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公开(公告)号:US20090285803A1
公开(公告)日:2009-11-19
申请号:US12465169
申请日:2009-05-13
申请人: Jasvinder Atwal , Marc Tessier-Lavigne , Yan Wu
发明人: Jasvinder Atwal , Marc Tessier-Lavigne , Yan Wu
IPC分类号: A61K39/395 , C07K16/00 , C12N15/13 , C12N15/85 , C12N1/00 , C12N5/16 , C12P21/02 , C07K16/42 , A61P25/28
CPC分类号: C07K16/2803 , C07K2317/56 , C07K2317/76
摘要: The present invention relates generally to neural development and neurological disorders. The invention specifically concerns identification of novel modulators of the myelin-associated inhibitory system and various uses of the modulators so identified.
摘要翻译: 本发明一般涉及神经发育和神经障碍。 本发明具体涉及鉴定髓鞘相关抑制系统的新型调节剂以及所鉴定的调节剂的各种用途。
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公开(公告)号:US08350010B2
公开(公告)日:2013-01-08
申请号:US13171289
申请日:2011-06-28
IPC分类号: C07K16/18
CPC分类号: A61K39/3955 , A61K45/06 , A61K51/1093 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K16/2842 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/74
摘要: The present invention relates to the use of VEGF antagonists and alpha5beta1 antagonists for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to use of a VEGFR agonists and alpha5beta1 agonists to promote angiogenesis and vascular permeability. The present invention also relates to new anti-alpha5beta1 antibodies, compositions and kits comprising them and methods of making and using them.
摘要翻译: 本发明涉及VEGF拮抗剂和α5β1拮抗剂用于治疗癌症并抑制血管生成和/或血管通透性的用途,包括抑制疾病中的异常血管发生。 本发明还涉及VEGFR激动剂和α5β1激动剂促进血管生成和血管通透性的用途。 本发明还涉及新的抗α5β1抗体,包含它们的组合物和试剂盒以及制备和使用它们的方法。
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公开(公告)号:US20120195908A1
公开(公告)日:2012-08-02
申请号:US13171289
申请日:2011-06-28
IPC分类号: A61K39/395 , A61P7/00 , C12N9/96 , C07K16/28
CPC分类号: A61K39/3955 , A61K45/06 , A61K51/1093 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K16/2842 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/74
摘要: The present invention relates to the use of VEGF antagonists and alpha5beta1 antagonists for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to use of a VEGFR agonists and alpha5beta1 agonists to promote angiogenesis and vascular permeability. The present invention also relates to new anti-alpha5beta1 antibodies, compositions and kits comprising them and methods of making and using them.
摘要翻译: 本发明涉及VEGF拮抗剂和α5β1拮抗剂用于治疗癌症并抑制血管生成和/或血管通透性的用途,包括抑制疾病中的异常血管发生。 本发明还涉及VEGFR激动剂和α5β1激动剂促进血管生成和血管通透性的用途。 本发明还涉及新的抗α5β1抗体,包含它们的组合物和试剂盒以及制备和使用它们的方法。
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公开(公告)号:US20090220504A1
公开(公告)日:2009-09-03
申请号:US12293382
申请日:2007-03-21
IPC分类号: A61K39/395 , C07K16/28 , C07H21/00 , C12N15/63 , C12N5/00 , G01N33/53 , A61P35/00 , A61P37/00 , A61P27/02
CPC分类号: A61K39/3955 , A61K45/06 , A61K51/1093 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K16/2842 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/74
摘要: The present invention relates to the use of VEGF antagonists and alpha5beta1 antagonists for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to use of a VEGFR agonists and alpha5beta1 agonists to promote angiogenesis and vascular permeability. The present invention also relates to new anti-alpha5beta1 antibodies, compositions and kits comprising them and methods of making and using them.
摘要翻译: 本发明涉及VEGF拮抗剂和α5β1拮抗剂用于治疗癌症并抑制血管生成和/或血管通透性的用途,包括抑制疾病中的异常血管发生。 本发明还涉及VEGFR激动剂和α5β1激动剂促进血管生成和血管通透性的用途。 本发明还涉及新的抗α5β1抗体,包含它们的组合物和试剂盒以及制备和使用它们的方法。
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公开(公告)号:US20120148599A1
公开(公告)日:2012-06-14
申请号:US13292633
申请日:2011-11-09
申请人: Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
发明人: Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
IPC分类号: A61K39/395 , C12N15/13 , C12N5/10 , C12P21/02 , G01N33/573 , C12N9/50 , C07K16/40 , C07K19/00
CPC分类号: C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
摘要: The invention provides antibodies to specific neural proteins and methods of using the same.
