公开(公告)号：US20150187691A1

公开(公告)日：2015-07-02

申请号：US14408887

申请日：2013-06-25

Applicant: Research Triangle Institute

Inventor： Eric Paul Vick

IPC: H01L23/498 ,  H01L23/00 ,  H01L21/768

CPC classification number: H01L23/49827 ,  H01L21/02107 ,  H01L21/76898 ,  H01L24/24 ,  H01L24/29 ,  H01L24/80 ,  H01L24/82 ,  H01L24/83 ,  H01L24/92 ,  H01L24/94 ,  H01L24/95 ,  H01L25/0657 ,  H01L25/162 ,  H01L25/50 ,  H01L2224/24146 ,  H01L2224/2919 ,  H01L2224/80203 ,  H01L2224/8036 ,  H01L2224/80896 ,  H01L2224/82031 ,  H01L2224/821 ,  H01L2224/83203 ,  H01L2224/8336 ,  H01L2224/92 ,  H01L2224/9202 ,  H01L2224/9212 ,  H01L2224/92144 ,  H01L2224/94 ,  H01L2225/06541 ,  H01L2924/0002 ,  H01L2924/0665 ,  H01L2924/0675 ,  H01L2924/07025 ,  H01L2924/12042 ,  H01L2924/00 ,  H01L2924/00014 ,  H01L2224/80001 ,  H01L2224/82 ,  H05K3/4661 ,  H01L2224/83

Abstract: An electronic package may be fabricated by forming a first layer of insulating material on a first substrate such that the first layer covers a contact pad; forming an opening through the first layer to expose the contact pad; forming an un-patterned second layer on the first layer, the second layer including an adhesive having a viscosity less than that of the first layer, wherein a region of the second layer obstructs the contact pad; removing the region to re-expose the contact pad; aligning a second substrate with the first substrate such that a via of the second substrate is aligned with the opening; bonding the first substrate and the second substrate together at the second layer; and forming an interconnect in contact with the contact pad by depositing a conductive material through the via and the opening.

Abstract translation: 可以通过在第一基板上形成第一绝缘材料层来制造电子封装，使得第一层覆盖接触垫; 通过所述第一层形成开口以暴露所述接触垫; 在所述第一层上形成未图案化的第二层，所述第二层包括粘度小于所述第一层粘度的粘合剂，其中所述第二层的区域阻碍所述接触垫; 去除区域以重新暴露接触垫; 将第二基板与第一基板对准，使得第二基板的通孔与开口对准; 在第二层将第一基板和第二基板接合在一起; 以及通过通过所述通孔和所述开口沉积导电材料来形成与所述接触焊盘接触的互连。

公开(公告)号：US20150141416A1

公开(公告)日：2015-05-21

申请号：US14537124

申请日：2014-11-10

Applicant: Research Triangle Institute ,  Dignity Health d/b/a St. Joseph's Hospital and Medical Center and Barrow Neurological Institute ,  Virginia Commonwealth University

Inventor： Frank Ivy Carroll ,  Bruce E. Blough ,  Hernan A. Navarro ,  S. Wayne Mascarella ,  Ana Zamfira Muresan ,  M. Imad Damaj ,  Ronald J. Lukas

IPC: C07D265/32

CPC classification number: C07D265/32 ,  A61K31/5375

Abstract: The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.

Abstract translation: 本发明提供能够抑制一种或多种单胺再摄取和/或在烟碱型乙酰胆碱受体上作为拮抗剂的羟基安非他丁类似物。 所述化合物可以选择性地结合一种或多种单胺转运蛋白，包括用于多巴胺，去甲肾上腺素和5-羟色胺的单胺转运蛋白和/或可以选择性地结合一种或多种烟碱型乙酰胆碱受体亚型。 这些化合物可用于治疗对单胺水平的修饰和/或烟碱乙酰胆碱受体的拮抗作用有反应的病症，包括药物依赖性，抑郁症和肥胖症。

