公开(公告)号：US20140014231A1

公开(公告)日：2014-01-16

申请号：US14032358

申请日：2013-09-20

Applicant: EMD Millipore Corporation

Inventor： Pierre Guedon

IPC: G01N1/10

CPC classification number: C12M33/07 ,  B01L3/567 ,  G01N1/10 ,  G01N35/1097 ,  G01N2001/022

Abstract: The device for the transfer of a medium comprises a magazine having two main faces (17) of which one is adapted to cooperate with a container and a lateral face (18) extending between said main faces (17) as well as at least one sliding valve (3) housed in a cavity of said magazine (2) and in which there is formed a transfer duct (59) for said medium which issues on said face (17) adapted to cooperate with said container, said valve (3) having a closed position in which it sealingly isolates said duct (59) from said container and an open position in which said duct (59) is placed in communication with said container; said valve (3) comprising a valve member (40), an isolation sleeve (41) surrounding at least partially said valve member (40) as well as spring means (58) adapted to be compressed by said valve member (40) when said valve (3) is in its open position.

公开(公告)号：US20130306539A1

公开(公告)日：2013-11-21

申请号：US13950646

申请日：2013-07-25

Applicant: EMD Millipore Corporation

Inventor： Sebastien Cirou ,  Jean-Louis Weissenbach ,  Rene Reinbigler ,  Jean-Luc Beulay ,  Frans Mels ,  Cecile Delbos

IPC: B01D25/12

CPC classification number: B23P19/04 ,  B01D25/127 ,  B01D25/14 ,  B01D25/164 ,  B01D25/19 ,  B01D61/18 ,  B01D61/20 ,  B01D63/082 ,  B01D2313/02 ,  B01D2313/06 ,  B01D2313/105 ,  B01D2313/125 ,  Y10T29/49826

Abstract: The invention concerns a filtration device comprising a manifold (3) providing fluid connection and mechanical connection comprising a clamping plate (4) movably mounted relative to the manifold (3) and adapted to compress at least one cassette (2) against the manifold (3), means for driving and guiding the clamping plate comprising a rod (6) extending between the manifold (3) and the plate (4), an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold (3), and the member carrying the rod (6) and driving the plate (4) via the rod (6) to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.

Abstract translation: 本发明涉及一种过滤装置，其包括提供流体连接的歧管（3）和包括相对于歧管（3）可移动地安装并适于将至少一个盒（2）压靠在歧管（3）上的夹板 ），用于驱动和引导夹持板的装置，其包括在歧管（3）和板（4）之间延伸的杆（6），致动器，其设置有主体和相对于主体可移动的构件，该构件适于 在延伸位置和缩回位置之间移动预定行程，主体由歧管（3）承载，并且承载杆（6）并且通过杆（6）驱动板（4）的构件被夹紧 其中构件处于其相对于其延伸位置移动经过比预定行程更短的行程的中间缩回位置的位置。

公开(公告)号：US20130269425A1

公开(公告)日：2013-10-17

申请号：US13914880

申请日：2013-06-11

Applicant: EMD Millipore Corporation

Inventor： Pascal Rajagopalan ,  Antony Vanheghe ,  Celine Le Ninivin ,  Aristotelis Dimitrakopoulos

IPC: G01N27/06

CPC classification number: G01N27/06 ,  G01N33/1826 ,  Y02A20/206

Abstract: This is a device for analyzing the quantity of organic compounds existing in a liquid, such as ultrapure water, at the outlet from a purification device including in series filter means (1), oxidation means (2) and polishing means (3), further including means for measuring the resistivity of water to determine the purity thereof, characterized in that it includes only one resistivity measuring cell (4) and in that the outlet points of said filter means (1) and said oxidation means (2) are connected to said resistivity measuring cell (4) by pipes provided with an analysis valve (6) and/or check valves (5) selectively enabling circulation of said liquid within them.

