公开(公告)号：US06335404B1

公开(公告)日：2002-01-01

申请号：US08223351

申请日：1994-04-05

Applicant: Thomas Cleveland Kirk ,  David Witiak

Inventor： Thomas Cleveland Kirk ,  David Witiak

IPC: C08F216

CPC classification number: C08F220/04 ,  C02F5/10 ,  C11D3/3757 ,  C11D3/3769 ,  C11D3/3773 ,  C11D3/3776 ,  C11D3/3784 ,  C23F11/173 ,  C23F14/02

Abstract: The present invention provides an efficient aqueous polymerization process for preparing a water soluble polymer product having a molecular weight of less than 30,000. The polymer product is formed from about 3 to about 50 weight percent of at least one monoethylenically unsaturated dicarboxylic acid monomer, from about 50 to about 97 weight percent of at least one monoethylenically unsaturated monocarboxylic acid monomer, and from 0 to about 40 weight percent of one or more carboxyl-free monoethylenically unsaturated monomers. The process of the present invention may be run as a batch or continuous process. The process uses at least one chain transfer agent and is conducted at an aqueous solution pH of about 3 or less to keep the molecular weight of the polymer product below 30,000. The polymer product produced by the process of the present invention is useful as an additive in detergents, cleaning formulations, and water circulating systems.

Abstract translation: 本发明提供了一种用于制备分子量小于30,000的水溶性聚合物产品的有效的水性聚合方法。 聚合物产物由约3至约50重量％的至少一种单烯键式不饱和二羧酸单体，约50至约97重量％的至少一种单烯属不饱和单羧酸单体和0至约40重量％ 一种或多种无羧基单烯属不饱和单体。 本发明的方法可以以分批或连续方法进行。 该方法使用至少一种链转移剂，并在约3或更低的水溶液pH下进行，以保持聚合物产物的分子量低于30,000。 通过本发明方法生产的聚合物产品可用作洗涤剂，清洁配方和水循环系统中的添加剂。

公开(公告)号：US6065181A

公开(公告)日：2000-05-23

申请号：US146498

申请日：1998-09-03

Applicant: Thomas Cleveland ,  Gregory A. Cleveland

Inventor： Thomas Cleveland ,  Gregory A. Cleveland

IPC: A47L5/26 ,  A63F3/06

CPC classification number: A63F3/068 ,  A47L5/26

Abstract: A lottery ticket scratching device is provided including a housing adapted to contain at least one battery and a motor assembly including a motor mounted within the housing and including a rotor. Also included is a scratch assembly in communication with the rotor and positioned at an opening of the housing for removing a film from a ticket upon the rotation of the scratch assembly. A switch is connected between the motor and the battery for selectively rotating the scratch assembly.

Abstract translation: 提供一种彩票刮刮装置，其包括适于容纳至少一个电池的壳体和包括安装在壳体内并包括转子的电动机的电动机组件。 还包括与转子连通并且定位在壳体的开口处的刮擦组件，用于在刮擦组件旋转时从票上移除胶片。 开关连接在电动机和电池之间，用于选择性地旋转刮擦组件。

公开(公告)号：US20170196862A2

公开(公告)日：2017-07-13

申请号：US14876525

申请日：2015-10-06

Applicant: Mark Thomas Miller ,  Corey Anderson ,  Vijayalaksmi Arumugam ,  Brian Richard Bear ,  Hayley Marie Binch ,  Jeremy J. Ciemens ,  Thomas Cleveland ,  Erica Conroy ,  Timothy Richard Coon ,  Bryan A. Frieman ,  Peter Diederik Jan Grootenhuis ,  Raymond Stanley Gross ,  Sara Sabina Hadida-Ruah ,  Haripada Khatuya ,  Pramod Virupax Joshi ,  Paul John Krenitsky ,  Chun-Chieh Lin ,  Gulin Erdogan Marelius ,  Vito Melillo ,  Jason McCartney ,  Georgia McGaughey Nicholls ,  Fabrice Jean Denis Pierre ,  Alina Silina ,  Andreas P. Termin ,  Johnny Uy ,  Jinglan Zhou

