公开(公告)号：US11241156B2

公开(公告)日：2022-02-08

申请号：US17135233

申请日：2020-12-28

Applicant: Omni Medsci, Inc.

Inventor： Mohammed N. Islam

IPC: G01J3/00 ,  A61B5/00 ,  A61C19/04 ,  G16Z99/00 ,  G16H40/67 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/02 ,  G01J3/10 ,  G01J3/14 ,  G01J3/28 ,  G01J3/42 ,  G01J3/453 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/15 ,  G01N33/44 ,  G01N33/49 ,  H01S3/067 ,  H01S3/00 ,  A61C1/00 ,  G01J3/18 ,  G01J3/12 ,  G01M3/38 ,  G01N21/85 ,  G01N21/95 ,  H01S3/30

Abstract: A measurement system is provided with an array of laser diodes with one or more Bragg reflectors. At least a portion of the light generated by the array is configured to penetrate tissue comprising skin. A detection system configured to: measure a phase shift, and a time-of-flight, of at least a portion of the light from the array of laser diodes reflected from the tissue relative to the portion of the light generated by the array; generate one or more images of the tissue; detect oxy- or deoxy-hemoglobin in the tissue; non-invasively measure blood in blood vessels within or below a dermis layer within the skin; measure one or more physiological parameters based at least in part on the non-invasively measured blood; and measure a variation in the blood or physiological parameter over a period of time.

公开(公告)号：US11160455B2

公开(公告)日：2021-11-02

申请号：US17078771

申请日：2020-10-23

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J3/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G16H40/67 ,  G06F19/00 ,  G01J3/02 ,  G01J3/10 ,  G01J3/14 ,  G01J3/28 ,  G01J3/42 ,  G01J3/453 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/15 ,  G01N33/44 ,  G01N33/49 ,  G01J3/18 ,  G01J3/12 ,  G01M3/38 ,  G01N21/85 ,  G01N21/95 ,  H01S3/00 ,  H01S3/067 ,  H01S3/30

Abstract: A system for measuring one or more physiological parameters is provided with a wearable device that includes a light source comprising a driver and a plurality of semiconductor sources that generate an output optical light. The wearable device comprises: one or more lenses to receive at least a portion of the output optical light and to deliver a lens output light to tissue, and a detection system to receive at least a portion of the lens output light reflected from the tissue and to generate an output signal having a signal-to-noise ratio, and to be synchronized to the light source. The detection system comprises at least one analog to digital converter coupled to at least one spatially separated detector. The plurality of semiconductor sources comprises six light emitting diodes, and wherein the plurality of semiconductor sources and the plurality of spatially separated detectors are located on one or more arcs.

公开(公告)号：US20210181175A1

公开(公告)日：2021-06-17

申请号：US17181887

申请日：2021-02-22

Applicant: Omni Medsci, Inc.

Inventor： Mohammed N. ISLAM

IPC: G01N33/15 ,  G01N21/3504 ,  G01N21/359 ,  G01J3/02 ,  G01J3/42 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/10 ,  G01J3/28 ,  G01J3/453 ,  G01N21/3563 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/44 ,  G01N33/49

Abstract: A measurement system is provided with an array of laser diodes to generate light having one or more optical wavelengths. A detection system is provided with at least one photo-detector, a lens and a spectral filter at an input to the at least one photo-detector. The measurement system is further configured to transmit at least a portion of the output signal, indicative of an output status, to a cloud service over a transmission link. The cloud service is configured to receive the output status, to generate processed data based on the received output status, and to store the processed data, and wherein the cloud service is capable of storing a history of at least a portion of the received output status over a specified period of time.

公开(公告)号：US10918287B2

公开(公告)日：2021-02-16

申请号：US16880095

申请日：2020-05-21

Applicant: Omni Medsci, Inc.