Abstract translation: 这是用于在包括串联过滤装置（1），氧化装置（2）和抛光装置（3）的净化装置的出口处分析存在于液体中的有机化合物如超纯水的量的装置， 包括用于测量水的电阻率以确定其纯度的装置，其特征在于，其仅包括一个电阻率测量单元（4），并且所述过滤装置（1）和所述氧化装置（2）的出口点连接到 所述电阻率测量单元（4）由设有分析阀（6）和/或止回阀（5）的管道选择性地使所述液体在其内循环。

公开(公告)号：US20130248371A1

公开(公告)日：2013-09-26

申请号：US13887657

申请日：2013-05-06

Applicant: EMD Millipore Corporation

Inventor： Andrej Grabowski

IPC: C02F1/469

CPC classification number: C02F1/4695 ,  B01D61/485 ,  B01D61/52 ,  B01D61/54 ,  B01J47/028 ,  B01J47/04 ,  B01J47/06 ,  B01J49/09 ,  B01J49/30 ,  C02F2209/03 ,  C02F2303/16

Abstract: Device for the removal of ions from a polar liquid, e.g. water, comprising at least one compartment which comprises at least one inlet for an entering polar liquid flow and at least one outlet for an outgoing deionized liquid flow, in which said compartment an electrochemically regenerable ion-exchange material fills a zone through which zone a liquid flow is able to pass, the device being characterized in that it comprises one sensor of at least one dimensional change of the ion-exchange material. The sensor can comprise a photo-sensor or a sensor of mechanical stress. Preferably an apparatus connected to the sensor is able to analyze this dimensional change and to control the electric current. Method of using said device, whereby the electrical current applied to the device is controlled according to the expansion of the resin.

Abstract translation: 用于从极性液体除去离子的装置，例如 水，包括至少一个隔室，其包括用于进入的极性液体流的至少一个入口和用于输出的去离子液体流的至少一个出口，其中所述隔室为电化学可再生的离子交换材料填充通过该区域的液体 流动能够通过，该装置的特征在于它包括离子交换材料的至少一维变化的一个传感器。 传感器可以包括光传感器或机械应力传感器。 优选地，连接到传感器的装置能够分析该尺寸变化并控制电流。 使用所述装置的方法，由此根据树脂的膨胀来控制施加到装置的电流。

公开(公告)号：US20130236926A1

公开(公告)日：2013-09-12

申请号：US13868263

申请日：2013-04-23

Applicant: EMD MILLIPORE CORPORATION

Inventor： Christian Schann ,  Bruno Duquet ,  Abdel Hajila ,  Frederic Olivieri

IPC: G01N21/76

CPC classification number: C12Q1/24 ,  B05B12/20 ,  G01N21/763

Abstract: The device for spraying a reagent onto a support (81) adapted to retain microorganisms on a predetermined surface (82), comprises a spraying bell (3) as well as a nozzle (71) for emitting a jet of droplets of said reagent into a spraying chamber (34) comprised by said bell (3), said device also comprising an absorbent pad (5) mounted against said bell (3) transversely to said jet and closing said chamber (34) from the opposite side to said nozzle (71) with the exception of a circular central opening (51) provided in said pad (5), the diameter of said central opening (51) being adapted to enable a portion of said jet, when said device faces said support (81) and is at a predetermined distance therefrom, to pass through said central opening (51) over its entire area and be deposited on the whole of said predetermined surface (82) of said support (81).

Abstract translation: 用于将试剂喷洒到适于将微生物保留在预定表面（82）上的支撑体（81）上的装置包括喷雾钟（3）以及喷嘴（71），用于将所述试剂的液滴喷射到 喷雾室（34），所述装置还包括一个吸收垫（5），该吸收垫（5）横向于所述射流安装在所述钟形（3）上，并从所述喷嘴（71）的相对侧关闭所述腔室 ），除了设置在所述垫（5）中的圆形中心开口（51）之外，所述中心开口（51）的直径适于使所述装置的一部分当所述装置面向所述支撑件（81）并且是 在其预定距离处穿过所述中心开口（51）遍及其整个区域并且沉积在所述支撑件（81）的整个所述预定表面（82）上。

公开(公告)号：US20130062280A1

公开(公告)日：2013-03-14

申请号：US13669494

申请日：2012-11-06

Applicant: EMD MILLIPORE CORPORATION

Inventor： David P. Yavorsky

IPC: B01D39/14

CPC classification number: B01D39/2079 ,  B01D2239/0407 ,  B01D2239/08 ,  B01J20/10 ,  B01J20/103 ,  B01J20/14 ,  B01J20/165 ,  B01J20/18 ,  B01J20/20 ,  B01J20/28026 ,  B01J20/2803

