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21.发明授权3-[2-(Mono-and dialkylamino)propyl]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-C]pyridin- 5-ones useful for treating bronchospastic diseases 失效丙基] -1,2,3,4-四氢-5H- [1]苯并吡喃并[3,4-C]吡啶-5-酮可用于治疗支气管痉挛性疾病
公开(公告)号：US4382939A
公开(公告)日：1983-05-10
申请号：US351554
申请日：1982-02-23
IPC分类号： A61K31/435 , A61P11/00 , C07D491/04 , C07D491/052 , A61K31/455
CPC分类号： C07D491/04
摘要： Anticholinergic 3-[2-(mono- and dialkylamino)-propyl]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]-pyridin-5-ones useful for treating bronchospastic diseases in mammals are disclosed. Also disclosed are methods for preparing said compounds, pharmaceutical compositions containing them and methods for using said pharmaceutical compositions.A method for preparing the intermediate which is required to prepare the unsubstituted benzopyrano-[3,4-c]pyridin-5-ones of the invention is also disclosed.
摘要翻译： 抗胆碱能的3- [2-（单 - 和二烷基氨基） - 丙基] -1,2,3,4-四氢-5H- [1]苯并吡喃并[3,4-c] - 吡啶-5-酮可用于治疗支气管痉挛 公开了哺乳动物的疾病。 还公开了制备所述化合物的方法，含有它们的药物组合物和使用所述药物组合物的方法。 还公开了制备本发明的未取代的苯并吡喃并[3,4-c]吡啶-5-酮所需中间体的方法。
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公开(公告)号：US4287340A
公开(公告)日：1981-09-01
申请号：US132603
申请日：1980-03-21
申请人： Francis J. Tinney , David T. Connor , Wiaczeslaw A. Cetenko , Joseph J. Kerbleski , Roderick J. Sorenson
发明人： Francis J. Tinney , David T. Connor , Wiaczeslaw A. Cetenko , Joseph J. Kerbleski , Roderick J. Sorenson
IPC分类号： C07D333/38 , C07D495/14
CPC分类号： C07D495/14 , C07D333/38
摘要： Oxo-pyrido[1,2-a]thienopyrimidine compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating allergies using said compositions are disclosed.
摘要翻译： 公开了氧 - 吡啶并[1,2-a]噻吩并嘧啶化合物，其盐，生产方法，其制备中间体，含有所述化合物的药物组合物和使用所述组合物治疗过敏症的方法。
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23.发明授权7-O-(2,6-Dideoxy-.alpha.-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone 失效7-O-（2,6-二脱氧-α-L-赖索 - 六吡喃糖基） - 日光霉素酮，去甲氧基道诺霉素，阿霉素酮和卡明霉素酮
公开(公告)号：US4201773A
公开(公告)日：1980-05-06
申请号：US928252
申请日：1978-07-26
申请人： Derek Horton , Wolfgang Weckerle , Ernst F. Fuchs , Tak M. Cheung , Beat Winter , Roderick J. Sorenson
发明人： Derek Horton , Wolfgang Weckerle , Ernst F. Fuchs , Tak M. Cheung , Beat Winter , Roderick J. Sorenson
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , A61P35/02 , C07H3/02 , C07H13/04 , C07H15/04 , C07H15/252 , A61K31/71 , C07H15/24
CPC分类号： C07H15/04 , C07H13/04 , C07H15/252 , C07H3/02 , Y10S514/908
摘要： A series of compounds showing high antileukemic activity against P388 murine leukemia and increased aqueous solubility due to substitution of --OH for the known --NH.sub.2 at the 3' position of the hexopyranose sugar, i.e., daunosamine.These compounds are coupled products of aglycon selected from daunomycinone, desmethoxy daunomycinone, adriamycinone and carminomycinone. These compounds are coupled at the 0-7 position of the aglycon with an .alpha.-L-lyxo hexopyranose sugar, which sugar isomer particularly sustains or potentiates the biological activity of the coupled compound as well as ameliorates the dose related cardiotoxicity of the parent and known compounds set out below: ##STR1##
摘要翻译： 一系列化合物对P388鼠白血病显示出高抗白血病活性，并且由于在六吡喃糖糖的3'位置即daunosamine上取代-OH已知的-NH 2而增加水溶性。 这些化合物是选自道诺霉素酮，去甲氧基道诺霉素酮，阿霉素酮和卡明霉素酮的糖苷配基的偶联产物。 这些化合物在糖苷配基的0-7位与α-L-赖索倍半吡糖糖偶联，所述糖异构体特别维持或增强偶联化合物的生物活性，并且改善了母体的剂量相关的心脏毒性和已知的 化合物如下：
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24.发明授权3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents 失效2-取代噻唑烷酮，恶唑烷酮和咪唑啉酮的3,5-二叔丁基-4-羟基苯基亚甲基衍生物作为抗炎剂
公开(公告)号：US5494927A
公开(公告)日：1996-02-27
申请号：US353166
申请日：1994-12-09
申请人： Wiaczeslaw A. Cetenko , David T. Connor , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst
发明人： Wiaczeslaw A. Cetenko , David T. Connor , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst
IPC分类号： A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61P29/00 , C07D233/96 , C07D263/40 , C07D263/46 , C07D263/48 , C07D277/20 , C07D277/34 , C07D277/36 , C07D277/48 , C07D277/50 , C07D277/54 , C07D233/86
CPC分类号： C07D277/20 , C07D233/96 , C07D263/46 , C07D263/48
摘要： The novel 3,5-ditertiarybutyl-4-hydroxy-phenylmethylene derivative of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents having inhibiting activity for 5-lipoxygenase, cyclooxygenase, or both.
