公开(公告)号：US20190310085A1

公开(公告)日：2019-10-10

申请号：US16400764

申请日：2019-05-01

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE - CNR ,  UNIVERSITA DEGLI STUDI DI FIRENZE

Inventor： Massimiliano LOCATELLI ,  Pasquale POGGI ,  Eugenio PUGLIESE ,  Giorgio LACANNA

IPC: G01C15/00 ,  G01M5/00 ,  G03H1/04 ,  G03H1/00 ,  G01B11/16 ,  G03H1/08 ,  G01B9/02

Abstract: A system for monitoring a building structure is described. The system comprises a laser source which emits an infrared radiation and an interferometric arrangement which divides the radiation into an object beam and a reference beam. The object beam irradiates the building structure and is scattered by it, while the reference beam interferes with the scattered object beam so as to create a hologram of the building. The system also comprises a sensor which detects a sequence of holograms and a processing unit which reconstructs the evolution in time of deformations or displacements of the building by numerically processing the sequence of holograms. The system—being based on digital holography—offers various advantages compared to known monitoring techniques, for example techniques which make use of seismometers (possibility of remote monitoring, substantial space-time continuity of the monitoring, capacity for detecting a wider range of deformations and displacements).

公开(公告)号：US10429519B2

公开(公告)日：2019-10-01

申请号：US15763985

申请日：2016-09-19

Applicant: UNIVERSITÀ DEGLI STUDI DI PARMA ,  CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Jacopo Aleotti ,  Stefano Caselli ,  Giorgio Micconi ,  Giacomo Benassi ,  Nicola Zambelli ,  Andrea Zappettini ,  Davide Calestani

IPC: G01T1/169 ,  G01T7/00 ,  G01V5/02 ,  G05D1/00

Abstract: A system (10) for the remote detection of substances, comprising a vehicle (20) that is mobile in space and remote-piloted using a control device (40) with a haptic interface suitable to return a force feedback to a user of the control device (40), wherein the vehicle (20) is equipped with a position sensor (22) and a sensor (21) for detecting a physical quantity whose intensity depends on the distance of at least one substance present in a detection point located in a vicinity of the position of the vehicle (20).

公开(公告)号：US10286085B2

公开(公告)日：2019-05-14

申请号：US14909854

申请日：2014-07-26

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Claudio Passananti ,  Nicoletta Corbi ,  Maria Grazia Di Certo ,  Elisabetta Mattei ,  Cinzia Pisani ,  Georgios Strimpakos

IPC: A61K48/00 ,  C07K14/47 ,  G01N33/68 ,  C07K14/005 ,  C12N15/86 ,  A61K38/00

Abstract: The present invention features recombinant adeno-associated vectors for delivery of genes to both skeletal and cardiac muscle and methods for treatment of muscle defects, including Duchenne's muscular dystrophy.

公开(公告)号：US20180344843A1

公开(公告)日：2018-12-06

申请号：US16007685

申请日：2018-06-13

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Angelo FONTANA ,  Emiliano MANZO ,  Adele CUTIGNANO ,  Raffaele DE PALMA

IPC: A61K39/39 ,  C07H13/06

Abstract: The present invention relates to beta-glycolipid derivatives, their preparation and use as adjuvants in vaccines, as being suitable for being co-administered with antigens for vaccine prophylaxis and therapy.In certain embodiments, the beta-glycolipid derivatives of the invention also in their salified or complex form, are suitable for being co-administered with antigens for both therapeutic and prophylactic purposes or for vaccine prophylaxis and therapy.

公开(公告)号：US10101208B2

公开(公告)日：2018-10-16

申请号：US14784705

申请日：2014-04-15

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Giovanni Giusfredi ,  Iacopo Galli ,  Pablo Cancio Pastor ,  Davide Mazzotti ,  Paolo De Natale

IPC: G01J3/42 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/39 ,  G01J3/02 ,  G01N21/27 ,  G01N21/03

Abstract: The present invention relates to a ring-down spectrometry apparatus in absorption saturation condition, for measuring the concentration of a gas through a measurement of the spectrum of a molecular transition of said gas. The apparatus includes a laser source, an adjuster for varying the wavelength of said radiation emitted by said laser, and a resonant cavity. A photodetector is adapted to detect an electromagnetic radiation beam and is adapted to generate a decay signal. An electronic circuit receives the signal from the photodetector and is adapted to convert it to a processor. A processor is adapted to receive said decay signal from the photodetector and perform interpolation to obtain a concentration of said gas.

