公开(公告)号：US08623069B2

公开(公告)日：2014-01-07

申请号：US13758674

申请日：2013-02-04

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Syed F. A. Hossainy ,  David C. Gale

IPC: A61F2/06

CPC classification number: A61F2/91 ,  A61F2210/0004 ,  A61F2250/0018 ,  A61F2250/0042 ,  B29C35/0266 ,  B29C71/0063 ,  B29C71/02 ,  B29L2031/753

Abstract: A medical device such as a stent having selected regions with different material properties than other regions is disclosed. Selection and modification of the regions may be based on facilitating a desired mechanical behavior and/or therapeutic prophylactic property of the device.

Abstract translation: 公开了一种诸如具有与其它区域不同的材料特性的选定区域的支架的医疗装置。 区域的选择和修饰可以基于促进装置的期望的机械行为和/或治疗性预防性质。

公开(公告)号：US20140004312A1

公开(公告)日：2014-01-02

申请号：US13969476

申请日：2013-08-16

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Philip Foreman ,  Charles W. Snyder ,  Gregg Teaby ,  Eric Penn

IPC: A61L31/08

CPC classification number: A61L31/08 ,  A61F2/82 ,  A61F2/915 ,  A61F2002/91575 ,  A61F2250/0036 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L2420/02 ,  Y10T428/24612 ,  Y10T428/24802

Abstract: A coating and a method of coating an implantable medical device, such as a stent, is disclosed. The coating compensates for regions of higher stress and resulting strain due to the geometry of the device. Certain embodiments may include a nonuniform coating on the device in which a strain on the nonuniform coating is less than a strain on a uniform coating when the device is placed under an applied stress during use. Other embodiments may include a coating with a greater resistance to strain on higher strain regions of the device.

Abstract translation: 公开了涂覆和涂覆可植入医疗装置（例如支架）的方法。 该涂层由于器件的几何形状而补偿较高应力和结果的应变区域。 某些实施方案可以包括在该装置上的不均匀涂层，其中当该装置在使用过程中施加应力时，该不均匀涂层上的应变小于均匀涂层上的应变。 其它实施方案可以包括在器件的较高应变区上具有较大耐应变性的涂层。

公开(公告)号：US20140004250A1

公开(公告)日：2014-01-02

申请号：US13953656

申请日：2013-07-29

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Syed F.A. Hossainy ,  Fuh-Wei Tang ,  Lothar W. Kleiner ,  Thierry Glauser ,  Yiwen Tang ,  Wouter E. Roorda ,  Stephen D. Pacetti ,  Gina Zhang ,  Yung-Ming Chen ,  Andrew F. McNiven ,  Sean A. McNiven ,  Brandon J. Yoe

IPC: A61L31/10

CPC classification number: A61L31/10 ,  A61L27/40 ,  A61L27/44 ,  A61L27/50 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/00

Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.

Abstract translation: 本公开教导了控制来自聚合物基质的试剂的释放速率的方法，其包括在聚合物基质中设计和产生预定的初始形态（IM）分布。 教导尤其表明，对药剂释放速率的控制可以提供对药剂施用的改进控制，以及对聚合物基质的机械完整性和吸收速率的影响。

公开(公告)号：US20130344047A1

公开(公告)日：2013-12-26

申请号：US14014659

申请日：2013-08-30

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS, INC.

Inventor： Stephen D. Pacetti ,  Jeffrey B. Huff ,  Paul Consigny

IPC: A61K35/14 ,  A61K38/19 ,  A61K45/06

CPC classification number: A61K35/19 ,  A61K38/195 ,  A61K38/196 ,  A61K45/06 ,  A61M25/104 ,  A61M2025/0087 ,  A61M2025/009 ,  A61M2025/105 ,  A61K2300/00

Abstract: Methods and compositions for treating heart failure by administration of beneficial agents to the heart.

Abstract translation: 通过向心脏施用有益剂治疗心力衰竭的方法和组合物。

公开(公告)号：US20130338634A1

公开(公告)日：2013-12-19

申请号：US13898413

申请日：2013-05-20

Applicant: Abbott Cardiovascular Systems, Inc.

Inventor： Shubhayu Basu ,  Gregory Waimong Chan ,  Sungwoo Min

IPC: A61M25/00

CPC classification number: A61M25/003 ,  A61K9/0019 ,  A61K9/06 ,  A61M25/0084 ,  A61M25/10 ,  A61M2025/0085 ,  A61M2025/0087

Abstract: Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.

