公开(公告)号：US08968676B2

公开(公告)日：2015-03-03

申请号：US14273661

申请日：2014-05-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Ulrich Porsch ,  Bernd Steiger ,  Gertrud Albrecht ,  Uwe Wittmann

IPC: G01N33/00 ,  G06F19/24 ,  A61B5/145 ,  G01N33/487 ,  G06F19/00

CPC classification number: G06F19/24 ,  A61B5/14532 ,  G01N33/48764 ,  G06F19/00 ,  G16H40/40

Abstract: A hand-held device for measuring an analyte concentration in a sample of a body liquid includes a display means for displaying measured values; a measured-value storage for storing measured values; a measuring unit for generating measured values through measurements of the analyte concentration; a clock; a control unit for generating measured value datasets, each containing a measured value supplied by the measuring unit as well as the date and hour of the measurement by which the measured value was obtained, and for writing them into the measured-value storage; and operating elements that can be actuated by the user to set the clock, in which case the control unit will generate a time-correction dataset indicating the amount and direction of the setting effected. The control unit writes time-correction datasets into the measured-value storage so that a chronologically ordered sequence is generated containing time-correction datasets and measured value datasets.

Abstract translation: 用于测量体液的样品中的分析物浓度的手持式装置包括显示测量值的显示装置; 用于存储测量值的测量值存储器; 测量单元，用于通过测量分析物浓度产生测量值; 一个钟; 用于产生测量值数据集的控制单元，每个测量值数据集包含由测量单元提供的测量值以及获得测量值的测量的日期和时间，并将其写入测量值存储器中; 以及可由用户启动以设置时钟的操作元件，在这种情况下，控制单元将产生指示所设置的数量和方向的时间校正数据集。 控制单元将时间校正数据集写入测量值存储器，从而生成包含时间校正数据集和测量值数据集的按时间顺序排序的序列。

公开(公告)号：US20150057616A1

公开(公告)日：2015-02-26

申请号：US14189139

申请日：2014-02-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Oliver Shergold ,  Simon Scheurer

IPC: A61M5/19 ,  A61M5/168 ,  A61M5/34 ,  A61M5/142 ,  A61M5/315

CPC classification number: A61M5/19 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/157 ,  A61M5/14216 ,  A61M5/16809 ,  A61M5/1723 ,  A61M5/20 ,  A61M5/204 ,  A61M5/24 ,  A61M5/31548 ,  A61M5/31593 ,  A61M5/34 ,  A61M2005/14268 ,  A61M2005/1587 ,  A61M2005/3128 ,  A61M2205/3327 ,  A61M2205/3561 ,  A61M2205/52

Abstract: At least one hand-held injection device for the metered injection of a liquid drug into a person's tissue is disclosed. The exemplary injection device comprises an elongated drug reservoir having a longitudinal reservoir axis (A), an elongated dosing unit having a dosing unit inlet, a dosing unit outlet, and a metering cavity, the dosing unit having a longitudinal dosing unit axis (A′), the elongated drug reservoir being fluidically coupled to the dosing unit inlet. The dosing unit and the drug reservoir are arranged such that the longitudinal dosing unit axis (A′) is in parallel alignment with the reservoir axis (A). The dosing unit structured to allow the flow of the liquid drug from the drug reservoir into the metering cavity via the dosing unit inlet, thus charging the metering cavity, and to subsequently discharge the metering cavity by dosing drug out of the metering cavity into the dosing unit outlet.

