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公开(公告)号：US10456295B2
公开(公告)日：2019-10-29
申请号：US14408246
申请日：2013-06-13
Inventor： Vadim Shmukler , Yoseph Glovinsky
IPC: A61F9/007 , A61B10/02 , A61B17/3207 , A61B17/16 , A61B17/00
Abstract: The present disclosure provides a device, an assembly comprising the device and a method making use of same, the device comprising an elongated member extending between a first end and a second end, and a segment proximal to the second end extending along a longitudinal axis X, said segment comprises at least one depression axially extending along at least a portion of said segment and an external surface having a circumference C; and one or more blades with a cutting edge peripheral to C and the one or more blades extending along at least part of said segment; the first end comprising an engagement element for engagement with a grip unit comprising a rotor to cause rotation of said device about said axis upon actuation of the rotor and the second end comprising a tissue piercing tip. The device, assembly and method are useful in creating a channel in a biological soft tissue, such as a drainage channel in the sclero-corneal junction area of the eye. This may be useful in reducing intra-ocular pressure.
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公开(公告)号：US20190231522A1
公开(公告)日：2019-08-01
申请号：US16374240
申请日：2019-04-03
Inventor： Ehud RAANANI , Boris ORLOV , Boaz HARARI , Oded MEIRI , Lichen ROZITSKY
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2/243 , A61F2/2436 , A61F2/2457 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/0013 , A61F2230/005 , A61F2230/0078 , A61F2250/006
Abstract: Apparatus and methods are described including a valve frame configured to support a prosthetic valve within a native atrio-ventricular valve. The valve frame includes a frame body that includes an atrial portion configured to be positioned such that, when the valve frame is deployed, at least a portion of the atrial portion is disposed on an atrial side of the native atrio-ventricular valve, and a ventricular portion configured to be positioned such that, when the valve frame is deployed, at least a portion of the ventricular portion is disposed within a ventricle of the subject. At least one arm is configured to extend from the ventricular portion of the frame body. Other applications are also described.
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23.发明申请公开(公告)号：US20190139202A1
公开(公告)日：2019-05-09
申请号：US16097285
申请日：2017-05-04
Applicant: TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Arnaldo MAYER , Michael GREEN , Nahum KIRYATI , Edith M. MAROM , Eli KONEN
Abstract: A method of providing a medical image of a ROI of a patient, the method comprising: acquiring a first medical image of a region of interest (ROI) of a patient, the medical image characterized hy a first signal to noise ratio (SNR); determining for a given pixel in the first image a plurality of different first image patches in the first image, each having a pixel that is coincident with the given pixel; determining for each first image patch a similar second image patch having a second SNR greater than the first SNR; determining an enhanced pixel value for the given pixel having an enhanced SNR greater than the first SNR responsive to pixel values of pixels in the determined second image patches; and using the determined pixel value to generate a second medical image of the ROI having an enhanced SNR greater than the first SNR.
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公开(公告)号：US20190133519A1
公开(公告)日：2019-05-09
申请号：US16233361
申请日：2018-12-27
Applicant: Ramot at Tel-Aviv University Ltd. , Tel HaShomer Medical Research Infrastructure and Services Ltd. , Afeka Yissumim Ltd.
Inventor： Israel GANNOT , Oshrit HOFFER , Dror ALEZRA , Merav A. BEN-DAVID , Eyal KATZ
Abstract: A method of monitoring a malignant tissue response to cancer treatment, including: acquiring, throughout a treatment course, one or more thermal images of the treated malignant tissue; processing the one or more thermal images to detect changes in the malignant tissue following the treatment; and analyzing the processed images to determine an effect of the treatment on the malignant tissue based on said detected changes.
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公开(公告)号：US10275680B2
公开(公告)日：2019-04-30
申请号：US14352099
申请日：2012-10-18
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , Ramot at Tel-Aviv University Ltd.
Inventor： Leor Zach , David Guez , David Last , Dianne Daniels , Yael Mardor
Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.
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Patent Agency Ranking
公开(公告)号：US10179151B2
公开(公告)日：2019-01-15
申请号：US14983657
申请日：2015-12-30
Inventor： Sarah Ferber
Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic β-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
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公开(公告)号：US10136818B2
公开(公告)日：2018-11-27
申请号：US15307012
申请日：2015-04-28
Applicant: Tel Hashomer Medical Research, Infrastructure and Services Ltd. , Ramot at Tel Aviv University Ltd.
Inventor： Eli Konen , Arnaldo Mayer , Moshe Hadani , Nahum Kiryati , Ori Weber
Abstract: A method of providing an intraoperative magnetic resonance image of a target site of a patient body at which a medical procedure is performed comprising determining a rigid body transform that transforms a high resolution preoperative magnetic resonance image, MRIo, of the target site to a preoperative magnetic resonance image, iMRIo, of the target site acquired by an interoperative iMRI scanner, and a non-rigid body transform that transforms the iMRIo image to an image iMRI1 image of the site acquired by the interoperative iMRI scanner during the medical procedure, and using the rigid and non-rigid body transforms to transform the high resolution MRIo image.
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公开(公告)号：US09975944B2
公开(公告)日：2018-05-22
申请号：US14774088
申请日：2014-03-11
Inventor： Yehuda Shoenfeld , Howard Amital , Smadar Gertel
CPC classification number: C07K14/78 , A61K38/00 , C07K14/47 , C07K14/4713 , C07K14/75 , C07K2319/00 , C12N9/88 , C12Y402/01011
Abstract: The present invention provides synthetic peptides, including peptides comprising a plurality of epitopes, each epitope being derived from a different protein, and peptides comprising a plurality of citrullinated residues. The present invention also related to use of said peptides for the treatment of autoimmune diseases and disorder.
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公开(公告)号：US20180016311A1
公开(公告)日：2018-01-18
申请号：US15721404
申请日：2017-09-29
Inventor： Amir ZLOTKIN , Hen Kestenboim
IPC: C07K14/435 , A61L27/22 , C07K14/415 , C07K7/08 , C07K7/06 , C07K14/46 , A61L27/34 , C02F1/50 , A61L31/16 , A61L31/10 , A61L31/04 , A61L29/16 , A61L29/08 , A61L29/04 , C09D5/16 , C02F3/34
CPC classification number: C07K14/43595 , A61L27/227 , A61L27/34 , A61L29/048 , A61L29/085 , A61L29/16 , A61L31/047 , A61L31/10 , A61L31/16 , C02F1/50 , C02F3/34 , C02F2303/20 , C07K7/06 , C07K7/08 , C07K14/415 , C07K14/461 , C09D5/1625
Abstract: Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of YDYNWY (SEQ ID NO: 1), YDYNLY (SEQ ID NO: 2), FDYNFY (SEQ ID NO: 3), FDYNLY (SEQ ID NO: 4), FDYNWY (SEQ ID NO: 5), YDWNLY (SEQ ID NO: 6), YDWHLY (SEQ ID NO: 7), and WDYNLY (SEQ ID NO: 8), extracted from organisms such as aquatic organisms and moss or any other sequence described herein, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.
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公开(公告)号：US09782387B2
公开(公告)日：2017-10-10
申请号：US15101079
申请日：2014-10-29
Inventor： Merav Leiba , Gabriela Rozic
IPC: A61K31/404 , A61K45/06 , C07D405/04
CPC classification number: A61K31/404 , A61K45/06 , C07D405/04 , A61K2300/00
Abstract: A compound represented by Formula I is provided for use in the treatment of a hematological malignancy in a subject in need thereof. Also provided are compositions and kits which comprise the compound.
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