公开(公告)号：US11920162B2

公开(公告)日：2024-03-05

申请号：US16499333

申请日：2018-04-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ravid Straussman ,  Nancy Gavert

IPC: A61K9/20 ,  A61K31/138 ,  A61K31/337 ,  A61K31/439 ,  A61K31/4545 ,  A61K31/4748 ,  A61K31/502 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/704 ,  A61K31/7068 ,  A61K33/243 ,  A61L27/26 ,  A61L27/54 ,  A61L27/58 ,  A61P35/00 ,  C12M1/12 ,  C12N5/0775 ,  C12N5/09 ,  G01N33/50

CPC classification number: C12N5/0693 ,  A61K31/138 ,  A61K31/337 ,  A61K31/439 ,  A61K31/4545 ,  A61K31/4748 ,  A61K31/502 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/704 ,  A61K31/7068 ,  A61K33/243 ,  A61P35/00 ,  C12M25/00 ,  G01N33/5011 ,  C12N2503/02 ,  C12N2503/04 ,  C12N2513/00

Abstract: Ex-vivo culture systems are provided. Accordingly there is provided a culture system comprising a culture medium and a precision-cut tissue slice placed on a tissue culture insert, wherein the precision-cut tissue slice is maintained in a highly oxygenated atmosphere containing at least 50% oxygen and wherein said culture is rotationally agitated facilitating intermittent submersion of the tissue slice in the culture medium. Also provided are methods of culturing a tissue and methods of using the culture system for selecting a drug for the treatment of a disease.

公开(公告)号：US11898220B2

公开(公告)日：2024-02-13

申请号：US16591644

申请日：2019-10-03

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Igor Lubomirsky ,  Valery Kaplan

IPC: C22B11/06 ,  C01G55/00 ,  B01J19/08 ,  C22B11/00

CPC classification number: C22B11/06 ,  B01J19/08 ,  C01G55/005 ,  C22B11/048 ,  Y02P10/20

Abstract: A method for recovery of platinum group metals from a spent catalyst is described. The method includes crushing the spent catalyst to obtain a catalyst particulate material including particles having a predetermined grain size. The method includes subjecting the catalyst particulate material to a chlorinating treatment in the reaction zone at a predetermined temperature for a predetermined time period by putting the catalyst particulate material in contact with the chlorine containing gas. The method also includes applying an electromagnetic field to the chlorine-containing gas in the reaction zone to provide ionization of chlorine; thereby to cause a chemical reaction between platinum group metals and chlorine ions and provide a volatile platinum group metal-containing chloride product in the reaction zone. Following this, the volatile platinum group metal-containing chloride product is cooled to convert the product into solid phase platinum group metal-containing materials.

公开(公告)号：US11897884B2

公开(公告)日：2024-02-13

申请号：US16621278

申请日：2018-06-13

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Boris Rybtchinski ,  Haim Weissman ,  Tamar Wolf ,  Angelica Elkan ,  Sounak Dutta ,  Raja Bhaskar Kanth Siram

IPC: C07D471/22 ,  B01D69/12 ,  H10K30/35 ,  C01B32/174 ,  C09B5/62 ,  H10K85/20 ,  H10K85/60 ,  B01D61/02 ,  B01D61/14 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: C07D471/22 ,  B01D69/12 ,  C01B32/174 ,  C09B5/62 ,  H10K30/352 ,  H10K85/221 ,  H10K85/621 ,  H10K85/6572 ,  B01D61/027 ,  B01D61/147 ,  B01D2325/02 ,  B01D2325/20 ,  B82Y30/00 ,  B82Y40/00 ,  Y02E10/549

Abstract: This invention is directed to an aromatic material based free-standing film, a hybrid of organic crystalline materials and inorganic carbon nanomaterials, process of preparation and uses thereof. The film, which comprises a fibrous organic nanocrystals of an aromatic material, is mechanically and thermally stable. This film is optionally reinforced by hybridization with a reinforcement material, such as carbon nanotube, carbon material, a polysaccharide, a nanoclay a metal, metal alloy, or an organic polymer. The hybrid film of organic nanocrystals and carbon nanotubes (ONC/CNT) has high conductivity and high thermal stability. The films or hybrids of this invention are used as microfiltration membranes for various materials, in electrodes or perovskite solar cells.

公开(公告)号：US11892613B2

公开(公告)日：2024-02-06

申请号：US17624344

申请日：2020-07-02

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Dan Oron ,  Uri Rossman ,  Ron Tenne ,  Yonina C. Eldar

IPC: G02B21/00 ,  G01N21/64

CPC classification number: G02B21/008 ,  G02B21/0076 ,  G01N21/6458

Abstract: A method of generating an image of a sample is provided. The method comprises providing a plurality of photon detectors, scanning the sample with an excitation beam over a predetermined time period, the detectors receiving photons emitted by the sample due to the excitation during the time period. A plurality of intensity images associated with each of the detectors are generated, each being proportional to the mean number of photons detected per unit time. A plurality of correlation images associated with each combination of two of the detectors are generated, each of the correlation images being proportional to the variance of the distribution of detected photons per unit time. The image of the sample is generated using joint sparse recovery from the plurality of intensity and correlation images, wherein the intensity and correlation images have common support.