Abstract translation: 公开了用于将液体药物计量注射到人的组织中的至少一个手持式注射装置。 示例性注射装置包括具有纵向储存器轴线（A）的细长药物储存器，具有计量单元入口，计量单位出口和计量腔的细长计量单元，所述计量单元具有纵向给药单位轴线（A' ），细长的药物储存器流体耦合到计量单元入口。 配量单元和药物储存器布置成使得纵向计量单元轴线（A'）与储存器轴线（A）平行对准。 所述计量单元被构造成允许液体药物从药物储存器经由计量单元入口流入计量空腔，从而对计量腔进行充电，并且随后通过将药物从计量腔排出到计量腔中而排出计量腔 单位出口

公开(公告)号：US20150037898A1

公开(公告)日：2015-02-05

申请号：US14516653

申请日：2014-10-17

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Susanne Baldus ,  Jochen Schulat ,  Sebastian Trick

IPC: G01N21/27 ,  G01N33/50 ,  G01N33/66

CPC classification number: G01N21/272 ,  G01N21/8483 ,  G01N33/50 ,  G01N33/66 ,  Y10T436/142222 ,  Y10T436/144444

Abstract: Devices and methods are provided for determining concentration of at least one analyte in a body fluid sample such as blood, especially a blood glucose concentration. In the methods, a test element is provided that has at least one reagent element configured so as to carry out at least one optically detectable detection reaction in the presence of the analyte. The body fluid sample is applied to the test element and a time course of at least one optical measurement variable of the reagent element is detected. At least one first time interval of the time course of the optical measurement variable is used to determine at least one disturbance variable value in the body fluid sample, in particular a concentration of a disturbance variable such as hematocrit. At least one second time interval of the time course is used to determine analyte concentration. The at least one disturbance variable value can be used to correct/compensate the analyte concentration.

Abstract translation: 提供了用于确定体液样品如血液中的至少一种分析物的浓度，特别是血糖浓度的装置和方法。 在所述方法中，提供了具有至少一个试剂元件的测试元件，其被配置为在分析物存在下进行至少一种可光学检测的检测反应。 将体液样品施加到测试元件，并且检测到试剂元件的至少一个光学测量变量的时间过程。 使用光学测量变量的时间过程的至少一个第一时间间隔来确定体液样品中的至少一个干扰变量值，特别是诸如血细胞比容的干扰变量的浓度。 使用时间过程的至少一个第二时间间隔来确定分析物浓度。 可以使用至少一个干扰变量值来校正/补偿分析物浓度。

公开(公告)号：US20150024429A1

公开(公告)日：2015-01-22

申请号：US14503473

申请日：2014-10-01

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Otter ,  Thomas Fischer ,  Stefanie Froehner ,  Phillip Miller ,  Matthew Mette

IPC: G01N1/31 ,  B05D1/40 ,  B05C5/02 ,  G01N1/30

CPC classification number: G01N1/31 ,  B05C5/02 ,  B05D1/40 ,  G01N1/2813 ,  G01N1/30 ,  G01N35/00069

Abstract: A method for the homogeneous distribution of cell components suspended in a liquid on a surface and a device for the implementation thereof.

Abstract translation: 用于均匀分布悬浮在表面上的液体中的细胞组分的均匀分布的方法和用于实施它的装置。

公开(公告)号：USD721177S1

公开(公告)日：2015-01-13

申请号：US29490174

申请日：2014-05-07

Applicant: Roche Diagnostics Operations, Inc.

Designer： Joakim Ahlstrom ,  Michel A. Cadio ,  Sebastian Liedtke ,  Aydin Mert

公开(公告)号：US20150012027A1

公开(公告)日：2015-01-08

申请号：US14325471

申请日：2014-07-08

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Ahmet Konya

IPC: A61B5/15

CPC classification number: A61B5/1411 ,  A61B5/14 ,  A61B5/15 ,  A61B5/150022 ,  A61B5/150412 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150519 ,  A61B5/151 ,  A61B5/15111 ,  A61B5/15117 ,  A61B5/15128 ,  A61B5/15146 ,  A61B5/1519 ,  A61B5/15194

Abstract: A lancing actuator (114) includes a drive element (118) for driving a lancing element, the drive element being guided within a housing (112), a combined compression and torsion element (120) which, by a relaxing movement thereof, is adapted to drive the lancing motion, a combined triggering and driving device (122) having an actuating element (124) and a locking device (126), wherein the actuating element has an initial state and an actuated state and is accessible from the outside of the housing, wherein, in the initial state, the drive element is locked in the locking device under a torsional stress exerted by the combined compression and torsion element, wherein the combined triggering and driving device is configured in a manner that, when the actuating element makes a movement along an actuation path from the initial state into the actuated state, a torque is exerted on the drive element which prevails over the torsional stress exerted by the combined compression and torsion element such that the drive element is released from the locking device, which results in a triggering of the lancing motion.

