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21.发明授权公开(公告)号：US11180545B2
公开(公告)日：2021-11-23
申请号：US16413335
申请日：2019-05-15
发明人： Jan Grimm , Aubin Michalon
IPC分类号： A61K39/00 , A61K39/395 , A61K38/17 , C07K16/18 , G01N33/68
摘要： Provided are novel human-derived antibodies specific for transthyretin (TTR), preferably capable of binding misfolded, misassembled, and/or aggregated TTR species, as well as methods related thereto. In addition, methods of diagnosing and/or monitoring diseases and treatments thereof which are associated with TTR amyloidosis are provided. Assays and kits related to antibodies specific for TTR or TTR deposits and aggregates are also disclosed. The novel anti-TTR antibodies can be used in pharmaceutical and diagnostic compositions for TTR targeted immunotherapy and diagnostics.
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公开(公告)号：US20210107972A1
公开(公告)日：2021-04-15
申请号：US17113600
申请日：2020-12-07
发明人： Jan GRIMM , Fabrice HEITZ , Feng CHEN , Ioana COMBALUZIER
IPC分类号： C07K16/18 , C07K7/06 , G01N33/543 , G01N33/577 , G01N33/68 , C07K14/47
摘要： Provided are novel human islet amyloid polypeptide, also known as amylin and IAPP and proIAPP respectively, specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for IAPP and/or proIAPP are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for IAPP and/or proIAPP targeted immunotherapy and diagnostics, respectively.
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公开(公告)号：US20180346558A1
公开(公告)日：2018-12-06
申请号：US16058630
申请日：2018-08-08
发明人： Jan GRIMM , Fabrice Heitz , Feng Chen , Ioana Combaluzier
IPC分类号： C07K16/18 , C07K7/06 , C07K14/47 , G01N33/543 , G01N33/577 , G01N33/68 , A61K39/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K7/06 , C07K14/4711 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/54306 , G01N33/577 , G01N33/6893 , G01N2333/47 , G01N2333/4709 , G01N2800/042 , G01N2800/52 , G01N2800/56
摘要： Provided are novel human islet amyloid polypeptide, also known as amylin and IAPP and proIAPP respectively, specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for IAPP and/or proIAPP are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for IAPP and/or proIAPP targeted immunotherapy and diagnostics, respectively.
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24.发明申请公开(公告)号：US20180037635A1
公开(公告)日：2018-02-08
申请号：US15678965
申请日：2017-08-16
发明人： Jan GRIMM , Roland MARTIN , Benoit COMBALUZIER , Ivan JELCIC
IPC分类号： C07K16/08 , C07K14/005 , G01N33/569 , C12N7/00 , A61K39/42 , A61K45/06 , G01N33/68
CPC分类号： C07K16/084 , A61K39/42 , A61K45/06 , C07K14/005 , C07K16/081 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C12N7/00 , C12N2710/22022 , G01N33/56983 , G01N33/6893 , G01N2333/025
摘要： Provided are novel human-derived antibodies specifically recognizing polyomavirus polypeptides, preferably capable of binding to polyomaviruses of the type of JC virus (JCV) and/or BK virus (BKV) as well as methods related thereto. Furthermore, assays and kits related to antibodies specific for polyomaviruses, polyomavirus VP1 and or polyomavirus VP1 Virus-Like Particles (VLPs), preferably of the type of JCV and/or BKV, are disclosed. The human-derived antibodies as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for polyomavirus targeted immunotherapy and diagnostics.
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公开(公告)号：US20170369592A1
公开(公告)日：2017-12-28
申请号：US15541998
申请日：2016-01-11
发明人： Chad BROKOPP , Jan GRIMM , Benoit COMBALUZIER , Mareike GOERANSON , Christine LOHMANN , Simon HOERSTRUP , Roger NITSCH
IPC分类号： C07K16/40 , G01N33/573 , A61K47/68 , C12N9/48 , C07K16/28 , G01N33/574
CPC分类号： C07K16/40 , A61K47/6871 , A61K2039/505 , C07K16/2878 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N9/485 , C12Y304/14005 , G01N33/573 , G01N33/57492 , G01N2333/948 , G01N2800/224 , G01N2800/226 , G01N2800/323 , G01N2800/52
摘要： Provided are novel human-derived antibodies specific for Fibroblast Activation Protein (FAP), preferably capable of selectively inhibiting the enzymatic activity of FAP, as well as methods related thereto. In addition, methods of diagnosing and/or monitoring diseases and treatments thereof which are associated with FAP are provided. Assays and kits related to antibodies specific for FAP are also disclosed. The novel anti-FAP antibodies can be used in pharmaceutical and diagnostic compositions for FAP-targeted immunotherapy and diagnostics.
