公开(公告)号：US07975800B2

公开(公告)日：2011-07-12

申请号：US10549399

申请日：2004-03-12

申请人： Stefan Hummel ,  Falk Hecker ,  Matthias Horn ,  Herbert Schramm

发明人： Stefan Hummel ,  Falk Hecker ,  Matthias Horn ,  Herbert Schramm

IPC分类号： B62D5/04 ,  B62D5/06 ,  B62D13/00

CPC分类号： B62D7/144

摘要： A steering device for vehicles having a pair of wheels which can be steered freely as a function of the current driving state of the vehicle or whose steered position can be locked by an electronically actuable locking device, having an electronic control device and having sensors which are connected to the electronic control device and have the purpose of monitoring current driving state values, with the electronic control device actuating the locking device when a minimum velocity of the vehicle is exceeded, in such a way that the steered position of the pair of wheels is locked, characterized in that driving state values which characterize critical driving situations are additionally stored in the electronic control device, in which the steered position of the pair of wheels is locked in critical driving situations, and in which, after a critical driving situation, the locking device does not release the pair of wheels again until predefined critical driving state values are undershot at least for a predefined period of time.

摘要翻译： 一种用于车辆的转向装置，其具有可以根据车辆的当前驾驶状态自由地转向的一对车轮，或者其转向位置可以由电子可致动的锁定装置锁定，具有电子控制装置并且具有传感器 连接到电子控制装置，并且具有监视当前驱动状态值的目的，当超过车辆的最小速度时，电子控制装置致动锁定装置，使得一对车轮的转向位置为 其特征在于，将表征关键驾驶状况的驾驶状态值另外存储在所述电子控制装置中，在所述电子控制装置中，所述一对车轮的转向位置在关键驾驶状况下被锁定，并且在所述电动控制装置中， 锁定装置不再释放一对轮子，直到预定义的关键驾驶状态值为低 至少在预定义的时间段内。

公开(公告)号：US07765868B2

公开(公告)日：2010-08-03

申请号：US10571297

申请日：2004-09-20

申请人： Matthias Pirsch ,  Stefan Hummel

发明人： Matthias Pirsch ,  Stefan Hummel

IPC分类号： G01N21/01 ,  G01D11/24

CPC分类号： B01L1/00 ,  B01L2300/10 ,  B01L2300/1838 ,  C12M23/48 ,  C12M23/54 ,  C12M41/14 ,  C12M41/36 ,  G02B21/24

摘要： A climate chamber, which is in particular suitable for chemical and/or biological samples, comprises a climate compartment defined by a housing. Inside the climate compartment an analysis device, such as a microscope, is at least partially arranged. Further, the housing comprises an inlet opening for supplying a conditioning medium flow. For preventing condensation at condensate-sensitive components the medium flow is directed such that it at least partially flows against the analysis device and/or the sample carrier.

摘要翻译： 特别适用于化学和/或生物样品的气候室包括由壳体限定的气候室。 在气候室内，分析装置如显微镜至少部分地布置。 此外，壳体包括用于供应调节介质流的入口。 为了防止在冷凝物敏感组分处的冷凝，引导介质流，使得其至少部分地流过分析装置和/或样品载体。

公开(公告)号：US20060198766A1

公开(公告)日：2006-09-07

申请号：US10556095

申请日：2004-05-10

申请人： Torsten Muller ,  Stefan Hummel ,  Annette Pfennig

发明人： Torsten Muller ,  Stefan Hummel ,  Annette Pfennig

IPC分类号： B01L9/00

CPC分类号： B01L9/523 ,  B01J2219/00804 ,  B01J2219/0081 ,  B01L9/52 ,  B01L13/02 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/028

摘要： The invention relates to a docking device (100) for retaining a fluidic microsystem (10), comprising a base plate (20) and a retaining frame (30), movable relative to the base plate (20) and used to fasten the microsystem (10) on the base plate (20). The retaining frame (30) is adapted to detachably receive the microsystem (10) and can be detached from the base plate (20) together with the microsystem (10). The device is also provided with a clamping device (40) with which the microsystem (10) on the retaining frame (30) can be pushed against the base plate (20). The invention also relates to methods for operating a fluidic microsystem (10) using said docking device (100).

