公开(公告)号：US11624065B2

公开(公告)日：2023-04-11

申请号：US16155688

申请日：2018-10-09

申请人： FLAGSHIP PIONEERING INNOVATIONS V, INC.

发明人： Laura Gabriela Lande ,  David Arthur Berry ,  Rahul Karnik

IPC分类号： C12N15/113 ,  C12N9/22 ,  C12N15/63 ,  C12N15/85 ,  C12N15/87 ,  C12N15/90 ,  C12N9/00 ,  C12N9/10 ,  C12N9/80 ,  A61K35/12

摘要： The present disclosure provides compositions with a modulating gene expression and methods for modulating transcription.

公开(公告)号：US11618893B2

公开(公告)日：2023-04-04

申请号：US16567771

申请日：2019-09-11

申请人： Icahn School of Medicine at Mount Sinai

发明人： Efrat Eliyahu ,  Adam Vincek ,  Anthony Fargnoli ,  Michael Katz

IPC分类号： C12N9/80 ,  C12N15/86 ,  C12N15/52 ,  A61K48/00

摘要： The present disclosure relates generally to the use of sphingolipid-metabolizing proteins to mitigate or minimize tissue damage resulting from injury or from disease, for example, pulmonary arterial hypertension (PAH) when the sphingolipid-metabolizing protein is delivered via expression from an Anc80 vector.

公开(公告)号：US11518990B2

公开(公告)日：2022-12-06

申请号：US16741460

申请日：2020-01-13

申请人： SHANGHAI TECHWELL BIOPHARMACEUTICAL CO., LTD

发明人： Shidong Liu ,  Zhaoli Zhang ,  Xiaoming Ji

IPC分类号： C12N11/14 ,  C12P21/02 ,  C12N9/80 ,  C07K7/56 ,  C12N11/087 ,  C12N9/86

摘要： Disclosed in the present invention are an immobilized cycloaliphatic peptide acyltransferase and a preparation method and use thereof. The cycloaliphatic peptide acyltransferase is immobilized on a carrier; the cycloaliphatic peptide acyltransferase is derived from natural or artificial mutants or variants thereof, or can be obtained by introducing a foreign cyclic acyltransferase gene and transforming thereafter; the material of the carrier is selected from an inorganic carrier or a polypropylene resin carrier. Also disclosed in the present invention are the preparation method for the immobilized cycloaliphatic peptide acyltransferase and uses thereof.

公开(公告)号：US20220356498A1

公开(公告)日：2022-11-10

申请号：US17879663

申请日：2022-08-02

申请人： Biotelliga Holdings Limited

发明人： Damien James FLEETWOOD ,  Mikhail FOKIN ,  Kelly Alexander STYLES ,  Amritha Suhasini WICKRAMAGE ,  Sanjay SAIKIA

IPC分类号： C12P17/18 ,  C12N9/02 ,  C12N9/10 ,  C12N9/16 ,  C12N9/80 ,  C12N15/80

摘要： The invention generally relates to methods of producing loline alkaloids or precursors thereof, expression constructs, and host cells useful for producing loline alkaloids or precursors thereof, and methods for producing loline alkaloids or precursors thereof in a host cell.

公开(公告)号：US11466300B2

公开(公告)日：2022-10-11

申请号：US16091865

申请日：2017-04-14

申请人： Lan Sun

发明人： Lan Sun

IPC分类号： C07K14/195 ,  C12P19/26 ,  C12N9/10 ,  C12N9/12 ,  C12N9/80 ,  C12N9/90 ,  C12N15/70 ,  C12N9/78 ,  C12N9/88 ,  C12P19/02 ,  C12N1/20 ,  C12R1/19

摘要： This Invention discloses a method for production of N-Acetyl-D-Glucosamine and/or D-Glucosamine Salt by microbial fermentation. The method is intended to manufacture N-Acetyl-D-Glucosamine and/or D-Glucosamine Salt in higher efficiency and higher yield, by increasing the effects of N-Acetyl-D-Mannosamine Kinase.

公开(公告)号：US11375719B2

公开(公告)日：2022-07-05

申请号：US15262004

申请日：2016-09-11

申请人： Guenevere Diane Perry

发明人： Guenevere Diane Perry

IPC分类号： A01N63/20 ,  C12P13/00 ,  C12N1/20 ,  C12N1/38 ,  C12N9/02 ,  C12N9/78 ,  C12N9/80 ,  C12N9/88

摘要： The present invention is directed to methods of modifying the plant development process comprising of exposing a plant or plant part to volatiles biosynthesized by one or more bacteria or enzymes. Specifically, the embodiment uses one or more bacteria selected from the plant growth promoting bacteria group consisting of Rhodococcus spp., Pseudomonas spp., Bacillus spp., or Xanthobacter spp., or a mixture thereof. A closed apparatus, FIG. 1A, containing a tri-phasic system is used to expose the bacteria to hydrocarbons, iron, cyanide, and/or ammonium compounds; the method induces the biocatalyst to biosynthesize volatile compound(s) that deter ethylene production in climacteric plants or fruit resulting in the biocatalyst ability to delay fruit ripening.

公开(公告)号：US11365400B2

公开(公告)日：2022-06-21

申请号：US17074203

申请日：2020-10-19

申请人： CJ Cheiljedang Corporation

发明人： Su Jin Park ,  Young Lyeol Yang ,  Hye Won Um ,  Hong Xian Li ,  Kyoung Min Lee ,  Baek Seok Lee ,  Hyo Hyoung Lee ,  Hee Kyoung Jung

IPC分类号： C12N9/10 ,  C12N9/80 ,  C12P13/00 ,  C12N15/52 ,  C12N1/00 ,  C12N15/00 ,  C12N9/12 ,  C12N9/88 ,  C12N9/00 ,  C12P13/10

摘要： Disclosed is a modified microorganism producing putrescine or ornithine, and a method for producing putrescine or ornithine using the same.

公开(公告)号：US20220169998A1

公开(公告)日：2022-06-02

申请号：US17674558

申请日：2022-02-17

申请人： The General Hospital Corporation

发明人： J. Keith Joung ,  Benjamin Kleinstiver

IPC分类号： C12N9/22 ,  C12N9/10 ,  C12N9/02 ,  C12N9/78 ,  C12N15/90 ,  C12N15/11 ,  C12N9/80

摘要： Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.

公开(公告)号：US20220098572A1

公开(公告)日：2022-03-31

申请号：US17427410

申请日：2020-01-31

申请人： BEAM THERAPEUTICS INC.

发明人： Ian SLAYMAKER ,  Jason Michael GEHRKE ,  Nicole GAUDELLI ,  Yi YU

IPC分类号： C12N15/10 ,  C12N15/62 ,  C12N9/22 ,  C12N9/80 ,  C12N15/11 ,  C40B40/10

摘要： The invention features base editors having reduced non-target deamination, methods of using the base editors, and assays for characterizing base editors as having decreased non-target deamination, e.g. compared to programmed, on-target deamination.

公开(公告)号：US11286468B2

公开(公告)日：2022-03-29

申请号：US16109657

申请日：2018-08-22

申请人： The General Hospital Corporation

发明人： J. Keith Joung ,  Benjamin Kleinstiver

IPC分类号： C12N9/22 ,  C12N9/10 ,  C12N9/78 ,  C12N15/90 ,  C12N15/11 ,  C12N9/80 ,  C12N9/02 ,  A61K38/00

摘要： Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.