Abstract translation: 牵引致动器（114）包括用于驱动穿刺元件的驱动元件（118），所述驱动元件在壳体（112）内被引导，组合的压缩和扭转元件（120）通过其轻松的移动被适配 驱动穿刺运动的组合的触发和驱动装置（122）具有致动元件（124）和锁定装置（126），其中致动元件具有初始状态和致动状态，并且可从外部 壳体，其中，在初始状态下，驱动元件在组合的压缩和扭转元件施加的扭转应力下被锁定在锁定装置中，其中组合的触发和驱动装置被构造成使得当致动元件 沿着从初始状态到致动状态的致动路径的运动，扭矩施加在驱动元件上，其主要超过由组合的压缩和扭转元件施加的扭转应力 使得驱动元件从锁定装置释放，这导致刺血运动的触发。

公开(公告)号：US20150005605A1

公开(公告)日：2015-01-01

申请号：US14486402

申请日：2014-09-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Arnulf Staib ,  Marcel Thiele ,  Karl-Heinz Koelker ,  Ewald Rieger

IPC: G01N27/327 ,  A61B5/145 ,  A61B5/1486

Abstract: An electrode system is disclosed for measuring a concentration or presence of an analyte under in-vivo conditions, where the electrode system includes at least one electrode with immobilized enzyme molecules and an improved diffusion barrier that controls diffusion of the analyte from body fluid surrounding the electrode system to the enzyme molecules. The diffusion barrier includes a hydrophilic polyurethane or a block copolymer having at least one hydrophilic block and at least one hydrophobic block. The electrode system also can include a spacer membrane that includes a hydrophilic copolymer of acrylic and/or methacrylic monomers.

Abstract translation: 公开了用于在体内条件下测量分析物的浓度或存在的电极系统，其中电极系统包括具有固定化酶分子的至少一个电极和改善的扩散阻挡层，其控制分析物从电极周围的体液的扩散 系统对酶分子。 扩散阻挡层包括具有至少一个亲水嵌段和至少一个疏水嵌段的亲水性聚氨酯或嵌段共聚物。 电极系统还可以包括间隔膜，其包括丙烯酸和/或甲基丙烯酸单体的亲水共聚物。

公开(公告)号：US20140371630A1

公开(公告)日：2014-12-18

申请号：US14473015

申请日：2014-08-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Steven N. Roe

IPC: A61B5/151 ,  A61B5/145 ,  A61B5/15 ,  A61B5/157 ,  A61B5/00

CPC classification number: A61B5/15117 ,  A61B5/14532 ,  A61B5/150229 ,  A61B5/15128 ,  A61B5/15192 ,  A61B5/157 ,  A61B5/742 ,  F01D9/023 ,  F01D17/085 ,  F01D21/003 ,  F05D2260/80 ,  F05D2260/83 ,  G01M15/14 ,  G01N21/8422 ,  G01N25/72 ,  Y02T50/675

Abstract: A lancet housing assembly for use in a portable handheld medical diagnostic device for sampling bodily fluids from a skin site of a patient is provided. The lancet housing assembly comprises an outer facing side and an inner facing side. An opening is located at the outer facing side that is arranged and configured to align with a lancet port of the medical diagnostic device. A floor extends between the outer facing side and the inner facing side and having a reagent material. A lancet structure having a skin penetrating end and a blood transport portion adjacent the skin penetrating end is located in housing assembly. The blood transport portion is arranged and configured receive the amount of blood from the skin penetrating end and to carry the amount of blood away from the skin site and to the reagent material.