摘要翻译： 本发明涉及一种用于保持流体微系统（10）的对接装置（100），其包括可相对于基板（20）移动并用于紧固微系统（20）的基板（20）和保持框架（30） 10）在基板（20）上。 保持框架（30）适于可拆卸地接收微系统（10）并且可以与微系统（10）一起从基板（20）拆下。 该装置还设置有夹紧装置（40），保持框架（30）上的微系统（10）可以通过该夹紧装置推靠在基板（20）上。 本发明还涉及使用所述对接装置（100）操作流体微系统（10）的方法。

公开(公告)号：US6122098A

公开(公告)日：2000-09-19

申请号：US202333

申请日：1998-12-11

申请人： Peet Kask ,  Stefan Hummel

发明人： Peet Kask ,  Stefan Hummel

IPC分类号： G02B26/12 ,  G02B21/00 ,  G02B26/10

CPC分类号： G02B21/0076 ,  G02B21/0024 ,  G02B21/0048

摘要： A confocal microscope for optical detection of an observation volume includes a light source, a dichroic mirror, and an objective lens arrangement which further includes a mechanical aperture and an observation optic arrangement. Between the dichroic mirror and the objective lens arrangement, a deflection mirror arrangement is located having a planar deflection mirror on the side of the objective which is arranged to oscillate about a normal position. The objective-side deflection mirror is designed so that, upon oscillation of the objective-side mirror, optical axes of the reflected excitation light intersect in a substantially common intersection in the area of the mechanical aperture of the objective lens arrangement, and so that, when the objective-side deflection mirror is in its normal position the oscillation axis of the objective-side deflection mirror coincides with the line of intersection of the plane in which the objective-side deflection mirror lies, and a plane extending through the common intersection of the optical axes of the reflected excitation light which is perpendicular to the optical axis of the reflected light.

摘要翻译： PCT No.PCT / EP97 / 03022 Sec。 371 1998年12月11日第 102（e）日期1998年12月11日PCT提交1997年6月11日PCT公布。 WO97 / 48001 PCT出版物 日期1997年12月18日用于观察体积的光学检测的共焦显微镜包括光源，分色镜和物镜装置，其进一步包括机械孔和观察光学装置。 在分色镜和物镜布置之间，偏转镜布置被定位成具有在物镜侧面上的平面偏转镜，该反射镜布置成围绕正常位置摆动。 物镜侧偏转镜被设计为使得在物镜侧反射镜的振荡时，反射的激发光的光轴在物镜装置的机械孔的区域中与基本相同的交叉点相交， 当物镜侧偏转镜处于其正常位置时，物镜侧偏转镜的摆动轴与物镜侧偏转镜所在的平面的交点相交， 与反射光的光轴垂直的反射的激发光的光轴。

公开(公告)号：US07510685B2

公开(公告)日：2009-03-31

申请号：US10556017

申请日：2004-05-10

申请人： Torsten Müller ,  Stefan Hummel ,  Annette Pfennig

发明人： Torsten Müller ,  Stefan Hummel ,  Annette Pfennig

IPC分类号： B01L3/00

CPC分类号： G01N15/1404 ,  G01N2015/1409 ,  G01N2015/1413 ,  G01N2015/1418

摘要： The invention relates to a particle injector for introducing particles into a carrier flow of a microfluidic system, especially for injecting biological cells into the carrier flow of a cell sorter. The particle injector includes an inlet for receiving the carrier flow, an outlet for discharging the carrier flow including the introduced particles, a carrier flow channel which connects the inlet to the outlet, and an injection channel flowing into the carrier flow channel for introducing the particles into the carrier flow. The inventive particle injector is characterized in that the carrier flow channel has substantially no dead volume.

摘要翻译： 本发明涉及一种用于将颗粒引入微流体系统的载体流中的颗粒注入器，特别是用于将生物细胞注入到细胞分选器的载体流中。 颗粒注射器包括用于接收载体流的入口，用于排出包括引入的颗粒的载体流的出口，将入口连接到出口的载体流动通道和流入载体流动通道中以引入颗粒的注入通道 进入载体流。 本发明的颗粒注射器的特征在于载体流动通道基本上没有死体积。

公开(公告)号：US07475916B2

公开(公告)日：2009-01-13

申请号：US10509190

申请日：2003-03-25

申请人： Torsten Müller ,  Annette Pfennig ,  Stephen Shirley ,  Stefan Hummel ,  Martin Reichel