摘要翻译： 2-取代的噻唑烷酮，恶唑烷酮和咪唑啉酮的3,5-二叔丁基-4-羟基 - 苯基亚甲基衍生物作为具有5-脂氧合酶抑制活性，环加氧酶或两者的抗炎剂。
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25.发明授权3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents 失效作为抗炎药的2-取代的噻唑烷酮，奥昔洛芬和咪唑啉二酮的3,5-二叔丁基-4-羟基苯基乙烯衍生物
公开(公告)号：US5143928A
公开(公告)日：1992-09-01
申请号：US640711
申请日：1991-01-18
申请人： Wiaczeslaw A. Cetenko , David T. Connor , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst
发明人： Wiaczeslaw A. Cetenko , David T. Connor , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst
IPC分类号： A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61P29/00 , C07D233/96 , C07D263/40 , C07D263/46 , C07D263/48 , C07D277/20 , C07D277/34 , C07D277/36 , C07D277/48 , C07D277/50 , C07D277/54
CPC分类号： C07D277/20 , C07D233/96 , C07D263/46 , C07D263/48
摘要： The novel 3,5-ditertiarybutyl-4-hydroxy-phenylmethylene derivative of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents having inhibiting activity for 5-lipoxygenase, cyclooxygenase, or both.
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公开(公告)号：US4868200A
公开(公告)日：1989-09-19
申请号：US166146
申请日：1988-03-09
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
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公开(公告)号：US4562006A
公开(公告)日：1985-12-31
申请号：US569814
申请日：1984-01-11
IPC分类号： C07C33/05 , C07C45/29 , C07C45/59 , C07C45/72 , C07C47/225 , C07C47/45 , C07C57/26 , C07D317/12 , C07C57/03 , A61K31/215 , C11C3/02
CPC分类号： C07D317/12 , C07C33/05 , C07C45/292 , C07C45/59 , C07C45/72 , C07C47/225 , C07C47/45 , C07C57/26
摘要： Cycloheptadiene analogues of arachidonic acid as well as their cyclopropyl intermediates are described as inhibiting human leukocyte lipoxygenase and antagonizing SRS-A. Methods of manufacture and pharmaceutical compositions are described. The compounds are useful in treating allergic diseases, cardiovascular diseases and immunoinflammatory diseases.
摘要翻译： 花生四烯酸的环己二烯类似物及其环丙基中间体被描述为抑制人白细胞脂氧合酶和拮抗SRS-A。 描述了制造方法和药物组合物。 该化合物可用于治疗过敏性疾病，心血管疾病和免疫炎性疾病。
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28.发明授权3-[2-(Azabicyclo) ethyl]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-ones 失效3- [2-（氮杂双环）乙基] -1,2,3,4-四氢-5H- [1]苯并吡喃并[3,4-c]吡啶-5-酮
公开(公告)号：US4404138A
公开(公告)日：1983-09-13
申请号：US391197
申请日：1982-06-22
IPC分类号： C07D453/06 , A61K31/435 , A61P11/08 , C07D491/04 , C07D491/052 , C07D491/14 , C07D519/00
CPC分类号： C07D491/04 , C07D491/14 , Y10S514/826
摘要： Anticholinergic 3-[2-(azabicyclo)ethyl]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-ones useful for treating bronchospastic diseases in mammals are disclosed. Also disclosed are methods for preparing said compounds, pharmaceutical compositions containing them and methods for using said pharmaceutical compositions.
摘要翻译： 公开了用于治疗哺乳动物支气管痉挛疾病的抗胆碱能3-3- [2-（氮杂双环）乙基] -1,2,3,4-四氢-5H- [1]苯并吡喃并[3,4-c]吡啶-5- 。 还公开了制备所述化合物的方法，含有它们的药物组合物和使用所述药物组合物的方法。
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