公开(公告)号：US09022649B2

公开(公告)日：2015-05-05

申请号：US13645765

申请日：2012-10-05

Applicant: Research Triangle Institute, International

Inventor： John Lewis ,  Ethan Klem ,  Jeffrey Robert Piascik ,  Garry Brian Cunningham

IPC: G01K11/00 ,  G01K11/32

CPC classification number: G01K11/3213

Abstract: A temperature sensor includes a photon source, a fluorescent element and a photodetector. The fluorescent element includes a temperature-insensitive first fluorophore and a temperature-sensitive second fluorophore. The photodetector includes a first photosensor exhibiting a first spectral responsivity and a second photosensor exhibiting a second spectral responsivity. To measure a temperature of a surface, the fluorescent element may be placed adjacent to the surface and irradiated with a photon beam. First photons emitted from the first fluorophore and second photons emitted from the second fluorophore are collected. The first and second photons may be transmitted as a single dichromatic beam to the photodetector. The photosensors generate two different photodetector output signals, the ratio of which may be correlated to temperature.

Abstract translation: 温度传感器包括光子源，荧光元件和光电检测器。 荧光元件包括温度不敏感的第一荧光团和温度敏感的第二荧光团。 光检测器包括具有第一光谱响应性的第一光电传感器和呈现第二光谱响应度的第二光电传感器。 为了测量表面的温度，荧光元件可以放置在表面附近并用光子束照射。 从第一荧光团发射的第一光子和从第二荧光团发射的第二光子被收集。 第一和第二光子可以作为单个二色光束传输到光电检测器。 光电传感器产生两个不同的光电检测器输出信号，其比例可能与温度相关。

公开(公告)号：US20150079408A1

公开(公告)日：2015-03-19

申请号：US14395230

申请日：2013-04-18

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Jeffrey Robert Piascik ,  Brian R. Stoner

IPC: A61C13/083 ,  A61C5/10 ,  A61C13/08 ,  A61C5/08 ,  A61C8/00

CPC classification number: A61C13/083 ,  A61C5/20 ,  A61C5/70 ,  A61C5/73 ,  A61C5/77 ,  A61C8/005 ,  A61C13/082 ,  A61K6/0017 ,  A61K6/0235 ,  A61K6/024 ,  A61L27/10 ,  A61L27/306 ,  A61L2430/12

Abstract: A fluorine-containing porcelain, such as a porcelain material comprising a fluorine-doped glass, is provided for use in dental applications. The porcelain may be used to overlie at least a portion of a dental component such that an interface between the porcelain and the dental component comprises a fluorinated metal oxide. Methods for producing such fluorine-containing porcelains and for treating dental components with such fluorine-containing porcelains are also provided. The fluorine-containing porcelain may exhibit enhanced bonding to the underlying dental component such as a high strength ceramic.

Abstract translation: 提供含氟陶瓷，例如包含掺氟玻璃的瓷材料，用于牙科应用。 瓷器可以用于覆盖牙齿部件的至少一部分，使得瓷器和牙科部件之间的界面包括氟化金属氧化物。 还提供了用这种含氟瓷制造这种含氟瓷和用于处理牙科成分的方法。 含氟瓷可以显示出与诸如高强度陶瓷等底层牙科成分的增强的粘结。

公开(公告)号：US20150031689A1

公开(公告)日：2015-01-29

申请号：US14378479

申请日：2013-02-15

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Rangan Maitra ,  Alan Bradley Fulp ,  Yanan Zhang ,  Herbert H. Seltzman

IPC: C07D473/34

CPC classification number: C07D473/34

Abstract: The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.

Abstract translation: 本发明提供了能够根据下式用作大麻素受体拮抗剂的化合物：这些化合物可用于治疗涉及大麻素受体系统的病症，例如肥胖症，肝病，糖尿病，疼痛和炎症。

公开(公告)号：US20150005315A1

公开(公告)日：2015-01-01

申请号：US14364003

申请日：2012-12-10

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Frank I. Carroll ,  James B. Thomas ,  Hernan A. Navarro ,  S. Wayne Mascarella ,  Scott P. Runyon ,  Chunyang Jin ,  Chad M. Kormos

IPC: C07D401/12 ,  C07D241/04

CPC classification number: C07D401/12 ,  C07D241/04 ,  C07D295/13

Abstract: Provided are compounds represented by the formula: where R, Y3, R1, R2, R3, R4, R6, G, R7, E1, E2, A, B, W, X, Y and Z are as defined herein.