公开(公告)号：US20180008968A1

公开(公告)日：2018-01-11

申请号：US15545536

申请日：2016-01-21

Applicant: UNIVERSITÉ DE STRASBOURG ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - ,  CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Cuong PHAM-HUU ,  Giuliano GIAMBASTIANI ,  Yuefeng LIU ,  Housseinou BA ,  Lam NGUYEN-DINH ,  Jean-Mario NHUT ,  Cuong DUONG-VIET

IPC: B01J27/24 ,  B01J37/02 ,  B01J27/224 ,  B01J35/00 ,  B01J35/02 ,  C01B17/04 ,  B01J37/04 ,  B01J21/04 ,  B01J35/10 ,  H01M4/96 ,  C07C5/333

Abstract: Some embodiments are directed to a new methodology aimed at preparing highly N-doped mesoporous carbon macroscopic composites, and their use as highly efficient heterogeneous metal-free catalysts in a number of industrially relevant catalytic transformations.

公开(公告)号：US20170371211A1

公开(公告)日：2017-12-28

申请号：US15538809

申请日：2014-12-23

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE - CNR ,  LABORATORIO EUROPEO DI SPETTROSCOPIE NON LINEARI (LENS)

Inventor： Hao ZENG ,  Piotr Jan WASYLCZYK ,  Diederik Sybolt WIERSMA ,  Camilla PARMEGGIANI ,  Chih-Hua HO

IPC: G02F1/1337 ,  G02F1/1341

CPC classification number: G02F1/133788 ,  G02F1/133753 ,  G02F1/1341 ,  G02F2001/133726

Abstract: A method is disclosed for realizing a liquid crystal tri-dimensional aligned structure, including: providing a first substrate having a first surface; forming a liquid crystal layer in contact to said first surface, said liquid crystal layer including a polymerizable liquid crystal compound; realizing a first aligning formation within said liquid crystal layer by irradiating a first portion of said liquid crystal layer with electromagnetic or electron beam radiation according to a given first pattern, so that said first portion of liquid crystal compound becomes polymerized and said first aligning formation is made of said polymerized liquid crystal compound according to said given first pattern, said first aligning structure defining a first aligning axis; locally orienting optical axes of molecules of said liquid crystal layer along said first aligning axis.

公开(公告)号：US20170313988A1

公开(公告)日：2017-11-02

申请号：US15520227

申请日：2015-10-19

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Ileana ZUCCHI ,  Valeria TRIA ,  Rolland Alvons REINBOLD

IPC: C12N5/074 ,  A61K35/12 ,  C07K14/47

CPC classification number: C12N5/0696 ,  A61K35/12 ,  C07K14/47 ,  C12N2501/998

Abstract: The present invention relates to a new transcript referred to here as INT6-5a, which is an isoform of the human transcript, known in the literature, INT6 full length (INT6-FL) encoded by the gene EIF3E (gene ID 3646, mRNA NM_001568.2), the use thereof in cellular reprogramming methods for the production of induced pluripotent stem cells or somatic stem cells, the cells obtained from such methods, and use thereof.

公开(公告)号：US20170204059A1

公开(公告)日：2017-07-20

申请号：US15469411

申请日：2017-03-24

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  UNIVERSITÀ CATTOLICA DEL SACRO CUORE

Inventor： Maria Cristina DE ROSA ,  Francesco RIA ,  Bruno GIARDINA ,  Gianfranco FERRACCIOLI ,  Davide PIROLLI ,  Chiara NICOLO'

IPC: C07D209/86

CPC classification number: C07D209/86 ,  A61K31/165 ,  A61K31/343 ,  A61K31/381 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4439 ,  C07C251/86 ,  C07C2603/18 ,  C07D207/06 ,  C07D207/08 ,  C07D209/88 ,  C07D307/91 ,  C07D401/04 ,  C07D407/12 ,  C07D409/12

Abstract: The T cells specific to human collagen type II, one of the possible autoantigens, have a crucial role in the development of rheumatoid arthritis in the context of HLA-DR4. The protein-protein interactions between the T cell receptor (TCR) and the type II collagen linked to the allele MHC of class II HLA-DR4 may thus represent the target for the development of new drugs against rheumatoid arthritis. Using computational virtual screening techniques, families of pharmacologically active molecules have been identified that interfere with the TCR/collagen II-MHCII interaction. The compounds identified here open up new possibilities in the treatment of rheumatoid arthritis.

公开(公告)号：US20170127971A1

公开(公告)日：2017-05-11

申请号：US15412265

申请日：2017-01-23

Applicant: Consiglio Nazionale delle Ricerche ,  Universita del Salento

Inventor： Sara Invitto ,  Giovanni Montagna ,  Simonetta Capone ,  Pietro Siciliano

IPC: A61B5/0484 ,  A61B5/00

CPC classification number: A61B5/04847 ,  A61B5/4011 ,  A61B5/7246 ,  A61B5/743

Abstract: Method and related system for measuring physiological parameters of a human subject undergoing an olfactory stimulation comprising one or more smelling olfactory stimuli, where by means of said system and according to said method a human subject is undergone to said olfactory stimulation by sending said one or more smelling olfactory stimuli to the human subject; one or more physiological parameters of the human subject are recorded; and said olfactory stimulation and physiological parameters recording are synchronized.