Inventor： Mohammed N. Islam

IPC: G01J3/00 ,  A61B5/00 ,  G01J3/10 ,  G01J3/28 ,  G01J3/14 ,  G01J3/453 ,  G01J3/42 ,  G01J3/02 ,  G01N21/35 ,  G16H40/67 ,  G01N21/359 ,  A61B5/145 ,  G01N33/15 ,  G01N33/49 ,  G01N21/3563 ,  G01N21/39 ,  G01N33/02 ,  G01N33/44 ,  G01N21/88 ,  A61B5/1455 ,  H01S3/30 ,  G01J3/18 ,  G01J3/12 ,  G01N21/85 ,  G01N21/95 ,  H01S3/067 ,  H01S3/00 ,  G01M3/38

Abstract: A measurement system comprises a pulsed laser diode array that includes one or more Bragg reflectors, and wherein the light generated by the array penetrates tissue comprising skin. At least some of the wavelengths of light are in the near infrared. The detection system is synchronized to the laser diode array and comprises an infrared camera and a first receiver comprising a plurality of detectors. The first receiver comprises one or more detector arrays and performs a time-of-flight measurement. The measurement system generates an image, the detection system non-invasively measures blood in blood vessels within or below a dermis layer within the skin based at least in part on near-infrared diffuse reflection from the skin, and the detection system measures absorption of hemoglobin between 700 and 1300 nanometers wavelength range. A processor compares the absorption of hemoglobin between different tissue spatial locations, and the measurement system processes the time-of-flight measurement.

公开(公告)号：US20200333312A1

公开(公告)日：2020-10-22

申请号：US16895727

申请日：2020-06-08

Applicant: Omni Medsci, Inc.

Inventor： Mohammed N. ISLAM

IPC: G01N33/15 ,  G01N21/3504 ,  G01N21/359 ,  G01J3/02 ,  G01J3/42 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/10 ,  G01J3/28 ,  G01J3/453 ,  G01N21/3563 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/44 ,  G01N33/49

Abstract: A measurement system comprises a pulsed, near-infrared array of laser diodes, the laser diode array comprising Bragg reflectors, and wherein laser diode light is configured to penetrate tissue comprising skin. A detection system comprising a camera is synchronized to the laser diodes, and the camera is configured to receive some of the laser diode light reflected from the tissue. The detection system is configured to non-invasively measure blood within the skin, the detection system is configured to measure absorption of hemoglobin in the wavelength range between 700 and 1300 nanometers, and the processor is configured to compare the absorption of hemoglobin between different spatial locations of tissue and over a period of time. Physiological parameters are measured by the system. The measurement system is configured to use artificial intelligence in making decisions, and the system is further configured to use regression signal processing, multivariate data analysis, or component analysis techniques.

公开(公告)号：US10517484B2

公开(公告)日：2019-12-31

申请号：US16506885

申请日：2019-07-09

Applicant: Omni Medsci, Inc.

Inventor： Mohammed N. Islam

IPC: G01J5/02 ,  A61B5/00 ,  G01N21/3563 ,  G01N33/02 ,  G01N33/15 ,  G01N33/44 ,  G01N33/49 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/02 ,  G01J3/10 ,  G01J3/14 ,  G01J3/28 ,  G01J3/42 ,  G01J3/453 ,  G01N21/35 ,  G01N21/359 ,  G01N21/39 ,  G01N21/88 ,  G01N21/85 ,  H01S3/067 ,  G01N21/95 ,  H01S3/30 ,  G01J3/12 ,  G01M3/38 ,  G01J3/18 ,  H01S3/00

Abstract: A wearable device includes a measurement device to measure a physiological parameter adapted to be placed on a wrist or an ear of a user. A plurality of semiconductor light sources such as light emitting diodes generate corresponding output light having an initial light intensity. A receiver includes spatially separated detectors receiving reflected light from the output lights and coupled to analog to digital converters. The receiver is configured to synchronize to the semiconductor source(s). The measurement device improves signal-to-noise ratio of the output signal by increasing light intensity relative to the initial light intensity and by increasing a pulse rate. Further improvement in signal-to-noise ratio is achieved by using change detection, where the receiver compares the signals with light on and with light off.

公开(公告)号：US10386230B1

公开(公告)日：2019-08-20

申请号：US16188194

申请日：2018-11-12

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J3/00 ,  G01J3/02 ,  G01J3/28 ,  G01J3/42

Abstract: A smart phone or tablet includes laser diodes configured to be pulsed and generate near-infrared light between 700-2500 nanometers. Lenses direct the light to a sample. A detection system includes a photodiode array with pixels coupled to CMOS transistors, and is configured to receive light reflected from the sample, to be synchronized to the light from the laser diodes, and to perform a time-of-flight measurement of a time difference between light from the laser diodes and light reflected from the sample. The detection system is configured to convert light received while the laser diodes are off into a first signal, and light received while at least one laser diodes is on, which includes light reflected from the sample, into a second signal. The smart phone or tablet is configured to difference the first signal and the second signal and to generate a two-dimensional or three-dimensional image using the time-of-flight measurement.

