公开(公告)号：US20140243197A1

公开(公告)日：2014-08-28

申请号：US14239221

申请日：2012-08-17

申请人： Prashant Deshmukh ,  Florian Kaiser ,  Karsten Körber ,  Markus Kordes ,  Joachim Dickhaut ,  Arun Narine ,  Nina Gertrud Bandur ,  Gemma Veitch ,  Deborah L. Culbertson ,  Paul Neese ,  Koshi Gunjima

发明人： Prashant Deshmukh ,  Florian Kaiser ,  Karsten Körber ,  Markus Kordes ,  Joachim Dickhaut ,  Arun Narine ,  Nina Gertrud Bandur ,  Gemma Veitch ,  Deborah L. Culbertson ,  Paul Neese ,  Koshi Gunjima

IPC分类号： C07D401/04 ,  A61K31/4439 ,  A01N43/56

CPC分类号： A61K31/4439 ,  A01N43/56 ,  C07D231/04 ,  C07D401/04

摘要： The present invention relates to substituted carbamoylmethoxy and carbamoylmethylthio benzamide compounds and the stereoisomers, salts, tautomers and N-oxides thereof and to compositions comprising the same. The invention also relates to the use of the carbamoylmethoxy- and carbamoylmethylthio-benzamide compounds or of the compositions comprising such compounds for combating invertebrate pests. Furthermore, the invention relates to methods of applying such compounds.

摘要翻译： 本发明涉及取代的氨基甲酰基甲氧基和氨基甲酰基甲硫基苯甲酰胺化合物及其立体异构体，盐，互变异构体和N-氧化物及其组合物。 本发明还涉及氨基甲酰基甲氧基 - 和氨基甲酰基甲硫基 - 苯甲酰胺化合物或包含这些化合物的组合物用于防治无脊椎动物害虫的用途。 此外，本发明涉及应用这些化合物的方法。

公开(公告)号：US20140163234A1

公开(公告)日：2014-06-12

申请号：US14235556

申请日：2012-08-10

申请人： Karsten Körber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frassetto ,  Gemma Veitch ,  Markus Kordes

发明人： Karsten Körber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frassetto ,  Gemma Veitch ,  Markus Kordes

IPC分类号： C07D401/04

CPC分类号： C07D401/04

摘要： The present invention relates to a process for preparing an N-substituted 1H-pyrazole-5-carbonylchloride compound of the formula (I) in which R1 is hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-fluoroalkyl, C3-C8-cycloalkyl, C3-C8-fluorocycloalkyl, C2-C6-alkenyl, C2-C6-fluoroalkenyl, C1-C6-alkoxy, C1-C6-fluoroalkoxy, C1-C4-fluoroalkoxy-C1-C4-alkyl, phenyl and the like; each R2 is independently selected from halogen, C1-C6-alkyl, C1-C6-fluoroalkyl, C3-C8-cycloalkyl, C3-C8-fluorocycloalkyl, C2-C6-alkenyl, C2-C6-fluoroalkenyl, C1-C6-alkoxy, phenyl and the like; r is 0, 1, 2, 3 or 4; comprising the steps of i) deprotonating a compound of the formula (II) in which the variables R1, R2 and r are each as defined above, with a base selected from lithium-organic base having a carbon or nitrogen bound lithium or with a magnesium-organic base having a carbon bound magnesium; and ii) subjecting the product obtained in step (i) to a chlorocarbonylation by reacting it with a reagent selected from the group consisting of phosgene or a phosgene equivalent, to obtain a compound of formula (I).

公开(公告)号：US08664235B2

公开(公告)日：2014-03-04

申请号：US10570854

申请日：2004-09-10

申请人： Ernst Baumann ,  Thomas Grote ,  Frank Schieweck ,  Wolfgang von Deyn ,  Norbert Götz ,  Michael Hofmann ,  Markus Kordes ,  Michael Puhl ,  Michael Rack ,  Thomas Schmidt ,  Toni Bucci ,  Henry Van Tuyl Cotter ,  Deborah L. Culbertson ,  Hassan Oloumi-Sadeghi

发明人： Ernst Baumann ,  Thomas Grote ,  Frank Schieweck ,  Wolfgang von Deyn ,  Norbert Götz ,  Michael Hofmann ,  Markus Kordes ,  Michael Puhl ,  Michael Rack ,  Thomas Schmidt ,  Toni Bucci ,  Henry Van Tuyl Cotter ,  Deborah L. Culbertson ,  Hassan Oloumi-Sadeghi

IPC分类号： A01N43/54 ,  A61K31/505 ,  A01N25/32

CPC分类号： C07D487/04 ,  A01N43/90

摘要： The present invention relates to a method of combating animal pests which comprises contacting the animal pests, their habit, breeding ground, food supply, plant, seed, soil, area, material or environment in which the animal pests are growing or may grow, or the materials, plants, seeds, soils, surfaces or spaces to be protected from animal attack or infestation with a pesticidally effective amount of at least one 6-halogeno[1,2,4]triazolo[1,5-a]-pyrimidine of the general formula (I), wherein X, R1, R2, R3 and R4 are as defined in claim 1 and/or the agriculturally useful salts thereof.

