公开(公告)号：US10696677B2

公开(公告)日：2020-06-30

申请号：US16472155

申请日：2017-12-20

Applicant: Research Triangle Institute

Inventor： Rangan Maitra ,  Robert W. Wiethe ,  Yanan Zhang ,  George S. Amato

IPC: C07D473/34 ,  C07D471/10 ,  A61K31/52 ,  A61P1/16

Abstract: This disclosure is directed to various compounds and methods of preparation of improved compounds that are capable of functioning as cannabinoid receptor 1 (CB1) antagonists with reduced central nervous system (CNS) side effects. The application is also directed to pharmaceutical compositions containing one or more of these compounds, which may also contain one or more additional therapeutic agents. It is also directed to methods of treatment of various conditions that may be responsive to antagonism of the CB1 receptors, including, but not limited to, metabolic syndromes (including liver disease, obesity, and diabetes).

公开(公告)号：US20200166494A1

公开(公告)日：2020-05-28

申请号：US16580683

申请日：2019-09-24

Applicant: Research Triangle Institute

Inventor： David S. Ensor ,  Li Han

IPC: G01N33/00 ,  G01N27/22 ,  G01N27/12

Abstract: A chemical sensor and a system and method for sensing a chemical species. The chemical sensor includes a plurality of nanofibers whose electrical impedance varies upon exposure to the chemical species, a substrate supporting and electrically isolating the fibers, a set of electrodes connected to the plurality of fibers at spatially separated points to permit the electrical impedance of the plurality of fibers to be measured, and a membrane encasing the fibers and having a thickness ranging from 50 μm to 5.0 mm. The system includes the chemical sensor, an impedance measuring device coupled to the electrodes and configured to determine an electrical impedance of the plurality of fibers, and an analyzer configured to identify the chemical species based on a change in the electrical impedance. The method measures at least one change in an electrical impedance between spatially separated electrodes connected to a plurality of fibers upon exposure of the fibers to the chemical species, and identifies the chemical species based on the measured change in the electrical impedance.

公开(公告)号：US10549233B2

公开(公告)日：2020-02-04

申请号：US15598927

申请日：2017-05-18

Applicant: Research Triangle Institute

Inventor： Marty Lail ,  Luke Coleman

IPC: B01D53/40 ,  B01D53/14

Abstract: A solvent system comprising a diluent and a nitrogenous base for the removal of CO2 from mixed gas streams is provided. Also provided is a process for removing CO2 from mixed gas streams using the disclosed solvent system. The solvent system may be utilized within a gas processing system.

公开(公告)号：US10414649B2

公开(公告)日：2019-09-17

申请号：US15521467

申请日：2015-10-20

Applicant: Research Triangle Institute

Inventor： David L. Denton ,  Raghubir P. Gupta ,  Brian S. Turk ,  Vijay Gupta ,  Himanshu Paliwal

IPC: C01B3/16 ,  B01D53/48 ,  B01D53/62 ,  B01D53/14 ,  B01D53/83 ,  B01D53/96 ,  B01J7/02 ,  B01J19/00 ,  C01B3/56 ,  C10K1/00 ,  C10K1/10 ,  C10K1/20 ,  C10K1/32 ,  C10K3/04 ,  C10L3/10 ,  B01D53/52 ,  B01J20/34 ,  C01B3/52 ,  C01B17/04 ,  C01B17/74

Abstract: Acid gas compounds are removed from a process gas such as, for example, syngas or natural gas, by flowing a feed gas into a desulfurization unit to remove a substantial fraction of sulfur compounds from the feed gas and flowing the resulting desulfurized gas into a CO2 removal unit to remove a substantial fraction of CO2 from the desulfurized gas.

公开(公告)号：US10345216B2

公开(公告)日：2019-07-09

申请号：US15504727

申请日：2015-08-20

Applicant: Research Triangle Institute

Inventor： Anthony Clint Clayton ,  Howard Jerome Walls ,  David S. Ensor ,  Andrei Yurievich Khlystov

IPC: G01N15/00 ,  G01N21/00 ,  G01N15/14 ,  G01N15/02 ,  G01N15/06 ,  G01N21/53 ,  G01N21/64 ,  C12Q3/00

Abstract: Sample monitoring and flow control systems and methods are disclosed for monitoring of airborne particulates. A system may include a particle collection filter. The system also includes a fluid moving device for moving a sample through the particle collection filter. Further, the system includes a light source configured to direct irradiating light towards the particle collection filter. The system also includes a light detector positioned to receive the irradiating light passing through the particle collection filter and configured to generate a signal representative of an amount of the received light. Further, the system includes a controller configured to receive the signal and to control the fluid moving device based on the amount of the received light.

公开(公告)号：US10264669B2

公开(公告)日：2019-04-16

申请号：US15141149

申请日：2016-04-28

Applicant: Research Triangle Institute

Inventor： Jay Lewis ,  Dorota Temple ,  Erik Vick ,  Ethan Klem

IPC: H05K1/00 ,  H05K1/02 ,  H05K1/18 ,  H05K3/30 ,  H05K3/40 ,  H05K3/46 ,  H05K1/11

Abstract: A flexible electronic assembly includes a flexible current-carrying device, an electrically insulating flexible substrate, and an electronic device embedded in the substrate. The electronic device is mounted face-down on the current-carrying device such that a contact side or component side of the electronic device faces the current-carrying device and is positioned at an interface between the current-carrying device and the substrate. The current-carrying device, substrate, and electronic device are co-planar at the interface. This configuration enables the flexible electronic assembly to have an ultra-thin thickness, for example on the order of micrometers.