发明人： Torsten Müller ,  Annette Pfennig ,  Stephen Shirley ,  Stefan Hummel ,  Martin Reichel

IPC分类号： F16L25/00 ,  F16L35/00

CPC分类号： F16L37/05

摘要： A coupling device (100), particularly for liquid-tight coupling of at least one liquid line (10) to a fluidic system (20), is described, which comprises: at least one sealing device (30), which is implemented to receive an end region (11) of the liquid line (10) and has a first sealing surface (31) for placement on an external surface (22) of the fluidic system in such a way that the end of the liquid line (10) is laterally enclosed by the first sealing surface (31) and points toward an opening (23) in the external surface (22), and a clamping device (40), using which the sealing device (30) may be pressed against the fluidic system (20), so that the first sealing surface (31) produces a liquid-tight connection with the external surface (22).

摘要翻译： 描述了一种尤其用于至少一条液体管线（10）与流体系统（20）的液密耦合的联接装置（100），其包括：至少一个密封装置（30），其被实施为接收 液体管线（10）的端部区域（11），并且具有用于放置在流体系统的外表面（22）上的第一密封表面（31），使得液体管线（10）的端部为 由第一密封表面（31）横向包围并指向外表面（22）中的开口（23）的夹紧装置（40），密封装置（30）可以被压靠流体系统 20），使得第一密封表面（31）产生与外表面（22）的液密连接。

公开(公告)号：US07304793B2

公开(公告)日：2007-12-04

申请号：US10478016

申请日：2002-05-08

申请人： Stefan Hummel

发明人： Stefan Hummel

IPC分类号： G02B21/06 ,  G02B3/00 ,  G01J3/30

CPC分类号： G02B21/33 ,  G02B21/0028

摘要： An apparatus for examination of chemical and/or biological samples, comprises a sample support (14) for receiving the samples (16). Further, the apparatus comprises an objective (10) for observation of the sample (16) through a sample support wall (18). A gap (22) is formed between an outer surface (20) of the sample support wall (18) and an exit lens (12) of the objective (10). According to the invention, an automatic supply device (24) for automatic supply of immersion medium (46) is provided between the outer surface (20) of the sample support wall (18) and the exit lens (12) of the objective (10).

摘要翻译： 一种用于检查化学和/或生物样品的装置，包括用于接收样品（16）的样品支架（14）。 此外，该装置包括用于通过样品支撑壁（18）观察样品（16）的物镜（10）。 在样品支撑壁（18）的外表面（20）和物镜（10）的出射透镜（12）之间形成间隙（22）。 根据本发明，在样品支撑壁（18）的外表面（20）和物镜（10）的出射透镜（12）之间设置用于自动供应浸没介质（46）的自动供应装置（24） ）。

公开(公告)号：US20060152708A1

公开(公告)日：2006-07-13

申请号：US10544423

申请日：2004-02-04

申请人： Torsten Muller ,  Stefan Hummel ,  Annette Pfennig ,  Gabriele Gradl ,  Axel Bonsen ,  Thomas Schnelle ,  Rudiger Meyer

发明人： Torsten Muller ,  Stefan Hummel ,  Annette Pfennig ,  Gabriele Gradl ,  Axel Bonsen ,  Thomas Schnelle ,  Rudiger Meyer

IPC分类号： G01N21/00

CPC分类号： G01N15/1459 ,  C12M47/04 ,  G01N15/1056 ,  G01N15/12 ,  G01N15/147 ,  G01N15/1484 ,  G01N2015/1006 ,  G01N2015/1037 ,  G01N2015/1081 ,  G01N2015/1477 ,  G01N2015/149 ,  G01N2015/1497 ,  G01N2035/00158

摘要： Disclosed is a method for measuring properties of particles that move through a fluidic microsystem, the particles being suspended in a liquid. According to the inventive method, a first parameter of a specific particle is first measured at a first test station (11). A second parameter of the particle is then measured at an interval from the first measurement at a second test station (12) which is spatially separated from the first test station (11), and the first and second parameters are jointly evaluated in a correlated manner, the first and second parameters being characteristic of different properties of the tested particle. The evaluation comprises a comparison of the first and second parameters with predetermined expected values. Another measurement is taken or manipulations are performed on the tested particle according to the result of the comparison. Also disclosed is a fluidic microsystem that is designed for implementing the inventive method.