公开(公告)号：US20180296097A1

公开(公告)日：2018-10-18

申请号：US16015737

申请日：2018-06-22

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. ISLAM

IPC: A61B5/00 ,  G01J3/28 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/39 ,  G06F19/00 ,  G01N21/88 ,  G16H40/67 ,  G01J3/02 ,  G01J3/10 ,  G01J3/14 ,  G01N33/02 ,  G01N21/359 ,  G01N21/3563 ,  G01N21/35 ,  G01N33/49 ,  G01N33/44 ,  G01N33/15 ,  G01J3/453 ,  G01J3/42 ,  G01J3/18 ,  G01J3/12 ,  G01M3/38 ,  G01N21/85 ,  G01N21/95 ,  H01S3/00 ,  H01S3/30 ,  H01S3/067

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302 ,  Y02A90/26

Abstract: A measurement system includes a light source having semiconductor sources, a multiplexer, and one or more fused silica fibers configured to form an output optical beam having one or more optical wavelengths modulated at a modulation frequency. A light beam set-up includes a monochromator forming a filtered optical beam. A measurement apparatus delivers the filtered optical beam to a sample. A receiver receives a spectroscopy output beam generated from the sample by the filtered optical beam. The receiver is configured to use a lock-in technique that detects the modulation frequency, and to generate first and second signals responsive to light received while the light source is off and on, respectively. The measurement system improves a signal-to-noise ratio of the spectroscopy output beam by differencing the first and second signals. The receiver processes the spectroscopy output beam using chemometrics or multivariate analysis to permit identification of materials within the sample.

公开(公告)号：US09993159B2

公开(公告)日：2018-06-12

申请号：US14109007

申请日：2013-12-17

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: A61B5/00

CPC classification number: A61B5/0075 ,  A61B5/0091 ,  A61B2562/0238

Abstract: A system and method for using near-infrared or short-wave infrared (SWIR) light sources for early detection and monitoring of breast cancer, as well as other kinds of cancers may detect decreases in lipid content and increases in collagen content, possibly with a shift in the collagen peak wavelengths and changes in spectral features associated with hemoglobin and water content as well. Wavelength ranges between 1000-1400 nm and 1600-1800 nm may permit relatively high penetration depths because they fall within local minima of water absorption, scattering loss decreases with increasing wavelength, and they have characteristic signatures corresponding to overtone and combination bands from chemical bonds of interest, such as hydrocarbons. Broadband light sources and detectors permit spectroscopy in transmission, reflection, and/or diffuse optical tomography. High signal-to-noise ratio may be achieved using a fiber-based super-continuum light source. Risk of pain or skin damage may be mitigated using surface cooling and focused infrared light.

公开(公告)号：US20180028061A1

公开(公告)日：2018-02-01

申请号：US15710804

申请日：2017-09-20

Applicant: Omni Medsci, Inc.

Inventor： Mohammed N. ISLAM

IPC: A61B5/00 ,  A61B1/00 ,  A61B5/021 ,  A61B34/00 ,  A61B5/02 ,  A61B5/06 ,  A61B5/1455 ,  H01S3/30 ,  A61B5/024

CPC classification number: A61B5/0075 ,  A61B1/00039 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0084 ,  A61B5/02042 ,  A61B5/021 ,  A61B5/024 ,  A61B5/06 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/7264 ,  A61B5/742 ,  A61B5/7435 ,  A61B5/7445 ,  A61B5/749 ,  A61B34/70 ,  A61B2505/05 ,  G06F19/00 ,  H01S3/302

Abstract: Measurement apparatus includes sensors configured to generate signals associated with physiological parameters and adapted to be coupled to tissue comprising blood and to communicate signals associated with the parameters to feedback control circuitry capable of generating physiological information from the signals. A software application is configured to operate on a control system capable of receiving the physiological information and configured to receive voice input signals and manually entered input signals. The control system includes a touch-screen, a proximity sensor, circuitry for obtaining movement information from a positioning sensor, a mechanical system having actuators, and a wireless transmitter to transmit the physiological information over a wireless link to a host. The host is configured to generate status information from the data and includes a memory storage device for recording the status information and a communication device communicating the status information to display output devices that may be located remotely.