公开(公告)号：US11883533B2

公开(公告)日：2024-01-30

申请号：US15319014

申请日：2015-06-15

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob Klein ,  Ronit Goldberg ,  Jasmine Seror

IPC: A61K9/127 ,  A61K9/00 ,  A61K47/32 ,  A61K47/10 ,  A61K47/36 ,  A61K9/08 ,  A61K31/728 ,  A61K31/77 ,  A61K31/79 ,  B65D35/00 ,  B65D75/36

CPC classification number: A61K9/127 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/728 ,  A61K31/77 ,  A61K31/79 ,  A61K47/10 ,  A61K47/32 ,  A61K47/36 ,  B65D35/00 ,  B65D75/36

Abstract: Formulations (e.g., solutions) comprising one or more water-soluble polymer(s), liposomes, and an aqueous carrier, are provided. The provided solutions are useful for rinsing, and/or immersing therein, a contact lens and/or in the treatment of ocular discomfort, for example, an ocular discomfort associated with a contact lens. Also provided are kits comprising the solution and a contact lens; articles-of-manufacturing comprising the solution and configured for dispending the solution; and methods utilizing the solution.

公开(公告)号：US11859080B2

公开(公告)日：2024-01-02

申请号：US17515890

申请日：2021-11-01

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  HOLON ACADEMIC INSTITUTE OF TECHNOLOGY

Inventor： Reshef Tenne ,  Hila Shalom ,  Lev Rapoport ,  Ofek Golan

IPC: C08L67/04 ,  C08K3/04 ,  C08K3/32 ,  A61L27/34 ,  A61L27/04 ,  C08K3/30

CPC classification number: C08L67/04 ,  A61L27/04 ,  A61L27/34 ,  C08K3/045 ,  C08K3/30 ,  C08K3/32 ,  C08K2003/3009 ,  C08K2003/325 ,  C08K2201/005 ,  C08K2201/011 ,  C08K2201/018 ,  C08L2201/06 ,  C08L2203/16

Abstract: This invention is directed to composites and films comprising hydroxyapatite, biodegradable polymer, a biocompatible surfactant with inorganic fullerene-like (IF) nanoparticles or inorganic nanotubes (INT); methods of preparation and uses thereof.

公开(公告)号：US20230398214A1

公开(公告)日：2023-12-14

申请号：US17633294

申请日：2020-08-06

Applicant: Yeda Research and Development Co. Ltd. ,  Board of Regents, The University of Texas System

Inventor： Yair REISNER ,  Esther BACHAR-LUSTIG ,  Assaf LASK ,  Noga OR-GEVA ,  Rotem GIDRON BUDOVSKY ,  Rakefet SIDLIK MUSKATEL

IPC: A61K39/00 ,  C12N5/0783 ,  A61K31/664 ,  A61P37/06

CPC classification number: A61K39/4622 ,  C12N5/0636 ,  A61K39/4633 ,  A61K39/4614 ,  A61K39/464411 ,  A61K39/46444 ,  A61K39/464838 ,  A61K31/664 ,  A61P37/06 ,  A61K39/464429 ,  A61K39/4621 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2502/1121

Abstract: Methods of generating an isolated population of non-graft versus host disease (GVHD) inducing cells comprising a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation, are disclosed. Cells generated by the methods, pharmaceutical compositions and methods of treatment are also disclosed.

公开(公告)号：US11834678B2

公开(公告)日：2023-12-05

申请号：US16762164

申请日：2018-11-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Idit Shachar ,  Shirly Herman

IPC: C12N5/0789 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61K35/28

CPC classification number: C12N5/0647 ,  A61K35/28 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/2833 ,  C12N2501/998

Abstract: A method of generating hematopoietic stem cells for transplantation is disclosed. The method comprising: (a) collecting hematopoietic stem cells; and (b) contacting the hematopoietic stem cells with an agent capable of decreasing an activity or expression of CD74 and/or of macrophage migration inhibitory factor (MIF), to thereby generate hematopoietic stem cells for transplantation, and wherein the hematopoietic stem cells are not transduced with a lentivirus. Methods of increasing mobilization of hematopoietic stem cells and methods of treatment are also provided.

公开(公告)号：US11795553B2

公开(公告)日：2023-10-24

申请号：US17512723

申请日：2021-10-28

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Ronny Neumann ,  Alexander Khenkin ,  Miriam Somekh

IPC: C25B3/23 ,  C25B3/07

CPC classification number: C25B3/23 ,  C25B3/07

Abstract: This invention relates to electrocatalytic processes for the formation of formate esters using at least one catalyst or pre-catalyst; wherein the formate ester can be further hydrolyzed.

公开(公告)号：US11795440B2

公开(公告)日：2023-10-24

申请号：US17467265

申请日：2021-09-05

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  SYNVACCINE LTD.

Inventor： Tamir Tuller ,  Eli Goz ,  Shimshi Atar ,  Hadas Zur

IPC: C12N7/00 ,  C12N7/04 ,  A61K39/12 ,  A61K35/76 ,  G16B99/00 ,  G16B15/10 ,  A61K39/00

CPC classification number: C12N7/00 ,  A61K39/12 ,  C12N7/04 ,  G16B15/10 ,  G16B99/00 ,  A61K35/76 ,  A61K2039/5254 ,  C12N2770/24121 ,  C12N2770/24162 ,  Y02A50/30

Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.