公开(公告)号：US20100135547A1

公开(公告)日：2010-06-03

申请号：US12341447

申请日：2008-12-22

Applicant: Chau-Hwang Lee ,  Jiunn-Yuan Lin

Inventor： Chau-Hwang Lee ,  Jiunn-Yuan Lin

IPC: G06K9/00

CPC classification number: G06T3/4084 ,  G02B21/367 ,  G06T2207/10056 ,  G06T2207/10152

Abstract: Systems and methods for optical sectioning microscopy with structured illumination are provided. A light source generates a light beam with a spatial pattern for successively illuminating a sample at each phase of a plurality of phases. A detector detects a first set of images of the sample at a first axial resolution and a first lateral resolution, each image being associated with a respective phase of the plurality of phases of the illumination. A processor processes the first set of images to generate an enhanced sectioned image of the sample. More specifically, the processor generates data representing a second set of images at a second axial resolution greater than the first axial resolution; and subsequently, performs spectral analysis on the data representing the second set of images to form data representing the enhanced sectioned image of the sample at a second lateral resolution greater than the first lateral resolution.

Abstract translation: 提供了具有结构照明的光学切片显微镜的系统和方法。 光源产生具有空间图案的光束，用于在多个相的每个相位处连续照射样品。 检测器以第一轴向分辨率和第一横向分辨率检测样本的第一组图像，每个图像与照明的多个相位的相应相位相关联。 处理器处理第一组图像以生成样本的增强分段图像。 更具体地，处理器以大于第一轴向分辨率的第二轴向分辨率产生表示第二组图像的数据; 并且随后对表示第二组图像的数据进行光谱分析，以形成大于第一横向分辨率的第二横向分辨率的表示样本的增强分段图像的数据。

公开(公告)号：US20100117060A1

公开(公告)日：2010-05-13

申请号：US12453088

申请日：2009-04-29

Applicant: Shiang-Yu Wang ,  Hong-Shi Ling ,  Ming-Cheng Lo ,  Chien-Ping Lee

Inventor： Shiang-Yu Wang ,  Hong-Shi Ling ,  Ming-Cheng Lo ,  Chien-Ping Lee

IPC: H01L31/0352

CPC classification number: H01L31/035236 ,  B82Y20/00 ,  H01L31/03046 ,  H01L31/105 ,  Y02E10/544 ,  Y02P70/521 ,  Y10S977/759

Abstract: The present invention is disclosed that a device capable of normal incident detection of infrared light to efficiently convert infrared light into electric signals. The device comprises a substrate, a first contact layer formed on the substrate, an active layer formed on the first contact layer, a barrier layer formed on the active layer and a second contact layer formed on the barrier layer, wherein the active layer comprises multiple quantum dot layers.

Abstract translation: 公开了能够正常入射检测红外光以有效地将红外光转换为电信号的装置的本发明。 该器件包括衬底，形成在衬底上的第一接触层，形成在第一接触层上的有源层，形成在有源层上的阻挡层和形成在阻挡层上的第二接触层，其中有源层包括多个 量子点层。

公开(公告)号：US07695738B2

公开(公告)日：2010-04-13

申请号：US10782076

申请日：2004-02-19

Applicant: Chun-Cheng Lin ,  Chia-Chun Chen ,  Yi-Chun Wu

Inventor： Chun-Cheng Lin ,  Chia-Chun Chen ,  Yi-Chun Wu

IPC: A61K9/14 ,  A61K9/16 ,  A61K31/70 ,  A61K33/24 ,  A61K33/04 ,  A01N43/04 ,  A01N43/16 ,  A01N59/02

CPC classification number: G01N33/587 ,  B82Y5/00 ,  G01N33/56916

Abstract: The present invention provides carbohydrate encapsulated nanoparticles. In particular, the present invention provides metallic nanoparticles (e.g. gold nanoparticles) that are encapsulated in biologically important carbohydrate molecules, such as sugars, sugar derivatives, P-blood group antigens and analogues thereof. The present invention also provides methods of employing these carbohydrate encapsulated nanoparticles in diagnostic and therapeutic applications.

Abstract translation: 本发明提供了碳水化合物包封的纳米颗粒。 特别地，本发明提供了包封在生物重要的碳水化合物分子中的金属纳米颗粒（例如金纳米颗粒），例如糖，糖衍生物，P-血型抗原及其类似物。 本发明还提供了在诊断和治疗应用中使用这些碳水化合物包封的纳米颗粒的方法。

公开(公告)号：US20100084081A1

公开(公告)日：2010-04-08

申请号：US12536718

申请日：2009-08-06

Applicant: Chih-Wei Chu ,  Zhong-Yo Ho

Inventor： Chih-Wei Chu ,  Zhong-Yo Ho

IPC: B32B37/02

CPC classification number: B32B37/025 ,  B32B2309/02 ,  B32B2309/04 ,  B32B2309/105 ,  B32B2315/08 ,  B32B2367/00 ,  B32B2457/206

Abstract: A method for fabricating organic optoelectronics multi-layer devices is disclosed. A polydimethylsiloxane (PDMS) surface is pretreated with an organic solvent and used to directly form a uniform optoelectrical thin-film from organic solution by spin coating. The optoelectrical thin-film films that are formed on the PDMS surface are easily transferable to any substrate by a slight, externally applied force for providing conformal contact with a target substrate and thermal annealing, depending on the polymers to be transferred. Pretreatment of the PDMS surface with the organic solvent combined with a dry transfer process provides an easier way to cascade polymer architecture fabrication. In addition, the method increases the performance of various types of organic photo electronics, and permits an extension of the types of research that can be performed in the field of photo electronics.

