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    Diagnostic control compositions
    23.
    发明授权
    Diagnostic control compositions 有权

    公开(公告)号：US11713491B2

    公开(公告)日：2023-08-01

    申请号：US17996919

    申请日：2021-04-23

    申请人： University of the Witwatersrand, Johannesburg

    发明人： Bavesh Davandara Kana ,  Edith Erika Machowski

    IPC分类号： C12N15/09 ,  C12Q1/68 ,  C12Q1/70 ,  C12Q1/00 ,  C12Q1/6806

    CPC分类号： C12Q1/70 ,  C12Q1/6806 ,  C12Q2522/101 ,  C12Q2525/143 ,  C12Q2545/113

    摘要： Provided herein is a nucleotide cassette comprising an inducible promoter, a nucleotide sequence that corresponds to at least one single stranded RNA diagnostic target, a nucleotide sequence that encodes artemin, a molecular switch and a nucleotide sequence that encodes a DNAse enzyme and is under control of the molecular switch, wherein the single stranded RNA diagnostic target is a sequence detected by a molecular diagnostic assay. In some embodiments the nucleotide cassette can be used to obtain an RNA expression product. Also provided are vectors and cells comprising the nucleotide cassette or the RNA expression product thereof. The nucleotide cassette can further be used to obtain a diagnostic control composition comprising a non-pathogenic recombinant bacterium having a modified genetic content comprising the nucleotide cassette and to methods of producing such recombinant bacteria.

    DIAGNOSTIC CONTROL COMPOSITIONS
    24.
    发明申请
    DIAGNOSTIC CONTROL COMPOSITIONS 有权

    公开(公告)号：US20230127238A1

    公开(公告)日：2023-04-27

    申请号：US17996919

    申请日：2021-04-23

    申请人： University of the Witwatersrand, Johannesburg

    发明人： Bavesh Davandara KANA ,  Edith Erika MACHOWSKI

    IPC分类号： C12Q1/70 ,  C12Q1/6806

    摘要： Provided herein is a nucleotide cassette comprising an inducible promoter, a nucleotide sequence that corresponds to at least one single stranded RNA diagnostic target, a nucleotide sequence that encodes artemin, a molecular switch and a nucleotide sequence that encodes a DNAse enzyme and is under control of the molecular switch, wherein the single stranded RNA diagnostic target is a sequence detected by a molecular diagnostic assay. In some embodiments the nucleotide cassette can be used to obtain an RNA expression product. Also provided are vectors and cells comprising the nucleotide cassette or the RNA expression product thereof. The nucleotide cassette can further be used to obtain a diagnostic control composition comprising a non-pathogenic recombinant bacterium having a modified genetic content comprising the nucleotide cassette and to methods of producing such recombinant bacteria.

    METHOD OF APPLYING AN ANTIMICROBIAL SURFACE COATING TO A SUBSTRATE
    26.
    发明申请
    METHOD OF APPLYING AN ANTIMICROBIAL SURFACE COATING TO A SUBSTRATE 审中-公开

    公开(公告)号：US20200299843A1

    公开(公告)日：2020-09-24

    申请号：US16652389

    申请日：2018-09-25

    申请人： University of the Witwatersrand, Johannesburg

    发明人： Ionel BOTEF ,  Michael David Ivan LUCAS ,  Sandy van VUUREN

    IPC分类号： C23C24/04 ,  A01N59/20 ,  A01N59/06

    摘要： THIS invention relates to a method of applying an antimicrobial surface coating to a substrate, and more particularly to a method of applying an antimicrobial surface coating to a polymeric substrate manufactured by way of additive manufacturing. The method includes the steps of providing a body to be coated, the body having a surface area and cold spraying an antimicrobial metal powder on at least part of the surface area of the body so as to form an antimicrobial coating on the body. The method is characterized in that the body is made from a polymeric material by way of an additive manufacturing process.

    OPTICAL COMMUNICATION METHOD AND SYSTEM
    27.
    发明申请
    OPTICAL COMMUNICATION METHOD AND SYSTEM 审中-公开

    公开(公告)号：US20200092028A1

    公开(公告)日：2020-03-19

    申请号：US15750959

    申请日：2016-08-05

    申请人： UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG ,  CSIR

    发明人： Andrew FORBES ,  Angela DUDLEY ,  Carmelo Guadalupe Rosales GUZMÁN

    IPC分类号： H04J14/04 ,  H04B10/516 ,  H04B10/66

    摘要： The invention relates to optical communication methods and systems. In particular, the invention relates to an optical communication method and system which is configured to create a multiplexed beam from an incident beam, wherein the multiplexed beam comprises a predetermined number of spatial modes simultaneously generated and multiplexed together in a fashion that is independent of wavelength. The spatial modes have two degrees of spatial freedom. The multiplexed beam is de-multiplexed downstream from multiplexing thereof in the communication system in a simultaneous fashion independent of wavelength to yield the predetermined number of spatial mode. The modes are used in optical communication as channels or as bits in a bit (de) encoding scheme.