公开(公告)号：US09901566B1

公开(公告)日：2018-02-27

申请号：US15401250

申请日：2017-01-09

Applicant: Macau University of Science and Technology

Inventor： Liang Liu ,  Ting Li ,  Guoyuan Zhu ,  Fen Yang

IPC: A61K31/365

CPC classification number: A61K31/365

Abstract: A method of treating a subject, in particular a human, suffering from an autoimmune disease, preferably but not exclusively selected from systemic lupus erythematosus, multiple sclerosis or rheumatoid arthritis includes the step of administering an effective amount of a limonoid to the subject. The present invention further relates to methods of inhibiting the differentiation of T helper 17 cells, T helper 1 cells, T helper 2 cells and/or regulatory T cells and a method of screening substances for their inhibition of one or more of T helper 17 cell, T helper 1 cell, T helper 2 cell and/or regulatory T cell differentiation that may be used to treat an autoimmune disease. This invention provides highly advantageous and promising treatment options for autoimmune diseases, namely for attenuating inflammatory lymphocyte function.

公开(公告)号：US20180047167A1

公开(公告)日：2018-02-15

申请号：US15236488

申请日：2016-08-15

Applicant: Macau University of Science and Technology

Inventor： Yi XU ,  Jiaxiang CHEN

IPC: G06T7/00

CPC classification number: G06T7/12 ,  G06T7/0085 ,  G06T7/0097 ,  G06T7/13 ,  G06T7/155 ,  G06T7/55 ,  G06T2207/10032 ,  G06T2207/20012 ,  G06T2207/20044 ,  G06T2207/30181

Abstract: A computer system executes a method that detects an edge of an object with a Canny operator. The method calculates a gradient strength of pixels of the image and applies non-maximum suppression to the image to avoid spurious responses to edge detection. The image is divided into multiple partitions based on a brightness distribution of the pixels in the image and a set of dynamic threshold values. Multiple images for the partitions are superimposed to detect an edge of the object.

公开(公告)号：US09884047B1

公开(公告)日：2018-02-06

申请号：US15632407

申请日：2017-06-26

Applicant: Macau University of Science and Technology

Inventor： Xiao Jun Yao ,  Lai Han Elaine Leung ,  Liang Liu ,  Xing Xing Fan ,  Chun Xie

IPC: A61K31/428 ,  G01N33/574 ,  C07D277/72 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/68 ,  A61K38/00

CPC classification number: A61K31/428 ,  A61K38/00 ,  C07D277/72 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/57484 ,  G01N33/68

Abstract: One example embodiment relates to a method of treating non-small cell lung cancer by administering a compound of formula (I) to a patient. Another example embodiment relates to a method of inhibiting progress of tumor growth in a patient with cancer, wherein tumor cells of the cancer have a mutant V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) gene, and the method includes administering to the patient the compound with the following formula I:

公开(公告)号：US20170329926A1

公开(公告)日：2017-11-16

申请号：US15150639

申请日：2016-05-10

Applicant: Macau University of Science and Technology

Inventor： Yong Liang ,  Hua Chai ,  Xiao-Ying Liu

IPC: G06F19/00 ,  G06F19/12

CPC classification number: G16H50/50 ,  G06F19/00 ,  G06F19/12

Abstract: A system and a method for determining an association of at least one biological feature with a medical condition, in particularly, but not exclusively, a system and a method of determining an association of at least one biological feature in form of a gene expression with cancer or a subtype of cancer that can include the generation of a simplified protein-protein interaction network based on processed biological data. The system and respective method is especially suitable for analysis of high dimensional and low sample size biological datasets such as in cancer research.

公开(公告)号：US20170329348A1

公开(公告)日：2017-11-16

申请号：US15153778

申请日：2016-05-13

Applicant: Macau University of Science and Technology

Inventor： Zhiwu Li ,  Oussama Karoui ,  Anis Koubaa ,  Mohamed Khalgui ,  Emna Guerfala ,  Eduardo Tovard ,  Naiqi Wu

IPC: G05D1/02 ,  G05D1/00

CPC classification number: G05D1/0295 ,  B60K31/00 ,  B60W30/14 ,  G05D1/0027 ,  G05D1/0212 ,  G05D1/0278 ,  G05D2201/0213 ,  G08G1/22

Abstract: A method for operating a follower vehicle in a vehicle platoon includes determining, during operation, whether the follower vehicle is operating in a normal state or an abnormal state based on an operation condition of a component of the follower vehicle, or a communication between the follower vehicle and a preceding vehicle in the vehicle platoon. The method further includes selecting a first control mode if the follower vehicle is in the normal state and a second control mode if the follower vehicle is in the abnormal state so as to control movement of the follower vehicle using the selected control mode. In the first control mode, the follower vehicle uses communication data received from the preceding vehicle in the vehicle platoon to control its movement. In the second control mode, the follower vehicle uses data obtained by one or more of its sensors to control its movement.

