公开(公告)号：US10329431B2

公开(公告)日：2019-06-25

申请号：US14866623

申请日：2015-09-25

Applicant: DSM IP ASSETS B.V.

Inventor： Johan F.G.A. Jansen ,  Jan Pieter Drijfhout

IPC: C09D5/03 ,  C09D167/06 ,  C08J7/04 ,  C08K5/00 ,  C08K5/10

Abstract: The invention relates to a one component heat curable powder coating composition comprising a resin containing reactive unsaturations and wherein all said reactive unsaturations are carbon carbon double bonds connected directly to an electron withdrawing group, a thermal initiation system comprising a peroxide chosen from the group of compounds represented by formula (1) wherein R1 and R2 each independently stand for an optionally substituted alkyl of 1 to 30 C-atoms, wherein the 1 to 30 C-atoms do not include the C-atoms of the substituents or for an optionally substituted aryl of 6 to 18 C-atoms, wherein the 6 to 18 C-atoms do not include the C-atoms of the substituents, and a co-crosslinker chosen from the group of vinylethers, vinyletherurethanes, vinylesters, vinylamides, itaconates, enamines, vinylureas and mixtures thereof.

公开(公告)号：US20190177754A1

公开(公告)日：2019-06-13

申请号：US16273273

申请日：2019-02-12

Applicant: DSM IP Assets B.V.

Inventor： James Casey LIPPMEIER ,  Joseph W. PFEIFER, III ,  Jon Milton HANSEN ,  Kirk E. APT ,  William Robert BARCLAY ,  Paul Warren BEHRENS ,  David Christian MARTIN

IPC: C12P7/64 ,  C10L1/02

Abstract: The present invention provides biological oils and methods and uses thereof. The biological oils are preferably produced by heterotrophic fermentation of one or more microorganisms using cellulose-containing feedstock as a main source of carbon. The present invention also provides methods of producing lipid-based biofuels and food, nutritional, and pharmaceutical products using the biological oils.

公开(公告)号：US20190144838A1

公开(公告)日：2019-05-16

申请号：US16300212

申请日：2017-05-11

Applicant: DSM IP Assets B.V.

Inventor： Anne-Cecile V. BAYNE ,  Ross E. ZIRKLE

IPC: C12N9/10 ,  C12N15/82

Abstract: The subject disclosure features, in one aspect, a method for producing lipids enriched for EPA, comprising modifying a microalga to increase expression of PFA1, and/or PFA3, and culturing the modified microalga under conditions which allow the expression of PFA1, and/or PFA3, wherein lipids enriched for EPA are produced. Also featured is a recombinant microalga in which PFA1, and/or PFA3, is overexpressed. Such recombinant microalgae have been demonstrated herein to produce very favorable fatty acid lipid profiles (e.g., increased levels of EPA, increased ratio of EPA:DHA, decreased levels of DPA n-6, etc.).

公开(公告)号：US20190144365A1

公开(公告)日：2019-05-16

申请号：US16300269

申请日：2017-05-11

Applicant: DSM IP ASSETS B.V.

Inventor： Matthias BELLER ,  Werner BONRATH ,  Johannes Gerardus DE VRIES ,  Yuting FAN ,  Sandra HÜBNER ,  Laurent LEFORT ,  Jonathan Alan MEDLOCK ,  Pim PUYLAERT ,  Richard VAN HECK

IPC: C07C29/149 ,  B01J31/18 ,  B01J31/22 ,  B01J31/24

CPC classification number: C07C29/149 ,  B01J31/0212 ,  B01J31/1805 ,  B01J31/181 ,  B01J31/226 ,  B01J31/24 ,  B01J31/2404 ,  B01J2231/643 ,  B01J2531/0258 ,  B01J2531/821 ,  B01J2531/825 ,  B01J2531/842 ,  B01J2531/845 ,  C07C31/125 ,  C07C33/14 ,  C07C33/22 ,  C07C33/32 ,  C07C2601/16 ,  C07C31/20

Abstract: The present invention relates to a selective reduction of esters to their corresponding alcohols.

公开(公告)号：US10280439B2

公开(公告)日：2019-05-07

申请号：US14997530

申请日：2014-07-18

Applicant: DSM IP ASSETS B.V. ,  ROQUETTE FRÈRES SA

Inventor： Mickel Leonardus August Jansen ,  René Verwaal ,  Laurent Segueilha ,  Mélanie Louchart ,  Tania Veiga Dos Inocentes

IPC: C12P7/44 ,  C12P7/46 ,  C12N1/18

Abstract: The present invention relates to a method for a dicarboxylic acid, which method comprises fermenting fungal cells in a vessel comprising a suitable fermentation medium, wherein a least a portion of the fungal cells are reused in the presence of a vitamin and/or a trace element.

公开(公告)号：US10233287B2

公开(公告)日：2019-03-19

申请号：US14763617

申请日：2014-01-30

Applicant: DSM IP ASSETS B.V.

Inventor： Rudy Rulkens ,  Renier Henricus Maria Kierkels ,  Geert Adelina Rudolf Vanden Poel ,  Theo Joseph Cuypers ,  Eric Grolman

IPC: C08G69/32 ,  C07C51/41 ,  C07C209/68 ,  C08G69/26 ,  C07C211/09 ,  C07C211/12 ,  C08G69/28

Abstract: The invention relates to a process for preparing a salt from diamine and dicarboxylic acid, the process comprising contacting a diamine gas, having a gas temperature T-gas, with a dicarboxylic acid, thereby forming a reaction mixture comprising diamine/dicarboxylic acid salt, wherein the dicarboxylic acid and the reaction mixture are kept at a temperature T-mixture of at least 10° C. below the lowest of the melting temperature of the dicarboxylic acid (Tm-acid) and the melting temperature of the resulting diamine/dicarboxylic acid salt (Tm-salt). The invention also relates to a process for preparing a polyamide comprising preparing a salt from diamine and dicarboxylic acid.