摘要翻译： 公开了一种用于测量移动通过流体微系统的颗粒的性质的方法，所述颗粒悬浮在液体中。 根据本发明的方法，首先在第一测试台（11）测量特定颗粒的第一参数。 然后在与第一测试站（11）在空间上分离的第二测试站（12）以与第一测量的间隔的间隔测量颗粒的第二参数，并且以相关方式联合评估第一和第二参数 ，第一和第二参数是测试颗粒的不同性质的特征。 评估包括第一和第二参数与预定预期值的比较。 根据比较的结果，对测试的颗粒进行另一测量或操作。 还公开了被设计用于实施本发明方法的流体微系统。

公开(公告)号：US20060139638A1

公开(公告)日：2006-06-29

申请号：US10544463

申请日：2004-02-04

申请人： Torsten Muller ,  Stefan Hummel ,  Annette Pfennig ,  Gabriele Gradl ,  Axel Bonsen ,  Rudiger Meyer

发明人： Torsten Muller ,  Stefan Hummel ,  Annette Pfennig ,  Gabriele Gradl ,  Axel Bonsen ,  Rudiger Meyer

IPC分类号： G01N21/00 ,  G01N21/64 ,  G01N15/02

CPC分类号： G01N15/1459 ,  C12M47/04 ,  G01N15/1056 ,  G01N15/12 ,  G01N15/147 ,  G01N15/1484 ,  G01N2015/1006 ,  G01N2015/1037 ,  G01N2015/1081 ,  G01N2015/1477 ,  G01N2015/149 ,  G01N2015/1497 ,  G01N2035/00158

摘要： The invention relates to an method of analysing biological particles, in particular to be conducted in a cell sorter, with following steps: placing the particles to be analysed into a carrier flow, carrying out a first analysis of the particles moving with the carrier flow, selecting at least one particle in dependence on the result of the first analysis, carrying out a second analysis of the selected particle in a decelerated condition. Furthermore, the invention comprises a corresponding analysis device.

摘要翻译： 本发明涉及一种分析生物颗粒的方法，特别是在细胞分选器中进行分析，其步骤如下：将要分析的颗粒放入载体流中，对载体流动的颗粒进行第一次分析， 根据第一次分析的结果选择至少一个粒子，在减速条件下进行所选粒子的第二次分析。 此外，本发明包括相应的分析装置。

公开(公告)号：US06314383B1

公开(公告)日：2001-11-06

申请号：US09110810

申请日：1998-07-06

申请人： Klaus-Dieter Leimbach ,  Hans Veil ,  Stefan Hummel

发明人： Klaus-Dieter Leimbach ,  Hans Veil ,  Stefan Hummel

IPC分类号： G01G1100

CPC分类号： G01G19/086 ,  B60T8/172 ,  B60T2250/02 ,  B60W40/076 ,  B60W40/13 ,  B60W2510/0657 ,  B60W2520/105 ,  F16H59/52

摘要： A method and a system for ascertaining a mass value representing the vehicle mass of a motor vehicle, particularly of a commercial vehicle, having a drive unit. An acquisition at least of a first and a second acceleration value is provided for this determination. These acceleration values represent the vehicle acceleration at a first and a second point of time. Further, at least one first and one second drive value are acquired. These drive values represent the drive force or the drive torque of the drive unit at the first and the second point of time. At least as a function of the acquired acceleration values and the acquired drive values, at least a first and a second driving-resistance value are then determined. The mass value is ascertained at least as a function of a comparison of the determined first driving-resistance or mass estimated value to the determined second driving-resistance or mass estimated value. A roadway slope is detected using the comparison, whereby an erroneous mass determination caused by the roadway slope is avoided.

摘要翻译： 一种用于确定代表具有驱动单元的机动车辆，特别是商业车辆的车辆质量的质量值的方法和系统。 提供至少第一和第二加速度值的获取用于该确定。 这些加速度值表示在第一和第二时间点的车辆加速度。 此外，获取至少一个第一和第二驱动值。 这些驱动值表示驱动单元在第一和第二时间点的驱动力或驱动扭矩。 至少根据所获取的加速度值和获取的驱动值的函数，至少确定第一和第二驱动电阻值。 至少确定质量值作为所确定的第一驱动阻力或质量估计值与所确定的第二驱动阻力或质量估计值的比较的函数。 使用比较来检测道路坡度，由此避免了由道路坡度引起的错误质量确定。