Abstract translation: 提供一种用于便携式手持式医疗诊断装置中用于从患者皮肤部位取样体液的柳叶刀壳体组件。 柳叶刀壳体组件包括外侧面和内侧面。 开口位于面向外侧的位置，该开口被布置和构造成与医疗诊断装置的刺血针端口对准。 地板在外侧面和内侧面之间延伸并具有试剂材料。 具有皮肤穿透端的刺血针结构和与皮肤穿透端相邻的血液输送部分位于壳体组件中。 血液输送部被配置和配置为接收来自皮肤穿透端的血液量，并且将血液量从皮肤部位运送到试剂材料。

公开(公告)号：US20140363259A1

公开(公告)日：2014-12-11

申请号：US14294197

申请日：2014-06-03

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Tom Lorenzen ,  Reto Andrin Meier

IPC: B65G65/32 ,  B65G47/44

CPC classification number: G01N35/04 ,  G01N2035/0406 ,  G01N2035/0462 ,  G01N2035/0465

Abstract: An apparatus for handling sample tubes is presented. The apparatus comprises a sample tube tray, a sample tube individualizer, a first conveyor, a second conveyor, a sample tube buffer, and a sample tube rack inserter. The sample tube tray stores sample tubes in bulk commodity.The sample tube individualizer sequentially unloads single sample tubes from the sample tube tray and sequentially provides the unloaded sample tubes to the first conveyor. The first conveyor conveys the sample tubes to the sample tube buffer. The sample tube buffer buffers the sample tubes provided by the first conveyor and provides buffered sample tubes to the second conveyor with a predeterminable, constant, sample tube rate. The second conveyor conveys the sample tubes to the sample tube rack inserter. The sample tube rack inserter inserts the sample tubes into a sample tube rack.

Abstract translation: 提出了一种处理样品管的设备。 该装置包括样品管托盘，样品管分离器，第一输送器，第二输送器，样品管缓冲器和样品管架插入器。 样品管托盘以大宗商品存储样品管。 样品管分离器顺序地从样品管盘中卸载单个样品管，并且将未加载的样品管依次提供给第一输送机。 第一个输送机将样品管传送到样品管缓冲液。 样品管缓冲液缓冲由第一输送机提供的样品管，并以可预定的，恒定的样品管速度将缓冲的样品管提供给第二输送机。 第二个输送器将样品管传送到样品管架插入器。 样品管支架插入器将样品管插入样品管架。

公开(公告)号：US08899290B2

公开(公告)日：2014-12-02

申请号：US13764999

申请日：2013-02-12

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Wolfgang Schwoebel ,  Joerg Dreibholz

IPC: B32B41/00 ,  B32B38/00 ,  B05C11/00 ,  G01N35/00

CPC classification number: B32B38/0008 ,  B05C11/00 ,  G01N35/00009 ,  G01N35/00029 ,  G01N35/00732 ,  G01N2035/00168 ,  Y10T29/49826 ,  Y10T156/10

Abstract: A method for producing an analytical consumable is proposed. The analytical consumable comprises at least one carrier and at least one analytical aid connected to the carrier. At least one optically sensitive material is applied to the carrier, said material being designed to carry out at least one optically detectable alteration in the event of action of an electromagnetic radiation. In at least one coding step, at least one function information item about the analytical consumable is introduced into the optically sensitive material by means of electromagnetic radiation. The function information item is designed to enable at least one analytical instrument to use the analytical consumable correctly.

Abstract translation: 提出了生产分析消耗品的方法。 分析消耗品包括至少一个载体和连接到载体的至少一种分析助剂。 至少一种光敏材料被施加到载体上，所述材料被设计成在电磁辐射的作用的情况下执行至少一种可光学检测的改变。 在至少一个编码步骤中，通过电磁辐射将关于分析耗材的至少一个功能信息项引入到光敏材料中。 功能信息项旨在使至少一个分析仪器正确使用分析耗材。