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38 条记录 (耗时 0.028 秒)

    Netrin receptors
    21.
    发明授权
    Netrin receptors 有权
    Netrin受体

    公开(公告)号：US07919588B2

    公开(公告)日：2011-04-05

    申请号：US12151062

    申请日：2008-05-01

    申请人： Marc Tessier-Lavigne ,  E. David Leonardo ,  Lindsay Hinck ,  Masayuki Masu ,  Kazuko Keino-Masu

    发明人： Marc Tessier-Lavigne ,  E. David Leonardo ,  Lindsay Hinck ,  Masayuki Masu ,  Kazuko Keino-Masu

    IPC分类号： G01N33/53 ,  C07K14/435

    CPC分类号： C07K14/71 ,  A61K39/00 ,  C07K16/2803 ,  C07K16/2863 ,  G01N33/6872

    摘要： The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

    摘要翻译： 本发明提供了与作为网蛋白的受体蛋白（一种细胞指导蛋白）起作用的脊椎动物UNC-5蛋白质相关的方法和组合物。 可以从所公开的编码脊椎动物UNC-5的核酸的转化宿主细胞重组产生蛋白质，或者从人细胞纯化。 本发明提供能够与所公开的脊椎动物unc-5基因，脊椎动物UNC-5特异性结合剂如特异性抗体特异性杂交的特异性杂交探针和引物，以及制备和使用本发明组合物在诊断，治疗和 生物制药行业。

    Recombinant polynucleotides encoding a slit polypeptide
    26.
    发明授权
    Recombinant polynucleotides encoding a slit polypeptide 失效
    编码狭缝多肽的重组多核苷酸

    公开(公告)号：US06270995B1

    公开(公告)日：2001-08-07

    申请号：US09540153

    申请日：2000-03-31

    申请人： Corey S. Goodman ,  Thomas Kidd ,  Katja Brose ,  Marc Tessier-Lavigne

    发明人： Corey S. Goodman ,  Thomas Kidd ,  Katja Brose ,  Marc Tessier-Lavigne

    IPC分类号： C12P2102

    CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/4702 ,  G01N33/566 ,  G01N33/68 ,  G01N2333/43573 ,  G01N2500/02

    摘要： Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides. The subject methods of modulating the interaction of Robo and a Robo ligand involve combining a Robo polypeptide, a Slit polypeptide and a modulator under conditions whereby, but for the presence of the modulator, the Robo and Slit polypeptides engage in a first interaction, whereby the Robo and Slit polypeptides engage in a second interaction different from the first interaction. In a particular embodiment, the modulator is dominant negative form of the Robo or Slit polypeptide.

    摘要翻译： 公开了用于鉴定调节Robo和Robo配体的相互作用并调节Robo和Robo配体的相互作用的试剂的方法和组合物。 用于鉴定Robo：配体调节剂的方法在商业药物筛选中发现具体应用。 这些方法通常包括（1）在条件下组合Robo多肽，狭缝多肽和候选试剂，但是对于所述试剂的存在，所述Robo和狭缝多肽参与第一相互作用，和（2）确定第二相互作用 的Robo和Slit多肽，其中所述第一和第二相互作用之间的差异指示所述琼脂调节所述Robo和Slit多肽的相互作用。 调节Robo和Robo配体的相互作用的主题方法包括在条件下组合Robo多肽，狭缝多肽和调节剂，但是对于调节剂的存在，Robo和Slit多肽参与第一相互作用，由此 Robo和Slit多肽参与与第一相互作用不同的第二相互作用。 在一个具体实施方案中，调节剂是Robo或Slit多肽的显性阴性形式。

    Nucleic acids encoding neural axon outgrowth modulators
    29.
    发明授权
    Nucleic acids encoding neural axon outgrowth modulators 失效
    核酸编码神经轴突生长调节剂

    公开(公告)号：US5565331A

    公开(公告)日：1996-10-15

    申请号：US152019

    申请日：1993-11-12

    申请人： Marc Tessier-Lavigne ,  Tito Serafini ,  Timothy Kennedy ,  Merysia Placzek ,  Thomas Jessell ,  Jane Dodd

    发明人： Marc Tessier-Lavigne ,  Tito Serafini ,  Timothy Kennedy ,  Merysia Placzek ,  Thomas Jessell ,  Jane Dodd

    IPC分类号： A01K67/027 ,  A61K38/00 ,  A61P25/00 ,  C07K14/47 ,  C07K14/475 ,  C07K14/48 ,  C07K14/705 ,  C07K14/71 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12R1/91 ,  G01N33/53 ,  G01N33/68 ,  C12N15/00

    CPC分类号： G01N33/6896 ,  C07K14/4705 ,  C07K14/475 ,  C07K14/705 ,  C07K14/71 ,  A61K38/00 ,  G01N2500/04

    摘要： A novel classes of neural axon outgrowth promoting and orienting proteins, nucleic acids encoding such proteins and receptors which selectively bind such proteins are disclosed. The disclosed neural axon outgrowth promoting and orienting proteins include the laminin-related p75/p78 family; a family of vertebrate proteins which promote axon outgrowth and/or orientation, and p75/p78 family-specific receptors, including receptors found on spinal nerve axons, especially growth cones. Also disclosed are agents including peptides derived from the disclosed neural axon outgrowth promoting proteins capable of effecting axon outgrowth, orientation and regeneration. These agents provide small molecular weight modulators of nerve cell growth useful in the treatment of neurological disease and injury. The disclosed compositions also find use variously in screening chemical libraries for regulators of axon outgrowth and orientation, in genetic mapping, as probes for related genes, as diagnostic reagents for genetic neurological disease and in the production of specific cellular and animal systems for the development of neurological disease therapy.

    摘要翻译： 公开了一类促进和定向蛋白质的神经轴突生长，编码这种蛋白质的核酸和选择性结合这些蛋白质的受体。 所公开的神经轴突生长促进和定向蛋白质包括层粘连蛋白相关的p75 / p78家族; 促进轴突生长和/或取向的脊椎动物蛋白家族，以及p75 / p78家族特异性受体，包括在脊髓神经轴突，特别是生长锥上发现的受体。 还公开了包括衍生自所公开的神经轴突生长促进能够产生轴突向外生长，取向和再生的蛋白质的肽的试剂。 这些试剂提供了可用于治疗神经疾病和损伤的神经细胞生长的小分子量调节剂。 所公开的组合物还可用于筛选用于轴突生长和取向的调节剂的化学文库，遗传作图中作为相关基因的探针，作为遗传神经疾病的诊断试剂，以及用于开发特异性细胞和动物系统的生产 神经疾病治疗。