Abstract translation: 公开了一种制造有机光电子多层器件的方法。 聚二甲基硅氧烷（PDMS）表面用有机溶剂预处理，用于通过旋涂从有机溶液中直接形成均匀的光电薄膜。 形成在PDMS表面上的光电薄膜通过轻微的外部施加的力很容易地转移到任何基底上，以提供与目标基底的共形接触和热退火，这取决于待转移的聚合物。 用有机溶剂与干转移方法预处理PDMS表面提供了一种更容易的级联聚合物结构制造的方法。 此外，该方法增加了各种类型的有机光电子器件的性能，并且允许扩展可在照相电子学领域中进行的研究类型。

公开(公告)号：US07687064B2

公开(公告)日：2010-03-30

申请号：US11534204

申请日：2006-09-21

Applicant: Kuo-Feng Hua ,  Hsien-Yeh Hsu ,  Chi-Huey Wong

Inventor： Kuo-Feng Hua ,  Hsien-Yeh Hsu ,  Chi-Huey Wong

IPC: A61K36/06 ,  A61K9/00 ,  A61K47/00 ,  A23K1/17

CPC classification number: A61K36/074

Abstract: The present disclosure provides methods for increasing the lipopolysaccharide-induced secretion of IL-1 by macrophages, for increasing serum levels of IL-1 in a mammal, for increasing the serum level of IL-1 receptor antagonist (IL-1Ra) in a mammal, for increasing the secretion of IL-1 by a monocyte, for increasing the secretion of IL-1Ra by a monocyte, for increasing the secretion of IL-1Ra by a macrophage, for increasing expression of TLR4 on the surface of a macrophage, for increasing expression of CD14 on the surface of macrophage, for increasing the uptake and clearance of lipopolysaccharide (LPS) by a LPS-stimulated macrophage, and for increasing lipopolysaccharide (LPS)-stimulated activation of at least one of ERK, JNK, and p38 in a macrophage. The methods of the disclosure involve the administration to mammals and immune cells of a fucose-containing glycoprotein fraction from Ganoderma lucidum.

Abstract translation: 本公开提供了增加脂多糖诱导的巨噬细胞分泌IL-1的方法，用于增加哺乳动物中IL-1的血清水平，以增加哺乳动物中IL-1受体拮抗剂（IL-1Ra）的血清水平 用于增加单核细胞分泌IL-1，增加单核细胞分泌IL-1Ra，增加巨噬细胞分泌IL-1Ra，增加巨噬细胞表面TLR4的表达，为 增加巨噬细胞表面CD14的表达，增加LPS刺激的巨噬细胞对脂多糖（LPS）的吸收和清除，并增加脂多糖（​​LPS）刺激ERK，JNK和p38中的至少一种的活化 巨噬细胞 本公开的方法涉及从灵芝向哺乳动物和免疫细胞施用含岩藻糖的糖蛋白部分。

公开(公告)号：US20100076205A1

公开(公告)日：2010-03-25

申请号：US12468069

申请日：2009-05-19

Applicant: Tahsin J. Chow ,  Yuan-Chieh Chang

Inventor： Tahsin J. Chow ,  Yuan-Chieh Chang

IPC: C07D409/14 ,  C07D409/04 ,  C07D333/22 ,  C07C255/34

CPC classification number: C07D333/24 ,  C07C255/42 ,  C07D333/36 ,  C09B23/005 ,  C09B23/0058 ,  C09B23/105 ,  C09B57/008 ,  H01G9/2031 ,  H01G9/2059 ,  H01L51/006 ,  H01L51/0061 ,  H01L51/0068 ,  Y02E10/542 ,  Y02E10/549

Abstract: A dye compound is described, which is expressed by formula (I): wherein A1, A2 and A3 each independently represent a substituted or unsubstituted 1,4-phenylene or 2,5-thiophene group, and B1 and B2 each independently represent a substituted or unsubstituted aryl group. The dye compound is suitably used as a dye sensitizer in a dye sensitized solar cell (DSSC).

