公开(公告)号：US20210348173A1

公开(公告)日：2021-11-11

申请号：US17335812

申请日：2021-06-01

Applicant: Genomatica, Inc.

Inventor： Derek L. GREENFIELD ,  Andreas W. SCHIRMER ,  Elizabeth J. CLARKE ,  Eli S. GROBAN ,  Bernardo M. DA COSTA ,  Zhihao HU ,  Kevin HOLDEN ,  Noah HELMAN

IPC: C12N15/70 ,  C12N9/04 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12N9/90 ,  C12N9/00 ,  C12P7/04 ,  C12P7/64

Abstract: The disclosure relates to recombinant host cells including strain modifications effective to improve titer, yield and/or productivity of fatty acid derivatives. The disclosure further relates to cell cultures including the recombinant host cells for the fermentative production of fatty acid derivatives and compositions thereof.

公开(公告)号：US20210324430A1

公开(公告)日：2021-10-21

申请号：US17164025

申请日：2021-02-01

Applicant: Genomatica, Inc.

Inventor： Zhihao HU ,  Vikranth ARLAGADDA

IPC: C12P7/64 ,  C12N1/20 ,  B21D51/26 ,  C12P7/04

Abstract: Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.

公开(公告)号：US20210238609A1

公开(公告)日：2021-08-05

申请号：US17008243

申请日：2020-08-31

Applicant: Genomatica, Inc.

Inventor： Anthony P. Burgard ,  Robin E. Osterhout ,  Priti Pharkya ,  Stefan Andrae ,  Ewa Teresa Lis ,  Carla Risso ,  John Douglas Trawick

IPC: C12N15/63 ,  C12P5/02 ,  C12P7/04 ,  C12P7/18 ,  C12N9/88 ,  C07K14/195 ,  C12N15/52 ,  C12N9/10 ,  C12N9/90 ,  C07C1/24 ,  C07C11/167 ,  C07C31/20 ,  C07C33/025 ,  C09D147/00 ,  C09J147/00

Abstract: Provided herein are non-naturally occurring microbial organisms having a FaldFP, a FAP and/or metabolic modifications which can further include a MMP, a MOP, a hydrogenase and/or a CODH. These microbial organisms can further include a butadiene, 13BDO, CrotOH, MVC or 3-buten-1-ol pathway. Additionally provided are methods of using such microbial organisms to produce butadiene, 13BDO, CrotOH, MVC or 3-buten-1-ol.

公开(公告)号：US11046635B2

公开(公告)日：2021-06-29

申请号：US15954451

申请日：2018-04-16

Applicant: GENOMATICA, INC.

Inventor： Zhihao Hu ,  Fernando Valle

IPC: C07C69/533 ,  C12N1/20 ,  C12N1/16 ,  C12N1/14 ,  C12N1/12 ,  C07C69/34 ,  C07C69/52 ,  C10L1/02 ,  C10L1/19 ,  C11C3/00 ,  C12P7/64 ,  C12N9/02 ,  C12N9/10 ,  C12N9/16 ,  C12N9/00

Abstract: Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as biofuels.

公开(公告)号：US20210164002A1

公开(公告)日：2021-06-03

申请号：US17120586

申请日：2020-12-14

Applicant: Genomatica, Inc.

Inventor： Stephen B. DEL CARDAYRE ,  Louis G. HOM

IPC: C12P13/00 ,  C12N9/02 ,  C12N9/10 ,  C12N9/16 ,  C12N9/00 ,  C12N9/06

Abstract: The disclosure relates to recombinant microorganisms for the production of fatty amines and derivatives thereof. Further contemplated are cultured recombinant host cells as well as methods of producing fatty amines by employing these host cells.

公开(公告)号：US10975402B2

公开(公告)日：2021-04-13

申请号：US16548545

申请日：2019-08-22

Applicant: GENOMATICA, INC.

Inventor： Jason J. Lutes ,  Stephen B. Del Cardayre

IPC: C12N1/20 ,  C12P13/02 ,  C12N9/18 ,  C12N9/10 ,  C12N15/70 ,  C12N9/16

Abstract: The disclosure relates to a recombinant microorganism engineered to express an enzyme which catalyzes the conversion of a primary amine and an acyl thioester to a fatty amide. The disclosure further encompasses a method of producing a fatty amide by culturing the recombinant microorganism in the presence of a carbon source.

公开(公告)号：US20210040514A1

公开(公告)日：2021-02-11

申请号：US16736405

申请日：2020-01-07

Applicant: Genomatica, Inc.

Inventor： Andreas W. Schirmer ,  Mathew A. Rude ,  Shane A. BRUBAKER

IPC: C12P7/64 ,  C12N9/02 ,  C10L1/02 ,  C12N9/88 ,  C12P7/04 ,  C12P7/24 ,  C12P5/02

Abstract: Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein. The aldehydes, alkanes, and alkenes can be used in biofuels.

公开(公告)号：US10894953B2

公开(公告)日：2021-01-19

申请号：US15873977

申请日：2018-01-18

Applicant: Genomatica, Inc.

Inventor： Andrew M. Shumaker ,  Bernardo M. da Costa ,  Kevin Holden ,  Louis G. Hom ,  Tarah S. Baron ,  Noah Helman

IPC: C12N9/18 ,  C12N9/10 ,  C12P7/64

Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.

公开(公告)号：US20210009983A1

公开(公告)日：2021-01-14

申请号：US16802133

申请日：2020-02-26

Applicant: Genomatica, Inc.

Inventor： Derek L. GREENFIELD ,  Donald E. TRIMBUR ,  Andreas W. SCHIRMER ,  Cindy CHANG ,  Behnaz BEHROUZIAN ,  Jessica WINGER

IPC: C12N9/00 ,  C07K14/245 ,  C12P7/64

Abstract: The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.

公开(公告)号：US20210002195A1

公开(公告)日：2021-01-07

申请号：US16799743

申请日：2020-02-24

Applicant: Genomatica, Inc.

Inventor： SVB Janardhan Garikipati ,  Michael Japs ,  Ishmael M. Sonico

IPC: C07C29/80 ,  C12P7/18 ,  C08G18/32 ,  C08G65/34 ,  B01D3/00 ,  B01D3/14 ,  C07C31/20

Abstract: A process of purifying 1,4-butanediol (1,4-BDO) from a fermentation broth including separating solid materials, salts and water, and subjecting the resulting material to a two, three or four column distillation system, that can include a wiped film evaporator to produce a purified 1,4-butanediol.