公开(公告)号：US09808477B2

公开(公告)日：2017-11-07

申请号：US14848358

申请日：2015-09-09

Applicant: Macau University of Science and Technology

Inventor： Wen-zhe Ma ,  Sen-ling Feng ,  Xiao-jun Yao ,  Zhong-wen Yuan ,  Liang Liu ,  Ying Xie

IPC: A61K31/352 ,  A61K31/337 ,  A61K45/06 ,  A61K31/704

CPC classification number: A61K31/366 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention discloses a pharmaceutical composition of treating multidrug resistance cancer, comprising a citrus methoxyflavone and a chemotherapeutic drug, in which the citrus methoxyflavone is nobiletin. A method of treating multidrug resistance cancer comprising administrating citrus methoxyflavone and a chemotherapeutic drug is also disclosed.

公开(公告)号：US20170312267A1

公开(公告)日：2017-11-02

申请号：US15142407

申请日：2016-04-29

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Jing-Rong Wang ,  Cheng-Yu Chen ,  Guo-Yuan Zhu

IPC: A61K31/4745 ,  A61K36/24

CPC classification number: A61K31/4745 ,  A61K36/27

Abstract: A method of isolating at least one phenanthroindolizidine alkaloid, in particular with telomerase inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about six to eight phenanthroindolizidine alkaloids, including at least four new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional telomerase inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. Still further, a method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata. Also, a method of treating a subject suffering from cancer includes administering to the subject at least one phenanthroindolizidine alkaloid having certain formula.

公开(公告)号：US20170214321A1

公开(公告)日：2017-07-27

申请号：US15007486

申请日：2016-01-27

Applicant: Macau University of Science and Technology

Inventor： Xiaodong Li

IPC: H02M3/335

CPC classification number: H02J3/38 ,  H02J3/32 ,  H02J3/386 ,  H02J7/34 ,  H02M3/33584 ,  Y02E10/763 ,  Y02E10/766 ,  Y02E70/30

Abstract: A method for controlling an operation of a converter circuit adapted to regulate power transfer between a first voltage source and a second voltage source includes detecting a first voltage level of the first voltage source and a second voltage level of the second voltage source; calculating a power value based on the detected first voltage level and the detected second voltage level; comparing the calculated power value with a reference power value; and determining switching time of one or more switches in the converter circuit based on a compared result so as to regulate power transfer between the first voltage source and the second voltage source.

公开(公告)号：US20170160954A1

公开(公告)日：2017-06-08

申请号：US14972047

申请日：2015-12-16

Applicant: Macau University of Science and Technology

Inventor： Li Feng ,  Liang Zhou ,  Zhijun Xu ,  Yujun Zhang

IPC: G06F3/06

CPC classification number: G06F3/0613 ,  G06F3/0659 ,  G06F3/068 ,  G06F13/00 ,  H04L47/50 ,  H04L69/12 ,  H04L69/321

Abstract: A method for implementing a packet I/O engine on a programmable computing platform is provided, where the engine performs I/O functions for plural threads generated by a plurality of user applications. In the method, the platform is configured such that only one thread is permitted to initialize and configure the resources. Furthermore, I/O-device queues each for buffering packets either transmitted to or received from an individual external I/O device are set up. For a plurality of unsafe I/O-device queues determined, among the I/O-device queues, to be multi-thread unsafe, a plurality of multi-producer, multi-consumer software queues for buffering packets delivered between the plurality of the unsafe I/O-device queues and the plurality of user applications is set up. In particular, the plurality of multi-producer, multi-consumer software queues is configured such that the unsafe I/O-device queues are collectively synchronized to maintain data consistency in packet delivery in the presence of multiple threads.

公开(公告)号：US20170151212A1

公开(公告)日：2017-06-01

申请号：US14953860

申请日：2015-11-30

Applicant: Macau University of Science and Technology

Inventor： Kam Wai Wong ,  Yuen Kwan Law ,  Thomas Efferth ,  Onat Kadioglu ,  Liang Liu

IPC: A61K31/352 ,  A61K31/337 ,  A61K31/704

CPC classification number: A61K31/352 ,  A61K31/337 ,  A61K31/704 ,  A61K2300/00

Abstract: Prenylated isoflavones are suitable to specifically inhibit P-glycoprotein in multidrug-resistant cancer cells leading to an accumulation of cytotoxic compounds or therapeutic compounds in the cells while having exceptionally increased cytotoxic activity specifically towards multidrug-resistant cancer cells and while allowing for an increased activity of chemotherapeutic compounds towards which the cells are resistant.Also in accordance with the present invention is a method for specifically targeting cancer cells with multidrug-resistance as well as a method of potentiating the activity of a chemotherapeutic compound in multidrug-resistant cancer cells. In a further aspect, a kit including a prenylated isoflavone and a chemotherapeutic compound is provided.