公开(公告)号：US20190078105A1

公开(公告)日：2019-03-14

申请号：US15765549

申请日：2016-10-05

Applicant: DSM IP ASSETS B.V.

Inventor： Johannes Gustaaf Ernst VAN LEEUWEN ,  Priscilla ZWARTJENS ,  Viktor Marius BOER

IPC: C12N15/81 ,  C12N9/02 ,  C12N15/70 ,  C12N9/88

CPC classification number: C12N15/815 ,  C12N9/0071 ,  C12N9/0073 ,  C12N9/88 ,  C12N15/70 ,  C12P19/56 ,  C12Y114/14 ,  C12Y402/03019

Abstract: The present invention relates a variant polypeptide having kaurenoic acid 13-hydroxylase activity, which variant polypeptide comprises an amino acid sequence which, when aligned with a kaurenoic acid 13-hydroxylase comprising the sequence set out in SEQ ID NO: 1, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 72, 85, 108, 127, 129, 141, 172, 195, 196, 197, 199, 226, 236, 291, 302, 361 or 464, said positions being defined with reference to SEQ ID NO: 1 and wherein the variant has one or more modified properties as compared with a reference polypeptide having kaurenoic acid 13-hydroxylase activity. A variant polypeptide of the invention may be used in a recombinant host for the production of steviol or a steviol glycoside.

公开(公告)号：US20190062794A1

公开(公告)日：2019-02-28

申请号：US16173805

申请日：2018-10-29

Applicant: DSM IP ASSETS B.V.

Inventor： Bertus NOORDAM ,  Michael Petrus Jozef Berkhout

IPC: C12P19/02 ,  D21C3/26 ,  C13K13/00 ,  C12P19/14 ,  C13K1/02

CPC classification number: C12P19/02 ,  C12P19/14 ,  C12P2203/00 ,  C13K1/02 ,  C13K13/00 ,  C13K13/002 ,  D21C3/26 ,  Y02E50/16

Abstract: The invention relates to a process for the preparation of a fermentation product from lignocellulosic material, comprising the following steps: a) optionally, pre-treatment of the lignocellulosic material, b) optionally, washing of the optionally pretreated lignocellulosic material, c) enzymatic hydrolysis of the optionally washed and/or optionally pretreated lignocellulosic material using an enzyme composition comprising at least two cellulases and whereby the enzyme composition at least comprises LPMO, and optionally purifying the hydrolysed lignocellulosic material, d) fermentation of the hydrolysed lignocellulosic material to produce a fermentation product, and e) optionally, recovery of a fermentation product, wherein oxygen is consumed in amounts corresponding to between 20 and 5000 mmol molecular oxygen per kg glucan present in the lignocellulosic material, the oxygen is added after the pretreatment and before and/or during the enzymatic hydrolysis of the lignocellulosic material, preferably in an amount corresponding to at least 30 mmol molecular oxygen per kg glucan present in the lignocellulosic material, more preferably in an amount corresponding to at least 40 mmol molecular oxygen per kg glucan present in the lignocellulosic material, and most preferably in an amount corresponding to at least 50 mmol molecular oxygen per kg glucan present in the lignocellulosic material is consumed.

公开(公告)号：US20190062577A1

公开(公告)日：2019-02-28

申请号：US16080389

申请日：2017-03-10

Applicant: DSM IP Assets B.V.

Inventor： Wilhelmus Frederikus ZOETELIEF ,  Alexander Antonius Marie STROEKS ,  Patrick Gerardus DUIS

IPC: C09D11/102 ,  C08G69/36 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  B29C64/118 ,  B29C64/209

Abstract: The invention relates to a method for forming a three-dimensional object by fused filament fabrication comprising the step of selectively dispensing a polymer composition containing a semi-crystalline copolyamide in accordance with the shape of a portion of a three-dimensional object, characterized that the semi-crystalline copolyamide comprises: a) At least 70 wt. % of aliphatic monomeric units derived from i. Aminoacid A, or ii. diamine B and diacid C, and b) At least 0.5 wt. % of further monomeric units derived from a cyclic monomer, wherein wt. % is with respect to the total weight of the semi-crystalline copolyamide. The invention relates also relates to objects attainable by this method and to the use of the said semi-crystalline copolyamide in fused filament fabrication.

公开(公告)号：US20190054063A1

公开(公告)日：2019-02-21

申请号：US16166357

申请日：2018-10-22

Applicant: DSM IP ASSETS B.V.

Inventor： Szabolcs PETER ,  Joseph SCHWAGER ,  Weerasinghe M. INDRASENA ,  Jaroslav A. KRALOVEC ,  Bernd MUSSLER

IPC: A61K31/355 ,  A61K31/22 ,  A61P1/16

CPC classification number: A61K31/355 ,  A61K31/22 ,  A61P1/16

Abstract: The present invention relates to the use of mixtures of vitamin E and polyunsaturated fatty acids (PUFAs) as agents for the prevention, control and/or treatment of conditions associated with excessive fat accumulation in the liver which is not caused by alcohol abuse. This includes prevention, control and/or treatment of non-alcoholic steatosis in the liver—known as non-alcoholic fatty liver disease (NAFLD)—and/or non-alcoholic steatohepatitis (NASH) in a subject in need thereof. In particular, the present invention relates to the use of such compounds comprising vitamin E acetate and DHA EE as active ingredients in the manufacture of medicaments for the prevention, control and/or treatment of conditions related to NAFLD.