摘要翻译： 本发明涉及一种对抗动物害虫的方法，其包括使动物害虫，其习惯，繁殖地，食物供应，植物，种子，土壤，面积，材料或动物害虫生长或可能生长的环境接触;或 要防止动物攻击或侵染的材料，植物，种子，土壤，表面或空间，具有杀虫有效量的至少一种6-卤代[1,2,4]三唑并[1,5-a] - 嘧啶 通式（I）其中X，R 1，R 2，R 3和R 4如权利要求1所定义，和/或其农业上有用的盐。

公开(公告)号：US08211924B2

公开(公告)日：2012-07-03

申请号：US12667299

申请日：2008-07-02

申请人： Markus Kordes ,  Christopher Koradin ,  Ronan Le Vezouet ,  Ernst Baumann ,  Deborah L. Culbertson ,  Douglas D. Anspaugh ,  Hassan Oloumi-Sadeghi ,  Cecille Ebuenga

发明人： Markus Kordes ,  Christopher Koradin ,  Ronan Le Vezouet ,  Ernst Baumann ,  Deborah L. Culbertson ,  Douglas D. Anspaugh ,  Hassan Oloumi-Sadeghi ,  Cecille Ebuenga

IPC分类号： A01N43/78 ,  A01N43/76 ,  A61K31/425 ,  A61K31/42 ,  C07D277/00 ,  C07D263/00

CPC分类号： C07D263/28 ,  A01N43/50 ,  A01N43/76 ,  A01N43/78 ,  A01N47/12 ,  A01N47/16 ,  C07D233/48 ,  C07D277/18 ,  C07D417/06 ,  C07D417/12

摘要： The present invention relates to 1-(azolin-2-yl)amino-1,2-diphenylethane compounds of the formula I and to their salts which are useful for combating animal pests. The invention also relates to a method for controlling animal pests by using these compounds, to seed and to an agricultural and veterinary composition comprising said compounds. wherein A is a radical of formulae A.1 or A.2 wherein # denotes the bond to the remaining compound of formula I, X is selected from O, S and NRX, R1 is selected from the group consisting of —ORA, —NRB1RB2, —C(═O)—RC, —C(═O)—ORD, —C(═O)—SRE, —C(═O)—NRB1RB2′, —C(═S)—RC′, —C(═S)—ORD′, —C(═S)—SRE′, —C(═S)—NRB1RB2, —C(═NR1a)—RC′, —C(═NR1b)—ORD′, —C(═NR1c)—SRE′, —C(═NR1d)—NRB1RB2, —S(═O)—RF, —S(═O)2—RG, —S(═O)2—NRB1RB2′, —P(═O)RH1RH2, —P(═S)RH1RH2, —B—C(═O)—RI, —B—O—C(═O)—RI, —B—S—C(═O)—RI, —B—N(RJ)—C(═O)—RK, —B—C(═S)—RK, —B—O—C(═S)—RK, —B—S—C(═S)—RK, —B—N(RJ)—C(═S)—RK, C1-C8-alkenyl, C1-C8-alkynyl, C3-C8-cycloalkyl, which is unsubstituted or may carry 1 to 4 substituents R1e, naphthyl, which is unsubstituted or may carry 1 to 4 substituents R1f, a saturated or partially unsaturated heterocycle, which is unsubstituted or may carry 1 to 4 substituents R1g, hetaryl, which is unsubstituted or may carry 1 to 4 substituents R1h, and C1-C6-alkyl, which carries a radical selected from the group consisting of —NR1iR1j, C1-C4-alkoxycarbonyl, C3-C8-cycloalkyl, aryl, aryloxy, arylthio, heterocyclyl, heterocyclyloxy and heterocyclylthio, R2, R3, R4, R5, R6 and R7 are each independently hydrogen, halogen, OH, SH, NH2, SO3H, COOH, cyano, nitro, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylamino etc.