Abstract translation: 提供了由下式表示的化合物：其中R，Y3，R1，R2，R3，R4，R6，G，R7，E1，E2，A，B，W，X，Y和Z如本文所定义。

公开(公告)号：US08864341B2

公开(公告)日：2014-10-21

申请号：US14103110

申请日：2013-12-11

Applicant: Research Triangle Institute

Inventor： James Lynn Davis ,  Larry Charles Michael ,  Karmann C. Mills

IPC: F21V7/10 ,  F21V13/08 ,  F21V9/00 ,  F21V5/00 ,  F21V7/22

CPC classification number: F21V7/10 ,  F21V5/00 ,  F21V7/0008 ,  F21V7/043 ,  F21V7/22 ,  F21V9/00 ,  F21V9/30 ,  F21V13/02 ,  F21V13/08

Abstract: A fiber-based reflective lighting device. The lighting device includes a source configured to generate a primary light, a substrate including a mat of reflective nanofibers, and a light exit configured to emanate the reflected light. The fibers have an average fiber diameter AFD less than 500 nm which diffusively reflects visible light upon illumination with at least the primary light. The mat has a basis weight less than 40 gram per square meter (gsm) and a reflectance greater than 80%.

Abstract translation: 一种基于光纤的反光照明装置。 照明装置包括：被配置为产生初级光的源，包括反射性纳米纤维的基板的基板和被配置为发出反射光的光出射。 纤维具有小于500nm的平均纤维直径AFD，其至少在初级光照射时扩散地反射可见光。 垫的基重小于40克/平方米（gsm），反射率大于80％。

公开(公告)号：US20140308688A1

公开(公告)日：2014-10-16

申请号：US14362942

申请日：2012-12-07

Applicant: Research Triangle Institute

Inventor： Sonia Grego ,  Brian Rhys Stoner ,  Kristin Hedgepath Gilchrist ,  Timothy Raymond Fennell ,  Ann Pitruzzello

IPC: G01N33/50

CPC classification number: G01N33/5014 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/028 ,  B01L2300/0645 ,  B01L2400/0481 ,  B01L2400/0487 ,  C12M21/08 ,  C12M23/16 ,  C12M23/44 ,  C12M35/08 ,  G01N33/5082

Abstract: A multiple flow-based microfluidic cell culture system that emulates mammalian physiology is provided. Tissue-mimicking cell cultures are connected by flow within a physiologically meaningful arrangement so that the pharmacokinetics of various agents to be tested in the system emulate in vivo conditions. The system includes at least two organ tissue modules, each organ tissue module including a first chamber containing an organ tissue cell, the first chamber including an inlet and an outlet for flow of an organ tissue cell-specific culture medium; a second chamber including an inlet and an outlet for flow of a blood material; and a semi-permeable membrane separating the first and second chambers. The flow of blood material through each organ tissue module is interconnected and the flow of tissue-cell specific culture medium is directed to a single organ tissue module.

Abstract translation: 提供了一种模拟哺乳动物生理学的基于多流的微流体细胞培养系统。 组织模拟细胞培养物在生理上有意义的排列下通过流动连接，使得在系统中待测试的各种试剂的药代动力学模拟体内条件。 所述系统包括至少两个器官组织模块，每个器官组织模块包括含有器官组织细胞的第一腔室，所述第一腔室包括用于器官组织细胞特异性培养基流动的入口和出口; 第二室，包括用于血液材料流动的入口和出口; 以及分离第一和第二室的半透膜。 通过每个器官组织模块的血液材料的流动相互连接，并且组织细胞特异性培养基的流动被引导到单个器官组织模块。