公开(公告)号：US20130333430A1

公开(公告)日：2013-12-19

申请号：US13954139

申请日：2013-07-30

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： William J. Boyle ,  Wayne E. Cornish ,  Raleigh A. Purtzer

IPC: A61M25/09

CPC classification number: A61M25/09 ,  A61M2025/09175 ,  Y10T29/49986 ,  Y10T29/5187

Abstract: A guide wire for use in a medical procedure having a shapeable tip integral with and made from the distal end of a superelastic nitinol distal section of the guide wire, wherein the shapeable tip can be finger kinked. Such a guide wire includes an elongated core made from a superelastic nitinol alloy at the distal end, the distal end of the elongated core having a tapered section leading to a shapeable distal tip. The shapeable tip is an extension of the distal end of the nitinol distal section, and includes permanent strain hardening from at least two different radial directions imparting crystallographic texture in the radial directions that eliminate superelasticity so that permanent deformation can be achieved with finger pressure.

Abstract translation: 一种用于医疗过程的导丝，其具有与引导线的超弹性镍钛诺远端部分的远端一体并由远端制成的可成形尖端，其中可成形尖端可以被扭曲。 这种导丝包括在远端由超弹性镍钛诺合金制成的细长芯，细长芯的远端具有通向可成形的远端的锥形部分。 可成形尖端是镍钛诺骨远端部分的远端的延伸部，并且包括从至少两个不同径向方向的永久性应变硬化，其赋予径向方向上的结晶学结构，从而消除超弹性，从而可以用手指压力实现永久变形。

公开(公告)号：US20130324676A1

公开(公告)日：2013-12-05

申请号：US13959651

申请日：2013-08-05

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Yunbing Wang

IPC: A61L31/06 ,  A61L31/04

CPC classification number: A61L31/06 ,  A61L31/041 ,  Y10T428/1352 ,  C08L67/04

Abstract: Medical devices, such as stents, fabricated at least in part from a polymer composite including a biodegradable elastomeric phase dispersed within a biodegradable polymeric matrix are disclosed. The composite is composed of a polyurethane block copolymer including soft polymer blocks and a hard polymer blocks.

公开(公告)号：US20130317591A1

公开(公告)日：2013-11-28

申请号：US13957349

申请日：2013-08-01

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Paul Consigny ,  Tracey KRAUSA ,  Matthew C. MARKERT

IPC: A61F2/82

CPC classification number: A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2/91 ,  A61F2250/0023 ,  A61F2250/0035 ,  A61F2250/0036 ,  A61F2250/0067 ,  A61M1/3655

Abstract: A drug-eluting stent having a first cell pattern at one end and a second cell pattern on an opposite end. The cells in the first cell pattern have a smaller MCUSA than those in the second cell pattern. An anti-restonic drug can be coated on the first cell pattern and an anti-thrombotic drug on the second, with the anti-thrombotic drug overlaying and covering both the first and second cell patterns. The stent is operatively positionable at a distal graft-vein anastomosis with the first cell pattern adjacent the stenosis, and with the second cell pattern positioned adjacent the vein or the graft.

Abstract translation: 药物洗脱支架在一端具有第一细胞图案，另一端具有第二细胞图案。 第一细胞图案中的细胞具有比第二细胞图案中的细胞更小的MCUSA。 抗重排药物可以涂覆在第一细胞图案和抗血栓形成药物上，其中抗血栓形成药物覆盖并覆盖第一和第二细胞图案。 支架可操作地定位在远端移植物静脉吻合处，第一细胞图案与狭窄相邻，并且第二细胞图案位于静脉或移植物附近。

公开(公告)号：US20130313237A1

公开(公告)日：2013-11-28

申请号：US13914524

申请日：2013-06-10

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Li Chen ,  Randolf Von Oepen

IPC: A61M25/00

CPC classification number: B23K26/067 ,  A61F2/82 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61M25/0013 ,  B23K26/0604 ,  B23K26/0626 ,  B23K26/064 ,  B23K26/324 ,  B23K26/36 ,  B23K26/361 ,  B23K26/362 ,  B23K26/38

Abstract: A system and method for precision cutting using multiple laser beams is described, The system and method includes a combination of optical components that split the output of a single laser into multiple beams, with the power, polarization status and spot size of each split beam being individually controllable, while providing a circularly polarized beam at the surface of a work piece to be cut by the laser beam. A system and method for tracking manufacture of individual stents is also provided.

Abstract translation: 描述了使用多个激光束进行精密切割的系统和方法。该系统和方法包括将单个激光器的输出分成多个光束的光学部件的组合，每个分束的功率，极化状态和光斑尺寸为 同时在由激光束切割的工件的表面提供圆偏振光束。 还提供了用于跟踪单个支架的制造的系统和方法。

公开(公告)号：US08591934B2

公开(公告)日：2013-11-26

申请号：US13677115

申请日：2012-11-14

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Syed Faiyaz Ahmed Hossainy ,  Thierry Glauser ,  Mikael O. Trollsas

IPC: A61F2/00

CPC classification number: A61K47/32 ,  A61F2/82 ,  A61K45/06 ,  A61K47/65 ,  A61K47/6957 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L33/26

Abstract: An implantable device including a conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided.

Abstract translation: 提供了包括由丙烯酰胺类共聚物和生物活性剂形成的共轭物的可植入装置。