Abstract: Adsorbent filter media particularly suited for removal of biological contaminants in process liquids. A porous fixed bed of adsorbent material is formed, using only a granular adsorbent and a water-insoluble thermoplastic binder. The resulting composite filter allows for a higher amount of adsorbent with smaller adsorbent particles than conventional depth filters. Elimination of cellulose fiber, as well as the elimination of the thermoset binder, results in reduced contamination of the process liquid.

Abstract translation: 吸附剂过滤介质特别适用于去除工艺液体中的生物污染物。 仅使用粒状吸附剂和水不溶性热塑性粘合剂形成吸附剂材料的多孔固定床。 所得到的复合过滤器允许比常规深度过滤器更大量的具有较小吸附剂颗粒的吸附剂。 消除纤维素纤维以及消除热固性粘合剂导致工艺液体的污染减少。

公开(公告)号：US20130039382A1

公开(公告)日：2013-02-14

申请号：US13654595

申请日：2012-10-18

Applicant: EMD Millipore Corporation

Inventor： Aaron Burke ,  Michael Felo ,  Brian Pereira ,  Elias Noukas ,  Dennis Wong

IPC: G01N25/00

CPC classification number: F25D29/00 ,  A01N1/0263 ,  F25D2331/802 ,  F25D2400/28 ,  F25D2400/30 ,  F25D2600/06 ,  F25D2700/12 ,  Y10T29/53

Abstract: The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.

Abstract translation: 本发明的生物容器提供了在生物药物材料的运输，冷冻和解冻期间遇到的许多问题的低成本，简单的解决方案。 本发明使得用户能够在低温过程期间监测每个生物药物容器的温度曲线，以便通过使用预先安装和预灭菌的温度传感器来确保每个生物容器内的材料的完整性。 在一些实施例中，传感器组件包括无线发射器，并且能够发送关于测量读数的信息。 在其他实施例中，传感器组件包括处理单元，其确定温度分布是否可接受。 在另一实施例中，包括指示器，使得处理单元可以指示生物药物材料是否已被适当地冷冻。 在其他实施例中，传感器组件还包括存储元件，其能够在冷冻过程期间存储各种参数。

公开(公告)号：US20130038469A1

公开(公告)日：2013-02-14

申请号：US13654593

申请日：2012-10-18

Applicant: EMD Millipore Corporation

Inventor： Aaron Burke ,  Michael Felo ,  Brian Pereira ,  Elias Noukas ,  Dennis Wong

IPC: G08C19/00

CPC classification number: F25D29/00 ,  A01N1/0263 ,  F25D2331/802 ,  F25D2400/28 ,  F25D2400/30 ,  F25D2600/06 ,  F25D2700/12 ,  Y10T29/53

Abstract: The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.

公开(公告)号：USD1073119S1

公开(公告)日：2025-04-29

申请号：US29865758

申请日：2022-08-11

Applicant: EMD Millipore Corporation

Designer： Paul Sydlowski

公开(公告)号：US12226737B2

公开(公告)日：2025-02-18

申请号：US16096516

申请日：2017-05-26

Applicant: EMD Millipore Corporation

Inventor： Jonathan Steen

IPC: B01D63/10 ,  B01D61/02 ,  B01D61/14 ,  B01D63/14

Abstract: The present invention provides a filter element (500) having a radial permeate discharge path (550). The filter element generally includes a closed membrane structure (510) wrapped about a core (530) in reciprocating clockwise and counterclockwise directions, forming semicircular folds of membrane about the core. The semicircular folds of membrane have opposingly situated apical ends (560) separated by a gap. The interior of the closed membrane structure (510) defines a feed channel and the exterior of the closed membrane structure defines at least one permeate channel (522). A radial permeate discharge path (550) extends through the gap between the apical ends of the semicircular folds of membrane. Systems containing, and methods of using, filter elements including radial permeate discharge paths are also provided.