公开(公告)号：US08847487B2

公开(公告)日：2014-09-30

申请号：US13938754

申请日：2013-07-10

Applicant: Research Triangle Institute

Inventor： James Lynn Davis ,  Anthony L. Andrady ,  David S. Ensor ,  Li Han ,  Howard J. Walls

IPC: F21V8/00 ,  D01D5/00 ,  D04H1/42 ,  D01F11/00 ,  D06M11/52 ,  H01L33/50

CPC classification number: G02B6/0008 ,  C09K11/565 ,  C09K11/883 ,  D01D5/0007 ,  D01F11/00 ,  D04H1/413 ,  D04H1/42 ,  D04H1/4382 ,  D06M11/52 ,  H01L33/501 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A device for stimulable light emission that includes a fiber mat of nanofibers having an average fiber diameter in a range between 100 and 2000 nm, and includes plural stimulable particles disposed in association with the nanofibers. The stimulable particles produce secondary light emission upon receiving primary light at a wavelength λ. The average fiber diameter is comparable in size to the wavelength λ in order to provide scattering sites within the fiber mat for the primary light. Various methods for making suitable luminescent nanofiber mats include: electrospinning a polymer solution including or not including the stimulable particles and forming from the electrospun solution nanofibers having an average fiber diameter between 100 and 2000 nm. Methods, which electrospin without the stimulable particles, introduce the stimulable particles during electrospinning or after electrospinning to the fibers and therefore to the resultant fiber mat.

Abstract translation: 一种可刺激发光的装置，其包括平均纤维直径在100和2000nm之间的纳米纤维的纤维垫，并且包括与纳米纤维相关联地设置的多个可刺激的颗粒。 可接受的颗粒在接收波长为λ的原始光时产生二次发光。 平均纤维直径在尺寸上与波长λ相当，以便为初级光提供纤维垫内的散射部位。 用于制备合适的发光纳米纤维毡的各种方法包括：将包含或不包含可刺激颗粒的聚合物溶液静电纺丝并由平均纤维直径在100和2000nm之间的电纺丝溶液纳米纤维形成。 没有刺激性颗粒的静电纺丝的方法是在静电纺丝过程中或静电纺丝后引入可刺激的颗粒到纤维上，从而导致所得的纤维垫。

公开(公告)号：US20140287230A1

公开(公告)日：2014-09-25

申请号：US14356755

申请日：2012-11-09

Applicant: RESEARCH TRIANGLE INSTITUTE ,  NORTH CAROLINA STATE UNIVERSITY

Inventor： Howard J. Walls ,  David S. Ensor ,  Christopher J. Oldham ,  Gregory N. Parsons

IPC: B01D39/08 ,  D03D1/00 ,  D03D15/00 ,  D04H1/728

CPC classification number: B01D39/08 ,  B01D39/1615 ,  B01D2239/025 ,  B01D2239/0492 ,  C23C16/403 ,  C23C16/4417 ,  C23C16/45555 ,  D03D1/00 ,  D03D15/0061 ,  D04H1/728 ,  Y10T428/268

Abstract: A fiber media and a filter device. The fiber media has a plurality of nanofibers formed of a polymer material, having diameters less than 1 micron, and formed into a fiber mat. A barrier layer is disposed on the nanofibers to prevent dissolution of the nanofibers in the fiber mat upon exposure of the fiber mat to a solvent of the polymer material. The barrier layer coated nanofibers have a maximum strain before breakage of at least 2%. The filter device includes the fiber media and a support attached to the fiber mat.

Abstract translation: 纤维介质和过滤装置。 纤维介质具有由聚合物材料形成的多个纳米纤维，其直径小于1微米，并形成纤维垫。 阻挡层设置在纳米纤维上，以防止纤维垫暴露于聚合物材料的溶剂时纳米纤维在纤维垫中的溶解。 阻隔层涂覆的纳米纤维在断裂之前具有至少2％的最大应变。 过滤装置包括纤维介质和附着到纤维垫的支撑件。