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21.发明申请HEMAGGLUTININ POLYPEPTIDES, AND REAGENTS AND METHODS RELATING THERETO 审中-公开HEMAGGLUTININ POLYPEPTIDES，以及与其相关的试剂和方法公开(公告)号：US20090081193A1
公开(公告)日：2009-03-26
申请号：US11969040
申请日：2008-01-03
申请人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
发明人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
IPC分类号： A61K39/395 , C07K14/435 , C07H21/00 , C12N15/64 , C12N1/21 , A61K31/7088 , A61P31/16 , C07K16/08 , C12N7/01 , C40B40/12 , A61K38/16
CPC分类号： G01N33/5308 , G01N2400/10
摘要： The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.
摘要翻译： 本发明提供了一种用于分析聚糖和与其结合的相互作用配偶体之间的相互作用的系统。 本发明还提供结合伞形拓扑聚糖的HA多肽，以及与其相关的试剂和方法。
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公开(公告)号：US20090000287A1
公开(公告)日：2009-01-01
申请号：US12120689
申请日：2008-05-15
IPC分类号： F01N7/08
CPC分类号： F01N3/2892 , B01F3/04049 , B01F5/0644 , B01F2005/0017 , F01N3/035 , F01N3/2066 , F01N13/0093 , F01N13/0097 , F01N13/08 , F01N2240/20 , F01N2610/02 , Y02A50/2325 , Y02T10/24
摘要： A flow device for an exhaust treatment system includes a base and at least one flow deflector tube secured to the base. The flow deflector tube includes a flow inlet, a flow outlet, and a passage that extends through the flow deflector tube from the flow inlet to the flow outlet. The flow outlet is at an angled orientation to the flow inlet. A method of mixing reactants and exhaust in an exhaust treatment system includes the steps of injecting reactants into exhaust gases flowing through an exhaust conduit used to convey the exhaust gases from an engine. Bent tubes are disposed in the exhaust conduit and used to mix the exhaust gases and the reactants.
摘要翻译： 用于排气处理系统的流动装置包括底座和固定到底座的至少一个导流管。 导流管包括流入口，流出口和通过导流管从流入口延伸到流出口的通道。 流出口与流入口成倾斜的方向。 在排气处理系统中混合反应物和废气的方法包括将反应物注入流过用于输送来自发动机的废气的排气导管的废气中的步骤。 弯管设置在排气管道中并用于混合排气和反应物。
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23.发明授权公开(公告)号：US09278998B2
公开(公告)日：2016-03-08
申请号：US12829931
申请日：2010-07-02
IPC分类号： A61K39/12 , A61K38/16 , C07K14/005
CPC分类号： G01N33/56983 , C07K14/005 , C12N2760/16122 , G01N2333/11 , G01N2800/50
摘要： The present invention provides HA polypeptides (e.g., H1 HA polypeptides) that bind to umbrella-topology glycans, and reagents and methods relating thereto. The present invention provides binding agents that bind to HA polypeptides (e.g., H1 HA polypeptides), and reagents and methods relating thereto. The present invention provides interfering agents that inhibit the binding of HA polypeptides (e.g., H1 HA polypeptides) to HA receptors, and reagents and methods relating thereto. The present invention provides compositions and methods for treating, preventing, and/or diagnosing influenza infection utilizing HA polypeptides, HA polypeptide binding agents, HA polypeptide interfering agents, and/or vaccine compositions comprising any of the foregoing.
摘要翻译： 本发明提供结合伞形拓扑聚糖的HA多肽（例如，H1 HA多肽），以及与其相关的试剂和方法。 本发明提供了结合HA多肽（例如，H1HA多肽）的结合剂，以及与其相关的试剂和方法。 本发明提供抑制HA多肽（例如H1 HA多肽）与HA受体结合的干扰剂，以及与其相关的试剂和方法。 本发明提供了使用HA多肽，HA多肽结合剂，HA多肽干扰剂和/或包含任何前述物质的疫苗组合物来治疗，预防和/或诊断流感感染的组合物和方法。
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公开(公告)号：US20140148581A1
公开(公告)日：2014-05-29
申请号：US14051405
申请日：2013-10-10
IPC分类号： C07K16/10
CPC分类号： C07K16/1018 , A61K39/145 , A61K39/395 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/56983
摘要： This disclosure relates to novel peptide agents, e.g., antibodies and antigen-binding fragments thereof, that bind hemagglutinin protein of influenza viruses, and methods of their use.
摘要翻译： 本公开涉及结合流感病毒血凝素蛋白的新型肽试剂，例如其抗体及其抗原结合片段及其使用方法。
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公开(公告)号：US20130302349A1
公开(公告)日：2013-11-14
申请号：US13830367
申请日：2013-03-14
CPC分类号： C07K16/1018 , A61K39/145 , A61K39/395 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/56983
摘要： This disclosure relates to novel peptide agents, e.g., antibodies and antigen-binding fragments thereof, that bind hemagglutinin protein of influenza viruses, and methods of their use.
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26.发明申请公开(公告)号：US20120289415A1
公开(公告)日：2012-11-15
申请号：US13478662
申请日：2012-05-23
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
IPC分类号： C40B20/08
CPC分类号： G01N33/6851 , G01N33/66 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2400/10 , G16C20/20
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。
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27.发明申请INFLUENZA TREATMENT AND/OR CHARACTERIZATION, HUMAN-ADAPTED HA POLYPEPTIDES; VACCINES 有权流感病毒治疗和/或表征，人类适应的HA多肽; 疫苗公开(公告)号：US20120219585A1
公开(公告)日：2012-08-30
申请号：US13239376
申请日：2011-09-21
IPC分类号： A61K39/145 , A61P31/16 , C12Q1/70 , C07K14/11
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , C07K16/1018 , C12N7/00 , C12N2760/16122 , C12N2760/16133 , C12N2760/16134 , G01N33/56983 , G01N2333/11
摘要： The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.
摘要翻译： 本发明尤其提供用于治疗，检测，分析和/或表征流感感染的方法，试剂和系统。
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28.发明授权公开(公告)号：US08209132B2
公开(公告)日：2012-06-26
申请号：US12623070
申请日：2009-11-20
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
IPC分类号： G01N31/00
CPC分类号： G01N33/6851 , G01N33/66 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2400/10 , G06F19/703
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。
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