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26.发明申请RECOMBINANT HUMAN ANTIBODIES FOR THERAPY AND PREVENTION OF POLYOMAVIRUS-RELATED DISEASES 有权用于治疗和预防多发性骨髓瘤相关疾病的重组人类抗体公开(公告)号：US20160052996A1
公开(公告)日：2016-02-25
申请号：US14758615
申请日：2014-01-02
发明人： Jan GRIMM , Roland MARTIN , Benoit COMBALUZIER , Ivan JELCIC
IPC分类号： C07K16/08 , C12N7/00 , C07K14/005 , A61K39/42 , A61K45/06
CPC分类号： C07K16/084 , A61K39/42 , A61K45/06 , C07K14/005 , C07K16/081 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C12N7/00 , C12N2710/22022 , G01N33/56983 , G01N33/6893 , G01N2333/025
摘要： Provided are novel human-derived antibodies specifically recognizing polyomavirus polypeptides, preferably capable of binding to polyomaviruses of the type of JC virus (JCV) and/or BK virus (BKV) as well as methods related thereto. Furthermore, assays and kits related to antibodies specific for polyomaviruses, polyomavirus VP1 and or polyomavirus VP1 Virus-Like Particles (VLPs), preferably of the type of JCV and/or BKV, are disclosed. The human-derived antibodies as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for polyomavirus targeted immunotherapy and diagnostics.
摘要翻译： 提供了特异性识别多瘤病毒多肽的新型人源性抗体，优选能够结合JC病毒（JCV）和/或BK病毒（BKV）类型的多瘤病毒以及与之相关的方法。 此外，公开了与针对多瘤病毒，多瘤病毒VP1和/或多瘤病毒VP1病毒样颗粒（VLP），特别是JCV和/或BKV类型的抗体相关的测定和试剂盒。 人源抗体以及其结合片段，衍生物和变体可以用于用于多瘤病毒靶向免疫治疗和诊断的药物和诊断组合物中。
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27.发明申请公开(公告)号：US20150315267A1
公开(公告)日：2015-11-05
申请号：US14650200
申请日：2013-12-06
申请人： Thierry BUSSIERE , Paul H. WEINREB , Thomas ENGBER , Kenneth RHODES , Joseph ARNDT , Fang QIAN , Robert W. DUNSTAN , Shailendra PATEL , BIOGEN IDEC INTERNATIONAL NEUROSCIENCE GMBH , Neurimmune Holding AG
发明人： Thierry Bussiere , Paul H. Weinreb , Thomas Engber , Kenneth Rhodes , Joseph Arndt , Fang Qian , Robert W. Dunstan , Shailendra Patel , Jan Grimm , Marcel Maier
CPC分类号： C07K16/18 , A61K51/1018 , A61K51/1093 , A61K2039/505 , A61K2039/545 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： This disclosure relates to the use of anti-Aβ antibody or antigen-binding fragment thereof to reduce brain amyloid plaques, or minimizes the occurrence of microhemorrhage during chronic dosing of an anti-Aβ antibody or antigen-binding fragment thereof. For example, the disclosure relates to the method of reducing brain amyloid plaques, comprising administering to a subject an anti-Aβ antibody or antigen-binding fragment thereof that binds to the same epitope as BIIB037 antibody, wherein the administration can reduce amyloid plaques in brain without affecting vascular amyloid, and wherein BIIB037 antibody binds to an epitope comprising amino acids 3-6 of Aβ.
