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公开(公告)号:US11124761B2
公开(公告)日:2021-09-21
申请号:US16212212
申请日:2018-12-06
Inventor: Chien-Chi Lin , Camron Scott Dawes , Heiko Konig
Abstract: Embodiments of the current invention include a hydrogel formed from crosslinked polyethylene glycol into which acrylated glucose oxidase has been immobilized through crosslinking to the gel. These hydrogels can be used to create hypoxia under ambient conditions for at least 72 hours and can be used to create hypoxic gradients. These embodiments permit the study of cells under a variety of hypoxic conditions.
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公开(公告)号:US11090560B2
公开(公告)日:2021-08-17
申请号:US16076297
申请日:2017-02-16
Inventor: Chauncey Eugene Frend
Abstract: A physical device interface for a virtual reality system is provided, comprising: a microprocessor board including a microprocessor, a plurality of control outputs, a first communication port and a second communication port; a plurality of receptacles configured to provide power to a corresponding plurality of physical devices; and a power board coupled to the plurality of control outputs and the plurality of receptacles, the power board including a plurality of channels controlled by the plurality of control outputs to provide power to the plurality of receptacles. The first communication port is configured to communicate with a computer for configuration of the interface and the second communication port is configured to communicate with another interface.
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公开(公告)号:US20210128187A1
公开(公告)日:2021-05-06
申请号:US17145574
申请日:2021-01-11
Inventor: Luke G. Gutwein , Rajiv Sood , Barry Davignon
IPC: A61B17/3201 , A61B17/285
Abstract: A scar subcision devices comprising a first elongated element comprising a pivotal connection to a second elongated element, the first elongated element having a blunt distal end, the second elongated element having a proximal-facing cutting edge at a distal end thereof, the device having a first state wherein the cutting edge is retracted to a location within an outer perimeter of the first elongated element, and a second state wherein the cutting edge is exposed outside of the outer perimeter of the first elongated element and the device transitioning between the first state and the second state by the first elongated element and the second elongated element rotating relative to each other about the pivotal connection are disclosed. Methods are also disclosed.
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公开(公告)号:US20210102177A1
公开(公告)日:2021-04-08
申请号:US17119484
申请日:2020-12-11
Inventor: Karl Russell Koehler , Jiyoon Lee
IPC: C12N5/071 , A61L27/60 , A61L27/38 , A61K35/36 , C12N5/077 , A61L27/36 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , C12Q1/6876
Abstract: Provided herein are methods for directing differentiation of human pluripotent stem cells into a three-dimensional multilayered skin composition comprising an epidermal layer, a dermal layer, and a plurality of cells capable of forming a functional hair follicle. Also provided herein are three-dimensional, multilayered engineered skin compositions and methods of using the same for drug screening, for screening compounds for effects on hair growth, and for other applications.
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公开(公告)号:US20210076647A1
公开(公告)日:2021-03-18
申请号:US16855905
申请日:2020-04-22
Inventor: A. Joseph Tector
IPC: A01K67/027 , C12N9/10 , A61K35/407 , C12N15/85 , C12N9/02 , C12N9/22 , C12N9/40 , C12N15/877 , C12N15/90
Abstract: The invention provides double knockout transgenic pigs (GT/CMAH-KO pigs) lacking expression of any functional αGAL and CMAH. Double knockout GT/CMAH-KO transgenic organs, tissues and cells are also provided. Methods of making and using the GT/CMAH-KO pigs and tissue are also provided.
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公开(公告)号:US10946174B2
公开(公告)日:2021-03-16
申请号:US15925829
申请日:2018-03-20
Inventor: Samer Abu-Sultaneh , Terri Bogue
Abstract: A tube securing device is provided comprising: a base including a lower plate and a pair of inner walls, each of the inner walls including a ledge extending therefrom which forms a notch between the ledge and the lower plate, the base further including a groove between the inner walls sized to receive a tube in communication with a cavity of a patient; and a retainer including an upper plate and a pair of retention beams, each of the retention beams including a ridge extending therefrom, the retainer further including a groove between the retention beams sized to receive the tube. The tube is retained in the groove of the base and the groove of the retainer when the retainer is attached to the base by forcing the ridges over the ledges until the ridges snap into notches.
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公开(公告)号:US20210060116A1
公开(公告)日:2021-03-04
申请号:US17094950
申请日:2020-11-11
Inventor: Mythily SRINIVASAN , Debomoy LAHIRI
Abstract: The present disclosure provides pharmaceutical compositions comprising rationally designed peptide analogs of the p65-TAD binding region of GILZ to selectively sequester activated p65. Structural and functional analyses suggest that select GILZ analog (GA) bind p65-TAD with optimum affinity, exhibit an estimated half minimal lethal dose comparable to known peptide drugs and suppress Aβ1-42 induced cytotoxicity. Furthermore, the present disclosure provides uses and methods of using the pharmaceutical compositions, and uses and methods of using pharmaceutical formulations comprising the pharmaceutical compositions, for the treatment of neurodegenerative diseases such as Alzheimer's Disease, Parkinson's Disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS).
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公开(公告)号:US20210038553A1
公开(公告)日:2021-02-11
申请号:US17026671
申请日:2020-09-21
Inventor: Mark R. Kelley , Melissa L. Fishel
IPC: A61K31/201 , A61K31/165 , A61K31/343 , A61K31/501 , A61K31/519 , A61K31/7068 , A61K31/713 , A61K33/24 , A61K45/06 , A61K31/337 , A61K31/192 , A61P35/00 , A61K33/243 , A61K31/18 , A61K31/20 , A61K31/282
Abstract: Combination therapies including a Apurinic/Apyrimidinic Endonuclease/reduction-oxidation (redox) Factor-1 (APE1/Ref-1) inhibitor specific to inhibit the redox function of APE1/Ref-1 are disclosed herein. The Combination therapies can be used for treating various cancers, as well as other angiogenesis-mediated diseases (e.g., retinal diseases, cardiovascular diseases).
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公开(公告)号:US20210037052A1
公开(公告)日:2021-02-04
申请号:US15999673
申请日:2017-02-17
Inventor: L. Jean Camp
Abstract: A system comprising a processor in electrical communication with a network and a non-transitory memory having instructions that, in response to an execution by the processor, cause the processor to monitor a routing information base (“RIB”) of the network, identify a change in the RIB, calculate a probability of suspiciousness of the change in the RIB, and classify the change in the RIB based on a continuum of trust are disclosed. Methods of managing routers are also disclosed.
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30.
公开(公告)号:US10828337B2
公开(公告)日:2020-11-10
申请号:US15891252
申请日:2018-02-07
Inventor: Mervin C. Yoder , Paul Critser , Sherry Voytik-Harbin
Abstract: Materials and methods are disclosed for controlling vasculogenesis using building blocks of a collagen matrix and endothelial colony forming cells (ECFC). The building blocks may be isolated by fractionating an acid soluble Type I collagen. The building blocks comprising monomers and/or oligomers may be recombined in desired ratios to alter the matrix microenvironment and to influence ECFC behavior.
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