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公开(公告)号：US20210059654A1
公开(公告)日：2021-03-04
申请号：US16961224
申请日：2019-01-10
发明人： Garrett Ryan , Colm McGarvey
摘要： A system for performing a minimally invasive percutaneous procedure comprises a medical device comprising a hydrogel delivery needle (4) with a tip and a hydrogel outlet (6), an injectable, shear-thinning, self-healing viscoelastic hydrogel that exhibits a storage modulus (G) of at least 600 Pa, and a tan δ (G″/G) from 0.1 to 0.6 in dynamic viscoelasticity measured by a rheometer at 1 Hz and 1% strain rate at 25° C. The system may also comprise a coaxial cannula (2) having a lumen configured for receipt of the hydrogel delivery needle (4), wherein the hydrogel delivery needle comprises an adjustable positioning mechanism (8) configured to limit the advancement depth of the hydrogel delivery needle through the coaxial cannula to a predetermined depth distal to a distal-most end of the coaxial cannula.
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22.发明申请公开(公告)号：US20180284107A1
公开(公告)日：2018-10-04
申请号：US15765846
申请日：2016-10-07
申请人： The Provost, Fellows, Scholars and Other Members of Board of Trinity College Dublin , University College Cork - National University of Ireland, Cork
发明人： Peter Fleming , Michael Morris , Thomas Fitzgerald , Ramesh Babu , Paul Delaney , Clifton Ngan , Niamh Hennesey , Kamran Beyzavi
IPC分类号： G01N33/545 , B01D67/00 , B01D69/02 , B01D71/40 , G01N33/543
摘要： A poly(methyl methacrylate) (PMMA) membrane having a highly porous, reticulated, 3-D structure suitable for lateral flow diagnostic applications is described. Also described is a method for producing a poly(methyl methacrylate) (PMMA) membrane that comprises the steps of mixing a suitable amount of PMMA, a solvent and a optionally one of either a co-solvent or a non-solvent to produce a solution, casting a thin film of the solution onto a support, and removal of the solvent from the solution to produce the PMMA membrane. A lateral flow diagnostic device comprising a highly porous PMMA membrane as a reaction membrane is also described.
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公开(公告)号：US11998660B2
公开(公告)日：2024-06-04
申请号：US16795770
申请日：2020-02-20
发明人： Daniel John Kelly , Grainne Cunniffe , Henrique Almeida , Rajalakshmanan Eswaramoorthy , Conor Buckley , Pedro Jose Diaz Payno , David Browe
IPC分类号： A61L27/50 , A61L27/36 , A61L27/38 , A61L27/44 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58
CPC分类号： A61L27/3633 , A61L27/3612 , A61L27/365 , A61L27/3654 , A61L27/3683 , A61L27/3691 , A61L27/3695 , A61L27/3817 , A61L27/3821 , A61L27/3847 , A61L27/3852 , A61L27/44 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/64 , A61L2430/02 , A61L2430/06 , A61L2430/40
摘要： A method for making a porous devitalised scaffold suitable for use in repair of osseous, chondral, or osteochondral defects in a mammal comprises the steps of providing micronized extracellular matrix (ECM) tissue, mixing the micronized extracellular matrix with a liquid to provide a slurry, and freeze-drying the slurry to provide the porous scaffold. A porous scaffold suitable for use in repair of osseous, chondral, or osteochondral defects in a mammal and comprising a porous freeze-dried matrix formed from micronised decellularised extracellular matrix tissue is also described.
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公开(公告)号：US20240055117A1
公开(公告)日：2024-02-15
申请号：US18268708
申请日：2021-12-24
申请人： THE PROVOST, FELLOWS, SCHOLARS AND OTHER MEMBERS OF BOARD OF TRINITY COLLEGE DUBLIN , Royal College of Surgeons in Ireland
发明人： Dara MELDRUM
CPC分类号： G16H40/67 , G06F3/012 , A61B5/7475 , A61B5/7405 , A61B5/742 , G16H20/30
摘要： A system and method for vestibular and/or balance rehabilitation by monitoring and measuring head motion data of a user having vestibular impairment. The system as includes a user device, a head tracking device, and a remote server device. The user device receives therapeutical configuration data prescribed by a therapist using the remote server device. A visual and auditory and/or haptic stimuli is generated in the user interface according to the received therapeutic configuration data during a training session or initial assessment session. Head motion data from the head tracking device during the training session is received along with user inputted data pertaining to symptoms of the user. The remote server device receives and processes the head motion and positional data, the user inputted symptoms data and communicates a set of updated therapeutic configuration data to the user device based on the processed data for use in a next training session.