Inventor： Mark Thomas Miller ,  Corey Anderson ,  Vijayalaksmi Arumugam ,  Brian Richard Bear ,  Hayley Marie Binch ,  Jeremy J. Ciemens ,  Thomas Cleveland ,  Erica Conroy ,  Timothy Richard Coon ,  Bryan A. Frieman ,  Peter Diederik Jan Grootenhuis ,  Raymond Stanley Gross ,  Sara Sabina Hadida-Ruah ,  Haripada Khatuya ,  Pramod Virupax Joshi ,  Paul John Krenitsky ,  Chun-Chieh Lin ,  Gulin Erdogan Marelius ,  Vito Melillo ,  Jason McCartney ,  Georgia McGaughey Nicholls ,  Fabrice Jean Denis Pierre ,  Alina Silina ,  Andreas P. Termin ,  Johnny Uy ,  Jinglan Zhou

IPC: A61K31/506 ,  A61K31/4418 ,  A61K31/444 ,  A61K31/44 ,  C07D213/84 ,  C07D231/14 ,  A61K31/415 ,  C07D209/42 ,  A61K31/404 ,  C07D401/12 ,  A61K31/4439 ,  C07D401/14 ,  C07D231/12 ,  A61K31/497 ,  C07D417/12 ,  C07D405/14 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4525 ,  A61J1/03 ,  C07D213/82

CPC classification number: A61K31/506 ,  A61J1/035 ,  A61K31/404 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4525 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  C07D209/18 ,  C07D209/42 ,  C07D209/49 ,  C07D213/64 ,  C07D213/73 ,  C07D213/82 ,  C07D213/84 ,  C07D231/12 ,  C07D231/14 ,  C07D231/20 ,  C07D235/24 ,  C07D239/34 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D405/14 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

公开(公告)号：US08741939B2

公开(公告)日：2014-06-03

申请号：US13848970

申请日：2013-03-22

Applicant: Sara S. Hadida Ruah ,  Mark T. Miller ,  Ashvani K. Singh ,  Thomas Cleveland ,  Lewis R. Makings ,  Matthew Hamilton ,  Peter D. J. Grootenhuis

Inventor： Sara S. Hadida Ruah ,  Mark T. Miller ,  Ashvani K. Singh ,  Thomas Cleveland ,  Lewis R. Makings ,  Matthew Hamilton ,  Peter D. J. Grootenhuis

IPC: A61K31/427 ,  C07D277/20

CPC classification number: A61K31/426 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  C07D263/48 ,  C07D277/46 ,  C07D277/82 ,  C07D295/15 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  G01N33/5076

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：US20130252333A1

公开(公告)日：2013-09-26

申请号：US13848970

申请日：2013-03-22

Applicant: Sara S. Hadida Ruah ,  Mark T. Miller ,  Ashvani K. Singh ,  Thomas Cleveland ,  Lewis R. Makings ,  Matthew Hamilton ,  Peter D.J. Grootenhuis

Inventor： Sara S. Hadida Ruah ,  Mark T. Miller ,  Ashvani K. Singh ,  Thomas Cleveland ,  Lewis R. Makings ,  Matthew Hamilton ,  Peter D.J. Grootenhuis

IPC: C07D277/46 ,  C07D295/15 ,  C07D417/06

CPC classification number: A61K31/426 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  C07D263/48 ,  C07D277/46 ,  C07D277/82 ,  C07D295/15 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  G01N33/5076

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括CF跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

公开(公告)号：US08431605B2

公开(公告)日：2013-04-30

申请号：US13174844

申请日：2011-07-01

Applicant: Sara S. Hadida Ruah ,  Mark T. Miller ,  Ashvani K. Singh ,  Thomas Cleveland ,  Lewis R. Makings ,  Matthew Hamilton ,  Peter D. J. Grootenhuis

Inventor： Sara S. Hadida Ruah ,  Mark T. Miller ,  Ashvani K. Singh ,  Thomas Cleveland ,  Lewis R. Makings ,  Matthew Hamilton ,  Peter D. J. Grootenhuis

IPC: A61K31/427 ,  C07D277/20

CPC classification number: A61K31/426 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  C07D263/48 ,  C07D277/46 ,  C07D277/82 ,  C07D295/15 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  G01N33/5076

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括CF跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

