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    Burdock fruit extract containing arctigenin and method for producing same
    21.
    发明授权
    Burdock fruit extract containing arctigenin and method for producing same 有权
    含有赤霉素的牛蒡果实提取物及其制造方法

    公开(公告)号：US09072718B2

    公开(公告)日：2015-07-07

    申请号：US13849302

    申请日：2013-03-22

    Applicant: Kracie Pharma, Ltd. ,  National Cancer Center ,  National University Corporation University of Toyama

    Inventor： Toshiki Okubo ,  Satoshi Yomoda ,  Takafumi Fuse ,  Takanori Kawashima ,  Hiroyasu Esumi ,  Chika Miyoshi ,  Shigetoshi Kadota

    IPC: A01N65/00 ,  A61K36/28 ,  A61K31/365 ,  A61K31/7048 ,  C07D307/33

    CPC classification number: A61K36/28 ,  A61K31/365 ,  A61K31/7048 ,  A61K2236/19 ,  C07D307/33

    Abstract: PROBLEM TO BE SOLVEDThe present invention is intended to provide a burdock fruit extract comprising arctigenin and arctiin at a definite ratio and a method for producing the same. More particularly, the present invention is intended to provide a method for producing a burdock fruit extract comprising arctigenin and arctiin at a weight ratio of approximately 1:1.SOLUTIONA method for producing a burdock fruit extract comprising arctigenin and arctiin at a weight ratio of arctigenin/arctiin=0.7 to 1.3 is provided, including the steps of: cutting a burdock fruit and converting arctiin which is inherent in the burdock fruit into arctigenin by enzymatic conversion by beta-glucosidase which is inherent in the burdock fruit, wherein the enzymatic conversion includes reaction at a temperature from 20° C. to 50° C. Also provided is the method further including a step of extracting an extract comprising arctigenin and arctiin by adding an organic solvent and heating to reflux.

    Abstract translation: 待解决的问题本发明旨在提供一种以确定的比例含有弓形虫属和弓形虫的牛蒡果实提取物及其制造方法。 更具体地，本发明旨在提供一种生产牛蒡果实提取物的方法，所述牛蒡果实提取物包含重量比为约1:1的抗坏血酸和铁蛋白。 解决方案提供一种生产牛蒡果实提取物的方法，该方法包括以赤霉素/ arctinin = 0.7〜1.3的重量比计含有赤霉素和arctiin的方法，包括以下步骤：将牛蒡水果切割成牛蒡果实固有的arctiin， 牛蒡果实中固有的β-葡糖苷酶进行酶转化，其中酶促转化包括在20℃至50℃的温度下进行反应。还提供了一种方法，其还包括提取包含抗坏血酸和脯氨酸的提取物的步骤 通过加入有机溶剂并加热回流。

    FILLING/CUSHIONING MEMBER FOR SKIN GRAFTS ON AURICULAR SKIN DEFECTS
    25.
    发明公开
    FILLING/CUSHIONING MEMBER FOR SKIN GRAFTS ON AURICULAR SKIN DEFECTS 审中-公开

    公开(公告)号：US20230293767A1

    公开(公告)日：2023-09-21

    申请号：US18021113

    申请日：2020-10-30

    Applicant: National University Corporation University of Toyama ,  SAKURA SEIKI CO., LTD.

    Inventor： Michiro FUJISAKA ,  Hideo SHOJAKU ,  Shinsuke ITO ,  Toshiko YOSHIDA ,  Motonori OKABE ,  Chika SOKO ,  Masahiko ARAKAWA

    IPC: A61L27/36 ,  A61L27/54 ,  A61L27/60

    CPC classification number: A61L27/3604 ,  A61L27/3691 ,  A61L27/54 ,  A61L27/60 ,  A61L2430/14

    Abstract: The present invention addresses the problem of providing a material as a scaffold used to prevent poor skin grafting when there is a defect in the perichondrium or periosteum or a defect in subcutaneous tissue. As a solution, there is provided a dry amniotic membrane manufactured according to a specific drying process. In more detail, a raw amniotic membrane placed in a processing tank (10) is continuously heated by a far-infrared heater (14) provided inside the processing tank (10), while performing a decompression operation where the interior of the processing tank (10) is placed in a decompressed state and irradiation of the raw amniotic membrane with microwaves from a microwave generating device (30) provided inside the processing tank (10) to apply energy to water molecules present inside the amniotic membrane and cause drying during a pressure recovery operation that slightly raises the pressure inside the depressurized processing tank (10) toward atmospheric pressure. By providing amniotic membrane, which has been dried by repeating the above process a plurality of times to retain its cellular and tissue structure, as a scaffold used to prevent poor skin grafting when there is a defect in the perichondrium or periosteum or a defect in the subcutaneous tissue, it is possible to enhance the healing effect of a skin graft.