公开(公告)号：US08173675B2

公开(公告)日：2012-05-08

申请号：US12601017

申请日：2008-05-13

申请人： Christopher Koradin ,  Markus Kordes ,  Ernst Baumann ,  Ronan Le Vezouet ,  Deborah L. Culbertson

发明人： Christopher Koradin ,  Markus Kordes ,  Ernst Baumann ,  Ronan Le Vezouet ,  Deborah L. Culbertson

IPC分类号： A61K31/47 ,  C07D215/14

CPC分类号： A01N47/36 ,  A01N47/32 ,  C07C335/14 ,  C07C2602/08 ,  C07C2602/10 ,  C07D307/82 ,  C07D333/66

摘要： The invention relates to substituted amino-thiourea compounds of formula (I), to the enantiomers, diastereomers and salts thereof and to compositions comprising such compounds. The invention also relates to the use of the substituted amino-thiourea compounds, of their salts or of compositions comprising them for combating animal pests. Furthermore the invention relates also to methods of applying such compounds. The substituted amino-thiourea compounds are defined by the following formula (I): wherein A, B, R1, R2, R3, R4, R5.1, R5.2 and R6 are defined as in the description.

摘要翻译： 本发明涉及式（I）的取代的氨基 - 硫脲化合物，其涉及其对映体，非对映异构体和盐以及包含这些化合物的组合物。 本发明还涉及取代的氨基 - 硫脲化合物，其盐或包含它们的组合物用于对抗动物害虫的用途。 此外，本发明还涉及应用这些化合物的方法。 取代的氨基 - 硫脲化合物由下式（I）定义：其中A，B，R1，R2，R3，R4，R5.1，R5.2和R6如说明书所定义。

公开(公告)号：US07981437B2

公开(公告)日：2011-07-19

申请号：US12094854

申请日：2006-11-15

申请人： Markus Kordes ,  Christopher Koradin ,  Deborah L. Culbertson

发明人： Markus Kordes ,  Christopher Koradin ,  Deborah L. Culbertson

IPC分类号： A61K31/4168 ,  A61K31/42 ,  A61K31/426 ,  A01N43/50 ,  A01N43/76 ,  A01N43/78 ,  C07D277/04 ,  C07D277/18 ,  C07D233/02 ,  C07D233/50 ,  C07D263/04 ,  C07D263/28

CPC分类号： C07D277/18 ,  C07D233/50 ,  C07D263/28

摘要： The present invention relates to Indanyl- and Tetrahydronaphthyl-amino-azoline compounds of formula I wherein the variables R1 and R2 are as defined in description. The invention relates also to methods of combating or controlling insects, arachnids or nematodes, to methods for protecting growing plants from attack or infestation by insects, arachnids or nematodes, to methods for the protection of seeds from soil insects and of the seedlings' roots and shoots from soil and foliar insects and to methods for treating, controlling, preventing or protecting animals against infestation or infection by parasites.

摘要翻译： 本发明涉及式I的茚满基和四氢萘基 - 氨基 - 唑啉化合物，其中变量R1和R2如描述中所定义。 本发明还涉及防治昆虫，蜘蛛或线虫的方法，用于保护生长植物免受昆虫，蜘蛛或线虫侵袭或侵染的方法，用于保护种子免受土壤昆虫和幼苗根部和 来自土壤和叶面昆虫的芽，以及用于治疗，控制，预防或保护动物免受寄生虫感染或感染的方法。

公开(公告)号：US20110118116A1

公开(公告)日：2011-05-19

申请号：US13003927

申请日：2009-07-14

申请人： Ronan Le Vezouet ,  Markus Kordes ,  Ralph Paulini ,  Deborah L. Culbertson

发明人： Ronan Le Vezouet ,  Markus Kordes ,  Ralph Paulini ,  Deborah L. Culbertson

IPC分类号： A01N43/78 ,  C07D277/42 ,  C07C335/12 ,  A61K31/426 ,  A01P7/04 ,  A01P7/02 ,  A61P33/14 ,  A01C1/06

CPC分类号： C07D277/10 ,  A01N43/50 ,  A01N43/76 ,  A01N43/78 ,  A01N47/28 ,  C07C275/24 ,  C07C335/12

摘要： The present invention relates to azolin-2-ylamino compounds of formula (I), wherein A is a radical of the formulae (A.1) or (A.2), wherein * denotes the binding site and wherein the indices and variables are as defined in the description. The present invention relates as well as to the precursor compounds thereof, which are both useful for combating animal pests selected from insects, arachnids and nematodes. The invention also relates to methods for controlling and/or combating such animal pests by using these compounds, to methods of protecting crops and plant propargation material, and further also to seeds and agricultural and veterinary composition comprising said compounds.