公开(公告)号：US20120040020A1

公开(公告)日：2012-02-16

申请号：US13104291

申请日：2011-10-27

Applicant: Jean-Damien Charrier ,  Steven John Durrant ,  David Kay ,  Michael O'Donnell ,  Ronald Marcellus Alphonsus Knegtel ,  Somhairle MacCormick ,  Joanne Pinder ,  Stephen Clinton Young ,  Haley Marie Binch ,  Thomas Cleveland ,  Lev Tyler Dewey Fanning ,  Dennis James Hurley ,  Pramod Joshi ,  Urvi Jagdishbhai Sheth ,  Alina Silina ,  Philip Michael Reaper ,  Anisa Nizarali Virani

Inventor： Jean-Damien Charrier ,  Steven John Durrant ,  David Kay ,  Michael O'Donnell ,  Ronald Marcellus Alphonsus Knegtel ,  Somhairle MacCormick ,  Joanne Pinder ,  Stephen Clinton Young ,  Haley Marie Binch ,  Thomas Cleveland ,  Lev Tyler Dewey Fanning ,  Dennis James Hurley ,  Pramod Joshi ,  Urvi Jagdishbhai Sheth ,  Alina Silina ,  Philip Michael Reaper ,  Anisa Nizarali Virani

IPC: A61K33/24 ,  C07D401/14 ,  C07D413/14 ,  A61K31/551 ,  A61K31/497 ,  A61K31/5377 ,  C07D417/14 ,  A61K31/541 ,  C07D405/14 ,  C07D471/04 ,  C07D491/113 ,  A61K31/506 ,  C07D513/04 ,  C07D409/14 ,  C07D487/04 ,  A61K31/4985 ,  C07D487/10 ,  A61K38/16 ,  A61K31/704 ,  A61K31/675 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/706 ,  A61K38/12 ,  A61P17/06 ,  A61P35/00 ,  A61P31/18 ,  A61P1/16 ,  A61P31/20 ,  C07D403/14

CPC classification number: C07D403/14 ,  A61K31/497 ,  A61K31/541 ,  A61K31/551 ,  A61K45/06 ,  C07D241/28 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D491/113

Abstract: The present disclosure relates to pyrazine compounds of formula I: wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.

Abstract translation: 本公开涉及式I的吡嗪化合物：其中L，n，R 1和R 2如说明书中所述。 这些化合物可用作ATR蛋白激酶的抑制剂。 本公开还涉及包含本公开内容的化合物的药学上可接受的组合物; 使用本公开的化合物治疗各种疾病，病症和病症的方法; 制备本公开的化合物的方法; 用于制备本公开的化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。

公开(公告)号：US20070287847A1

公开(公告)日：2007-12-13

申请号：US11457996

申请日：2006-07-17

Applicant: Nathan Tait Allen ,  Brian Leslie Goodall ,  Thomas Cleveland Kirk ,  Lester Howard McIntosh

Inventor： Nathan Tait Allen ,  Brian Leslie Goodall ,  Thomas Cleveland Kirk ,  Lester Howard McIntosh

IPC: C07F9/70

CPC classification number: C07F9/5022

Abstract: Ligand synthesis methods for the preparation of ligands having the formula wherein Q is selected from phosphorus, arsenic and antimony; wherein X1, X2 and X3 are carbon anions; and, wherein R15 is selected from —SO3, —SO2N(R18), —CO2, —PO3, —AsO3, —SiO2, —C(CF3)2O; where R18 is selected from a hydrogen, a halogen, a hydrocarbyl group and a substituted hydrocarbyl group, are disclosed. Also disclosed are methods of complexing the ligands with late transition metals to form catalyst complexes that catalyze polymerization reactions and/or Heck coupling reactions.

Abstract translation: 用于制备具有下式的配体的配体合成方法其中Q选自磷，砷和锑; 其中X 1，X 2和X 3是碳阴离子; 和其中R 15选自-SO 3，-SO 2 N（R 18）， - CO 2，-PO 3，-AsO 3，-SiO 2，-C（CF 3）2， 3 O 2; 其中R 18选自氢，卤素，烃基和取代的烃基。 还公开了使配体与后过渡金属络合以形成催化聚合反应和/或Heck偶联反应的催化剂络合物的方法。