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公开(公告)号：US20240002947A1
公开(公告)日：2024-01-04
申请号：US18066693
申请日：2022-12-15
申请人： The Provost, Fellows, Scholars and Other Members of Board of Trinity College Dublin , University College Dublin, National University of Ireland, Dublin
发明人： Adrian Bracken , Fiona Lanigan , William Gallagher
IPC分类号： C12Q1/6886 , G01N33/574 , A61K31/519
CPC分类号： C12Q1/6886 , G01N33/57415 , G01N33/57484 , A61K31/519 , C12Q2600/158 , C12Q2600/118 , C12Q2600/106
摘要： A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least two genes or proteins encoded by those genes selected from the group consisting of FOXM1, UHRF1, PTTG1, E2F1, MYBL2, HMGB2, ATAD2, E2F8, ZNF367 and TCF19, wherein positive expression of the at least two genes correlates with increased risk of recurrence of cancer compared with an individual who does not exhibit positive expression of the at least two genes or proteins encoded by those genes.
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公开(公告)号：US20230054776A1
公开(公告)日：2023-02-23
申请号：US17809187
申请日：2022-06-27
发明人： Garrett Ryan , Colm McGarvey
摘要： A system for performing a minimally invasive percutaneous procedure comprises a medical device comprising a hydrogel delivery needle (4) with a tip and a hydrogel outlet (6), an injectable, shear-thinning, self-healing viscoelastic hydrogel that exhibits a storage modulus (G′) of at least 600 Pa, and a tan δ (G"/G′) from 0.1 to 0.6 in dynamic viscoelasticity measured by a rheometer at 1 Hz and 1% strain rate at 25° C. The system may also comprise a coaxial cannula (2) having a lumen configured for receipt of the hydrogel delivery needle (4), wherein the hydrogel delivery needle comprises an adjustable positioning mechanism (8) configured to limit the advancement depth of the hydrogel delivery needle through the coaxial cannula to a predetermined depth distal to a distal-most end of the coaxial cannula.
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27.发明授权公开(公告)号：US11318637B2
公开(公告)日：2022-05-03
申请号：US15587638
申请日：2017-05-05
发明人： Graham Cross , James Annett
摘要： A method for patterning layers of 2D material by inducing self-assembly on a support substrate, the method comprising the steps of depositing a layer of 2D material on the support substrate; applying a force at a region consisting of a point, a line, or an a real region of the 2D material such that the 2D material forms a folded, self-contacting structure at that region.
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公开(公告)号：US20210403775A1
公开(公告)日：2021-12-30
申请号：US16762495
申请日：2018-11-08
摘要： An adhesive formulation such as a hot melt adhesive or a pressure sensitive adhesive is provided comprising 5 to 98% (by weight) biodegradable substantially non-crystalline mcl-PHA. The mcl-PHA may be cured with a peroxide curing agent. The adhesive formulation may include an additional biodegradable polymer, or a non-biodegradable thermoplastic elastomer. Hot melt adhesives comprising significant amounts of biodegradable mcl-PHA, waxes, and tackifiers are also provided.
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29.发明申请公开(公告)号：US20200383070A1
公开(公告)日：2020-12-03
申请号：US16754275
申请日：2018-10-08
发明人： Thomas Farrell , Haris Kremo , Justin Tallon
摘要： The invention provides a system and method of identifying when a message is received at a control station from at least one device in a network having a plurality of devices, said method comprising the steps of receiving at the control station a low bandwidth signal from at least one device; obtaining a coarse timestamp estimate of when said low bandwidth signal is received by correlating with a pre-programmed signal template; generating a higher resolution correlation estimate by phase shifting the pre-programmed signal template and repeating the correlation; and detecting where the correlation is above a preselected value; and applying a curve fitting function about the higher resolution correlation estimate to obtain an accurate timestamp when the message was received.
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公开(公告)号：US20200157643A1
公开(公告)日：2020-05-21
申请号：US16722041
申请日：2019-12-20
申请人： THE PROVOST, FELLOWS, SCHOLARS AND OTHER MEMBERS OF BOARD OF TRINITY COLLEGE DUBLIN , UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
发明人： Adrian BRACKEN , Fiona LANIGAN , William GALLAGHER
IPC分类号： C12Q1/6886 , G01N33/574 , A61K31/519
摘要： A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least two genes or proteins encoded by those genes selected from the group consisting of FOXM1, UHRF1, PTTG1, E2F1, MYBL2, HMGB2, ATAD2, E2F8, ZNF367 and TCF19, wherein positive expression of the at least two genes correlates with increased risk of recurrence of cancer compared with an individual who does not exhibit positive expression of the at least two genes or proteins encoded by those genes.
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