摘要翻译： 本发明涉及式（I）的唑啉-2-基氨基化合物，其中A是式（A.1）或（A.2）的基团，其中*表示结合位点，其中指数和变量是 如说明书中所定义。 本发明涉及其前体化合物，它们都可用于对抗选自昆虫，蜘蛛和线虫的动物害虫。 本发明还涉及通过使用这些化合物来控制和/或对抗这种动物害虫的方法，以及用于保护作物和植物提取物质的方法，还涉及包含所述化合物的种子和农业和兽医组合物。

公开(公告)号：US07871960B2

公开(公告)日：2011-01-18

申请号：US11914992

申请日：2006-05-18

申请人： Markus Kordes ,  Norbert Götz ,  Michael Rack ,  Christopher Koradin ,  Livio Tedeschi ,  Deborah L. Culbertson

发明人： Markus Kordes ,  Norbert Götz ,  Michael Rack ,  Christopher Koradin ,  Livio Tedeschi ,  Deborah L. Culbertson

IPC分类号： A01N43/50 ,  C07D233/04

CPC分类号： A01N43/50 ,  C07D233/48

摘要： The present invention relates to 1-(imidazolin-2-yl)amino-1,2-diphenylethane compounds of the formula I and their agriculturally acceptable salts, wherein A is a radical of the formula A1 or A2. The invention relates also to agricultural compositions and to seed comprising at least one compound I and/or a salt thereof, as well as a method of combating animal pests, a method for protecting crops from attack or infestation by animal pests and a method for protecting non-living materials from attack or infestation by animal pests, a method for the protection of seeds from animal pests and of the seedlings' roots and shoots from animal pests by applying a pesticidally effective amount of at least one 1-(imidazolin-2-yl)amino-1,2-diphenylethane compound I and/or a salt thereof.

摘要翻译： 本发明涉及式I的1-（咪唑啉-2-基）氨基-1,2-二苯基乙烷化合物及其农业上可接受的盐，其中A是式A1或A2的基团。 本发明还涉及农业组合物和包含至少一种化合物I和/或其盐的种子，以及防治动物害虫的方法，用于保护作物免受动物害虫侵袭或侵染的方法和保护方法 通过施用杀虫有效量的至少一种1-（咪唑啉-2-酮）的动物害虫的攻击或感染的非生物材料，动物害虫的种子保护方法和来自动物害虫的幼苗的根和芽， 氨基-1,2-二苯基乙烷化合物I和/或其盐。

公开(公告)号：US07655600B2

公开(公告)日：2010-02-02

申请号：US10583710

申请日：2004-12-22

申请人： Markus Kordes ,  Michael Hofmann ,  Michael Puhl ,  Norbert Götz ,  Michael Rack ,  Ernst Baumann ,  Wolfgang von Deyn ,  Thomas Schmidt ,  Livio Tedeschi ,  Michael F. Treacy ,  Deborah L. Culbertson ,  Toni Bucci ,  David G. Kuhn

发明人： Markus Kordes ,  Michael Hofmann ,  Michael Puhl ,  Norbert Götz ,  Michael Rack ,  Ernst Baumann ,  Wolfgang von Deyn ,  Thomas Schmidt ,  Livio Tedeschi ,  Michael F. Treacy ,  Deborah L. Culbertson ,  Toni Bucci ,  David G. Kuhn

IPC分类号： A01N43/76 ,  A01N43/78 ,  C07D277/04 ,  C07D277/08

CPC分类号： C07D263/28 ,  A01N43/76 ,  A01N43/78 ,  C07D277/18

摘要： The present invention relates to 1-(azolin-2-yl)amino-1,2-diphenylethane compounds of the general formula (I) wherein A is a radical of the formulae A′ or A2: NRA′A2 and wherein m is 0, 1, 2, 3, 4 or 5, n is 0, 1, 2, 3, 4 or 5, X is sulfur or oxygen, and wherein the variables R1, R2, R3, R4, R5a, R5b, R5c, R5d are as defined in the claims, and to the agriculturally acceptable salts thereof. The invention relates also to a method of combating animal pests, selected from insects, arachnids and nematodes and to a method for protecting crops from attack or infestation by insects, arachnids or nematodes, which comprises contacting a crop with a pesticidally effective amount of a 1-(azolin-2-yl)amino-1,2-diphenylethane compounds of the general formula I and/or at least one salt thereof.