公开(公告)号：US10018551B2

公开(公告)日：2018-07-10

申请号：US15877991

申请日：2018-01-23

Applicant: Research Triangle Institute

Inventor： Howard Jerome Walls ,  Anthony Clint Clayton ,  Randall J. Newsome ,  Paul G. Hoertz

IPC: G01N15/14 ,  G01N15/02 ,  G01N21/47 ,  G01N21/64 ,  G01N15/00 ,  G01N21/53

CPC classification number: G01N15/1436 ,  G01N15/0205 ,  G01N15/1459 ,  G01N21/53 ,  G01N21/645 ,  G01N21/6486 ,  G01N2015/0046 ,  G01N2015/1486 ,  G01N2015/1493 ,  G01N2021/4721 ,  G01N2201/06113 ,  G01N2201/062

Abstract: A particle detector includes a housing, a light source, and a photo-responsive material. The housing includes a sample inlet and a sample outlet, and encloses a detection cavity. The light source directs irradiating light along a longitudinal axis to particles of a sample fluid flowing in the detection cavity. The photo-responsive material surrounds at least a portion of the detection cavity, and receives measurement light propagating from the particles in a plurality of measurement light paths angled relative to the longitudinal axis. The particle detector may be utilized to measure scattered light and/or light emitted due to autofluorescence. Fluids sampled may include aerosols, bio-aerosols, and liquids.

公开(公告)号：US09943466B1

公开(公告)日：2018-04-17

申请号：US15622238

申请日：2017-06-14

Applicant: Research Triangle Institute ,  The University of North Carolina at Chapel Hill

Inventor： Leah Marie Johnson ,  Ginger Denison Rothrock ,  Sarah Dorothy Shepherd ,  Sandra Cordel O'Buckley ,  Andrea Gail Neely

IPC: A61K9/16 ,  A61K6/00 ,  A61K9/00 ,  A61K47/42

CPC classification number: A61K6/0067 ,  A61K6/0002 ,  A61K9/0002 ,  A61K9/1647 ,  A61K47/42 ,  A61K2300/00

Abstract: The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.

公开(公告)号：US09915600B2

公开(公告)日：2018-03-13

申请号：US15048199

申请日：2016-02-19

Applicant: Research Triangle Institute

Inventor： Howard Jerome Walls ,  Anthony Clint Clayton ,  Randall J. Newsome ,  Paul G. Hoertz

IPC: G01N15/14 ,  G01N21/64 ,  G01N21/53 ,  G01N21/47

CPC classification number: G01N15/1436 ,  G01N15/0205 ,  G01N15/1459 ,  G01N21/53 ,  G01N21/645 ,  G01N21/6486 ,  G01N2015/0046 ,  G01N2015/1486 ,  G01N2015/1493 ,  G01N2021/4721 ,  G01N2201/06113 ,  G01N2201/062

Abstract: A particle detector includes a housing, a light source, and a photo-responsive material. The housing includes a sample inlet and a sample outlet, and encloses a detection cavity. The light source directs irradiating light to particles of a sample fluid flowing in the detection cavity. The photo-responsive material faces the detection cavity, and receives measurement light propagating from the particles in a plurality of measurement light paths angled relative to a longitudinal axis. The particle detector may be utilized to measure scattered light and/or light emitted due to autofluorescence. Fluids sampled may include aerosols, bio-aerosols, and liquids.

公开(公告)号：US09881905B2

公开(公告)日：2018-01-30

申请号：US15304858

申请日：2015-04-20

Applicant: Research Triangle Institute

Inventor： Eric Paul Vick ,  Dorota Temple

IPC: H01L25/065 ,  H01L23/48 ,  H01L25/00

CPC classification number: H01L25/0657 ,  H01L23/481 ,  H01L23/49822 ,  H01L23/49827 ,  H01L24/24 ,  H01L24/25 ,  H01L24/29 ,  H01L24/82 ,  H01L24/83 ,  H01L24/92 ,  H01L25/50 ,  H01L2224/24051 ,  H01L2224/24105 ,  H01L2224/24146 ,  H01L2224/244 ,  H01L2224/245 ,  H01L2224/2511 ,  H01L2224/32145 ,  H01L2224/83191 ,  H01L2224/83203 ,  H01L2224/8385 ,  H01L2224/92144 ,  H01L2224/94 ,  H01L2225/06513 ,  H01L2225/06524 ,  H01L2225/06527 ,  H01L2225/06531 ,  H01L2225/06541 ,  H01L2225/06544 ,  H01L2225/06565 ,  H01L2924/01029 ,  H01L2924/01074 ,  H01L2924/01022 ,  H01L2224/83 ,  H01L2224/82

Abstract: An electronic package includes an adhesion layer between a first substrate and a second substrate. The adhesion layer is patterned to define openings aligned with through-substrate interconnects and corresponding bond pads. A conductive plane is formed between the first substrate and the second substrate, adjacent to the adhesion layer.