Abstract translation: 描述了由式（I）表示的染料化合物：其中A1，A2和A3各自独立地表示取代或未取代的1,4-亚苯基或2,5-噻吩基团，B1和B2各自独立地表示取代的 或未取代的芳基。 染料化合物适合用作染料敏化太阳能电池（DSSC）中的染料敏化剂。

公开(公告)号：US07655453B2

公开(公告)日：2010-02-02

申请号：US11841492

申请日：2007-08-20

Applicant: Jei-fu Shaw ,  Guan-chiun Lee ,  Shye-Jye Tang

Inventor： Jei-fu Shaw ,  Guan-chiun Lee ,  Shye-Jye Tang

IPC: C12N15/55 ,  C12N1/21 ,  C12N1/15 ,  C12N9/20

CPC classification number: C12N9/20 ,  C07K2319/00

Abstract: The present invention features an isolated nucleic acid that includes a mutant DNA encoding a Candida rugosa lipase, wherein the mutant DNA is 80% identical to a wild-type DNA encoding the Candida rugosa lipase, and includes at least 12 (e.g., 13, 15, 17, or all) universal serine codons corresponding to CTG codons in the wild-type DNA. Each of the universal serine codons, independently, is TCT, TCC, TCA, TCG, AGT, or AGC. The Candida rugosa lipase can be Candida rugosa lipase 1, 2, 3, 4, 5, or 8.

Abstract translation: 本发明的特征在于分离的核酸，其包含编码假丝酵母假单胞菌脂肪酶的突变DNA，其中突变DNA与编码假丝酵母脂肪酶的野生型DNA具有80％同一性，并且包括至少12个（例如13,15 ，17或全部）对应于野生型DNA中的CTG密码子的通用丝氨酸密码子。 每个通用丝氨酸密码子独立地是TCT，TCC，TCA，TCG，AGT或AGC。 假丝酵母粗脂肪酶可以是1号，2号，3号，4号，5号或8号念珠菌。

公开(公告)号：US20090317837A1

公开(公告)日：2009-12-24

申请号：US12485516

申请日：2009-06-16

Applicant: Chi-Huey Wong ,  Chung-Yi Wu ,  Cheng-Chi Wang

Inventor： Chi-Huey Wong ,  Chung-Yi Wu ,  Cheng-Chi Wang

IPC: G01N33/574

CPC classification number: G01N33/57488 ,  G01N33/57415

Abstract: A cancer diagnostic method using a glycan array that contains Gb5 and Globo H, Bb2, Bb3, and/or Bb4.

Abstract translation: 使用含有Gb5和Globo H，Bb2，Bb3和/或Bb4的聚糖阵列的癌症诊断方法。

公开(公告)号：US07527967B2

公开(公告)日：2009-05-05

申请号：US10997775

申请日：2004-11-24

Applicant: Yu-Chan Chao ,  Yen-Yen Liu

Inventor： Yu-Chan Chao ,  Yen-Yen Liu

IPC: C12N1/00 ,  A61K39/155 ,  A61K39/215

CPC classification number: C07K14/005 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N7/00 ,  C12N15/1131 ,  C12N15/86 ,  C12N2310/14 ,  C12N2710/14123 ,  C12N2710/14143 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/20022 ,  C12N2770/20034 ,  G01N33/5005 ,  G01N2333/11 ,  G01N2333/165 ,  G01N2500/02

Abstract: Recombinant baculoviruses, virus-like particles, and polypeptide that contain a protein sequence of a heterologous virus, related compositions, and related preparation, screening, delivery, detection, and treatment methods.

Abstract translation: 重组杆状病毒，病毒样颗粒和含有异源病毒蛋白质序列的多肽，相关组合物及相关制备，筛选，递送，检测和治疗方法。

公开(公告)号：US20090062216A1

公开(公告)日：2009-03-05

申请号：US12263896

申请日：2008-11-03

Applicant: Wen-Chin Yang ,  Shu-Lin Chang ,  Lee-Tian Chang ,  Yi-Ming Chiang ,  Lie-Fen Shyur

Inventor： Wen-Chin Yang ,  Shu-Lin Chang ,  Lee-Tian Chang ,  Yi-Ming Chiang ,  Lie-Fen Shyur

IPC: A61K31/7028 ,  A61P37/00

CPC classification number: A61K36/28 ,  C07H15/10

Abstract: A method of treating a Th1-mediated disorder includes administering to a subject in need of the treatment an effective amount of a compound of the formula I: wherein R1 is H, alkyl, aryl, or cyclyl; R2 is pyranose; R3 is H or alkyl; m is 2, 3, 4, 5, or 6; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, 4; p is 1, 2, 3, or 4; and the Th1-mediated disorder is non-obese diabetes, Crohn's colitis, autoimmune hemolytic anemia, rheumatoid arthritis, autoimmune encephalitis, multiple sclerosis, or autoimmune myocarditis. Also disclosed is a pharmaceutical composition including a compound of formula I above and a pharmaceutically acceptable carrier.

Abstract translation: 治疗Th1介导的病症的方法包括向需要治疗的受试者施用有效量的式I化合物：其中R 1是H，烷基，芳基或环基; R2是吡喃糖; R3是H或烷基; m为2,3,4,5或6; n为0,1,2或3; o是0，1，2，3，4; p是1,2,3或4; 并且Th1介导的病症是非肥胖性糖尿病，克罗恩病的结肠炎，自身免疫性溶血性贫血，类风湿性关节炎，自身免疫性脑炎，多发性硬化或自身免疫性心肌炎。 还公开了包含上述式I化合物和药学上可接受的载体的药物组合物。