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21.发明授权Methods for identifying sets of oligonucleotides for use in an in vitro recombination procedure 有权用于鉴定用于体外重组程序的寡核苷酸组的方法公开(公告)号：US07620502B2
公开(公告)日：2009-11-17
申请号：US11339090
申请日：2006-01-24
Applicant: Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
Inventor： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
CPC classification number: G06F19/16 , B01J2219/007 , C40B50/02 , G06F19/14 , G06F19/18 , G06F19/22 , G06F19/24
Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators are used to identify sets of oligonucleotides for in vitro recombination.
Abstract translation: 在计算机核酸重组方法中，利用遗传算子的相关综合系统用于鉴定用于体外重组的寡核苷酸组。
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公开(公告)号：US07462469B2
公开(公告)日：2008-12-09
申请号：US10154936
申请日：2002-05-23
Applicant: Steven H. Bass , S. Christopher Davis , Phillip A. Patten , Matthew Tobin , Jeremy Minshull , Mark Welch , Claes Gustafsson , Brian Carr , Stephane Jenne , Sun Ai Raillard , Andreas Crameri , Willem P. C. Stemmer , Robin Emig , Pascal Longchamp , Stanley Goldman , Lorraine J. Giver , Joseph A. Affholter
Inventor： Steven H. Bass , S. Christopher Davis , Phillip A. Patten , Matthew Tobin , Jeremy Minshull , Mark Welch , Claes Gustafsson , Brian Carr , Stephane Jenne , Sun Ai Raillard , Andreas Crameri , Willem P. C. Stemmer , Robin Emig , Pascal Longchamp , Stanley Goldman , Lorraine J. Giver , Joseph A. Affholter
CPC classification number: C12N15/1031 , B01J19/0046 , B01J2219/00378 , B01J2219/00585 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/00722 , B82Y30/00 , C12N15/1027 , C40B60/04 , G06F19/18 , Y02A90/22
Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
Abstract translation: 提供了用于多样化生成和筛选的集成系统和方法。 该系统使用普通液体和阵列处理组分来提供核酸多样化，转录，翻译，产物筛选和随后的多样化反应。
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23.发明授权公开(公告)号：US07148054B2
公开(公告)日：2006-12-12
申请号：US10194686
申请日：2002-07-11
Applicant: Stephen delCardayre , Matthew Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswatan Subramanian , Linda A. Castle , Claus M. Krebber , Steve Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph A. Affholter
Inventor： Stephen delCardayre , Matthew Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswatan Subramanian , Linda A. Castle , Claus M. Krebber , Steve Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph A. Affholter
CPC classification number: C12R1/465 , A01K2267/02 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N15/90 , C12P17/162 , C12Q1/6811 , C12Q1/6827
Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
Abstract translation: 本发明提供了使用重组和选择/筛选整个细胞和生物体以获得所需性质的进化的迭代循环的方法。这些性质的实例包括增加的重组原型，基因组拷贝数和蛋白质和次级代谢物的表达和/或分泌能力 。
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24.发明授权公开(公告)号：US06326204B1
公开(公告)日：2001-12-04
申请号：US09116188
申请日：1998-07-15
Applicant: Stephen delCardayre , Matthew Tobin , William P. C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswatan Subramanian , Linda Castle , Steve Bass
Inventor： Stephen delCardayre , Matthew Tobin , William P. C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswatan Subramanian , Linda Castle , Steve Bass
IPC: C12N1500
CPC classification number: C12N15/102 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12P17/162 , C12Q1/68 , C12Q1/6811 , C12Q1/6827 , C12R1/465
Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
Abstract translation: 本发明提供了采用迭代循环重组和选择/筛选全细胞和生物体以获得所需性质的方法的方法。 这些性质的实例包括增加的重组原性，基因组拷贝数以及蛋白质和次级代谢物的表达和/或分泌能力。
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公开(公告)号：US06251674B1
公开(公告)日：2001-06-26
申请号：US09499505
申请日：2000-02-07
Applicant: Matthew Tobin , William P. C. Stemmer , Jon E. Ness , Jeremy Minshull
Inventor： Matthew Tobin , William P. C. Stemmer , Jon E. Ness , Jeremy Minshull
IPC: C12N1500
CPC classification number: A01H1/00 , A01K2217/05 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12Q1/6811
Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
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Patent Agency Ranking
公开(公告)号：US20120040437A1
公开(公告)日：2012-02-16
申请号：US13223604
申请日：2011-09-01
Applicant: Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
Inventor： Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
IPC: C12N9/90
Abstract: The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.