摘要翻译: 本发明提供了针对特定神经蛋白的抗体及其使用方法。
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公开(公告)号:US08772457B2
公开(公告)日:2014-07-08
申请号:US13292633
申请日:2011-11-09
申请人: Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
发明人: Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
IPC分类号: C07K16/18 , C12P21/08 , A61K39/395
CPC分类号: C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
摘要: The invention provides antibodies to specific neural proteins and methods of using the same.
摘要翻译: 本发明提供了针对特定神经蛋白的抗体及其使用方法。
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7.
公开(公告)号:US09786906B2
公开(公告)日:2017-10-10
申请号:US14420198
申请日:2012-08-08
申请人: Jihui Yang , Yan Wu , Yong Yang , Sihui Wang
发明人: Jihui Yang , Yan Wu , Yong Yang , Sihui Wang
IPC分类号: H01M4/36 , H01M10/0525 , H01M4/505 , H01M4/525
CPC分类号: H01M4/364 , H01M4/362 , H01M4/505 , H01M4/525 , H01M10/0525
摘要: Composite materials for a cathode of an electrochemical cell. The composite materials comprise Li[M1−xLix]O2 or yLi2MnO3.(1−y)LiMO2 (M=Ni, Co, Mn, 0
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公开(公告)号:US09249255B2
公开(公告)日:2016-02-02
申请号:US14385816
申请日:2012-03-20
申请人: Yan Wu , Chen Chen , Yue Shen , Yurun Yang
发明人: Yan Wu , Chen Chen , Yue Shen , Yurun Yang
IPC分类号: C09D163/02 , C09D7/00 , C09D193/00 , C08G59/24 , C08L63/00 , C09D163/00 , C08G59/22 , C08G59/62 , C08G59/64
CPC分类号: C09D163/00 , C08G59/223 , C08G59/245 , C08L63/00
摘要: This invention relates to a cardanol modified epoxy resin composition, especially, relates to a cardanol and/or dihydric phenol modified epoxy resin composition, a process making thereof and its application in low VOC high solids coating.
摘要翻译: 本发明涉及一种腰果酚改性环氧树脂组合物,特别涉及一种腰果酚和/或二元酚改性环氧树脂组合物,其制备方法及其在低VOC高固含量涂料中的应用。
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公开(公告)号:US09109035B2
公开(公告)日:2015-08-18
申请号:US13450326
申请日:2012-04-18
申请人: Wei-Ching Liang , Chie Sakanaka , Yan Wu
发明人: Wei-Ching Liang , Chie Sakanaka , Yan Wu
CPC分类号: A61K47/48638 , A61K47/6811 , A61K47/6851 , A61K47/6889 , A61K51/1045 , A61K2039/505 , C07K16/005 , C07K16/30 , C07K16/3069 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92 , C12N9/96
摘要: Anti-TAT226 antibodies and immunoconjugates thereof are provided. Methods of using anti-TAT226 antibodies and immunoconjugates thereof are provided.
摘要翻译: 提供抗TAT226抗体及其免疫偶联物。 提供了使用抗TAT226抗体及其免疫偶联物的方法。
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公开(公告)号:US08846041B2
公开(公告)日:2014-09-30
申请号:US13069582
申请日:2011-03-23
申请人: Eric Bourhis , Tim Cao , Rick Carano , Andrea Cochran , Mike Costa , Venita DeAlmeida , James Ernst , Yan Gong , Rami Hannoush , Paul Polakis , Bonnee Rubinfeld , Mark Solloway , Yan Wu
发明人: Eric Bourhis , Tim Cao , Rick Carano , Andrea Cochran , Mike Costa , Venita DeAlmeida , James Ernst , Yan Gong , Rami Hannoush , Paul Polakis , Bonnee Rubinfeld , Mark Solloway , Yan Wu
IPC分类号: A61K39/395 , C07K16/28 , C12P21/08 , A61K39/00
CPC分类号: C07K16/28 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/526 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要: The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.
摘要翻译: 本发明提供抗LRP6抗体及其使用方法。 本发明的一个特定方面提供了抑制多种Wnt同种型的信号通路的双特异性抗LRP6抗体。
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