    METHOD FOR DETERMINING BACTERIAL NUMBER IN SPECIMEN
    26.
    发明申请
    METHOD FOR DETERMINING BACTERIAL NUMBER IN SPECIMEN 有权

    公开(公告)号：US20210102239A1

    公开(公告)日：2021-04-08

    申请号：US15733166

    申请日：2018-06-21

    Applicant: MITSUI CHEMICALS, INC. ,  NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA

    Inventor： Hideki Niimi ,  Isao Kitajima ,  Akio MIYAKOSHI ,  Yoshitsugu HIGASHI

    IPC: C12Q1/689 ,  C12Q1/686

    Abstract: A method for enabling rapid and accurate determination of the number of bacterial cells in a specimen using a PCR method includes the following steps: (1) a first PCR step of carrying out a PCR method using a nucleic acid derived from a specimen as a template and a universal primer pair for amplifying a bacterial 16S rRNA gene to obtain a first amplification product; (2) a second PCR step of carrying out a nested PCR method using a primer pair(s) for amplifying an internal sequence(s) of the sequence of the first amplification product obtained by the first PCR step to obtain a second amplification product; and (3) a bacterial number determination step of obtaining the number of bacterial cells in the specimen based on the amount of the second amplification product obtained in the second PCR step and using calibration data.

    METHOD FOR PRODUCING ANTIGEN SPECIFIC MONOCLONAL ANTIBODY
    27.
    发明申请
    METHOD FOR PRODUCING ANTIGEN SPECIFIC MONOCLONAL ANTIBODY 审中-公开

    公开(公告)号：US20180292407A1

    公开(公告)日：2018-10-11

    申请号：US15751792

    申请日：2016-08-10

    Applicant: National University Corporation University of Toyama

    Inventor： Nobuyuki Kurosawa ,  Masaharu Isobe

    IPC: G01N33/577 ,  C07K16/40

    CPC classification number: G01N33/577 ,  C07K16/18 ,  C07K16/40 ,  C07K2317/565 ,  C12N1/02 ,  C12N5/12 ,  C12N9/50 ,  C12N11/14 ,  C12N15/09 ,  G01N33/53

    Abstract: A method for separating cells capable of producing target antigen-specific monoclonal antibodies (TASMAs) wherein a cell group including antibody-producing cells is immobilized using a reversible crosslinking agent having cell membrane-permeating properties. The immobilized cell group is subjected to cell membrane dissolution using a surface active agent; and the cell group is reacted with a labeling target antigen. In the stained cell group a that has reacted with the labeling target antigen is separated. A method to produce TASMAs by separating mRNA from the cell separated using the method; preparing cDNA and preparing antigen-specific monoclonal antibodies or fragments thereof from the prepared cDNA. Also provided are a method whereby at least one cell capable of producing TASMAs is separated and a method whereby said antibodies can be produced by using the separated cell. Threonine 18 phosphorylated p53 (pT18-p53) and threonine 68 phosphorylated CHK2 (pT68-CHK2) specific monoclonal antibodies are also disclosed.

    Burdock Fruit Extract Containing Arctigenin and Method for Producing Same
    30.
    发明申请
    Burdock Fruit Extract Containing Arctigenin and Method for Producing Same 有权
    含牛蒡子苷的牛蒡果提取物及其生产方法

    公开(公告)号：US20140037770A1

    公开(公告)日：2014-02-06

    申请号：US13849302

    申请日：2013-03-22

    Applicant: Kracie Pharma, Ltd. ,  National Cancer Center ,  National University Corporation University of Toyama

    Inventor： Toshiki Okubo ,  Satoshi Yomoda ,  Takafumi Fuse ,  Takanori Kawashima ,  Hiroyasu Esumi ,  Chika Miyoshi ,  Shigetoshi Kadota

    IPC: A61K36/28

    CPC classification number: A61K36/28 ,  A61K31/365 ,  A61K31/7048 ,  A61K2236/19 ,  C07D307/33

    Abstract: The present invention is intended to provide a burdock fruit extract comprising arctigenin and arctiin at a definite ratio and a method for producing the same. More particularly, the present invention is intended to provide a method for producing a burdock fruit extract comprising arctigenin and arctiin at a weight ratio of approximately 1:1.A method for producing a burdock fruit extract comprising arctigenin and arctiin at a weight ratio of arctigenin/arctiin =0.7 to 1.3 is provided, including the steps of: cutting a burdock fruit and converting arctiin which is inherent in the burdock fruit into arctigenin by enzymatic conversion by beta-glucosidase which is inherent in the burdock fruit, wherein the enzymatic conversion includes reaction at a temperature from 20° C. to 50° C. Also provided is the method further including a step of extracting an extract comprising arctigenin and arctiin by adding an organic solvent and heating to reflux.

    Abstract translation: 本发明的目的在于提供一种以确定的比例含有抗坏血酸和铁蛋白的牛蒡果实提取物及其制造方法。 更具体地，本发明旨在提供一种生产牛蒡果实提取物的方法，所述牛蒡果实提取物包含重量比为约1:1的抗坏血酸和铁蛋白。 本发明提供一种以牛蒡子苷/ ar in in = = = = = = = a a a a i i i extract extract extract extract extract for for for for for for A A A A A A A A A A A A A A A A A A A A A enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic enzymatic 牛蒡果实固有的β-葡糖苷酶的转化，其中酶促转化包括在20℃至50℃的温度下的反应。还提供了该方法还包括通过以下步骤提取包含arctigenin和arctiin的提取物： 加入有机溶剂并加热回流。

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