Abstract translation: 本公开一般涉及具有改进的丙氨酸2,3-氨基变位酶（AAM）活性的多肽，编码AAM多肽的多核苷酸，以及用于表达AAM多肽的表达载体和宿主细胞。
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27.发明申请公开(公告)号：US20110190140A1
公开(公告)日：2011-08-04
申请号：US12580056
申请日：2009-10-15
Applicant: Stephen del Cardayre , Matthew Tobin , Willem P.C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswatan Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph A. Affholter
Inventor： Stephen del Cardayre , Matthew Tobin , Willem P.C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswatan Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph A. Affholter
CPC classification number: C12R1/465 , A01K2267/02 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N15/90 , C12P17/162 , C12Q1/6811 , C12Q1/6827
Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
Abstract translation: 本发明提供了采用迭代循环重组和选择/筛选全细胞和生物体以获得所需性质的方法的方法。 这些性质的实例包括增加的重组原性，基因组拷贝数以及蛋白质和次级代谢物的表达和/或分泌能力。
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28.发明授权Methods for identifying sets of oligonucleotides for use in an in vitro recombination procedures 有权用于鉴定用于体外重组程序的寡核苷酸组的方法公开(公告)号：US07904249B2
公开(公告)日：2011-03-08
申请号：US11982405
申请日：2007-10-31
Applicant: Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
Inventor： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
CPC classification number: G06F19/16 , B01J2219/007 , C40B50/02 , G06F19/14 , G06F19/18 , G06F19/22 , G06F19/24
Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators are used to identify sets of oligonucleotides for in vitro recombination. In certain embodiments, the methods involve inputting amino acid sequence character strings into a digital system and back-translating the amino acid character strings into a plurality of nucleic acid character strings. The nucleic acid character strings are then processed to define and select at least one recombinant nucleic acid for use in identifying one or more oligonucleotides for in vitro recombination.
Abstract translation: 在计算机核酸重组方法中，利用遗传算子的相关综合系统用于鉴定用于体外重组的寡核苷酸组。 在某些实施方案中，所述方法包括将氨基酸序列字符串输入到数字系统中，并将氨基酸字符串逆向翻译成多个核酸字符串。 然后处理核酸字符串以限定和选择至少一种用于鉴定用于体外重组的一种或多种寡核苷酸的重组核酸。
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公开(公告)号：US20070048775A1
公开(公告)日：2007-03-01
申请号：US11506142
申请日：2006-08-17
Applicant: Stephen Cardayre , Matthew Tobin , Willem Stemmer , Jon Ness , Jeremy Minshull , Phillip Patten , Venkiteswaran Subramanian , Linda Castle , Claus Krebber , Steven Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph Affholter
Inventor： Stephen Cardayre , Matthew Tobin , Willem Stemmer , Jon Ness , Jeremy Minshull , Phillip Patten , Venkiteswaran Subramanian , Linda Castle , Claus Krebber , Steven Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph Affholter
CPC classification number: C12R1/465 , A01K2267/02 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N15/90 , C12P17/162 , C12Q1/6811 , C12Q1/6827
Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
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30.发明申请Methods for making character strings, polynucleotides and polypeptides having desired characteristics 有权制备具有所需特征的字符串，多核苷酸和多肽的方法公开(公告)号：US20060142950A1
公开(公告)日：2006-06-29
申请号：US11339090
申请日：2006-01-24
Applicant: Sergey Selifonov , Willem Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip Patten , Jeremy Minshull , Lorraine Giver
Inventor： Sergey Selifonov , Willem Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip Patten , Jeremy Minshull , Lorraine Giver
IPC: G06F19/00
CPC classification number: G06F19/16 , B01J2219/007 , C40B50/02 , G06F19/14 , G06F19/18 , G06F19/22 , G06F19/24
Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
Abstract translation: 在硅胶核酸重组方法中，提供了利用遗传算子和通过计算机改组方法制备的文库的相关综合系统。
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