公开(公告)号：US20230303712A1

公开(公告)日：2023-09-28

申请号：US18122194

申请日：2023-03-16

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Eilam YEINI

IPC: C07K16/28 ,  A61K31/554 ,  C12N15/113 ,  A61P35/00 ,  A61P25/00 ,  A61K45/06

CPC classification number: C07K16/2896 ,  A61K31/554 ,  A61K45/06 ,  A61P25/00 ,  A61P35/00 ,  C12N15/1138 ,  C07K2317/76 ,  C12N2310/531

Abstract: A method of treating glioblastoma in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent that specifically decreases an amount and/or activity of P-selectin.

公开(公告)号：US20230301200A1

公开(公告)日：2023-09-21

申请号：US17909774

申请日：2021-03-08

Applicant: Ramot at Tel-Aviv University Ltd. ,  Yeda Research and Development Co. Ltd. ,  Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Inventor： Ehud GAZIT ,  Ron NAAMAN ,  Yossi PALTIEL ,  Shira YOCHELIS ,  Sharon GILEAD ,  Pandeeswar MAKAM ,  Amit Kumar MONDAL ,  Noam BROWN ,  Naama GOREN

IPC: H10N50/80 ,  H10N50/20 ,  H10N50/01

CPC classification number: H10N50/80 ,  H10N50/20 ,  H10N50/01

Abstract: A spin-selective conduction structure comprises a crystal having a monolayer of metal atoms between two layers of chiral organic molecules. Each metal atom is coupled to two chiral organic molecules, one at each layer, wherein a chirality of organic molecules in one of the two layers is the same as a chirality of organic molecules in another one of the two layers.

公开(公告)号：US20230258554A1

公开(公告)日：2023-08-17

申请号：US18006205

申请日：2021-07-21

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E. V.

Inventor： Natan Tzvi SHAKED ,  Itay BARNEA ,  Matan DUDAIE ,  Noga NISSIM ,  Michael KIRSCHBAUM ,  Marten Tobias GERLING

IPC: G01N15/14 ,  B01L3/00

CPC classification number: G01N15/1475 ,  B01L3/502761 ,  B01L3/502715 ,  G01N15/147 ,  B01L2400/0424 ,  B01L2300/0654 ,  B01L2300/0864 ,  B01L2200/0652 ,  G01N2015/1006

Abstract: The present invention relates to an automatic real-time label-free holography-activated sorting of the cell's technique. The technique provides high-discriminative power on the level of the individual cell. The technique includes rapid automated cell processing during cell visualization and flow, with high discriminative power on the level of the individual cell. The technique may be useful in detection of cancer and to identify different stages of oncogenesis.

公开(公告)号：US11708421B2

公开(公告)日：2023-07-25

申请号：US16316629

申请日：2017-07-18

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ranit Kedmi ,  Nuphar Veiga ,  Itai Benhar ,  Dan Peer

IPC: C07K16/30 ,  A61K47/54 ,  A61K9/127 ,  C07K16/28 ,  C07K16/42 ,  C12N15/11 ,  A61P35/00

CPC classification number: C07K16/30 ,  A61K9/127 ,  A61K47/543 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/2812 ,  C07K16/2815 ,  C07K16/2845 ,  C07K16/2866 ,  C07K16/2896 ,  C07K16/4241 ,  C12N15/11 ,  C12N15/111 ,  C12N2320/32

Abstract: A lipidated secondary antibody is disclosed. Particles comprising same are also disclosed.

公开(公告)号：US20230220410A1

公开(公告)日：2023-07-13

申请号：US18001626

申请日：2021-06-13

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Daniel CHAMOVITZ ,  Alin FINKELSHTEIN

IPC: C12N15/82

CPC classification number: C12N15/8279

Abstract: The present invention relates to plants, particularly crop plants, having enhanced tolerance to biotic stress, particularly enhanced tolerance to stress caused by a wide range of plant pathogens. The tolerant plants of the invention show enhanced expression of Arabidopsis S30 protein or of homologs or orthologs thereof.