摘要翻译： 本发明涉及通式（I）的1-（唑啉-2-基）氨基-1,2-二苯基乙烷化合物，其中A为式A'或A2的基团：NRA'A2，其中m为0 ，1,2,3,4或5，n为0,1,2,3,4或5，X为硫或氧，其中R1，R2，R3，R4，R5a，R5b，R5c，R5d 如权利要求书中所定义，以及其农业上可接受的盐。 本发明还涉及一种对抗昆虫，蜘蛛和线虫的动物害虫的方法，还涉及一种保护作物免受昆虫，蜘蛛或线虫袭击或侵染的方法，其中包括使农作物与杀虫有效量的1 - （唑啉-2-基）氨基-1,2-二苯基乙烷化合物和/或其至少一种盐。

公开(公告)号：US20090209598A1

公开(公告)日：2009-08-20

申请号：US12093543

申请日：2006-11-10

申请人： Michael Puhl ,  Markus Kordes ,  Matthias Pohlman ,  Norbert Götz ,  Michael Rack ,  Jürgen Langewald ,  Felix Schneider ,  Douglas D. Anspaugh ,  Deborah L. Culbertson ,  Hassan Oloumi-Sadeghi ,  David G. Kuhn

发明人： Michael Puhl ,  Markus Kordes ,  Matthias Pohlman ,  Norbert Götz ,  Michael Rack ,  Jürgen Langewald ,  Felix Schneider ,  Douglas D. Anspaugh ,  Deborah L. Culbertson ,  Hassan Oloumi-Sadeghi ,  David G. Kuhn

IPC分类号： A01N43/40 ,  A01N43/38 ,  C07D401/04 ,  C07D209/54

CPC分类号： C07D213/64 ,  C07D277/34 ,  C07D307/80

摘要： This invention relates to resorcine derivatives of formula (I) wherein R1 is phenyl or a 5- to 6-membered heteroaromatic ring which may contain 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur, wherein phenyl or the heteroaromatic ring may be fused to a ring selected from phenyl and a 5- to 6-membered saturated, partially unsaturated or aromatic heterocyclic ring which may contain 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur, wherein phenyl or the 5- to 6-membered heteroaromatic ring or the respective fused ring systems may be unsubstituted or substituted by any combination of 1 to 6 optionally substituted groups R3, wherein R3 is halogen, cyano, nitro, hydroxy, mercapto, amino, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, haloalkyl, haloalkenyl, haloalkynyl, halocycloalkyl, halocycloalkenyl, alkoxy, alkenyloxy, alkynyloxy, haloalkoxy, haloalkenyloxy, haloalkynyloxy, alkylthio, alkenylthio, alkynylthio, haloalkylthio, haloalkenylthio, haloalkynylthio, alkylamino, alkenylamino, alkynylamino, dialkylamino, dialkenylamino, dialkynylamino, alkyl-alkenylamino, alkyl-alkynylamino, alkenyl-alkynylamino, trialkylsilyl, or phenyl or a 5- to 7-membered saturated or partially unsaturated heterocyclic ring which may contain 1 to 3 heteroatoms selected from oxygen, sulfur and nitrogen or a 5- to 6-membered heteraromatic ring system which may contain 1 to 4 heteroatoms selected from oxygen, nitrogen and sulfur, which phenyl and which heteroaromatic ring may be bonded via an oxygen or a sulfur atom, or —C(=G)Ra, —C(=G)ORa, —C(=G)NRa2, —C(=G)[N═SRa2], —C(═NORa)Ra, —C(═NORa)NRa2, —C(═NNRa2)Ra, —OC(=G)-OC(=G)ORa, N═SRa2, —NRaC(=G)Ra, —N[C(=G)Ra]2, —NRaC(=G)ORa, —C(=G)NRa—NRa2, —C(=G)NRa—NRa[C(=G)Ra], —NRa—C(=G)NRa2, —NRa—NRaC(=G)Ra, —NRa—N[C(=G)Ra]2, —N[(C=G)Ra]—NRa2, —NRa—NRa[(C=G)GRa], —NRa[(C=G)NRa2, —NRa[C═NRa]Ra, —NRa(C═NRa)NRa2, —O—NRa2, —O—NRa(C=G)Ra, —SO2NRa2, —NRaSO2Ra, —S(═O)Ra, —S(═O)2Ra, —SO2ORa, or —OSO2Ra, wherein G is oxygen or sulfur and Ra is as defined in the description, R2 is hydrogen, halogen, cyano, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, or haloalkoxy, x is 2, 3, 4, 5, 6, or 7, or the diastereomers, enantiomers, salts or N-oxides thereof, with the proviso that R1 is not 5-chloro-2,2,-dimethyl-2,3-dihydrobenzo[b]furan-7-yl when R2 is hydrogen and x is 3 or 4, processes and intermediates for the preparation of compounds I, use of compounds I for combating insects, acarids, or nematodes, and a method for treating, controlling, preventing or protecting animals against infestation or infection by parasites using compounds I.