaubert

IPC分类号： C11D1/20 ,  C11D1/14 ,  C07D333/16 ,  C07D317/22 ,  C07D307/56 ,  C07D307/40 ,  C07C329/06 ,  C07C323/12 ,  C07C309/16 ,  C07C309/15 ,  C07C309/14 ,  C07C309/10

摘要： The invention provides surfactant compounds of formulas I-IX, which can be used in methods for aiding the solubilization, digestion, preparation, analysis, and/or characterization of biological material, for example, proteins or cell membranes. The compounds can also aid in the recovery of peptides generated during protein digestion, particularly for in-gel digestion protocol. Additionally, the compounds can improve enzymatic protein deglycosylation without interfering with downstream sample preparation steps and mass spectrometric analysis. The compounds can be specifically useful as digestion aids that can be decomposed by an acid, by heat, or a combination thereof. Decomposition of the surfactants allows for facile separation from isolated samples, and/or allows for analysis of the sample without interfering with the sensitivity of various analytical techniques.

公开(公告)号：US09152044B2

公开(公告)日：2015-10-06

申请号：US13627208

申请日：2012-09-26

申请人： JSR CORPORATION

发明人： Yusuke Asano

IPC分类号： G03F7/004 ,  C07C309/19 ,  C07C309/12 ,  C07C381/12 ,  G03F7/20 ,  G03F7/039 ,  G03F7/11 ,  C07C309/07 ,  C07C309/16 ,  C07C309/17 ,  C07C309/65 ,  C07C317/12 ,  C07D295/185

摘要： A radiation-sensitive resin composition includes an acid generating agent to generate a compound represented by a following formula (1) by irradiation with a radioactive ray. In the formula (1), R1 represents a monovalent organic group having 1 to 20 carbon atoms. R2 represents a hydrogen atom or a monovalent organic group having 1 to 20 carbon atoms. The compound represented by the formula (1) is preferably a compound represented by a following formula (1-1). In the formula (1-1), R2 is as defined in the above formula (1). X represents an electron attractive group. R3 represents a monovalent organic group having 1 to 20 carbon atoms.

公开(公告)号：US5840972A

公开(公告)日：1998-11-24

申请号：US549795

申请日：1995-02-22

申请人： Rajnikant Patel ,  Amrik Singh Mahal ,  Donald Lloyd Winston Burford

发明人： Rajnikant Patel ,  Amrik Singh Mahal ,  Donald Lloyd Winston Burford

IPC分类号： C07C277/08 ,  C07C279/14 ,  C07C303/16 ,  C07C309/16 ,  C07C381/14 ,  C07C249/02 ,  C07C277/00 ,  C07C279/12

CPC分类号： C07C277/08 ,  C07C381/14

摘要： A process is disclosed for the preparation of N.sup.G -monoalkyl-L-arginine and related compounds and salts thereof, for example N.sup.G -monomethyl-L-arginine by reacting N-alkylaminoiminomethane sulphonic acid of formula (II) with an amino acid of formula (III).

摘要翻译： PCT No.PCT / GB94 / 00966 Sec。 371日期1995年2月22日 102（e）1995年2月22日PCT PCT 1994年5月5日PCT公布。 出版物WO94 / 26701 日本公开1994年11月24日（III）（III）公开了制备NG-单烷基-L-精氨酸及其相关化合物及其盐的方法，例如NG-单甲基-L-精氨酸 使式（II）的N-烷基氨基亚氨基甲磺酸与式（III）的氨基酸反应。

公开(公告)号：US5312839A

公开(公告)日：1994-05-17

申请号：US664933

申请日：1991-03-05

申请人： Tsutomu Nakada

发明人： Tsutomu Nakada

IPC分类号： A61K31/185 ,  A61K31/19 ,  A61K31/495 ,  A61K31/5375 ,  A61P3/00 ,  A61P9/00 ,  C07C211/00 ,  C07C229/00 ,  C07C233/02 ,  C07C239/08 ,  C07C271/00 ,  C07C275/00 ,  C07C279/00 ,  C07C309/14 ,  C07C309/16 ,  A01N37/52 ,  C07C239/00

CPC分类号： A61K31/5375 ,  A61K31/185 ,  A61K31/495

摘要： Compounds and a method useful for protection of tissue cells in a mammalian body from irreversible damages due to lactic acidosis caused by oxygen deficiency. The protection is achieved by administering a compound having a cell membrane permeability and/or ability to cross the blood brain barrier and being able to provide a buffering action to prevent an increase in a hydrogen ion concentration over the physiologically acceptable levels.

摘要翻译： 用于保护哺乳动物体内的组织细胞的化合物和方法免受由于缺氧导致的乳酸性酸中毒引起的不可逆损伤。 通过施用具有细胞膜通透性和/或穿过血脑屏障的能力的化合物并且能够提供缓冲作用以防止氢生物学上可接受水平的氢离子浓度增加来实现保护。

公开(公告)号：US4656291A

公开(公告)日：1987-04-07

申请号：US868231

申请日：1986-05-28

申请人： Cynthia A. Maryanoff ,  James N. Plampin ,  Robin C. Stanzione

发明人： Cynthia A. Maryanoff ,  James N. Plampin ,  Robin C. Stanzione

IPC分类号： C07B61/00 ,  B01J23/28 ,  C07C67/00 ,  C07C279/00 ,  C07C301/00 ,  C07C303/02 ,  C07C309/16 ,  C07C381/14 ,  C07D207/26 ,  C07D207/273 ,  C07D295/215 ,  C07C139/00 ,  C07D233/42

CPC分类号： C07D207/273 ,  C07C381/14 ,  C07D295/215

摘要： An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): ##STR1## with H.sub.2 O.sub.2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

摘要翻译： 喹啉的有效合成，例如 的式（III）化合物，通过氧化硫脲，例如 的下式（II）：用H 2 O 2和钼催化剂制备氨基亚氨基甲烷磺酸，然后可与胺反应，然后进行任选的转氨步骤。