公开(公告)号：US11699236B2

公开(公告)日：2023-07-11

申请号：US17487082

申请日：2021-09-28

Applicant: Ramot at Tel-Aviv University Ltd. ,  Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Yitzhak Avital ,  Nahum Kiryati ,  Eli Konen ,  Arnaldo Mayer

IPC: G06T7/11 ,  A61B34/20 ,  A61B34/32 ,  A61B5/00 ,  A61B5/055 ,  G01R33/56 ,  G06N3/08

CPC classification number: G06T7/11 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/4381 ,  A61B5/7267 ,  A61B34/20 ,  A61B34/32 ,  G01R33/5602 ,  G01R33/5608 ,  G06N3/08 ,  G06T2200/04 ,  G06T2207/10092 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/20132 ,  G06T2207/20156 ,  G06T2207/30016 ,  G06T2207/30081 ,  G06T2207/30096

Abstract: There is provided a computer implemented method of automatic segmentation of three dimensional (3D) anatomical region of interest(s) (ROI) that includes predefined anatomical structure(s) of a target individual, comprising: receiving 3D images of a target individual, each including the predefined anatomical structure(s), each 3D image is based on a different respective imaging modality. In one implementation, each respective 3D image is inputted into a respective processing component of a multi-modal neural network, wherein each processing component independently computes a respective intermediate, and the intermediate outputs are inputted into a common last convolutional layer(s) for computing the indication of segmented 3D ROI(s). In another implementation, each respective 3D image is inputted into a respective encoding-contracting component a multi-modal neural network, wherein each encoding-contracting component independently computes a respective intermediate output. The intermediate outputs are inputted into a single common decoding-expanding component for computing the indication of segmented 3D ROI(s).

公开(公告)号：US20230204716A1

公开(公告)日：2023-06-29

申请号：US17918340

申请日：2021-04-16

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Pavel GINZBURG ,  Vitali KOZLOV ,  Dmytro VOVCHUK

IPC: G01S7/38 ,  G01S7/02 ,  H01Q15/14 ,  H01Q15/00

CPC classification number: G01S7/38 ,  G01S7/021 ,  H01Q15/002 ,  H01Q15/148

Abstract: A cloaking and/or deception system comprises: a structure having a plurality of resonators characterized by a controllable resonance frequency, wherein the resonators are arranged to collectively ensure that variation of the resonance frequency over a predetermined range of resonance frequencies generates a phase shift between the an electromagnetic wave incident on the structure and an electromagnetic wave scattered off the structure; and a controller configured for controlling the resonance frequency to provide a time-varying resonance frequency characterized by a temporal function which comprises a linear time-dependence.

公开(公告)号：US20230185116A1

公开(公告)日：2023-06-15

申请号：US17925027

申请日：2021-05-14

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Tal Ellenbogen ,  Guixin Li

IPC: G02F1/01 ,  H01Q9/02

CPC classification number: G02F1/0136 ,  H01Q9/02 ,  G02F2203/13

Abstract: Apparatus for generating THz (teraftertz) radiation, the apparatus comprising: a substrate; a planar array of subwave-length antennas formed on the substrate having rotational symmetry, Cn, of order “n” greater than or equal to 3 and rotational symmetry cycle 2π/η, which are excitable by near infrared (NIR)_pump radiation to radiate THz radiation having wavelengths that are substantially larger than characteristic dimensions of the subwavelength antenna; wherein the array comprises a plurality of sections each comprising plurality of subwavelength antennas exhibiting a spatial pattern different from that of an adjacent section of the plurality of sections.

公开(公告)号：US11677215B2

公开(公告)日：2023-06-13

申请号：US17408592

申请日：2021-08-23

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Roei Aviram Cohen ,  Ofer Amrani ,  Shlomo Ruschin

IPC: H01S5/10 ,  H01S5/12 ,  H01S5/06

CPC classification number: H01S5/1003 ,  H01S5/1028 ,  H01S5/124 ,  H01S5/0608

Abstract: Structures for response shaping in frequency and time domain, include an optical response shaper and/or a modulator device with multiple injection. The device comprises a resonator having an enclosed geometric structure, for example a ring or racetrack structure, at least two injecting optical waveguides approaching the resonator to define at least two coupling regions between the resonator and the injecting waveguides, and may define at least two Free Spectral Range states.
One or both of the coupling regions has a coupling coefficient selected for a predetermined frequency or time response, and the coupling coefficient or other device parameters may be variable, in some case in real time to render the response programmably variable.

公开(公告)号：US20230174664A1

公开(公告)日：2023-06-08

申请号：US17779720

申请日：2020-11-25

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Vered PADLER-KARAVANI ,  Ron AMON ,  Ronit ROSENFELD

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  G01N33/574

CPC classification number: C07K16/2896 ,  A61K47/6849 ,  A61P35/00 ,  G01N33/57492 ,  C07K2317/92 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/734 ,  G01N2400/02

Abstract: The present invention discloses novel monoclonal antibodies and functional fragments thereof that specifically bind to SLeA carbohydrate antigen with high specificity and selectivity. The invention further provides compositions comprising the antibodies or fragments thereof as well as uses of the antibodies, fragments and compositions.