摘要翻译： 本公开涉及抗A＆bgr的用途; 抗体或其抗原结合片段以减少脑淀粉样蛋白斑块，或者在慢性给药抗A药物期间最小化微出血的发生; 抗体或其抗原结合片段。 例如，本公开涉及减少脑淀粉样蛋白斑块的方法，包括向受试者施用抗Aβ抗体; 抗体或抗原结合片段，其结合与BIIB037抗体相同的表位，其中所述施用可以减少脑中的淀粉样蛋白斑，而不影响血管淀粉样蛋白，并且其中BIIB037抗体结合包含A＆bgr的氨基酸3-6的表位。
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28.发明申请HUMAN ISLET AMYLOID POLYPEPTIDE (HIAPP) SPECIFIC ANTIBODIES AND USES THEREOF 有权人类间叶酸多肽（HIAPP）特异性抗体及其用途公开(公告)号：US20150210759A1
公开(公告)日：2015-07-30
申请号：US14427575
申请日：2013-09-12
发明人： Jan Grimm , Fabrice Heitz , Feng Cheng , Ioana Combaluzier
IPC分类号： C07K16/18 , C07K7/06 , G01N33/543
CPC分类号： C07K16/18 , A61K2039/505 , C07K7/06 , C07K14/4711 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/54306 , G01N33/577 , G01N33/6893 , G01N2333/47 , G01N2333/4709 , G01N2800/042 , G01N2800/52 , G01N2800/56
摘要： Provided are novel human islet amyloid polypeptide, also known as amylin and IAPP and proIAPP respectively, specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for IAPP and/or proIAPP are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for IAPP and/or proIAPP targeted immunotherapy and diagnostics, respectively.
摘要翻译： 提供了新颖的人胰岛淀粉样多肽，也分别称为胰岛淀粉样多肽和IAPP和proIAPP，特异性抗体以及其片段，衍生物和变体以及与之相关的方法。 还公开了与IAPP和/或proIAPP特异性抗体相关的测定，试剂盒和固体支持物。 抗体，免疫球蛋白链以及其结合片段，衍生物和变体可分别用于IAPP和/或proIAPP靶向免疫治疗和诊断的药物和诊断组合物中。
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公开(公告)号：US20240279361A1
公开(公告)日：2024-08-22
申请号：US18492146
申请日：2023-10-23
发明人： Fabio Montrasio , Jan Grimm
CPC分类号： C07K16/44 , A61P25/28 , G01N33/6896 , C07K2317/21 , C07K2317/33 , C07K2317/76 , C07K2317/92 , G01N2800/2814
摘要： Provided are novel human-derived dipeptide repeat (DPR) specific antibodies as well as synthetic variants and biotechnological derivatives thereof, preferably capable of binding C9ORF72 DPRs, as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for DPRs and DPR proteins such C9ORF72 DPRs are also disclosed. The antibody of the present invention can be used in pharmaceutical and diagnostic compositions for DPR protein-targeted immunotherapy and diagnostics.
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公开(公告)号：US20240254256A1
公开(公告)日：2024-08-01
申请号：US18442889
申请日：2024-02-15
发明人： Fabio Montrasio , Maria Grazia Barenco Montrasio , Jan Grimm , Roger Nitsch , Christoph Hock , Tobias Welt , Jordan McAfoose , Marcel Maier
IPC分类号： C07K16/40 , A61K39/00 , A61K39/395 , A61K45/06 , A61K47/68 , A61K49/08 , A61K51/10 , C07K14/435 , C12N9/02 , G01N33/573 , G01N33/577 , G01N33/68
CPC分类号： C07K16/40 , A61K39/0005 , A61K39/3955 , A61K45/06 , A61K47/6871 , A61K49/085 , A61K51/10 , C07K14/435 , C12N9/0089 , G01N33/573 , G01N33/577 , G01N33/6893 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/92 , G01N2333/90283 , G01N2800/28 , G01N2800/285
摘要： Provided are novel human copper-zinc superoxide dismutase, also known as superoxide dismutase 1 or SOD1, specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for SOD1 are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for SOD1 targeted immunotherapy and diagnosis, respectively.
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